We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...) for the representation of entities in the domain of disease and medical practice. Initial applications of ND will include the annotation and analysis of large data sets and patient records for Alzheimer’s disease, multiple sclerosis, and stroke. (shrink)

Recent increases in the volume and diversity of life science data and information and an increasing emphasis on data sharing and interoperability have resulted in the creation of a large number of biological ontologies, including the Cell Ontology (CL), designed to provide a standardized representation of cell types for data annotation. Ontologies have been shown to have significant benefits for computational analyses of large data sets and for automated reasoning applications, leading to organized attempts to improve the structure and formal (...) rigor of ontologies to better support computation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL's utility for computation and for cross-species data integration. Results: To enhance the CL's utility for computational analyses, we developed a method for the ontological representation of cells and applied this method to develop a dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. We avoid multiple uses of is_a by linking DC-CL terms to terms in other ontologies via additional, formally defined relations such as has_function. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. Accordingly, we propose our method as a general strategy for the ontological representation of cells. DC-CL is available from http://www.obofoundry.org. (shrink)

We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...) provides a set of general classes that can be used to describe general aspects of medical science. ND is being built with classes utilizing both textual and axiomatized definitions that describe and formalize the relations between instances of other classes within the ontology itself as well as to external ontologies such as the Gene Ontology, Cell Ontology, Protein Ontology, and Chemical Entities of Biological Interest. In addition, references to similar or associated terms in external ontologies, vocabularies and terminologies are included when possible. Initial work on ND is focused on the areas of Alzheimer’s and other diseases associated with dementia, multiple sclerosis, and stroke and cerebrovascular disease. Extensions to additional groups of neurological diseases are planned. The second ontology, the Neuro-Psychological Testing Ontology (NPT), is intended to provide a set of classes for the annotation of neuropsychological testing data. The intention of this ontology is to allow for the integration of results from a variety of neuropsychological tests that assay similar measures of cognitive functioning. Neuro-psychological testing is an important component in developing the clinical picture used in the diagnosis of patients with a range of neurological diseases, such as Alzheimer’s disease and multiple sclerosis, and following stroke or traumatic brain injury. NPT is being developed as an extension to the Ontology for Biomedical Investigations. (shrink)

Monoclonal antibodies are essential biomedical research and clinical reagents that are produced by companies and research laboratories. The NIAID ImmPort (Immunology Database and Analysis Portal) resource provides a long-term, sustainable data warehouse for immunological data generated by NIAID, DAIT and DMID funded investigators for data archiving and re-use. A variety of immunological data is generated using techniques that rely upon monoclonal antibody reagents, including flow cytometry, immunofluorescence, and ELISA. In order to facilitate querying, integration, and reuse of data, standardized terminology (...) for describing monoclonal antibody reagents and their targets needs to be used for annotating data submitted to ImmPort. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.

The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...) reference. We illustrate its use in facilitating an alignment between PRO and Reactome protein entities. We also address issues of scalability, describing our first steps into the use of text mining to identify protein-related entities, the large-scale import of proteoform information from expert curated resources, and our ability to dynamically generate PRO terms. Web views for individual terms are now more informative about closely-related terms, including for example an interactive multiple sequence alignment. Finally, we describe recent improvement in semantic utility, with PRO now represented in OWL and as a SPARQL endpoint. These developments will further support the anticipated growth of PRO and facilitate discoverability of and allow aggregation of data relating to protein entities. (shrink)

The Neurological Disease Ontology (ND) is being developed to provide a comprehensive framework for the representation of neurological diseases (Diehl et al., 2013). ND utilizes the model established by the Ontology for General Medical Science (OGMS) for the representation of entities in medicine and disease (Scheuermann et al., 2009). The goal of ND is to include information for each disease concerning its molecular, genetic, and environmental origins, the processes involved in its etiology and realization, as well as its clinical (...) presentation including signs and symptoms. (shrink)

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...) dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

The paper distinguishes three strategies by means of which empirical discoveries about the nature of morality can be used to undermine moral judgements. On the first strategy, moral judgements are shown to be unjustified in virtue of being shown to rest on ignorance or false belief. On the second strategy, moral judgements are shown to be false by being shown to entail claims inconsistent with the relevant empirical discoveries. On the third strategy, moral judgements are shown to be false in (...) virtue of being shown to be unjustified; truth having been defined epistemologically in terms of justification. By interpreting three recent error theoretical arguments in light of these strategies, the paper evaluates the epistemological and metaphysical relevance of empirical discoveries about morality as a naturally evolved phenomenon. (shrink)

Part 1 of 2, this is an introductory critical review of Michelle Alexander's "The New Jim Crow: Mass Incarceration In The Age of Colorblindness" (The New Press, 2010). See part 2: "Toward Détournement of The New Jim Crow" for an advanced critical reading.

Alexander Bird (2001; 2002; 2007) offers a powerful argument showing that, regardless of whether necessitarianism or contingentism about laws is true, salt necessarily dissolves in water. The argument is that the same laws of nature that are necessary for the constitution of salt necessitate the solubility of salt. This paper shows that Bird’s argument faces a serious objection if the possibility of emergentism – in particular, C. D. Broad’s account – is taken into account. The idea is (roughly) that (...) some emergent laws in some possible worlds may disrupt the solubility of salt without disrupting its constitution. (shrink)

This paper defends the Principle of Sufficient Reason, taking Baumgarten as its guide. The primary aim is not to vindicate the principle, but rather to explore the kinds of resources Baumgarten originally thought sufficient to justify the PSR against its early opponents. The paper also considers Baumgarten's possible responses to Kant's pre-Critical objections to the proof of the PSR. The paper finds that Baumgarten possesses reasonable responses to all these objections. While the paper notes that in the absence of a (...) response to Kant's Critical discussion of the PSR, this result does not vindicate the principle, it shows how this discussion provides a deeper understanding of what, according to Baumgarten, the PSR really assumes and intends, and prepares the way for a more responsible discussion of Kant's Critical objections to Baumgarten's supposed proof. (shrink)

When people suffer they always suffer as a whole human being. The emotional, cognitive and spiritual suffering of human beings cannot be completely separated from all other kinds of suffering, such as from harmful natural, ecological, political, economic and social conditions. In reality they interact with each other and influence each other. Human beings do not only suffer from somatic illnesses, physical pain, and the lack of decent opportunities to satisfy their basic vital, social and emotional needs. They also suffer (...) when they are not able to experience and grasp any meaning of life even if such suffering is not quite as obvious as most forms of physical, social and emotional suffering. Suffering from the lack for the sense of the meaning of life is a special form of emotional, cognitive, and spiritual suffering. Although all human beings share the same basic human need for some meaning of life, the fulfilment of this need is highly individual and personal. Although all forms of human suffering can be a challenge to the meaning of life, the personal conditions of suffering usually are a stronger challenge for the meaning of life. Among the personal conditions of human suffering, the Grenzsituationen cannot be cancelled or raised at all, but only accepted and coped with as existential aspects of the conditio humana. According to Karl Jaspers these are: death, suffering, struggling, guilt, and failing. The challenge for human beings to cope with these Grenzsituationen is a way to move from the mere Being-there to true human Existence. (shrink)

A new translation and edition of Aristotle's Protrepticus (with critical comments on the fragments) -/- Welcome -/- The Protrepticus was an early work of Aristotle, written while he was still a member of Plato's Academy, but it soon became one of the most famous works in the whole history of philosophy. Unfortunately it was not directly copied in the middle ages and so did not survive in its own manuscript tradition. But substantial fragments of it have been preserved in several (...) works by Iamblichus of Chalcis, a third century A.D. neo-Pythagorean philosopher and educator. On the basis of a close study of Iamblichus' extensive use and excerption of Aristotle's Protrepticus, it is possible to reconstruct the backbone of the lost work, and then to flesh it out with the other surviving reports about the work from antiquity (for example in Alexander of Aphrodisias and other ancient commentators on Aristotle). It is also possible to identify several papyrus fragments of the work, and many references and literary allusions in later authors, especially Cicero, whose own lost dialogue Hortensius was a defense of philosophy modeleld on Aristotle's. (shrink)

Jennifer Nagel (2010) has recently proposed a fascinating account of the decreased tendency to attribute knowledge in conversational contexts in which unrealized possibilities of error have been mentioned. Her account appeals to epistemic egocentrism, or what is sometimes called the curse of knowledge, an egocentric bias to attribute our own mental states to other people (and sometimes our own future and past selves). Our aim in this paper is to investigate the empirical merits of Nagel’s hypothesis about the psychology involved (...) in knowledge attribution. (shrink)

This essay is a close reading analysis of Plato's Eutyphron coming to the conclusion that Plato's Socrates is still a model for an open minded, but critical attitude towards the ethical and metaphysical claims of religions.

In seiner ‘Existenzerhellung der Freiheit’ reflektiert Jaspers, das Problemfeld der Freiheit in einem Kontrast zu den Begriffen, Phänomenen und Bedingungen der Unfreiheit und der Grenzen der Freiheit. Dem Problemfeld der Freiheit kann man im Denken und Handeln nur dann gerecht werden, wenn man nicht nur zwischen den verschiedenen Begriffen und Phänomenen der Freiheit unterscheidet, sondern auch zwischen den verschiedenen Begriffen und Phänomenen von Grenzen der Freiheit, wie z.B. durch die allgemeine Naturgesetzlichkeit und die menschliche Natur, durch besondere Bedingungen in Natur, (...) Kultur und Gesellschaft, durch gesundheitliches Befinden und individuelle Persönlichkeit, durch situative Begrenzungen, normative Forderungen und konkrete Grenzsituationen, wie z.B. von Leiden, Kampf, Schuld, Wagnis und Tod zeigen. Jaspers hat sich zum Problemfeld der Freiheit sowohl in seiner Allgemeinen Psychopathologie, in seinen pathographischen Untersuchungen, in seiner Psychologie der Weltanschauung und in einigen seiner philosophischen Schriften geäußert. Im zweiten Band seines frühen Hauptwerkes Philosophie mit dem Titel Existenzerhellung hat er jedoch eine umfassende Abhandlung zu dem komplexen Problemfeld der Freiheit verfasst. Dort behandelt Jaspers fast alle wesentlichen Begriffe und Phänomene der Freiheit bis hin zu seiner Konzeption einer existenziellen Freiheit. Jaspers geht anfangs von einem unbestimmten Begriff der Freiheit aus, dem kein bestimmtes Phänomen entspricht und der deswegen nur Illusionen erzeugen und einem ideologischem Denken dienen kann. Dann aber unterscheidet Jaspers zwischen verschiedenen Begriffen und Phänomenen der Freiheit. Dabei scheint er nicht nur wie die meisten zeitgenössischen Philosophen an Locke und Hume, Kant und Brentano, Wilhelm von Humboldt und John Stuart Mill anzuknüpfen, sondern auch an die Konzeptionen des Selbstbewusstseins bei Hegel, Fichte und Schelling. Da sich Jaspers nicht zuletzt auch mit den Schriften von Kierkegaard und Nietzsche auseinandergesetzt hat, gelangt er zu einer besonders umfangreichen und differenzierten Diskussion des ganzen Problemfeldes der Freiheit in der Moderne. Jaspers hat jedoch nicht nur verschiedene Freiheitsbegriffe und -phänomene unterschieden, sondern er hat auch zu den überlieferten Denkweisen im Form einer existenzphilosophischen Erhellung der Freiheit Stellung genommen. Dabei hat Jaspers’ Stellungnahme anders als viele zeitgenössische Beiträge über Freiheit und Determinimus den deutlichen und bewahrenswerten Vorzug, dass sie die unverfügbare und irreduzible Subjektivität der Willensfreiheit anerkennt. Damit knüpft Jaspers an Kants Einsicht an, dass der Freiheit des menschlichen Willens und ihrer praktischen Wirksamkeit immer nur die subjektive Evidenz inneren Erlebens zukommen kann. Dies unterscheidet sie von der Wahl- und Handlungsfreiheit, die man auch in konkreten Handlungssituationen objektiv feststellen kann. Der Freiheit des menschlichen Willens kommt damit weder die Objektivität empirischer Erkenntnis noch metaphysische Notwendigkeit zu. Die subjektive Evidenz des Erlebens eines freien Willens spricht nach Jaspers jedoch auch gegen einen weltanschaulichen, methodischen oder metaphysischen Determinismus, der sie aufgrund seiner Annahme einer kausal geschlossenen Wirklichkeit leichtfertig für eine bloße Illusion hält. Eine deterministische Weltanschauung oder Philosophie kann der condition humaine zumindest dann nicht gerecht werden, wenn sie die evidente Subjektivität eines freien Willens nicht auf eine plausible Art und Weise integriert. Jaspers’ wird der potentiellen Freiheit des menschlichen Willens dadurch gerecht, dass er ihre unverfügbare und irreduzible Subjektivität versteht und akzeptiert und erst gar nicht den abwegigen Versuch macht, sie durch eine objektivierende Einstellung zu objektivieren, wissenschaftlich zu erklären oder gar zu beweisen. (shrink)

This paper argues that higher-order doubt generates an epistemic dilemma. One has a higher-order doubt with regards to P insofar as one justifiably withholds belief as to what attitude towards P is justified. That is, one justifiably withholds belief as to whether one is justified in believing, disbelieving, or withholding belief in P. Using the resources provided by Richard Feldman’s recent discussion of how to respect one’s evidence, I argue that if one has a higher-order doubt with regards to P, (...) then one is not justified in having any attitude towards P. Otherwise put: No attitude towards the doubted proposition respects one’s higher-order doubt. I argue that the most promising response to this problem is to hold that when one has a higher-order doubt about P, the best one can do to respect such a doubt is to simply have no attitude towards P. Higher-order doubt is thus much more rationally corrosive than non-higher-order doubt, as it undermines the possibility of justifiably having any attitude towards the doubted proposition. (shrink)

Der Begriff der Vernunft gehört zu den Begriffen, die für Jaspers‘ philosophisches Denken und schriftliche verfaßte Philosophie eine besonders wichtige Rolle spielen. Gleichwohl kann es im Folgenden nicht um Jaspers‘ ganze Philosophie gehen, sondern nur um seinen Begriff der Vernunft. Sein Begriff der Vernunft ist jedoch für die wesentlichen Grundzüge seiner Philosophie konstitutiv und charakteristisch. Im ersten Teil werde ich kurz auf die Entwicklung der Schriften eingehen, in denen Jaspers hauptsächlich sein Verständnis von Vernunft dargelegt hat. Im zweiten Teil werde (...) ich dann Jaspers‘ Begriff der Vernunft anhand einiger wichtiger Aussagen in den genannten Werken rekonstruieren. Dabei kann jedoch nur der wesentliche Gehalt seines Begriffes der Vernunft berücksichtigt werden und nicht alle Strukturen, Formen und Funktionen der Vernunft, die dann für seine Philosophie charakteristisch und konstitutiv sind. Im dritten Teil werde ich dann kurz den systematischen Ort und Stellenwert von Jaspers‘ Begriff der Vernunft in seiner Vernunftphilosophie beleuchten. (shrink)

Das Thema der Misologie und Misanthropie lässt sich wie so viele anderen philosophischen Themen der europäischen Geistesgeschichte bis zu einem platonischen Dialog zurückverfolgen. In diesem Fall handelt es sich um Platons berühmten Dialog Phaidon. Nun handelt dieser Dialog bekanntlich von der Frage nach der Unsterblichkeit der menschlichen Seele. Dennoch verweist Sokrates an einer bestimmten Stelle des Dialoges auf die für den Menschen drohenden Gefahren der Misologie und der Misanthropie hin, dem Hass auf die Vernunft und den Hass auf den Menschen, (...) die seiner Auffassung nach zusammenhängen. Die sokratische Warnung vor der Misologie und Misanthropie ist um so eindringlicher, als sie auf dem Hintergrund des existenziellen Problems des Todes und der religiösen Frage nach einem Jenseits des Todes diskutiert wird. (Einleitung). (shrink)

Neidische Gedanken, neidische Gefühle, neidische Menschen sind im alltäglichen Leben gegenwärtig. Kaum vergeht ein Tag, an dem man nicht mit dem Phänomen des Neides konfrontiert wäre. Bei sich selbst mag man ihn schon gar nicht, denn der Neid ist ein schmerzliches und unschönes Gefühl. Obwohl der Neid ein alltägliches Phänomen ist, bleibt er im Alltag ein weitgehend tabuisiertes Thema: Über den Neid spricht man entweder gar nicht oder nur selten. Falls man doch über den Neid spricht, dann zumeist über den (...) Neid der Anderen. Den Neid der Anderen kann man nämlich als einen gewissen Triumph verbuchen: entweder als eine Art von Anerkennung des eigenen sozialen Status oder als ein Genuss dessen, was man bei den Anderen an Neid erregenden Gütern vorzuweisen hat. Der kleine Mann erfreut sich am Neid der Anderen. Entfremdet von der unmittelbaren Freude am eigenen Tun und Lassen sowie von den Früchten seiner Arbeit kann er sie nur noch auf dem Umweg über die Erniedrigung der Anderen erleben. Der Spießer braucht den neidischen Blick der kleineren Anderen, um zu bemerken, was er ist und was er hat. Denn der Spießer weiß nicht, wer er ist, und weil er nicht weiß, wer er ist, muss er ersatzweise wenigstens wissen, was er ist, und er ist vor allem das, was er erreicht hat und was er hat. (Einleitung). (shrink)

In § 6 of his General Psychopathology (1st edition 1913) Jaspers distinguished between drives, wants and volitions as three different and irreducible kinds of motivational phenomena which are involved in human decision making and which may lead to successful actions. He has characterized the qualitative differences between volitions in comparison with basic vital drives and emotional wants such as being (a.) intentional, (b.) content-specific and (b.) directed towards concrete objects and actions as goals. Furthermore, Jaspers has presented and discussed three (...) kinds of pathological problems about motivation and willing. (1.) The first kind is impulsive action or impulsive behaviour, as e.g. in psychoses or personality disorders, which he compares with instinctive action which are both without any previous hesitation, deliberation and reflection of any presumable consequences, but still very different with respect to their motivational content. (2.) The second kind of pathological problems about motivation and willing are the inhibitions of the will and Jaspers is discussing two major kinds of them: (a.) the energetic or motivational inhibition of the will which is an inability of willing due to the mere lack of any drives and motives, as in the case of any severe and pathological depression; (b.) the cognitive inhibition of the will which is due to the pathological inability to be aware of and understand properly the complexity and difficulty of real life situations in order to solve some given tasks by appropriate decision making, as e.g. in some cases of schizophrenia. (3.) The third kind is a pathological weakness of the will which is extraordinary and not familiar to normal human adults. This pathological kind of weakness of the will consist in the complete causal ineffectiveness of the subjectively felt impulse of willing which is not leading to any inward and outward observable action, such as e.g. as a movement of the limbs or some verbal utterance. This pathological weakness of the will is a complete ineffectiveness of the volitional impulse and therefore different from what philosophers discuss under the heading of weakness of the will which presuppose some evaluation of the intended resp. realized action as ethically, morally or religiously right or wrong. Finally, there are three kinds of normal or non-pathological weakness of the will, as discussed by philosophers: (A.) ethical weakness of the will as in Aristotle’s disagreement about akrasia with the Platonic Socrates; (B) moral weakness of the will as in Kant’s analysis of the absence or failure of any specific moral reasoning by pure practical reason as opposed to mere strategic and pragmatic reason or as the occurrence of a self-deceptive “dialectics of the exception“; (C.) religious weakness of the will as in Pauls personal insight about the incoherence between his high spiritual aspirations and his factual ethical achievements. (shrink)

We construct a machine that knows its own code, at the price of not knowing its own factivity.

Was kann ein Philosoph dazu beitragen, dass wir uns nicht nur ein adäquates Bild vom tatsächlichen Gesundheitswesen machen, sondern auch verstehen, wie in der Gesundheitspolitik ökonomische Rationalität dem übergeordneten Ziel der Realisierung humaner Verhältnisse dienen könnte? Wenn er kein weltfremder Utopist ist, dann wird er zunächst einmal anerkennen, dass die ökonomische Rationalität und die rechtsstaatliche Regulierung des Gesundheitswesens selbst schon notwendige Bedingungen für die Realisierung von Humanität sind. Denn humane Verhältnisse im Gesundheitswesen sind unter den Realbedingungen von mehr oder weniger (...) beschränkten Ressourcen immer schon eine normative Zielvorstellung, die mit Hilfe von moralischen, rechtlichen und politischen Konventionen und Institutionen den Interessenkonflikten und Verteilungskämpfen in der jeweiligen Gesellschaft abgetrotzt werden müssen. Sie ergeben sich nicht von selbst – weder aus der demokratischen Konsensbildung der Interessenkonflikte noch aus den Selbstregulierungskräften des Marktes alleine. Das gilt insbesondere in Zeiten, wo der Staat aufgrund wirtschaftlicher Stagnation, fehlender Steuereinnahmen und verschuldeter Staatshaushalte nicht umhin kommt, unter anderen Ausgaben für innere und äußere Sicherheit, Verwaltung, Wissenschaft, Kultur und Bildung auch die Sozialausgaben zu reduzieren. So viel common sense steht auch einem Philosophen gut an. (Einleitung) . (shrink)

This essay begins with the claim that intercultural dialogue is an art rather than a science or technique and it attempts to point out what it takes to learn the art of intercultural dialogue. In PART ONE some basic forms of intercultural dialogue are presented which correlate to some basic forms of human life, such as family, politics, economy, science, art and religion. Also a few common traits about how intercultural dialogue is practised today are specified. PART TWO is pointing (...) out that cultural pluralism is not merely a political ideology, but rather a realistic political attitude towards the social realities in all cultures. Cultural pluralism means to accept that a certain variety of different forms of life is existing already within every culture, country or nation. Further it it argued that any society whether it is governed by a modern democracy or by a more traditional political system, such as a monarchy, needs some ethical, legal and political orientation in order to guarantee civil liberties, but also to limit civil, economic and political freedom. A common normative orientation being based on ethical ideals, principles, norms and values can only be established by philosophy and jurisprudence and neither by science nor by religion and neither by democracy nor by economy alone. Finally, PART THREE presents and discusses shortly a few reflections about three philosophical models of dialogue by Buber, Jaspers and Gadamer which are relevant to intercultural dialogue, to interreligious dialogue and last, but not least to philosophical dialogue. (shrink)

Johann August Eberhard gründet 1788 die Zeitschrift "Philosophisches Magazin", um die sog. Leibniz-Wolffsche Schulphilosophie gegen die zunehmend erfolgreichen Angriffe der kantischen Philosophie zu verteidigen. Zu diesem Zweck publizierte er insgesamt sieben Artikel, um seiner Leserschaft zu zeigen, dass die ältere Philosophie Leibnizens bereits eine gründliche Vernunftkritik enthalte, die der neueren Vernunftkritik Kants nicht nur ebenbürtig, sondern sogar überlegen sei. Als Anhänger der leibnizianischen Vernunftkritik war Eberhard vor allem deswegen von ihrer Überlegenheit überzeugt, weil man mit ihr noch eine dogmatische Metaphysik (...) alten Zuschnitts begründen und verteidigen könne. -/- Immanuel Kant, der aus arbeitsökonomischen Gründen nur selten auf Angriffe auf seine kritische Philosophie reagierte, fühlte sich von Eberhard so sehr herausgefordert, dass er – wie zuvor auch schon einmal bei Emanuel Swedenborg – eine Ausnahme machte. Während es für ihn bei seiner Auseinandersetzung mit Swedenborg gerade auf die deutliche Abgrenzung von dessen konkretistischer Auffassung vom mundus intelligibilis und von dessen Verwechslung von philosophischer Metaphysik mit spekulativem Okkultismus ankam, ging es bei seiner Auseinandersetzung mit Eberhard bloß um eine innerphilosophische Abgrenzung von einer anderen Konzeption der formalen Struktur und epistemischen Reichweite der menschlichen Vernunft. (shrink)

If we define tradition too hastily we leave to one side the question of what the relevance of tradition is for us. Here the concept of tradition is opened up by considering the different views of it taken by Hannah Arendt, Michael Oakeshott and Alasdair MacIntyre. We see that each has put tradition into a fully developed picture of what our predicament is in modernity; and that each has differed in their assessment of what our relation to tradition is or (...) should be. Arendt sees tradition as something which no longer conditions action, Oakeshott sees tradition as something which conditions all action, and MacIntyre sees tradition as something which should condition right action. In each case, the view of tradition is clearly one element in an attempt to see how the most important constituent elements of human existence – variously called the human condition, human conduct, or human virtue – should be understood in a modernity which is ours because it has put the traditional concept of tradition into question. (shrink)

A variation of Fitch’s paradox is given, where no special rules of inference are assumed, only axioms. These axioms follow from the familiar assumptions which involve rules of inference. We show (by constructing a model) that by allowing that possibly the knower doesn’t know his own soundness (while still requiring he be sound), Fitch’s paradox is avoided. Provided one is willing to admit that sound knowers may be ignorant of their own soundness, this might offer a way out of the (...) paradox. (shrink)

Reinhardt’s conjecture, a formalization of the statement that a truthful knowing machine can know its own truthfulness and mechanicalness, was proved by Carlson using sophisticated structural results about the ordinals and transfinite induction just beyond the first epsilon number. We prove a weaker version of the conjecture, by elementary methods and transfinite induction up to a smaller ordinal.

Der Neid wirft als Thema der philosophischen und psychologischen Reflexion eine ganze Reihe von Fragen auf, die theoretischer Natur sind. Dazu gehören die Frage nach der Analyse des alltagspsychologischen Neidbegriffes, die damit verbundene Frage nach der Abgrenzung des psychologischen Phänomens des Neides im Verhältnis zu verwandten Emotionen, wie z.B. Eifersucht, Habgier, Ehrgeiz, Wetteifer, Geiz, etc., die Frage nach dem Wesen des Neides als einem reflexartigen und unkontrollierbaren Affekt, als einer dauerhaften und unbewussten Stimmung, als einem momentanen, intentionalen und bewussten Gefühl, (...) als einem selbst erzeugten Konstrukt aus Gedanken und Gefühlen, etc. und schließlich die Frage nach den Ursachen des Neides als einem gewissen Mangel an Selbstsein und als Folge einer langfristig scheiternden Selbstverwirklichung. -/- Der Neid wirft als Thema der philosophischen und psychologischen Reflexion aber auch verschiedene Fragen auf, die praktischer Natur sind. Diese Fragen gehören weitgehend in dem Umkreis der Probleme der philosophischen Lebenskunst. Zu den Fragen der philosophischen Lebenskunst, der ars vivendi, die als die wohl wichtigste menschliche Kunst auch die philosophische Kunst des Alterns und Sterbens, die ars moriendi umfasst, gehört einerseits das Problem der Abwehr der Neider durch die Beneideten und andererseits das Problem der Überwindung des Neides beim Neider selbst. In der Geschichte der europäischen Philosophie wurden seit der Antike vor allem immer wieder lebensphilosophische Ratschläge zur Bewältigung beider Probleme erteilt. Dabei standen jedoch die Ratschläge zur Abwehr der Neider im Vordergrund. Das kommt weitgehend daher, dass vor allem in der Antike, aber auch im Mittelalter und selbst noch in der Neuzeit diese Art von Literatur den Begüterten und Gebildeten diente, die auf Grund ihrer privilegierten sozialen Stellung im Großen und Ganzen eher ein Interesse an der Abwehr der Neider als an der Neidüberwindung hatten. Dennoch darf man nicht meinen, dass diese klassischen Autoren und ihre Leser selbst ganz ohne äußere und innere Anlässe für Neidgefühle und -gedanken gewesen wären. Deswegen darf man vermuten, dass auch die Scheu davor, sich selbst als einen gewohnheitsmäßig neidischen Menschen oder zumindest als einen Gelegenheitsneider zu präsentieren, dazu geführt haben mag, dass man sich aus einem gewissen Selbstschutz zurückgehalten hat, Überlegungen und Ratschläge zur Überwindung des eigenen Neides öffentlich zu äußern und zu erörtern. (Einleitung). (shrink)

Die Frage, ob Karl Jaspers ein Kantianer ist, wird nicht nur kompetente Jasperskenner überraschen, sondern auch die meisten Philosophiehistoriker, die mit der Geschichte der Philosophie der Neuzeit und Moderne vertraut sind. Denn einerseits werden nicht nur die meisten Jasperskenner, sondern auch die meisten Philosophiehistoriker überhaupt, diese Frage zunächst einmal mit einem gewissen Recht verneinen. Denn der überlieferten Lehrmeinung zufolge, war Jaspers kein Kantianer, sondern ein Existenzphilosoph. Andererseits werden vermutlich die meisten Jasperskenner und Philosophiehistoriker zugestehen, dass Kant für Jaspers zumindest einer (...) der wichtigsten Philosophen war, wenn nicht sogar der wichtigste Philosoph überhaupt. Das alleine reicht aber kaum aus, um Jaspers als einen Kantianer aufzufassen. Denn wer Jaspers als einen Kantianer bezeichnet, wird damit nicht nur meinen, dass Jaspers unter allen großen Philosophen immer noch Kant am nächsten stand und ihn am meisten schätze, sondern auch dass er selbst philosophische Auffassungen und Überzeugungen vertreten hat, die dem überlieferten Idealtypus eines Kantianers entsprechen. In diesem idealtypischen Sinne können und dürfen wir zumindest aus heuristischen Gründen z.B. Augustinus, Plotin und Bonaventura als Platoniker sowie Thomas von Aquin, Trendelenburg und Brentano als Aristoteliker bezeichnen. In diesem idealtypischen Sinne können und dürfen wir auch fragen, in welchem Sinne man Jaspers eher als einen Platoniker oder als einen Aristoteliker verstehen kann. Und in diesem Sinne kann man dann auch mit gewissen Fug und Recht fragen, ob Jaspers den wesentlichen Grundzügen seines Philosophierens zufolge ein Kantianer ist. (shrink)

A suprise may occur if we use a similar strategy to the Liar's paradox to mathematically formalize "This sentence does not contain the symbol X".

A biologically unavoidable sequence is an infinite gender sequence which occurs in every gendered, infinite genealogical network satisfying certain tame conditions. We show that every eventually periodic sequence is biologically unavoidable (this generalizes König's Lemma), and we exhibit some biologically avoidable sequences. Finally we give an application of unavoidable sequences to cellular automata.

L'écologie préénergétique des années 1905-1935 est à la recherche de ses objets d'étude. Des unités fondamentales de la nature (telles que formation végétale, association végétale, climax, biome, communauté biotique, écosystème) se trouvent en compétition et se succèdent les unes aux autres. Autour des années 1920 et 1930, la philosophie organiciste d'Alfred N. Whitehead, ainsi que la perspective évolutionniste d'Herbert Spencer et les propositions émergentistes de Samuel Alexander et Conwy L. Morgan, deviennent des références sous-jacentes au débat épistémologique concernant les (...) unités de base de l'écologie. Des auteurs comme Frederic E. Clements et John Phillips soutiendront plusieurs formes d'organicisme écologique, tandis que Henry A. Gleason interprétera l'association végétale comme le résultat d'une juxtaposition fortuite d'individus. Enfin, et paradoxalement, l'écosystème de Arthur G. Tansley, tout en faisant partie, à l'origine, d'une perspective anti-organiciste, deviendra l'unité fondamentale de programmes de recherche qui se voudront, au moins dans leurs intentions, émergentistes. (shrink)

In der Medizin gehören Kinder neben Ausländern, Behinderten und psychiatrisch Erkrankten zu den besonders vulnerablen Patientengruppen. Im Folgenden soll die Frage nach der Würde der Kinder in medizinethischer Hinsicht behandelt werden. Dazu werden drei Thesen erläutert und begründet: (1.) das Prinzip der Menschenwürde kann nicht ganz außer Acht gelassen werden, wenn Kinder als Patienten in medizinethischer Hinsicht thematisiert werden; (2.) das Prinzip der Menschenwürde wird in der Medizinethik nicht schon vollständig durch die medizinethischen Prinzipien der Patientenautonomie und der Fürsorge für (...) die Patienten abgedeckt; (3.) die habituelle und bewusste Achtung der Würde des Menschen bringt immer wieder neue und bisher noch wenig beachtete Aspekte des medizinischen, therapeutischen und pflegerischen Umgangs mit Patienten und Kindern als Patienten ans Licht. Diskussionen über den Gehalt des Prinzips der Menschenwürde gehen nicht nur in der Medizinethik, sondern auch in anderen Bereichen der angewandten Ethik in der Regel von Erwachsenen aus. Erwachsene gelten als die paradigmatischen Subjekte und Objekte der Wahrnehmung, Zuschreibung und Anerkennung von Würde. Meistens denkt man nur an Erwachsene, wenn man darauf besteht, dass die menschliche Würde (1.) vom moralischen und rechtlichen Standpunkt aus grundsätzlich zu achten ist, (2.) unter bestimmten psychologischen, sozialen und politischen Umständen gefährdet ist und (3.) in bestimmten Handlungssituationen mit anderen ethischen Forderungen in Konflikt geraten kann. Bei Erwachsenen ist es relativ leicht, ethische Intuitionen darüber, ob in bestimmten medizinischen Handlungssituationen die Würde eines Menschen verletzt wird, zu formulieren und zu begründen. Denn bei Erwachsenen steht die Würdeverletzung in einem engen Zusammenhang mit der Berücksichtigung verschiedener ethischer Forderungen: (1.) nach Achtung der willentlichen Selbstbestimmung und der normativen Autonomie, (2.) nach Berücksichtigung von persönlichen Lebenszielen und Wertpräferenzen, (3.) nach Bewahrung von mutmaßlichen Lebenschancen (4.) nach Berücksichtigung personaler Bedürfnisse nach Anerkennung, Gegenseitigkeit, Intimität, Integrität, etc. sowie (5.) nach Wahrnehmung und Anerkennung der unverwechselbaren Individualität des Anderen. Die Angemessenheit und Erfüllbarkeit dieser ethischen Forderungen hängt nun aber von soziologischen und psychologischen Gegebenheiten ab, die bei Kindern je nach Altersgruppe und individueller Ausprägung nicht in gleicher Weise gegeben sind. Deswegen soll hier gezeigt werden, welche besondere und zusätzliche Rolle eine medizinethische Erinnerung an die Würde der Kinder im Spannungsfeld zwischen Autonomie und Fürsorge spielen kann. Dabei zeigt sich, dass es gerade die Achtung vor der Würde des Kindes ist, die uns überhaupt erst ermöglicht, das Kind als Kind und damit als ein eigenständiges Subjekt und als ein besonderes menschliches Wesen zu entdecken. (shrink)

El objetivo de este trabajo es dar noticia de la recepción del pragmatismo en la obra y el pensamiento de Eugenio d’Ors, reuniendo algunos resultados de nuestros trabajos preceden- tes. Dedicamos una primera parte a describir el encuentro de Eugenio d’Ors con el pragmatismo. En segundo lugar describimos su conexión con William James a quien llegó a conocer en París. En tercer lugar, damos cuenta de en qué consiste la denominada “superación del pragmatismo” por parte de Eugenio d’Ors y, por (...) último, señalamos las afinidades más relevantes de su pensamiento con algunas de las intuiciones más originales del pragmatismo de Charles S. Peirce. (shrink)

This article shows the origin of the famous Aristotelian expression τὸ τί ἦν εἶναι in everyday language. The expression is analysable in τὸ εἶναι and τί ἦν, and this part is the core of the common language question τουτὶ τί ἦν; or τουτὶ τί ἦν τὸ πρᾶγμα; always in imperfect form. This question is often found in Aristophanes’ comedies, which represent common Attic language. The imperfect ἦν is noted as a common Attic form indicating the present already by early comentators (...) of Aristotle as Alexander of Aphrodisias, the scholia to Aristophanes, later by Budaeus, but also in the modern Greek Lexikon of D. Demetrakos. Therefore not the imperfect is the problem, by mere embarrassement it was called "philosophic." The situations in the Aristophanean comedies, in which the question occurs, show that the thing about which somebody asks, is present, in front of the speaker, that it is an individual thing and something absolutly unexspected. The questioner will ask "What on the whole is this?" He asks about the first ground of being of the thing. The term τὸ τί ἦν εἶναι quotes only the use of εἶναι in this question in common language (like many other terms are quotations as τὸ τί ἐστίν; τὸ οὗ ἕνεκα etc.) and may be paraphrased by "Think of ’to be’ as you use it in the question ’What at all is this?’ " See also my article: Sonderegger (2001). Zur Sprachform des Ausdrucks to ti en einai. Rheinisches Museum Für Philologie 144:113–122. -/- The consequences of this linguistic finding can be found in my comments on Metaphysik Z and Metaphysics Λ (English version from 2020). (shrink)

This paper argues that while Heidegger showed the importance of architecture in altering people's modes of being to avoid global ecological destruction, the work of Christopher Alexander offered a far more practical orientation to deal with this problem.

Aristotle sometimes claims that the perception of special perceptibles by their proper sense is unerring. This claim is striking, since it might seem that we quite often misperceive things like colours, sounds and smells. Aristotle also claims that the perception of common perceptibles is more prone to error than the perception of special perceptibles. This is puzzling in its own right, and also places constraints on the interpretation of. I argue that reading Alexander of Aphrodisias on perceptual error can (...) help to make good sense of both of Aristotle’s claims. (shrink)

ABSTRACT: Alexander of Aphrodisias’ commentaries on Aristotle’s Organon are valuable sources for both Stoic and early Peripatetic logic, and have often been used as such – in particular for early Peripatetic hypothetical syllogistic and Stoic propositional logic. By contrast, this paper explores the role Alexander himself played in the development and transmission of those theories. There are three areas in particular where he seems to have made a difference: First, he drew a connection between certain passages from Aristotle’s (...) Topics and Prior Analytics and the Stoic indemonstrable arguments, and, based on this connection, appropriated at least four kinds of Stoic indemonstrables as Aristotelian. Second, he developed and made use of a specifically Peripatetic terminology in which to describe and discuss those arguments – which facilitated the integration of the indemonstrables into Peripatetic logic. Third, he made some progress towards a solution to the problem of what place and interpretation the Stoic third indemonstrables should be given in a Peripatetic and Platonist setting. Overall, the picture emerges that Alexander persistently (if not always consistently) presented passages from Aristotle’s logical œuvre in a light that makes it appear as if Aristotle was in the possession of a Peripatetic correlate to the Stoic theory of indemonstrables. (shrink)

Identifying the necessary and sufficient conditions for individuating and classifying diseases is a matter of great importance in the fields of law, ethics, epidemiology, and of course, medicine. In this paper, I first propose a means of achieving this goal, ensuring that no two distinct disease-types could correctly be ascribed to the same disease-token. I then posit a metaphysical ontology of diseases—that is, I give an account of what a disease is. This is essential to providing the most effective means (...) of interfering with disease processes. Following existing work in the philosophy of medicine and epidemiology (primarily Christopher Boorse; Caroline Whitbeck; Alexander Broadbent), philosophy of biology (Joseph LaPorte; D.L. Hull), conditional analyses of causation (J.L. Mackie; David Lewis), and recent literature on dispositional essentialism (Stephen Mumford and Rani Anjum; Alexander Bird), I endorse a dispositional conception of disease. Following discussion of various conceptions of disease-identity, their relations to the clinical and pathological effects of the diseases in question, and how diseases are treated, I conclude (i) that diseases should be individuated by their causes, and (ii) that diseases are causal processes best seen as simultaneously acting sequences of mutually manifesting dispositions. (shrink)

Michèle Le Dœuff considers the relationship between Jean-Paul Sartre and Simone de Beauvoir as a paradigmatic case of what she calls an "erotico-theoretical transference" relationship: De Beauvoir devoted herself to Sartre theoretically by adopting his existentialist perspective for the analysis of reality in general and the analysis of women's oppression in particular. The latter is especially strange since Sartre used strongly sexist metaphors and adopted a macho attitude towards women. In her book Hipparchia's Choice, Le Dœuff speaks in this context (...) of "theoretical masculinism." She convincingly shows in this book that Sartre without using images could not have closed his existentialist philosophy: without the feminine drawback he would not have been able to explain why man cannot become god. Sartre not only understands gaining knowledge as a rape of a woman he also fears that the possessed feminine (body) could reverse its position from being dominated to the dominating force by appropriating the masculine through slime. In Being and Nothingness Sartre states that "slime is the revenge of the In-itself. A sickly–sweet, feminine revenge." Despite of the fact that De Beauvoir used Sartre's heterosexist ontology and metaphysics she managed to provide a highly influential depiction of women's condition and offered an original approach to the understanding of selfhood which places woman inside the subject. (shrink)