Epileptogenesis involves an increase in excitatory synaptic strength in the brain in a manner similar to synaptic potentiation. In the present study we investigated the mechanisms of short-term synaptic potentiation in patients with focal epilepsy by using 5 Hz repetitive transcranial magnetic stimulation (rTMS), a non invasive neurophysiological technique able to investigate the mechanisms of synaptic plasticity in humans. Ten patients with focal idiopathic cortical epilepsy were studied. 5 Hz-rTMS (10 stimuli-trains, 120% of motor threshold, RMT) (...) was delivered over the first dorsal interosseus (FDI) motor area of both (affected and unaffected) hemispheres. Changes in the motor evoked potential (MEP) size in the FDI muscle during the trains and the RMT were measured and compared between the hemispheres. 5 Hz-rTMS was also delivered in a group of healthy subjects over both hemispheres. 5 Hz-rTMS in patients elicited a reduced MEP facilitation compared to normal subjects. The reduced MEP amplitude was more evident in the affected hemisphere than in the unaffected hemisphere. RMT in the affected hemisphere was higher than in the unaffected hemisphere and in healthy subjects. Our findings showing a decreased response to 5 Hz-rTMS over the affected hemisphere, differently from the expected results suggest a reduced cortical excitability in epileptic patients. We hypothesize an altered balance between excitatory and inhibitory circuits in epileptic patients under chronic therapy. (shrink)

Dear editor, we read with interest the article by Gilio et al.. Previous transcranial magnetic stimulation studies in focal epileptic patients brought to controversial results.

Michael Ondaatje’s Warlight (2018), his latest novel to-date, contains nostalgic elements of strangeness and cartography. In this paper, I short-circuit such themes with health under medical humanities, which heeds a Nietzschean counsel of close reading in literature. To do so, I explore the case of Rachel's illness, namely her epileptic seizures, as an instance that drives her impetus for active forgetting and eventual convalescence. A close hermeneutical reading of the novel can reveal that both of Nietzsche’s ideas on active forgetting (...) and convalescence provide traction in terms of what this paper constructs as Rachel’s pathography or narration of illness. Shifting the focus from the main narrator, Nathaniel, I argue that it is not the novel's reliance on memory but the subplot events of Nathaniel's sister and her epilepsy that form a substantial case of medical or health humanities. (shrink)

Purpose: Some enigmatic remarks and behaviors of Socrates have been a subject of debate among scholars. We investigated the possibility of underlying epilepsy in Socrates by analyzing pathographic evidence in ancient literature from the viewpoint of the current understanding of seizure semiology. Methods: We performed a case study from a literature survey. Results: In 399 BCE, Socrates was tried and executed in Athens on the charge of “impiety.” His charges included the “introduction of new deities” and “not believing in (...) the gods of the state,” because he publicly claimed that he was periodically and personally receiving a “divine sign,” or daimonion, that directed him in various actions. We found textual evidence that his daimonion was probably a simple partial seizure (SPS) of temporal lobe origin. It was a brief voice that usually prohibited Socrates from initiating certain actions. It started when he was a child, and it visited Socrates unpredictably. Moreover, we found at least two descriptions of Socrates’ unique behavior that are consistent with complex partial seizures (CPSs). The fact that Socrates had been experiencing both SPSs and CPSs periodically since childhood makes the diagnosis of temporal lobe epilepsy (TLE) likely. Conclusions: We hypothesize that Socrates had a mild case of TLE without secondary generalization. This is the first report in 2,400 years to present a pathographic diagnosis of TLE in Socrates based on specific diagnostic features in the ancient textual evidence. Our study demonstrates that the knowledge of modern epileptology could help understand certain behaviors of historic figures. (shrink)

In this paper, I try to support Gerard Genette's conception of focalization, that was first proposed by him in his book Narrative Discourse (1980). Focalization is known as the perspective of the narrator in fiction. It includes a comparative study of layers of focalization in multicultural perspectives by analysing the narratological techniques in two of the most controversial novels. Those novels represent two worlds apart; one is AlaaAlaswany’sYacobian Building and the other is Malcolm Lowry’s Under the Volcano. In both novels, (...) the narrators are absent from the two stories told. These narrators are depersonalized and they are lacking definable personalities and opinions. (shrink)

In their work Gilio et al. investigate the mechanisms involved in the regulation of excitability of the cortex in epileptic subjects, and in particular their epileptogenic threshold.

Objective: The purpose of this study was to compare the depression and resilience scores of children and adolescents with epilepsy and healthy controls. Furthermore, its purpose was to investigate whether resilience mediates the relationship between epilepsy and depression. -/- Methods: 100 children and adolescents (46 patients and 54 healthy controls) were included in the study. Questionnaire on sociodemographic data was administered to the all participants at the time of application to our center and all participants were asked to (...) complete the Anxiety and Depression Scale in Children-Revised (RCADS-CV) and Child and Adolescent Psychological Resilience Scale (CYRM-12). -/- Results: 46 epilepsy patients had higher RCADS-CV depression scores (P=0.008) and lower psychological resilience scores (P= 0.001) compared to the control group. Although there was a negative correlation between psychological resilience scores and RCADS-CV depression scores in epilepsy patients and the control group, this correlation was not statistically significant. -/- Conclusion: We found that children and adolescents with epilepsy had lower psychological resilience and higher depression symptoms compared to healthy controls. (shrink)

As Peter Niebyl has documented, one of the issues in which the Wittenberg-based physician and philosopher Daniel Sennert (1572–1637) departed from Paracelsus and his followers was the concept of disease. Paracelsus and some of his followers regarded diseases as real beings—so-called “disease-entities” (entia morbis) that can enter into the body of a living being and thereafter possess a clearly defined location in the affected organism. 1 For Sennert, such a view is a dangerous confusion between disease and its causes. According (...) to him, causes of disease can be present in an organism without actually causing a disease (Sennert 1629, p. 253). Moreover, he shares the traditional Christian doctrine .. (shrink)

Can we consciously see more items at once than can be held in visual working memory? This question has elud- ed resolution because the ultimate evidence is subjects’ reports in which phenomenal consciousness is filtered through working memory. However, a new technique makes use of the fact that unattended ‘ensemble prop- erties’ can be detected ‘for free’ without decreasing working memory capacity.

This paper defends the idea that alterations in social perception of people with epilepsy may be crucial in the development of co-morbidities, involving a circular and mutual relationship between the person and her/his social environment, between the self and the world. We aim at exploring the role of these processes in psychopathological phenomena in people with epilepsy. Through a phenomenological and enactive account of intersubjectivity and the model of circular causality, enriched with interviews conducted with people with (...) class='Hi'>epilepsy, we develop the hypothesis that the originary domain of a person’s experience with epilepsy expands and modifies the fundamental interrogation of the sense of self. Furthermore, we observe how disturbances in the dynamical coupling and coordination among agents may contribute to psychopathological phenomena, and to changes in intersubjectivity and social perception. (shrink)

Following Shelly Kagan’s useful terminology, foundational consequentialists are those who hold that the ranking of outcomes is at the foundation of all moral assessment. That is, they hold that moral assessments of right and wrong, virtuous and vicious, morally good and morally bad, etc. are all ultimately a function of how outcomes rank. But foundational consequentialists disagree on what is to be directly evaluated in terms of the ranking of outcomes, which is to say that they disagree on what the (...) primary evaluative focal point is. Act-consequentialists take acts to be the primary evaluative focal point. They evaluate acts in terms of how their outcomes rank (the higher ranked the outcome, the morally better the act), but evaluate everything else in terms of the morally best acts. Thus, the morally best rules are those that would, if internalized, most reliably lead us to perform the morally best acts. Rule-consequentialists, by contrast, take rules to be the primary evaluative focal point. They evaluate rules according to how their outcomes rank and then assess everything else in terms of the morally best rules. Thus, the morally best acts are those that conform to the morally best rules. In this paper, I argue that foundational consequentialists should not take the primary evaluative focal point (or points) to be acts, rules, virtues, or even everything. In so doing, I argue against act-consequentialism, rule-consequentialism, and global consequentialism. But my project is not entirely negative, for I argue that the primary evaluative focal point should be a complex of acts and attitudes. In the end, then, I claim that foundational consequentialists should accept a new kind of consequentialism, which I call attitude-consequentialism. (shrink)

I develop an epistemic focal bias account of certain patterns of judgments about knowledge ascriptions by integrating it with a general dual process framework of human cognition. According to the focal bias account, judgments about knowledge ascriptions are generally reliable but systematically fallible because the cognitive processes that generate them are affected by what is in focus. I begin by considering some puzzling patters of judgments about knowledge ascriptions and sketch how a basic focal bias account seeks (...) to account for them. In doing so, I argue that the basic focal bias account should be integrated in a more general framework of human cognition. Consequently, I present some central aspects of a prominent general dual process theory of human cognition and discuss how focal bias may figure at various levels of processing. On the basis of this discussion, I attempt to categorize the relevant judgments about knowledge ascriptions. Given this categorization, I argue that the basic epistemic focal bias account of certain contrast effects and salient alternatives effects can be plausibly integrated with the dual process framework. Likewise, I try to explain the absence of strong intuitions in cases of far-fetched salient alternatives. As a manner of conclusion, I consider some methodological issues concerning the relationship between cognitive psychology, experimental data and epistemological theorizing. -/- . (shrink)

The aim of this study was to obtain a baseline for clinical application of electroencephalography (EEG) in children and to evaluate the EEG findings in children with various acute and chronic central nervous system disorders and nonepileptic events. EEG records of 250 patients were studied in Neurophysiology Departments of Queen Rania Al-Abdullah Hospital for Children in Jordan. For each patient who had undergone EEG the following data were recorded: age, sex, source of referral (inpatient or outpatient department), reason for EEG, (...) diagnostic impressions, clinical presentation, the result of the EEG examinations and clinical correlation between the seizure type and EEG finding. Males (55%) were slightly outnumbered than females. The majority of cases were between 6-12 years. Total of 63.2% of all referrals for EEG were from outpatient clinics while inpatients accounted for 36.8% of referred cases, with Pediatric Neurology Department referrals being the highest (28.8%). Majority of diagnosis at referral were suspected epilepsy (80%) with epileptiform EEG abnormalities in 32%. Over all 64% the EEG records were normal, including all EEG records of children with syncope and headache. We conclude that there are many unnecessary routine EEG recordings in children. Investigation of epilepsy and acute encephalopathies appear to be the most valuable indications for routine pediatric EEG. EEG can be helpful in classification of seizures. Finding a way to reduce EEG requests is recommended. (shrink)

This essay provides a medical theory that could clarify enigmas surrounding the historical Socrates. It offers textual evidence that Socrates had temporal lobe epilepsy and that its two types of seizure manifested as recurrent voices and peculiar behaviour, both of which were notorious hallmarks of Socrates. Common and immediate criticisms against the methodology of retrospective diagnosis are addressed first. Next, the diagnostic reasoning is presented in detail. The possibility of temporal lobe personality in Socrates is also considered. The important (...) implication of this theory is that one of the charges against Socrates, introducing new divinities, was a now well-known neurologic symptom. (shrink)

Objective: Kindling is an animal model of epilepsy induced by electrical stimulation of the brain. The present study aimed to present a different perspective with a bibliometric approach by using the literature data on the “Kindling model” related keywords in the Web of Science (WoS) online database between 1980 and 2023. -/- Methods: The bibliometric data were obtained from the online database WoS and analyzed and visualized with the VoS Viewer Program. The bibliometric datasets were analyzed and visualized regarding (...) article productivity numbers according to years, article productivity numbers according to countries, the most used keywords according to authors, and cross-country cooperation. -/- Result: Considering the results of the analysis of the published datasets, 2022 was determined as the year with the highest article productivity, and an acceleration was observed in the publication increase rate on the subject in general. When the order of the countries in the top three in the number of article productivity was examined, the USA, Germany, and Japan are the main countries, respectively. The most used keywords by the authors were determined as “Epilepsy”, “Kindling”, and “Hippocampus”. In the cooperation among countries, it was found that the USA, Germany, and Japan had more cooperation with other countries, respectively. -/- Conclusıon: This study will contribute to the literature by providing a detailed understanding of the research basis, relevant research results, current research boundaries and main research focus in the Kindling Model. (shrink)

According to the care crisis in modern medicine, the existential needs of patients are not sufficiently satisfied. One idea is that to address the crisis physicians should be educated to be virtuous. This suggestion is helpful but incomplete. It does not take into account the part of (non-)human factors, including (medical) technologies. In particular, the paper focuses on online caring forums and argues that they are technological factors that can play the role of focal things, in which the members (...) gather together to do a care-related focal practice. Furthermore, we empirically study the online forums of Ninisite, a popular Persian website on pregnancy, childbirth, and parenting, and suggest that these forums shape focal practices that are helpful in alleviating the care crisis. (shrink)

This paper examines the narrative techniques; setting, focalization and flashback, employed by Adekunle Mamudu and Sophia Akhuemokhan in The Beauty of Madness and Changing Colors respectively, to arouse deep meanings and intense emotions. These techniques contribute to the message the writers intend to pass across to the readers. While Akhuemokhan uses these techniques in Changing Colors to teach morals and promote ethnic principles, Mamudu’s aim in The Beauty of Madness is to expose some ills revolving in the society and launch (...) sanity back to the society. (shrink)

T. M. Scanlon suggests that the binding nature of promises itself plays a role in allowing a promisee rationally to expect follow through even while that binding nature itself depends on the promisee’s rational expectation of follow through. Kolodny and Wallace object that this makes the account viciously circular. The chapter defends Scanlon’s theory from this objection. It argues that the basic complaint is a form of wrong kinds of reason objection. The thought is that the promisee’s reason to expect (...) compliance are undermined if the promise is binding only when the promisee forms that very expectation. The chapter suggests that other uncontroversially rational processes of multi-person coordination involve beliefs with the very same feature. Focal point reasoning in the theory of games is one example. In coordination situations it can be rational to believe that another person will do something precisely because that person expects you to believe what one does about what they’ll do. An examination of the reasoning in such cases motivates a group reflection principle that vindicates the reasoning employed in Scanlon’s account. -/- . (shrink)

This dissertation is an attempt to find a single framework for understanding two seemingly conflicting aspects of Nabokov's Russian novels---the metaphysical and the existential. The metaphysical aspect is analyzed according to Leibniz's "Monadology," with its key concepts of the monad, pre-established harmony, the optimization of the universe, and sufficient reason. The existential aspect is examined according to Sartre's theory of the gaze from "Being and Nothingness"; its main notions are being-for-another, radical individuation and intersubjective struggle. Concern with the level of (...) being is assumed to be the most basic and unifying element of the Nabokovian worldview. It is shown that Nabokov conceives individual being as value, and that he understands self-authorship as self-ownership. The value of individual being is threatened by intersubjective contact: the other, via the gaze, can undermine its property status, and eventually alienate it. All particular plots are derived from these underlying premises. The key Nabokovian themes of blindness, non-transparency, loss, memory and art are demonstrated to refer back to the root concepts of the gaze and self-protection. ;The dissertation develops two original conceptual tools: a theory of unreliable focalization and a theory of paranoid experience ;Close readings of Nabokov's texts have resulted in several philological findings. Structural and textual parallels have been discovered between "Mashen'ka" and Shakespeare's "Hamlet," as well as between "Priglashenie na kazn'" and Descartes' "Meditations." It has also been shown that the protagonist's story in "Zashchita Luzhina" is repeated four times and not two. (shrink)

The focal point of this chapter is to discuss the concept of computer regulated testing and its implications in an era of Severe Acute Respiratory Syndrome (SARS) related infection pandemics. This is especially significant because during the outbreak of most SARS-related diseases (like the COVID-19), social and physical distancing is advocated by the government of different nations. SARS-related diseases are caused by a virus known as the coronavirus which affects the respiration of infected persons or animals. These diseases can (...) be spread through air if droplets from an infected get to a non-tainted individual. (shrink)

Introduction: We report an epileptic patient who experienced hallucinatory visual experiences of autobiographical memories from her past. These visual experiences were confined to the lower left quadrant of her visual field. -/- Methods: We carried out a single-case study that used brain-imaging, EEG and behavioural methods to study this patient. -/- Results: We found that this patient had an incomplete left inferior homonymous quadrantanopia due to a lesion of right occipital cortex, and also that she showed neurological abnormalities in right (...) temporal cortex, a region that is part of the brain’s autobiographical-memory circuit. -/- Conclusion: We attribute the occurrence of this patient’s autobiographical-memory hallucinations to the combination of degraded visual input to right temporal cortex plus hyperexcitability of that region. (shrink)

Neurological syndromes in which consciousness seems to malfunction, such as temporal lobe epilepsy, visual scotomas, Charles Bonnet syndrome, and synesthesia offer valuable clues about the normal functions of consciousness and ‘qualia’. An investigation into these syndromes reveals, we argue, that qualia are different from other brain states in that they possess three functional characteristics, which we state in the form of ‘three laws of qualia’. First, they are irrevocable: I cannot simply decide to start seeing the sunset as green, (...) or feel pain as if it were an itch; second, qualia do not always produce the same behaviour: given a set of qualia, we can choose from a potentially infinite set of possible behaviours to execute; and third, qualia endure in short-term memory, as opposed to non-conscious brain states involved in the on-line guidance of behaviour in real time. We suggest that qualia have evolved these and other attributes because of their role in facilitating non-automatic, decision-based action. We also suggest that the apparent epistemic barrier to knowing what qualia another person is experiencing can be overcome by using a ‘bridge’ of neurons; and we offer a hypothesis about the relation between qualia and one's sense of self. (shrink)

The zetetic turn in epistemology raises three questions about epistemic and zetetic norms. First, there is the relationship question: what is the relationship between epistemic and zetetic norms? Are some epistemic norms zetetic norms, or are epistemic and zetetic norms distinct? Second, there is the tension question: are traditional epistemic norms in tension with plausible zetetic norms? Third, there is the reaction question: how should theorists react to a tension between epistemic and zetetic norms? Drawing on an analogy to practical (...) philosophy, I develop a focal point view to resolve these motivating questions. On the focal point view, traditional epistemic norms and zetetic norms answer different types of normative questions. There is nevertheless a familiar type of evaluative tension between traditional epistemic norms and zetetic norms, but this tension is an unavoidable feature of the normative landscape and not a sign that traditional epistemic norms need revision. But if traditional epistemic norms are not zetetic norms, then in what sense is zetetic epistemology a project for epistemologists? I conclude by articulating a sense in which some nontraditional epistemic norms are zetetic norms, and in which zetetic epistemology is an important part of the study of theoretical rationality. (shrink)

Attention has become an important focal point of recent work in ethics and epistemology, yet philosophers continue to be noncommittal about what attention is. In this paper, I defend attention as selection for action in a weak form, namely that selection for action is sufficient for attention. I show that selection for action in this form is part of how we, the folk, experience it and how the cognitive scientist studies it. That is, selection for action pulls empirical and (...) folk-psychology together. Accordingly, philosophers who take seriously either source have reason to work with selection for action as their starting conception of attention. This conception provides a way to bridge empirical and philosophical concerns where attention is central. The theoretical advantages of selection for action have been obscured by the common opinion that it is easily refuted. I defend the position against many of the published objections and then deploy it to provide a foundation for the intuitive, but inchoate idea of attention being more or less, focusing on recent work in the ethics of attention. (shrink)

Debate about cognitive science explanations has been formulated in terms of identifying the proper level(s) of explanation. Views range from reductionist, favoring only neuroscience explanations, to mechanist, favoring the integration of multiple levels, to pluralist, favoring the preservation of even the most general, high-level explanations, such as those provided by embodied or dynamical approaches. In this paper, we challenge this framing. We suggest that these are not different levels of explanation at all but, rather, different styles of explanation that capture (...) different, cross-cutting patterns in cognitive phenomena. Which pattern is explanatory depends on both the cognitive phenomenon under investigation and the research interests occasioning the explanation. This reframing changes how we should answer the basic questions of which cognitive science approaches explain and how these explanations relate to one another. On this view, we should expect different approaches to offer independent explanations in terms of their different focal patterns and the value of those explanations to partly derive from the broad patterns they feature. (shrink)

Philosophy of immunology is a subfield of philosophy of biology dealing with ontological and epistemological issues related to the studies of the immune system. While speculative investigations and abstract analyses have always been part of immune theorizing, until recently philosophers have largely ignored immunology. Yet the implications for understanding the philosophical basis of organismal functions framed by immunity offer new perspectives on fundamental questions of biology and medicine. Developed in the context of history of medicine, theoretical biology, and medical anthropology, (...) philosophy of immunology differs from these related branches of study in its focus on traditional philosophical questions concerning identity, individuality, ecology, cognition, scientific methodology and theory construction. This broad agenda derives from immunology’s multifaceted research program that has developed from its initial clinical challenges of host defense, transplantation, autoimmunity, tumor immunology, and allergy. In addition to these well-established research areas, immunity is now understood to play a central role in other physiological functions, development, ecology, and evolutionary mechanics. Holding together these diverse domains of inquiry lie philosophical commitments oriented by organismal identity. In this regard, pertinent issues are raised concerning cognition (organization of immune perception and information processing), the character of individuality (framed by the ecological context of immune-mediated assimilation and rejection), and the dynamics of complex systems (understood as holistic systems biology). Indeed, immunology, in the context of cognitive science, evolutionary biology, environmental sciences, and development provides multi-focal perspectives for philosophy of science. (shrink)

The psychological and neurobiological processes underlying moral judgement have been the focus of many recent empirical studies1–11. Of central interest is whether emotions play a causal role in moral judgement, and, in parallel, how emotion-related areas of the brain contribute to moral judgement. Here we show that six patients with focal bilateral damage to the ventromedial prefrontal cortex (VMPC), a brain region necessary for the normal generation of emotions and, in particular, social emotions12–14, produce an abnor- mally ‘utilitarian’ pattern (...) of judgements on moral dilemmas that pit compelling considerations of aggregate welfare against highly emotionally aversive behaviours (for example, having to sacrifice one person’s life to save a number of other lives)7,8. In contrast, the VMPC patients’ judgements were normal in other classes of moral dilemmas. These findings indicate that, for a selective set of moral dilemmas, the VMPC is critical for normal judgements of right and wrong. The findings support a necessary role for emotion in the generation of those judgements. (shrink)

Unconscious perceptions have recently become a focal point in the debate for and against naive realism. In this paper I defend the naive realist side. More specifically, I use an idea of Martin’s to develop a new version of naive realism—neuro-computational naive realism. I argue that neuro-computational naive realism offers a uniform treatment of both conscious and unconscious perceptions. I also argue that it accommodates the possibility of phenomenally different conscious perceptions of the same items, and that it can (...) answer a further challenge to naive realism raised by Berger and Nanay. (shrink)

This paper offers the first careful analysis of the possibility that AI and humanity will go to war. The paper focuses on the case of artificial general intelligence, AI with broadly human capabilities. The paper uses a bargaining model of war to apply standard causes of war to the special case of AI/human conflict. The paper argues that information failures and commitment problems are especially likely in AI/human conflict. Information failures would be driven by the difficulty of measuring AI capabilities, (...) by the uninterpretability of AI systems, and by differences in how AIs and humans analyze information. Commitment problems would make it difficult for AIs and humans to strike credible bargains. Commitment problems could arise from power shifts, rapid and discontinuous increases in AI capabilities. Commitment problems could also arise from missing focal points, where AIs and humans fail to effectively coordinate on policies to limit war. In the face of this heightened chance of war, the paper proposes several interventions. War can be made less likely by improving the measurement of AI capabilities, capping improvements in AI capabilities, designing AI systems to be similar to humans, and by allowing AI systems to participate in democratic political institutions. (shrink)

According to the attentional resources account, mind wandering (or “task-unrelated thought”) is thought to compete with a focal task for attentional resources. Here, we tested two key predictions of this account: First, that mind wandering should not interfere with performance on a task that does not require attentional resources; second, that as task requirements become automatized, performance should improve and depth of mind wandering should increase. Here, we used a serial reaction time task with implicit- and explicit-learning groups to (...) test these predictions. Providing novel evidence for the attentional resource account’s first prediction, results indicated that depth of mind wandering was negatively associated with learning in the explicit, but not the implicit, group, indicating that mind wandering is associated with impaired explicit, but not implicit, learning. Corroborating the attention resource account’s second prediction, we also found that, overall, performance improved while at the same time depth of mind wandering increased. From an implicit learning perspective, these results are consistent with the claim that explicit learning is impaired under attentional load, but implicit learning is not. (shrink)

The question of the holistic structure of an organism is a recurring theme in the philosophy of biology and has been increasingly discussed again in recent years. Organisms have recently been described as complex systems that autonomously create, maintain and reproduce themselves while constantly interacting with their environment. Key focal points include their autopoiesis, autonomy, agency and teleological structure. This perspective marks a significant advancement from the 20th-century viewpoint, which predominantly saw organisms as genetically programmed, randomly generated and blindly (...) selected survival-machines. However, crucial questions about the shape and development of organisms still lack answers. Shape and development are deeply interconnected and seem to require a holistic approach. Here, I will briefly outline a phenomenological perspective which could provide a framework for seeking answers to these fundamental questions. In particular, I propose a common four-fold phenomenal structure of the developing organism and the cognising consciousness, which makes it possible to observe the agential and teleological structure of the organism "from within". This fourfold structure also describes the molecular level and thus provides a general organismic concept. It furthermore corresponds to the four Aristotelian "causes" (conditions). (shrink)

When our smartphones distract us, much more is at stake than a momentary lapse of attention. Our use of smartphones can interfere with the building-blocks of meaningfulness and the actions that shape our self-identity. -/- By analyzing social interactions and evolving experiences, Roholt reveals the mechanisms of smartphone-distraction that impact our meaningful projects and activities. Roholt’s conception of meaning in life draws from a disparate group of philosophers—Susan Wolf, John Dewey, Hubert Dreyfus, Martin Heidegger, and Albert Borgmann. Central to Roholt’s (...) argument are what Borgmann calls focal practices: dinners with friends, running, a college seminar, attending sporting events. As a recurring example, Roholt develops the classification of musical instruments as focal things, contending that musical performance can be fruitfully understood as a focal practice. -/- Through this exploration of what generates meaning in life, Roholt makes us rethink the place we allow smartphones to occupy in the everyday. But he remains cautiously optimistic. This thoughtful, needed interrogation of smartphones shows how we can establish a positive role for technologies within our lives. (shrink)

Corporate activities conducted under the banner of creating shared value (CSV) have gained popularity over the last decade, and some MNCs have espoused that CSV has entered the heart of their practices. There has, however, been criticism about the lack of a standard definition of CSV. The purpose of the current study was to develop a working definition of CSV by identifying distinctions between CSV and various conceptions of corporate social responsibility (CSR). We conducted 26 semi-structured interviews with managers and (...) stakeholder representatives of five multinational corporations (MNCs) and three small and medium enterprises (SMEs), all headquartered or rooted in Asia. These firms had received public recognition for their CSV engagement. We compared and contrasted interviewees’ conceptions and descriptions of CSV and traditional CSR (philanthropy) and mapped these against Carroll’s four-layer model of responsible corporate management. Interviewees tended to frame CSV as a sustainable business model that generates social and economic value simultaneously. Traditional CSR was characterized as “giving back” some of the surplus from economic returns. In addition, interviewees described examples of strategic CSR, which involved pump-priming interventions for empowering and enabling stakeholders of the CSV practices of the focal firm to participate in the associated wealth and well-being co-creation. Keywords: Corporate social responsibility, creating shared value, qualitative, Asia. (shrink)

This volume of twelve specially commissioned essays about species draws on the perspectives of prominent researchers from anthropology , botany, developmental psychology , the philosophy of biology and science, protozoology, and zoology . The concept of species has played a focal role in both evolutionary biology and the philosophy of biology , and the last decade has seen something of a publication boom on the topic (e.g., Otte and Endler 1989; Ereshefsky 1992b; Paterson 1994; lambert and Spence 1995; Claridge, (...) Dawah, and Wilson 1997; Wheeler and Meier 1999; Howard and Berlocher 1998). (shrink)

This paper presents a novel account of focal stress and pitch contour in English dialogue. We argue that one should analyse and treat focus and pitch contour jointly, since (i) some pragmatic interpretations vary with contour (e.g., whether an utterance accepts or rejects; or whether it implicates a positive or negative answer); and (ii) there are utterances with identical prosodic focus that in the same context are infelicitous with one contour, but felicitous with another. We offer an account of (...) two distinct pitch contours that predicts the correct felicity judgements and implicatures, outclassing other models in empirical coverage or formality. Prosodic focus triggers a presupposition, where what is presupposed and how the presupposition is resolved depends on prosodic contour. If resolving the presupposition entails the proffered content, then the proffered content is uninteresting and hence the utterance is in-felicitous. Otherwise, resolving the presupposition may lead to an implicature. We regiment this account in SDRT. (shrink)

Pronouns often convey information about a person’s social identity (e.g., gender). Consequently, pronouns have become a focal point in academic and public debates about whether pronouns should be changed to be more inclusive, such as for people whose identities do not fit current pronoun conventions (e.g., gender non-binary individuals). Here, we make an empirical contribution to these debates by investigating which social identities lay speakers think that pronouns should encode and why. Across four studies, participants were asked to evaluate (...) different types of real and hypothetical pronouns, including binary gender pronouns, race pronouns, and identity-neutral pronouns. We sampled participants from two languages with different pronoun systems: English (N = 1,120) and Turkish (N = 260). English pronouns commonly denote binary gender (e.g., he for men), whereas Turkish pronouns are identity-neutral (e.g., o for anyone). Participants’ reasoning about pronouns reflected both a familiarity preference (i.e., participants preferred the pronoun type used in their language) and—critically—participants’ social ideologies. In both language contexts, participants’ ideological beliefs that social groups are inherently distinct (essentialism) and should be hierarchal (social dominance orientation) predicted relatively greater endorsement of binary gender pronouns and race pronouns. A preregistered experimental study with an English-speaking sample showed that the relationship between ideology and pronoun endorsement is causal: Ideologies shape attitudes toward pronouns. Together, the present research contributes to linguistic and psychological theories concerning how people reason about language and informs policy-relevant questions about whether and how to implement language changes for social purposes. (shrink)

Disjunctive antecedent conditionals —conditionals of the form if A or B, C—sometimes seem to entail both of their simplifications and sometimes seem not to. I argue that this behavior reveals a genuine ambiguity in DACs. Along the way, I discuss a new observation about the role of focal stress in distinguishing the two interpretations of DACs. I propose a new theory, according to which the surface form of a DAC underdetermines its logical form: on one possible logical form, if (...) A or B, C does entail both of its simplifications, while on the other, it does not. (shrink)

The first serious scientific studies on the brain date back to the 1800s. Two events led the studies on the brain. The first incident is an accident involving Phineas Gage, a railway worker. The two-meter-long piece of iron that entered Gage's left eye and broke up the anterior frontal lobe of the brain prompted scientists to rethink the brain. Having lived a moral life before the accident, Gage became immoral and evil after the accident. This incident revealed that the brain (...) has a relationship with evil. -/- The second event affecting the brain studies is the split brain syndrome that occurs when the corpuscallosum of patients with epilepsy is cut. The separation of the right and left brains has caused some problems in individuals. For example, while the left brain smokes, the right brain tries to block it, while the left brain drives a car, the right brain wants to get out of the way. The right brain behaves in a childish and impulsive manner and cannot be controlled. -/- After all, any disease, accident or surgery that occurs in the brain can negatively affect people's behavior and make them worse. Then, the neuroscientific origins of the evil issue should be investigated and evaluated according to neuro-philosophy. In this paper, the limits of human freedom, scientific determinism and human responsibility will be set forth. Thus, in the issue of evil, it will be shown that the biological (and psychological) structure of the human being, together with external factors such as the environment, society, education, and culture, and the changes that occur in it, are determined in the human will and choosing evil. (shrink)

In the ancient Greek world, the concept of 'miasma,' which becomes permanent and has the potential to grow over time due to evil acts such as murder committed in the city, is a concept frequently referred to in many classical tragedies. To the extent that miasma has a bad connotation due to its nature and is a situation that occurs due to evil actions, it can be considered together with the philosophical problem of evil. In this study, we aim to (...) examine the concept of miasma by focusing on the characters in La Jauría, one of the most prominent films of recent South American cinema, rather than a purely conceptual analysis of the concept. Filmed in the jungles of Colombia and directed by Colombian director Andrés Ramírez Pulido, the 2022 film La Jauría is a psychological drama that focuses on the lives of young people involved in crime. The tragic story of Eliu, the protagonist of the film, which takes place mainly in a prison specially designed to rehabilitate inmates, seems to us to be a very suitable focal point for examining the concepts of miasma, catharsis, and ecstasy, which are frequently referred to in ancient Greek tragedy. To do so, we will first address the various contexts in which miasma has been used historically, considering the flow of events in the movie La Jauría. Then, we will look at the relationship of the concept of miasma with the problem of evil. Finally, we will discuss the possibilities of the concept of purification, which is seen as a kind of antidote to miasma. (shrink)

In the ever-evolving landscape of education, the debate between traditional and modern instructional methods remains a focal point of discussion. The more technology is integrated into classrooms, the more it becomes imperative to scrutinize its effectiveness, especially in the foundational years of learning. Studying the association between multimedia tools and the consonant-vowel-consonant (CVC) reading performance of preschool English as Secondary Language (ESL) students is vital. The study explored the effectiveness of multimedia tools on CVC reading performance and interest and (...) enthusiasm in phonics among Kindergarten Level 1 (K1) ESL students using a quasi-experimental design that lasted for eight weeks. Two enrolled classes were divided into traditional (14 participants) and multimedia groups (13 participants) according to their assigned classes. The study conducted a pre-test and post-test, comparing the two groups. The test questions were sourced from the school’s standardized assessments, ensuring validity and reliability. Data obtained were analyzed and interpreted using IBM SPSS Statistics. The findings revealed a partial enhancement in CVC reading performance and a notable increase in students' interest and enthusiasm for phonics, particularly in the participants’ positive attitudes. These improvements suggest a promising trajectory in the literacy development of young learners. Understanding which instructional method best supports foundational reading skills can provide valuable insights for educators and curriculum developers. This study is among the first to focus on early education, addressing a gap in research that predominantly targets older students. Nonetheless, it is essential to note that this study is limited to the K1 students enrolled in the research. (shrink)

The Computational Theory of Mind (CTM) holds that cognitive processes are essentially computational, and hence computation provides the scientific key to explaining mentality. The Representational Theory of Mind (RTM) holds that representational content is the key feature in distinguishing mental from non-mental systems. I argue that there is a deep incompatibility between these two theoretical frameworks, and that the acceptance of CTM provides strong grounds for rejecting RTM. The focal point of the incompatibility is the fact that representational content (...) is extrinsic to formal procedures as such, and the intended interpretation of syntax makes no difference to the execution of an algorithm. So the unique 'content' postulated by RTM is superfluous to the formal procedures of CTM. And once these procedures are implemented in a physical mechanism, it is exclusively the causal properties of the physical mechanism that are responsible for all aspects of the system's behaviour. So once again, postulated content is rendered superfluous. To the extent that semantic content may appear to play a role in behaviour, it must be syntactically encoded within the system, and just as in a standard computational artefact, so too with the human mind/brain - it's pure syntax all the way down to the level of physical implementation. Hence 'content' is at most a convenient meta-level gloss, projected from the outside by human theorists, which itself can play no role in cognitive processing. (shrink)

This article begins by tracing two issues to be kept in mind in discussing the theme of love as far back as Aristotle: on the one hand the polysemy of the term philia in Aristotle, and on the other hand the fact that there is a focal or core meaning of philia that provides order to that polysemy. Secondly, it is briefly suggested that the same issues are, mutatis mutandis, central for understanding the discussion of love or Liebe by (...) Hegel, the central classic reference in debates on recognition. Thirdly, by pointing out a certain ambiguity in Harry Frankfurt’s recent work on love, the article focuses more closely on the thought that love in the simple sense which Aristotle had pinpointed as the focal meaning of philia, which is arguably at the core of Hegel’s discussion of Liebe, and which still forms at least one of the core senses of the term, is a ‘personifying’ attitude of recognition. Finally, drawing on the above points the article addresses the question whether love as a form of recognition is restricted to intimate relations such as those between family-members, ‘lovers’, close friends and so on, or whether it has applications in interhuman relations more broadly. The answer to this question, it is suggested, is essential for the viability of ethically substantial notions of solidarity beyond circles of close acquaintances, whether within the civil society, across nations, or towards future generations. (shrink)

Chapter 14. Andrea Timár engages with literary representations of the experience of perpetrators of dehumanization. Her chapter focuses on perpetrators of dehumanization who do not violate laws of their society (i.e., they are not criminals) but exemplify what Simona Forti, inspired by Hannah Arendt, calls “the normality of evil.” Through the parallel examples of Dezső Kosztolányi’s Anna Édes (1926) and Doris Lessing’s The Grass is Singing (1950), Timár first explores a possible clash between criminals and perpetrators of dehumanization, showing literature’s (...) exceptional ability to reveal the gap between ethics and law. Second, she examines novels focalized through perpetrators and the difficult narrative empathy they provoke, arguing that only the critical reading of these novels can make one engage with the potential perpetrator in oneself. As case studies, Timár examines Daniel Defoe’s Robinson Crusoe (1719), which may potentially turn its reader into an accomplice in the process of dehumanization, and J.M. Coetzee’s Foe (1986), which puts on critical display the dehumanizing potentials of both aesthetic representation and sympathy as imaginative violence. Third, she reads Jonathan Littell’s The Kindly Ones [Les Bienveillantes, 2006], which can make the reader question, through the polyphony of the voice of its protagonist, the notions of narrative voice and readerly empathy, only to reveal that the difficulty involved in empathizing with perpetrator characters lies not so much in the characters’ being perpetrators, but rather in their being literary characters. Eventually, Timár briefly touches upon the problem of the aesthetic and the comic via Nabokov’s Lolita (1955) to ask whether one can avoid some necessarily dehumanizing aspects of humor. (shrink)

Attention plays a role in demonstrative thought: It sets the targets. Visual experience also plays a role. I argue here that it makes visual information available for use in the voluntary control of focal attention. To do so I use both introspection and neurophysiological evidence from projections between areas of attentional control and neural correlates of consciousness. Campbell and Smithies also identify roles for experience, but they further argue that only experience can play those roles. In contrast, I argue (...) that experience is not the only way in which visual information could be accessed for the voluntary control of attention. (shrink)

Abstract: The emergence of the novel coronavirus (COVID-19) in 2019 has presented the world with an unprecedented global health crisis. The rapid and widespread transmission of the virus has strained healthcare systems, disrupted economies, and challenged societies. In response to this monumental challenge, the intersection of technology and healthcare has become a focal point for innovation. This research endeavors to leverage the capabilities of Artificial Neural Networks (ANNs) to develop an advanced predictive model for forecasting the spread of COVID-19. (...) It involves the collection, analysis, and integration of diverse datasets encompassing epidemiological, clinical, and social factors that influence the virus's dissemination. (shrink)

The purpose of this paper is to describe the use of cognitive convenience in color naming and to find possible cognitive, physical, pragmatic, and logical reasons for such a phenomenon. By the term cognitive convenience, we mean the naming of or referring to objects of a certain color, for which their hue is not as important as their brightness, in which case, they might fall under another focal color. For example, in various languages, grapes are “white” and “black”, even (...) though their real hue is usually a certain shade of green or purple. Along with a brief typological comparison of examples of cognitive convenience in unrelated languages, we report the results of a survey demonstrating that vagueness and brightness context influenced color naming, thus confirming our main hypotheses. We concluded that in conversation, the main criterion for choosing and identifying a referent of an NP with a color adjective—when the choice is based on color—is the proximity of its shade to the prototypical shade of the named color. In this process, contextual factors may affect the speaker’s and hearer’s preciseness. We claim that this phenomenon can be explained not only from a philosophical and pragmatic standpoint, but from an information-entropy standpoint as well. For an overall unifying theory, we will connect the informational entropy to the pragmatic notion of semantic vagueness and then inspect the overall choice of a fuzzy predicate logic that is able to incorporate such references. (shrink)

It is often said that some kind of peripheral (or inattentional) conscious awareness accompanies our focal (attentional) consciousness. I agree that this is often the case, but clarity is needed on several fronts. In this paper, I lay out four distinct theses on peripheral awareness and show that three of them are true. However, I then argue that a fourth thesis, commonly associated with the so-called "self-representational approach to consciousness," is false. The claim here is that we have outer (...) focal consciousness accompanied often (or even always) by inner peripheral (self-)awareness. My criticisms stem from both methodological and phenomenological considerations. In doing so, I offer a diagnosis as to why the fourth thesis has seemed true to so many and also show how the so-called "transparency of experience," frequently invoked by representationalists, is importantly relevant to my diagnosis. Finally, I respond to several objections and to further attempts to show that thesis four is true. What emerges is that if one wishes to hold that some form of self-awareness accompanies all outer-directed conscious states, one is better off holding that such self-awareness is itself unconscious, as is held for example by standard higher-order theories of consciousness. (shrink)

In this article, we address the relevance of J.S. Mill’s political philosophy for a framework of public health ethics. In contrast to some readings of Mill, we reject the view that in the formulation of public policies liberties of all kinds enjoy an equal presumption in their favor. We argue that Mill also rejects this view and discuss the distinction that Mill makes between three kinds of liberty interests: interests that are immune from state interference; interests that enjoy a presumption (...) in favor of liberty; and interests that enjoy no such presumption. We argue that what is of focal importance for Mill in protecting liberty is captured by the essential role that the value of self-determination plays in human well-being. Finally, we make the case for the plausibility of a more complex and nuanced Millian framework for public health ethics that would modify how the balancing of some liberty and public health interests should proceed by taking the thumb off the liberty end of the scale. Mill’s arguments and the legacy of liberalism support certain forms of state interference with marketplace liberties for the sake of public health objectives without any presumption in favor of liberty. (shrink)

In the biomedical context, policy makers face a large amount of potentially discordant evidence from different sources. This prompts the question of how this evidence should be aggregated in the interests of best-informed policy recommendations. The starting point of our discussion is Hunter and Williams’ recent work on an automated aggregation method for medical evidence. Our negative claim is that it is far from clear what the relevant criteria for evaluating an evidence aggregator of this sort are. What is the (...) appropriate balance between explicitly coded algorithms and implicit reasoning involved, for instance, in the packaging of input evidence? In short: What is the optimal degree of ‘automation’? On the positive side: We propose the ability to perform an adequate robustness analysis as the focal criterion, primarily because it directs efforts to what is most important, namely, the structure of the algorithm and the appropriate extent of automation. Moreover, where there are resource constraints on the aggregation process, one must also consider what balance between volume of evidence and accuracy in the treatment of individual evidence best facilitates inference. There is no prerogative to aggregate the total evidence available if this would in fact reduce overall accuracy. (shrink)

This article makes the case for the necessity of a multi-focal conception of violence in religion and peacebuilding. I first trace the emergence and development of the analytical concepts of structural and cultural violence in peace studies, demonstrating how these lenses both draw central insights from, but also differ from and improve upon, critical theory and reflexive sociology. I argue that addressing structural and cultural forms of violence are concerns as central as addressing direct (explicit, personal) forms of violence (...) for purposes of building just and sustainable peace. Moreover, religiously informed and/or motivated peacebuilders are especially well-appointed and equipped to identify and address violence in its structural and cultural manifestations. I the examine how concepts of structural and cultural violence, in effect, centrally inform the efforts of Martin Luther King and Cornel West to cultivate just and sustainable peace in a context as putatively peaceful and prosperous as the United States. (shrink)