Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...) for the representation of entities in the domain of disease and medical practice. Initial applications of ND will include the annotation and analysis of large data sets and patient records for Alzheimer’s disease, multiple sclerosis, and stroke. (shrink)

We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...) provides a set of general classes that can be used to describe general aspects of medical science. ND is being built with classes utilizing both textual and axiomatized definitions that describe and formalize the relations between instances of other classes within the ontology itself as well as to external ontologies such as the Gene Ontology, Cell Ontology, Protein Ontology, and Chemical Entities of Biological Interest. In addition, references to similar or associated terms in external ontologies, vocabularies and terminologies are included when possible. Initial work on ND is focused on the areas of Alzheimer’s and other diseases associated with dementia, multiple sclerosis, and stroke and cerebrovascular disease. Extensions to additional groups of neurological diseases are planned. The second ontology, the Neuro-Psychological Testing Ontology (NPT), is intended to provide a set of classes for the annotation of neuropsychological testing data. The intention of this ontology is to allow for the integration of results from a variety of neuropsychological tests that assay similar measures of cognitive functioning. Neuro-psychological testing is an important component in developing the clinical picture used in the diagnosis of patients with a range of neurological diseases, such as Alzheimer’s disease and multiple sclerosis, and following stroke or traumatic brain injury. NPT is being developed as an extension to the Ontology for Biomedical Investigations. (shrink)

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...) dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...) reference. We illustrate its use in facilitating an alignment between PRO and Reactome protein entities. We also address issues of scalability, describing our first steps into the use of text mining to identify protein-related entities, the large-scale import of proteoform information from expert curated resources, and our ability to dynamically generate PRO terms. Web views for individual terms are now more informative about closely-related terms, including for example an interactive multiple sequence alignment. Finally, we describe recent improvement in semantic utility, with PRO now represented in OWL and as a SPARQL endpoint. These developments will further support the anticipated growth of PRO and facilitate discoverability of and allow aggregation of data relating to protein entities. (shrink)

Monoclonal antibodies are essential biomedical research and clinical reagents that are produced by companies and research laboratories. The NIAID ImmPort (Immunology Database and Analysis Portal) resource provides a long-term, sustainable data warehouse for immunological data generated by NIAID, DAIT and DMID funded investigators for data archiving and re-use. A variety of immunological data is generated using techniques that rely upon monoclonal antibody reagents, including flow cytometry, immunofluorescence, and ELISA. In order to facilitate querying, integration, and reuse of data, standardized terminology (...) for describing monoclonal antibody reagents and their targets needs to be used for annotating data submitted to ImmPort. (shrink)

The Neurological Disease Ontology (ND) is being developed to provide a comprehensive framework for the representation of neurological diseases (Diehl et al., 2013). ND utilizes the model established by the Ontology for General Medical Science (OGMS) for the representation of entities in medicine and disease (Scheuermann et al., 2009). The goal of ND is to include information for each disease concerning its molecular, genetic, and environmental origins, the processes involved in its etiology and realization, as well as its clinical (...) presentation including signs and symptoms. (shrink)

SUMMARY. The works of Alexander of Aphrodisias were written a few decades after the publication of the most successful -astrology hand- book in antiquity, Ptolemy's Tetrabiblos Syntaxis, which attempts to naturalize astrology, i.e. to make it agree with Aristotelian theory of science. A comparison of the doctrines between the Tetrabiblos and some passages of Alexander'p works on fate demostrates a noteworthy con¬vergere of the two scholars, and probably a dependence of the lasi great greek Aristotle's exegete on the (...) theories of Ptolemaic astrology, at least in reference to three points: theory of fate; justification of de- vining as a technical and naturai conjecture about man's fate; ana¬lysis of the stars' influence on the sublunary world in physical and phi¬losophical terms. (shrink)

This paper defends the Principle of Sufficient Reason, taking Baumgarten as its guide. The primary aim is not to vindicate the principle, but rather to explore the kinds of resources Baumgarten originally thought sufficient to justify the PSR against its early opponents. The paper also considers Baumgarten's possible responses to Kant's pre-Critical objections to the proof of the PSR. The paper finds that Baumgarten possesses reasonable responses to all these objections. While the paper notes that in the absence of a (...) response to Kant's Critical discussion of the PSR, this result does not vindicate the principle, it shows how this discussion provides a deeper understanding of what, according to Baumgarten, the PSR really assumes and intends, and prepares the way for a more responsible discussion of Kant's Critical objections to Baumgarten's supposed proof. (shrink)

Internodons are a formalization of Hennig's concept of species. We present an alternative construction of internodons imposing a tree structure on the genealogical network. We prove that the segments (trivial unary trees) from this tree structure are precisely the internodons. We obtain the following spin-offs. First, the generated tree turns out to be an organismal tree of life. Second, this organismal tree is homeomorphic to the phylogenetic Hennigian species tree of life, implying the discovery of a multi-level tree of life: (...) this phylogenetic tree can be obtained by zooming out from the organismal tree, or conversely, the organismal tree of life can be generated by expanding the phylogenetic nodes into unary trees. Finally, the definition of the organismal tree allows an efficient algorithmic transformation of a given genealogical network into its corresponding phylogenetic species tree of life. The latter will be presented in a separate paper. (shrink)

Part 1 of 2, this is an introductory critical review of Michelle Alexander's "The New Jim Crow: Mass Incarceration In The Age of Colorblindness" (The New Press, 2010). See part 2: "Toward Détournement of The New Jim Crow" for an advanced critical reading.

A fundamental question asked in modal logic is whether a given theory is consistent. But consistent with what? A typical way to address this question identifies a choice of background knowledge axioms (say, S4, D, etc.) and then shows the assumptions codified by the theory in question to be consistent with those background axioms. But determining the specific choice and division of background axioms is, at least sometimes, little more than tradition. This paper introduces generic theories for propositional modal logic (...) to address consistency results in a more robust way. As building blocks for background knowledge, generic theories provide a standard for categorical determinations of consistency. We argue that the results and methods of this paper help to elucidate problems in epistemology and enjoy sufficient scope and power to have purchase on problems bearing on modalities in judgement, inference, and decision making. (shrink)

There are numerous theoretical reasons which are usually said to undermine the case for mental causation. But in recent years, Libet‘s experiment on readiness potentials (Libet, Wright, and Gleason 1982; Libet, Gleason, Wright, and Pearl 1983), and a more recent replication by a research team led by John Dylan Haynes (Soon, C.S., Brass, M., Heinze, H.J., and Haynes, J.-D. [2008]) are often singled out because they appear to demonstrate empirically that consciousness is not causally involved in our choices and actions. (...) In this paper, an alternative interpretation of these studies is offered; one which is in accordance both with the empirical evidence and also with the phenomenology of the will, demonstrating that the two opposing views of agency – both the ones that deny the reality of free will and the ones that affirm it – are equally compatible with the outcomes of these two experiments. On this basis, it is shown that the claim that the results on the timing of readiness potential tip the scales in favour of one or the other view cannot be justified - neither from a neurological, nor from a philosophical perspective. (shrink)

"In the programs of Logic and History of Philosophy in the FHUCE study and introduction to logic is always done on the basis of Western classical Greek tradition, and its development is still exclusively through Western culture. This presentation aims to provide a path parallel to the West is the tradition of Nyaya-Vaisesika schools, which arise in the S. V B.C. like a response to the anti-Vedic Buddhist nihilism, and reached an important technical development at the beginning of S. II (...) D.C. when you know the Nyāyasutras attributed to Aksapada Gautama, and are considered the founding text of Nyāya tradition of Indian philosophy. The great virtue of the achievement of these schools is that although the system has Vaisesika been described as "a synthesis between philosophy of nature, ethics and soteriology" , which also applies to school Nyāya in the latter we are also a great emphasis on epistemology and the rules must be observed in philosophical debates. In their synthesis, Nyāya -Vaisesika system gets his language and jargon will be adopted by all who wish to discuss logical issues in India (especially in discussions Vedanta / Buddhism) without the need to adopt such language should assume his ontological, moral and religious premises. (shrink)

We argue that C. Darwin and more recently W. Hennig worked at times under the simplifying assumption of an eternal biosphere. So motivated, we explicitly consider the consequences which follow mathematically from this assumption, and the infinite graphs it leads to. This assumption admits certain clusters of organisms which have some ideal theoretical properties of species, shining some light onto the species problem. We prove a dualization of a law of T.A. Knight and C. Darwin, and sketch a decomposition result (...) involving the internodons of D. Kornet, J. Metz and H. Schellinx. A further goal of this paper is to respond to B. Sturmfels’ question, “Can biology lead to new theorems?”. (shrink)

In discussions of the Aharonov-Bohm effect, Healey and Lyre have attributed reality to loops $\sigma_0$ (or hoops $[\sigma_0]$), since the electromagnetic potential $A$ is currently unmeasurable and can therefore be transformed. I argue that $[A]=[A+d\lambda]_{\lambda}$ and the hoop $[\sigma_0]$ are related by a meaningful duality, so that however one feels about $[A]$ (or any potential $A\in[A]$), it is no worse than $[\sigma_0]$ (or any loop $\sigma_0\in[\sigma_0]$): no ontological firmness is gained by retreating to the loops, which are just as flimsy (...) as the potentials. And one wonders how the unmeasurability of one entity can invest another with physical reality; would an eventual observation of $A$ dissolve $\sigma_0$, consigning it to a realm of incorporeal mathematical abstractions? The reification of loops rests on the potential's ''gauge dependence''; which in turn rests on its unmeasurability; which is too shaky and arbitrary a notion to carry so much weight. (shrink)

A new translation and edition of Aristotle's Protrepticus (with critical comments on the fragments) -/- Welcome -/- The Protrepticus was an early work of Aristotle, written while he was still a member of Plato's Academy, but it soon became one of the most famous works in the whole history of philosophy. Unfortunately it was not directly copied in the middle ages and so did not survive in its own manuscript tradition. But substantial fragments of it have been preserved in several (...) works by Iamblichus of Chalcis, a third century A.D. neo-Pythagorean philosopher and educator. On the basis of a close study of Iamblichus' extensive use and excerption of Aristotle's Protrepticus, it is possible to reconstruct the backbone of the lost work, and then to flesh it out with the other surviving reports about the work from antiquity (for example in Alexander of Aphrodisias and other ancient commentators on Aristotle). It is also possible to identify several papyrus fragments of the work, and many references and literary allusions in later authors, especially Cicero, whose own lost dialogue Hortensius was a defense of philosophy modeleld on Aristotle's. (shrink)

Alexander Bird (2001; 2002; 2007) offers a powerful argument showing that, regardless of whether necessitarianism or contingentism about laws is true, salt necessarily dissolves in water. The argument is that the same laws of nature that are necessary for the constitution of salt necessitate the solubility of salt. This paper shows that Bird’s argument faces a serious objection if the possibility of emergentism – in particular, C. D. Broad’s account – is taken into account. The idea is (roughly) that (...) some emergent laws in some possible worlds may disrupt the solubility of salt without disrupting its constitution. (shrink)

The paper distinguishes three strategies by means of which empirical discoveries about the nature of morality can be used to undermine moral judgements. On the first strategy, moral judgements are shown to be unjustified in virtue of being shown to rest on ignorance or false belief. On the second strategy, moral judgements are shown to be false by being shown to entail claims inconsistent with the relevant empirical discoveries. On the third strategy, moral judgements are shown to be false in (...) virtue of being shown to be unjustified; truth having been defined epistemologically in terms of justification. By interpreting three recent error theoretical arguments in light of these strategies, the paper evaluates the epistemological and metaphysical relevance of empirical discoveries about morality as a naturally evolved phenomenon. (shrink)

As Alexander D’Entrees observed over forty years ago, the case for natural law “is not an easy one to put clearly and convincingly.” Furthermore, even if one can make the case for natural law in a clear and convincing manner, one should not expect such an argument to be clear and convincing for all time. Instead, the case for natural law must be an ongoing argument, addressing itself perpetually to the needs of the time as these needs shift and (...) change. In short, the case for natural law “must needs appear in a different light according to the angle in time or in place from which it is looked at.” With this precept in mind, I seek to examine Thomas Aquinas’s natural law teaching on the legislation of virtue in light of concerns that are especially acute from the perspective of contemporary liberalism. (shrink)

L'esistenza del commento di Alessandro di Afrodisia al De generatione aristotelico, perduto nella versione greca e nella traduzione araba, è attestata da numerose fonti arabe, tra le quali Averroè, nel suo commento alla stessa opera. L'A. rintraccia la presenza, la tipologia e la distribuzione delle citazioni tratte dal commento di Alessandro nel Kitab al-Tasrif, un'opera del corpus alchemico attribuita a Gabir ibn Hayyan. Secondo l'A., la sezione interessata dalle citazioni assembla tre diversi tipi di testi: 1) lemmi del De generatione (...) in traduzione araba; 2) frammenti lacunosi della traduzione araba del commento di Alessandro; 3) interventi di collegamento. Una più ampia discussione si trova in un saggio visibile sulla pagina "publicationslist" dell'autore: "Alessandro di Afrodisia sulle 'contrarietà tangibili' (De gen. et corr. II.2): fonti greche e arabe a confronto" in: Aristotele e Alessandro di Afrodisia nella tradizione araba, a c. di C. D'Ancona e G. Serra, “Il Poligrafo”, Padova 2002, pp. 151-189. Notasi che il testo ricostruito di Alessandro in GC 2.2-5 è stato pubblicato da E. Gannagé nella serie ACA, che però non menziona il contributo di SF, dalla cui iniziativa, dalle cui analisi e dalla cui ricostruzione integrale, svolta sul manoscritto arabo Paris. 5099, la ricerca prese l'avvio. (shrink)

Identifying the necessary and sufficient conditions for individuating and classifying diseases is a matter of great importance in the fields of law, ethics, epidemiology, and of course, medicine. In this paper, I first propose a means of achieving this goal, ensuring that no two distinct disease-types could correctly be ascribed to the same disease-token. I then posit a metaphysical ontology of diseases—that is, I give an account of what a disease is. This is essential to providing the most effective means (...) of interfering with disease processes. Following existing work in the philosophy of medicine and epidemiology (primarily Christopher Boorse; Caroline Whitbeck; Alexander Broadbent), philosophy of biology (Joseph LaPorte; D.L. Hull), conditional analyses of causation (J.L. Mackie; David Lewis), and recent literature on dispositional essentialism (Stephen Mumford and Rani Anjum; Alexander Bird), I endorse a dispositional conception of disease. Following discussion of various conceptions of disease-identity, their relations to the clinical and pathological effects of the diseases in question, and how diseases are treated, I conclude (i) that diseases should be individuated by their causes, and (ii) that diseases are causal processes best seen as simultaneously acting sequences of mutually manifesting dispositions. (shrink)

Öz: Frege özel adların (ve diğer dilsel simgelerin) anlamları ve gönderimleri arasında ünlü ayrımını yaptığı “Anlam ve Gönderim Üzerine” (1948) adlı makalesinde, bu ayrımın önemi, gerekliliği ve sonuçları üzerine uzun değerlendirmeler yapar ancak özel adın anlamından tam olarak ne anlaşılması gerektiğinden yalnızca bir dipnotta kısaca söz eder. Örneğin “Aristoteles” özel adının anlamının Platon’un öğrencisi ve Büyük İskender’in öğretmeni ya da Stagira’da doğan Büyük İskender’in öğretmeni olarak alınabileceğini söyler. Burada dikkat çeken nokta örnekteki özel adın olası anlamları olarak gösterilen belirli betimlemelerin (...) de özel ad içeriyor olması. Anlamın Frege için bileşimsel olduğu, bir başka deyişle bir dilsel simgenin anlamının (varsa) parçalarının anlamlarınca belirlendiği düşünülürse, örnekteki belirli betimlemelerin anlamlarının saptanabilmesi için içerdikleri özel adların da anlamları saptanıp betimleme içinde geçtikleri yere konmalıdır. Bu işlem hiçbir özel ad kalmayana kadar sürdürülmelidir. Ancak biraz düşünülünce bir özel adın nesnesini tekil olarak betimleyecek ve içinde özel ad geçmeyecek bir betimleme bulmanın kolay olmadığı görülür. Örneğin yukarıdaki betimlemelerde geçen “Platon”, “Büyük İskender” ve “Stagira” gibi özel adların anlamları olabilecek ancak özel ad içermeyen betimlemeler bulmak pek kolay görünmüyor. Ortaya bir sonsuz gerileme sorunu çıkmış gibi duruyor. Frege’nin anlam-gönderim ayrımını için ciddi sonuçları olabilecek bu sorunu Frege çözebilir mi? Bu yazıda bu sorunun yanıtını arayacağım. Sorunu betimledikten sonra Frege’nin önündeki seçenekleri (örneğin bağlama duyarlı terimlerden (gösterme adılları veya belirteçler) yararlanma veya bağlamı sınırlama gibi) değerlendireceğim. -/- Abstract: In his “Sense and Reference” (1948), Frege makes his famous distinction between the sense and the reference of a proper name (and other signs) and discusses at length the significance, necessity and consequences of the distinction, but he explains how the sense of a proper name should be understood very briefly in a footnote. According to him, for example, the sense of the proper name “Aristotle” can be taken as the pupil of Plato and teacher of Alexander the Great or the teacher of Alexander the Great who was born in Stagira. What is interesting here is that the definite descriptions given as the possible senses of this proper name do themselves contain proper names too. Since the sense is something compositional for Frege, which means the sense of a linguistic sign is determined by its constituents (if there are any), in order to determine the sense of definite descriptions in question, we should first determine the senses of proper names they contain and substitute these senses with the proper names themselves. This process should continue until no proper name remains. However, it does not seem easy to find a definite description which describes the object of a proper name uniquely but contains no proper name itself. For instance, could we find appropriate senses that contain no proper name for “Plato”, “Alexander the Great” and “Stagira”? It does not seem likely. A problem of infinite regress appears to arise. Can Frege solve this problem, which poses a serious threat for his sensereference distinction? I will explore this problem in this paper. After explaining the problem, I will discuss the options (e.g. turning to indexicals or context restriction) Frege can take to deal with it. (shrink)

This article shows the origin of the famous Aristotelian expression τὸ τί ἦν εἶναι in everyday language. The expression is analysable in τὸ εἶναι and τί ἦν, and this part is the core of the common language question τουτὶ τί ἦν; or τουτὶ τί ἦν τὸ πρᾶγμα; always in imperfect form. This question is often found in Aristophanes’ comedies, which represent common Attic language. The imperfect ἦν is noted as a common Attic form indicating the present already by early comentators (...) of Aristotle as Alexander of Aphrodisias, the scholia to Aristophanes, later by Budaeus, but also in the modern Greek Lexikon of D. Demetrakos. Therefore not the imperfect is the problem, by mere embarrassement it was called "philosophic." The situations in the Aristophanean comedies, in which the question occurs, show that the thing about which somebody asks, is present, in front of the speaker, that it is an individual thing and something absolutly unexspected. The questioner will ask "What on the whole is this?" He asks about the first ground of being of the thing. The term τὸ τί ἦν εἶναι quotes only the use of εἶναι in this question in common language (like many other terms are quotations as τὸ τί ἐστίν; τὸ οὗ ἕνεκα etc.) and may be paraphrased by "Think of ’to be’ as you use it in the question ’What at all is this?’ " See also my article: Sonderegger (2001). Zur Sprachform des Ausdrucks to ti en einai. Rheinisches Museum Für Philologie 144:113–122. -/- The consequences of this linguistic finding can be found in my comments on Metaphysik Z and Metaphysics Λ (English version from 2020). (shrink)

The paper discusses the sense in which the changes undergone by normative economics in the twentieth century can be said to be progressive. A simple criterion is proposed to decide whether a sequence of normative theories is progressive. This criterion is put to use on the historical transition from the new welfare economics to social choice theory. The paper reconstructs this classic case, and eventually concludes that the latter theory was progressive compared with the former. It also briefly comments on (...) the recent developments in normative economics and their connection with the previous two stages. (Published Online April 18 2006) Footnotes1 This paper suspersedes an earlier one entitled “Is There Progress in Normative Economics?” (Mongin 2002). I thank the organizers of the Fourth ESHET Conference (Graz 2000) for the opportunity they gave me to lecture on this topic. Thanks are also due to J. Alexander, K. Arrow, A. Bird, R. Bradley, M. Dascal, W. Gaertner, N. Gravel, D. Hausman, B. Hill, C. Howson, N. McClennen, A. Trannoy, J. Weymark, J. Worrall, two annonymous referees of this journal, and especially the editor M. Fleurbaey, for helpful comments. The editor's suggestions contributed to determine the final orientation of the paper. The author is grateful to the LSE and the Lachmann Foundation for their support at the time when he was writing the initial version. (shrink)

Wall, G. Locke's attack on innate knowledge.--Harris, J. Leibniz and Locke on innate ideas.--Greenlee, D. Locke's idea of idea.--Aspelin, G. Idea and perception in Locke's essay.--Greenlee, D. Idea and object in the essay.--Mathews, H. E. Locke, Malebranche and the representative theory.--Alexander, P. Boyle and Locke on primary and secondary qualities.--Ayers, M. R. The ideas of power and substance in Locke's philosophy.--Allison, H. E. Locke's theory of personal identity.--Kretzmann, N. The main thesis of Locke's semantic theory.--Woozley, A. D. Some remarks (...) on Locke's account of knowledge.--Laudan, L. The nature and sources of Locke's views on hypotheses. (shrink)

This article discusses the relationship (or lack thereof) between authors’ intentions and the meaning of literary works. It considers the advantages and disadvantages of Extreme and Modest Actual Intentionalism, Conventionalism, and two versions of Hypothetical Intentionalism, and discusses the role that one’s theoretical commitments about the robustness of linguistic conventions and the publicity of literary works should play in determining which view one accepts.

Résumé Le débat holisme-réductionnisme se structure autour de trois domaines sémantiques : l 'ontologie, la méthodologie et l'épistémologie. Généralement, une méthodologie analytique s'accompagne d'une ontologie atomiste et de la réduction des lois et théorie des niveaux d'organisation supérieurs aux lois et théorie des niveaux inférieurs. Par contre, une ontologie holiste, relationnelle peut s'accorder au concept d'émergence. En conséquence dans l'élaboration des lois et théories d'un phénomène appartenant à un niveau donné la prise en compte du niveau d'organisation supérieurs se révélera (...) déterminante. Les propositions philosophiques anti-mécanicistes de précurseur tels que Bradley, S. Alexander, A.N. Whitehead, C.L. Morgan, D.C. Broad, même en restant au niveau d'une forme de proto-émergentisme représentent le fondement épistémologique à partir duquel s'est développée une méthodologie véritablement émergentiste. Abstract The holism-reductionism debate is structured around three areas of semantics: ontology, methodology and epistemology. As a general rule, an analytical methodology goes with an atomist ontology, and the reduction of laws and theories from the higher levels of organisation to the laws and theories of lower levels. On the other hand, a holistic and relational ontology can be in unison with the concept of emergence. As a consequence, in elaborating laws and theories of a phenornenon of a given level, taking into account that the higher level of organisation will be determinant. The philosophical and anti-mechanistic propositions of precursors such as F. Bradley, S. Alexander, A.N. Whitehead, C.L. Morgan, D.C. Broad, even remaining at the level of a kind of proto-emergentism represent the epistemological basis on which a true emergentist methodology has been developed. (shrink)

Reedition of papers in English spanning from 1986 to 2009 /// Historical background -- An imposed legacy -- Twentieth century contemporaneity -- Appendix: The philosophy of teaching legal philosophy in Hungary /// HISTORICAL BACKGROUND -- PHILOSOPHY OF LAW IN CENTRAL & EASTERN EUROPE: A SKETCH OF HISTORY [1999] 11–21 // PHILOSOPHISING ON LAW IN THE TURMOIL OF COMMUNIST TAKEOVER IN HUNGARY (TWO PORTRAITS, INTERWAR AND POSTWAR: JULIUS MOÓR & ISTVÁN LOSONCZY) [2001–2002] 23–39: Julius Moór 23 / István Losonczy 29 // (...) ON THE SURVIVAL OF ILMAR TAMMELO’S LETTER AND MANUSCRIPT ADDRESSED TO PROFESSOR MOÓR [2009] 41–44 // PROFESSIONAL DISTRESS AND SCARCITY: ALEXANDER HORVÁTH AND THE LEGACY OF NATURAL LAW IN HUNGARY [2005] 45–50 // HUNGARIAN LEGAL PHILOSOPHY IN THE 20TH CENTURY [2011] 51–72: I. The Pre-war Period [1. Bódog (Felix) Somló (1871–1920) 52] / II. The Inter-war Period [2. Gyula (Julius) Moór (1888–1950) 54 / 3. Barna Horváth (1896–1973) 55 / 4. József Szabó (1909–1992) 57 / 5. István Bibó (1911–1979) 58 / 6. Tibor Vas (1911–1983) 59 / 7. István Losonczy (1918–1980) 60] III. The Post-war Period (Communism) 61 [8. Imre Szabó (1912–1991) 62 / 9. Vilmos Peschka (1929–2006) 63 / 10. Kálmán Kulcsár (1928–2010) 65] IV. Contemporary Trends and Perspectives 66 [11. Csaba Varga (b. 1941) 66 / 12. András Sajó (b. 1949) 69 / 13. Béla Pokol (b. 1950) 70] V. Our Understanding of the Law Today 71 --- AN IMPOSED LEGACY -- LOOKING BACK [1999] 75–94: 1. On Ideologies and Marxism in general 75 / 2. Life of an Intellectual in Communism 79 / 3. On Marxism and its Socialist Cultivation in Particular 82 / 4. Legal Philosophising [4.1. Approaches to Law 87 / 4.2. Arriving at a Legal Ontology 91] 5. Conclusion 94 // LEGAL PHILOSOPHY OF THE MARXISM OF SOCIALISM: HUNGARIAN OVERVIEW IN AN INTERNATIONAL PERSPECTIVE [2003] 95–151: I. Development and Balance of Marxist Philosophising on Law in Hungary [1. Preliminaries (until 1948) 96 / 2. Stalinism (from the Soviet Occupation on) {a) Liquidation of the »Residues« 98 / b) Soviet-type Uniformisation [Gleichschaltung] 99 / c) Denial of the Past, with a Dual Effect 99 / d) »Socialist Legality«, Drawn from the Progressive Past of Western Europe 103 / e) Search for the Germs of Scholarly Evolution 103} 3. Institutionalisation Accompanied by Relaxation (from the 1960s) [a) Epigonism Becoming the Scholarly Ideal 104 / b) Stalinism in a Critical Self-perspective 105 / c) Disciples Diversified Launching their own Trends 107 / d) Comparatism 110 / e) (Re)discovery of the Western Legal Philosophy as a Competitor 112 / f) A Leading Mediatory Role within the »Socialist World Order« 114} 4. Disintegration (in the 1980s) {a) Attempt at Laying New Foundations for Marxism with Epigonism Exhausted 115 / b) Competitive Trends Becoming Exclusive 115 / c) Western Legal Philosophy Acknowledged as a Fellow-traveller within the Socialist Orbit Proper 116 / d) Hungarian Legal Theory Transforming into a National Corpus 118 / e) The Practical Promotion of Some Balance 119} 5. End-game for a Substitute State Religion (in the 1990s) 120] II. Marxist Legal Philosophising in an International Perspective [Ad 1: To the Preliminaries 122 / Ad 2: To Stalinism 124 / Ad 3: To Institutionalisation Accompanied by Relaxation {a) Late Separation from Vishinskiy’s Theory 125 / b) From Ideological Self-closure to an Apparently Scholarly Openness 127 / c) From Political Ideology to Genuine Scholarship 130 / d) International Recognition of Socialist Jurisprudence as an Independent Trend 135 / e) Together with Western Trends 137} Ad 4: To Disintegration {a) Loss of Attraction as Mere Epigonism 139 / b) Exclusivity of Competing Trends 139 / c) Fellowship with »Bourgeois« Trends 140 / d) An own Trend, Internationally Recognised 141 / e) A yet Progressive Role 142} Ad 5: To the Present state 143] III. A Temporary Balance 145 // AUTONOMY AND INSTRUMENTALITY OF LAW IN A SUPERSTRUCTURAL PERSPECTIVE [1986] 151–175: 1. The Strange Fate of Concepts 151 / I. A Relational Category 2. Basis and Superstructure: The Genuine Meaning 154 / 3. Exerting Social Influence as a Conceptual Minimum 156 / 4. Relationships within the Prevailing Totality 158 / 5. Attempts at Interpretation in Hungary 159 / 6. The Lukácsian Stand 162 / 7. Lukács’s Recognitions 168 / 8. Some Criticism 169 / II. The Law’s Understanding 171 / 9. Law Interpreted as Superstructure 171 / 10. Conclusions Drawn for the Law’s Understanding 173 // LEGAL THEORY IN TRANSITION (A PREFACE FROM HUNGARY) [2000] 177–186 // DEVELOPMENT OF THEORETICAL LEGAL THOUGHT IN HUNGARY AT THE TURN OF THE MILLENNIUM [2006] 187–215: 1. International Environment 188 / 2. The Situation in Hungary 190 / 3. Outlook I: The Historical-comparative Study of Legal Cultures and of the Lawyerly Way of Thinking 203 / 4. Outlook II: The Paradigmatic Enigma of the Transition to Rule of Law 207 / 5. Incongruity in Practice 213 / 6. Perspectives 214 --- TWENTIETH CENTURY CONTEMPORANEITY -- CHANGE OF PARADIGMS IN LEGAL RECONSTRUCTION: CARL SCHMITT AND THE TEMPTATION TO FINALLY REACH A SYNTHESIS [2002] 219–234: 1. Dangers of Intellectualism 219 / 2. Schmitt in Facts 221 / 3. Schmitt and Kelsen 222 / 4. On Bordering Conditions 226 / 5. With Kelsen in Transubstantiation 230 / 6. Polarisation as the Path of Theoretical Development 232 // KELSENIAN DOCUMENTS IN HUNGARY: CHAPTERS ON CONTACTS, INCLUDING THE GENESIS OF AUTOBIOGRAPHY [2006] 235–243: 1. Preludes 235 / 2. The Search for Moór’s Bequeath 235 / 3. Moór’s Collegiality 238 / 4. Bibó as a Disciple Translating 241 // THE »HART-PHENOMENON« [2002] 245–267: I. The Hart-miracle 246 [1. The Scene of Britain at the Time 247 / 2. The Personal Career 250 / 3. The Opus’ Career 252 / 4. Verbal Sociologism 255 / 5. Growing into the British Pattern 259] II. The Hart-phenomenon 260 [6. Origination of a Strange Orthodoxy 261 / 7. Mastering Periods of the 20th Century 263 / 8. Raising the Issue of Reception in Hungary 365] // LITERATURE? A SUBSTITUTE FOR LEGAL PHILOSOPHY? [2007] 269–287: 1. The Enigma of Law and its Study 269 / 2. “Law and Literature” 271 / 3. Varieties of “Law and Literature” 274 / 4. The German Study of Artistic Representations 280 / 5. Some Literary Reconsiderations 285 / 6. Conclusion 287 --- APPENDIX -- THE PHILOSOPHY OF TEACHING LEGAL PHILOSOPHY IN HUNGARY [2007] 291–320: I. Why and How to Philosophise in Law? 291 / II. The State of Teaching Legal Philosophy 294 / III. The Philosophy of Teaching Legal Philosophy 296 / IV. Programme at the Catholic University of Hungary 300 [1. Graduate Studies 300 {a) Basic Subjects 301 / b) Facultative Seminars 305 / c) Closing Subjects 309 / d) Written Memoranda and the Thesis 312} 2. Postgraduate Studies 313 / 3. Conclusion 317] V. Perspectives 318 /// Index of Subjects 321 / Index of Normative Materials 328 / Index of Names 329 . (shrink)

This article presents a newly discovered votive inscription found during the course of the 2013 survey conducted at the ancient city of Phaselis and in its territory. The inscription was found where the stairs to the acropolis from the southwest of the theatre end, in front of the west wall of the tower structure give access to the acropolis. This inscription in the Doric dialect, on a limestone block measuring 0.315 x 0.77 x 0.61 m., records a dedication to Athena (...) Polias. The letters 0.03 m. high, exhibit Late Archaic - Early Classical Period features ( - - - - ) and, consequently the inscription can be dated to the Vth century B.C. -/- Phaselis and its Chief Goddess Athena Polias From the earliest times of Athena worship, especially in the Aegean Islands and Hellas, this goddess was the protectress of cities, institutions and mythological heroes and she manifested this function in various ways. In one of the earliest recorded examples she carries the epithet ἐρυσίπτολις (guardian of the cities), and in another example, in a Linear B inscription discovered in the Palace of Knossos on Crete as Atana Potnia (a-ta-na-po-ti-ni-ja), the mistress of the palace. But perhaps the most striking myth relating to this role of Athena is undoubtedly that of the Palladion statue, the reason for the fall of Troy and for defeat in the Trojan War. In this context, Troy could resist the Achaeans for as long as it was protected by the Palladion, but after it was stolen by Odysseus and Diomedes, the city was captured by the Achaeans. Subsequently, Athens, Argos and Sparta, the most powerful Greek cities, as later the city of Rome, in order to obtain Athena’s protection and so to gain legitimization for the expansion of their empires, invented their own myths claiming that the Palladion statue from Troy was brought to their cities. In another myth the Goddess became the protectress of Tegea through giving Medusa’s hair as a protective image to a hero of the city. Athena’s frequently used epithets, Polias (Πολιάς), Poliouchos (Πολιοῦχος), and the epithet the protectress of the Athenians (Ἀθηνᾶ Ἀθηνῶν μεδέουσα), employed as a means of religious propaganda by the city of Athens when it established the Delian League which subsequently evolved into an empire, clearly indicate Athena was regarded as guardian of the cities. Particularly during the Archaic and Classical Periods, it was this aspect of Athena that, politically placed the Goddess amongst the most important of deities with Zeus and Apollo, and she is most commonly found with the epithet Polias. The epithet Polias or similar, refers in particular to the heart of these cities, to their acropoleis, where Athena Polias was usually worshipped. Her temples located on the heights of the cities made her role particularly visible as the main protecting goddess. One of the best examples of this “visibility”concerns the earliest record of the epithet Polias as, although she wasn’t the chief deity of Argos, within the sanctuary of Athena Polias located on Larisa hill an inscription was found which supplies us with the text of a cult regulation which is datable to the VIth century. B.C.. The Anatolian goddess of Malija, equal to Athena (in Lycia), was attested in Hittite texts from IInd millennium B.C.. This goddess worshipped in Lycia, close to the city of Phaselis, is similarly in a relationship with cities and acropoleis. The Inscribed Pillar of Ksanthos dating from the Vth century B.C. records that many acropoleis were seized with the help of Athena ptoliporthos (πτολίπορθος) “Sacker of Cities”. In the same inscription the city of Patara was named together with Malija and it may refer to the Patara of Malija as in the example of the Lindian Athena (Lindos, city of Athena). Moreover, the goddess Malija was named with the epithet Wedrẽñni (regional, municipal) the equivalent of the epithet Polias in Rhodiapolis. During the great colonization movements (750-550 B.C.) the colonists brought the cult of Athena Polias to many Mediterranean cities, as was the case for example for Lindos on the island of Rhodos. As a matter of fact the strongest ties between Lindos and the colonies which Rhodes founded was the cult of Athena. In consequence, these cities offered precious gifts to the Temple of Athena in Lindos as a demonstration of both their veneration of the goddess and of loyalty. According to myth, the city of Phaselis was colonized in 691/690 B.C. by a group under the leadership of Lakios from Lindos and the Athena cult of the mother city was brought to Phaselis. Thereafter the Phaselitai dedicated the helmets and sickles to Athena Lindia upon which was inscribed, “Having taken them from the Solymoi, the Phaselitai offered them to Athena Lindia, when Lakios was the leader of the colonists”. In addition to this, the other evidence concerning the presence of Athena in the city confirms that this deity was the chief goddess of Phaselis. During the Classical, and especially in the Hellenistic Period, depictions of Athena’s owl, of her Palladion and of Athena Promachos are found. As mentioned above, the epithet Polias usually draws attention to a city’s acropolis with the temple of Athena Polias located there. In the case of Phaselis, the find spot of these votive inscriptions, reused in a wall of a tower that was built in defense of the acropolis, provides an additional indication for the localization of Athena’s temple to the acropolis. This temple most probably was on the acropolis where there are the ruins of a columned building and large ashlar blocks possibly indicating the site of a temple; however, due to the dense vegetation and in the absence of excavations, at present this localisation cannot be stated with certainty. Another reference indicating that Athena Polias was the chief deity of the city was the presence of a holy relic in the Temple of Athena, the spear of the hero of the Trojan War Achilles. During his campaign against the Persians, Alexander the Great stayed in Phaselis in the winter of 334/333 B.C. and he left Achilles’ spear in the Temple of Athena at Phaselis. During the Hellenistic Period, Hellenistic Kings were mentioned with the chief deities of the Archaic and Classical periods as were the emperors in Roman Imperial Period. And according with this practice, the boule and demos of Phaselis worshipped Athena Polias together with the deified emperors, known from an honorific inscription for a certain Ptolemaios. Evidence from the Late Roman Period, especially from the IIIrd century A.D., records the Palladeios agons (ἀγὼν Παλλάδειος) were held in the city in honour of the Goddess Athena. Consequently, philological, epigraphic as well as numismatic evidence shows the Goddess Athena was the chief deity of the city of Phaselis from the Archaic Period into the Late Roman Period. As the epithet Polias on this votive inscription indicates, the goddess had a temple which should be located on the acropolis where the holy relic (Achilles’ spear) was kept and where the officials of the goddess conducted their functions. This new votive inscription provides record of the role Athena occupied in this early post-colonisation period of the city’s political and socio-cultural history. Further, it is also a physical document dating from the city’s Late Archaic-Early Classical Period, aiding in the evaluation of both Phaselis and of the wider region’s history of settlement. (shrink)

L'écologie préénergétique des années 1905-1935 est à la recherche de ses objets d'étude. Des unités fondamentales de la nature (telles que formation végétale, association végétale, climax, biome, communauté biotique, écosystème) se trouvent en compétition et se succèdent les unes aux autres. Autour des années 1920 et 1930, la philosophie organiciste d'Alfred N. Whitehead, ainsi que la perspective évolutionniste d'Herbert Spencer et les propositions émergentistes de Samuel Alexander et Conwy L. Morgan, deviennent des références sous-jacentes au débat épistémologique concernant les (...) unités de base de l'écologie. Des auteurs comme Frederic E. Clements et John Phillips soutiendront plusieurs formes d'organicisme écologique, tandis que Henry A. Gleason interprétera l'association végétale comme le résultat d'une juxtaposition fortuite d'individus. Enfin, et paradoxalement, l'écosystème de Arthur G. Tansley, tout en faisant partie, à l'origine, d'une perspective anti-organiciste, deviendra l'unité fondamentale de programmes de recherche qui se voudront, au moins dans leurs intentions, émergentistes. (shrink)

This paper attempts to illustrate Aristotle’s logic mainly its concepts of genus, differentia and species and, more importantly, its theory of deduction as a theory of sets. If our articulation of them as sets is consistent, we might be allowed to conclude That what Aristotle had in mind in his logic was indeed a theory of sets. 1) Syllogism definition When two predications are arranged in a way that, without the addition of any other term or relation, a new predication (...) necessarily follows from them, we have a syllogism. Aristotle believes that ‘any form of persuasion’ is formed by syllogism. (PrA., B, 23, 68b9-18) A syllogism includes two premises. (PrA., A, 23, 41a4-7; PrA., A, 25, 42a32-35) A premise is a settlement, or rejection of a settlement, between two terms. (cf. PrA., A, 24a28-30) Aristotle also speaks of immediate premise (‌πρότασις ἄμεσος), a proposition that has no other proposition prior to it. He calls such a premiss the principle (ἀρχὴ) of demonstration. (PsA., A, 2, 72a7-8) He draws a distinction between dialectical and demonstrative premiss: ‘If it is dialectical, it assumes either part indifferently; if it is demonstrative, it lays down one part to the definite exclusion of the other because that part is true.’ (PsA., A, 2, 72a8-11) Every syllogism includes three terms (cf. PrA., A, 25a30-31): two extremes, a major and a minor, and one middle. (cf. PrA., A, 4, 25b35-37; 26a21-23) The middle element, which is the element that is related to both of the extremes and is stated in both premises (PrA., A, 32, 47a30-34), is the element that makes a third relation and thereby a syllogism possible. Therefore, no syllogism is possible without a middle. (PrA., A, 23, 40b40-41a4 and a7-13PrA, A, 23, 84b19-27; PrA, A, 32, 47b8-9; PrA., A, 23, 68b30-37) The number of middles, however, does not make a problem because no matter how many they are, the figures will be the same. (PrA., A, 23, 41a18-20) It is indeed the middle about which the question arises. (PsA, B, 2, 89b37-90a11) 2) Peculiar, general, necessary and essential syllogism An essential syllogism is a syllogism that its conclusion includes an essential relation. Here, the predicate in the conclusion belongs to the essence of its subject. A peculiar syllogism is a syllogism that its conclusion is a peculiar relation, which means the predicate is ‘peculiar’ to the subject. An essential predication in the conclusion does not happen unless both of the premises include an essential and univerdal predication; nor does a peculiar conclusion results without peculiar predication in both premises. Therefore, we have an essential syllogism when the predicates of the premises are essentially and universally to their subjects and belong to their essence. (PsA., B, 4, 91a18-25 and b7-11) Consequently, an essential conclusion does not result if only one of the premises has an essential relation. (PsA., B, 4, 91a21-23; 91b1-7) The same can be said about peculiar conclusion. (PsA., PsA., B, 4, 91a16-18; 8, 93a11-12) A general syllogism is a syllogism its conclusion includes a general relation. A general relation between a subject and a predicate is a relation in which though the predicate is not predicated of all the subjects ‘always and in every case,’ it is predicated of most of the cases or/and most of the times. Like an essential and a peculiar syllogism, a general syllogism also results only out of two general relations in the premises. (PsA., B, 12, 96a8-19) A necessary conclusion, however, does not need both of the relations in premises to be necessary. The reason is that if A has a necessary relation to B even when B has a simple full inclusion relation with C, A must be necessarily related to C. (PrA., A, 9, 30a17-20) 3) Whole-part relationship The whole-part relationship of the terms in syllogism can be proved both in the articulation of the figures of syllogism and in Aristotle’s own words. a) Whole-part relationship in Aristotle’s articulation of figures Based on the arrangement of the terms and the positions they take in these arrangements, there are three figures. We have the first figure when the arrangement of the terms is such: major-middle and middle-minor. In this figure, ‘the last is contained in the middle as in a whole, and the middle is contained, or excluded from, the first as in or from a whole.’ (PrA., 4, 25b32-34) In this figure, ‘the middle is contained in the major and contains the minor.’ (PsA., A, 4, 25b35-36) The order of terms based on largeness of size or extension is the basic order in which the name of terms matches their sizes: major-middle-minor. The first figure, thus, indicates the relations between the biggest and the smallest class through a medium class. We have the second figure when the arrangement of the elements in relations are such: major-middle and minor-middle. In this figure, the belonging of the same term to other two terms is the case and the middle is that which is predicated of both of the extremes and stands outside them. (PrA., A, 5, 26b34-27a3) The middle is, thus, the largest in extent. Though there must supposedly not be an absolute distinction between major and minor, Aristotle calls that term which is near the middle the major and that which is far away from the middle the minor. In fact, since the middle in this figure is of the largest extent, what is posited nearer to it will be of a larger inclusion. The order of terms based on the largeness of size or extension is: middle-major-minor. Here the major is only bigger than the minor. The second figure thus indicates the relation between two subclasses of a class. We have the third figure when the arrangement of the elements in relations are such: middle-major and middle minor. In this figure, the predication of two terms of the same subject is the case and the middle is that of which both of the extremes are predicated and is, thus, the smallest in size. That extreme which is farthest from the middle, and is thence the larger one, is called the major while the other, which is nearer to the middle, and is thence the smaller one, is called the minor. (PrA., A, 6, 28a10-15) The third figure thus indicates the relation between two classes of a subclass. We have thus three ways of connecting extremes by the middle. While the middle in the first figure stands between the extremes, predicating of one and being predicated of the other, it stands outside in the second figure predicating of both extremes but inside in the third figure of which both extremes are predicated. (PrA, A, 23, 41a13-18; 32, 47b1-5) In all three figures, Aristotle calls that which is the bigger among the extremes the major and that which is smaller the minor. If we have the rule that the predicate is wider in extent than its subject in mind, we can see how whole-part relationship is the basis of the articulation of syllogisms in figures. It is the size of the term that is implied in its position. Thereupon, that which is predicated of both of the other terms in the first figure is called the major because it is bigger and that of which both of the other terms are predicated is called the minor. In the second figure, since the middle is predicated of both of the extremes, it is in fact the largest and the major here is bigger only than the minor. Thus, Aristotle calls that which is near the middle, and thus the bigger, the major while that which is far away than the middle, and thus smaller, the minor. In the third figure, since both of the extremes are predicated of the middle, it is the smallest one. Thus, the minor here is smaller only than the major. It is for this reason that Aristotle calls the major and the minor in the opposite way, comparing with the second figure: that which is nearer to the middle, and thus the smaller, is called the minor while that which is far away from the middle, and thus the bigger, the major. b) Aristotle conceding whole–part relationship First of all, Aristotle repeatedly uses en holoi in Prior Analytics (e.g. 25b33, 30a2, 47a13, 53a21, 58b27-29, 66b15-16 and 79a36-40)) cf. B202, 19, n.12) and en merei or kata meros (e.g. 24a16-17, 25a5-6, 42a10, 42a16, 49b37, 64a17, 64b12, 69a14). Moreover, the whole-part relationship of elements in syllogism is conceded in Aristotle’s words when describing the relations between terms. Τhe formation of a syllogism, Aristotle says, thoroughly depends on whole-part relation: ‘For in general, if two things are not related as whole to part (ὡς ὃλον πρὸς μέρος) and part to whole, the prover does not prove from them, and no syllogism is formed.’ (PrA., A, 41, 49b37-39) At 266.20-30 Alexander interprets Aristotle as not saying simply that every deduction must have a universal premise but that every deduction must include a premise universal in relation to the subject term of the conclusion to be proved. Robin Smith criticizes Alexander because this means, he says, that ‘every deduction must include a premise which affirms or denies something universally of its minor term, then it is simply false, as evidenced by Darii, Ferio, Baroco, Festino, and the entire third figure.’ He believes, however, that this must be read in line with Aristotle’s inclination to talk as if every deduction were a first-figure universal deduction. 4) Quantity: four kinds of relations and six kinds of sets Regarding the quantity of relation, four kinds of relations and six kinds of sets can be recognized as follows: a) Full inclusion (ԑ) A full inclusion is a relation in which a set includes all the members of another set. In this inclusion, the including set we call Fullset and the included set Demiset. A full inclusion is thus a relation between a fullset and a demiset. b) Half inclusion (ᶓ) A half inclusion is a relation in which two sets overlap and each include some of the members of the other. Each of the sets in this relation we call an Overlapping set. c) Full exclusion (ɜ) A full exclusion is a relation in which a set excludes all of the members of another set. Each of the sets in this relation is called a Noset of the other. d) Half exclusion (ᶔ) A half exclusion is a relation in which a set excludes some of the members of the other set. The set that excludes we call Lowerlapping set and the set that is excluded Lowerlapped set. Aristotle calls this relation indefinite. (PrA., A, 4, 26b14-15) A. Rules of Fruitful Multirelations Having recognized the four kinds of relations and the eight kinds of sets, now we are to do our final duty in this paper and to show how valid Aristotelian syllogisms are indeed rules based on the relations and the sets. 1) Rule I (R1): Full extension of full inclusions to demisets The full inclusion of a set is necessarily a full inclusion of its full inclusions. Thus, the full set of a set is necessarily the fullset of its demisets. Iφ A is a fullset of B, it is also a fullset of every set for which B is a fullset. 2) Rule II (R2): Half extension of full inclusion to overlapping sets The full inclusion of a set is necessarily (at least) a half inclusion of its overlapping sets. Thus, two sets, one a fullset and the other an overlapping set, of a third set must themselves at least be overlapping. If A is a fullset of B, it is at least an overlapping set of every set for which B is an overlapping set. 3) Rule III (R3): Full extension of full exclusion to demisets The relation between a set and a demiset of its noset is full exclusion: neither a set can include any member of a demiset of its noset, nor a demiset of its noset can include any of its members. Thus, if A and B are nosets and C a demiset of B, neither A can include any of the members of C, nor C any of the members of A where Aristotle says: ‘If then the terms are related universally a syllogism will be possible whenever the middle belongs to all of one subject and to none of another.’ (PrA., A, 5, 27a3-5; cf. PrA., A, 5, 26b34-27a3) Thus both of the moods at PrA., A, 5, 27a5-14 are based on this rule. Also cf. PrA., A, 5, 27a37-b6). This rule is asserted by Aristotle himself: ‘If A belongs to no B and to all C, we conclude that B belongs to no C. If then D is subordinate to C, clearly B does not belong to it … And yet B does not belong to E, if E is subordinate to A.’ (PrA., B, 1, 53a25-34) Aristotle does not, however, accept the extension of the rule to D and E as a syllogism. 4) Rule IV (R4): Half exclusion between a noset and an overlapping set of a set There is half exclusion between an overlapping set of a set and its noset. Thus, an overlapping set of a set is necessarily a lowerlapped set of its noset. Ιf B be an overlapping set and C a noset of A, it is necessary that B must be a lowerlapped set of C are based on this rule: ‘If the middle term is related universally to one of the extremes, a particular negative syllogism must result whenever the middle term is related universally to the major whether positively or negatively, and particularly to the minor and in a manner opposite to that of the universal statement.’ (PrA., A, 5, 27a26-32; cf. a32-36) It is also the basis of a mood of the first ((AᶓB, BɜC→AᶔC) and (AɜB, BᶓC→CᶔA)) (PrA., A, 4, 26a17-20) and one mood of the third figure. ((BɜA, BᶓC→CᶔA) and (BᶓA, BɜC→AᶔC)) (PrA., A, 6, 28b31-35)). This rule is in strict contradiction with N5 in which it is said that there must be no necessary relation between a noset and an overlapping set of a set. One mood of the first (PrA., A, 4, 26a36-39) and one mood of the second figure (PrA., A, 5, 27b4-6) do not come to a necessary result based on this rule. Whereas it is asserted at PrA., A, 4, 26a17-20 that when no A is B but some B are C, there is a valid syllogism, it is asserted at PrA., A, 4, 26a36-39 that it cannot be a syllogism. It seems the problem arises out of Aristotle’s differentiation between major and minor: when the universal relation is on the side of the major we have a syllogism: AɜB, BᶓC→CᶔA But when the universal relation is on the side of the minor, there is no syllogism: CɜB, BᶓA→No syllogism It is obvious that if we do not differentiate major from minor, there will be no difference between the two above types. But how can we differentiate them? How can we distinguish the major from the minor out of the two mentioned relations? How can we say C is a minor but A a major when we have only those two relations? Should not we determine our major and minor based on our own relations? But there is no real major or minor in such relations. 5) Rule V (R5): Extension of half exclusion to demisets The half exclusion of a set is necessarily extendable to its demisets. Thus, a lowerlapped set of a set is necessarily a lowerlapped set of its demiset. If B is a demiset of A and C a lowerlapped set of it, it is necessary that C must be a lowerlapped set of B too. 6) Rule VI (R6): Half inclusion between two full inclusions of a third set Two sets that are both full sets of a set are necessarily overlapping sets. In other words, if a set be a demiset of two sets, these two sets must overlap each other. If B be a demiset of both A and C, A and C must necessarily be overlapping sets. 7) Rule VII (R7): Half Extension of full exclusion to fullsets The relation between a set and a fullset of its noset is necessarily a half exclusion. Thus, the fullset of a set has necessarily half exclusive relation with its noset. In other words, If a set is a demiset of another set and at the same time a noset of a third set, it is necessary for its fullset to be a lowerlapped set of its noset: suppose B is a demiset of A and a noset of C, it is necessary for A to be a lowerlapped set of C. This rule is both accepted and denied by Aristotle in one paragraph: ‘If R belongs to all S, and P to no S, there will be a syllogism to prove that P will necessarily not belong to some R. … But if R belongs to no S, P to all S, there will be no syllogism.’ (PrA., A, 6, 28a25-31) Thus: SԑR, SɜP→SᶔP SɜR, SԑP→No Syllogism But what is the difference between these two? They cannot be different if there was no difference between S and P. But how can they be different when we are concluding based on only two relations? Aristotle wants the major and the minor be taken as different even when the relations do not make them different. So how can they make one different from the other? The inconsistency, the, arises from this differentiation, which is not meaningful when we take them as sets. 8) Rule VIII (R8): Extension of half inclusion to full sets The half inclusion relation with a set is extendable to its fullsets. In other words, half inclusion of a set necessarily leads to the half inclusion of its fullsets. Thus, if a set is a lowerlapped set of another set, its fullset must also be at least a lowerlapped set of it. If B is a lowelapped set of C, and A a fullset of B, it is necessary that A must be at least a lowerlapped set of C. This rule is in contradiction with N11 where there is no necessary relation between a fullset and a lowerlapped set of a set. (PrA., A, 6, 28b22-23) Thus, we have two following formulae: SԑR, SᶔP→RᶔP SԑP, SᶔR→ No Syllogism As we pointed out in our discussion of R4 and R7, this inconsistency is backed by Aristotle’s differentiation between major and minor while they cannot be differentiated. B. Cases where multirelationd are not fruithful In the same way as the rules of fruithful multirelations, our reconstruction of relations and sets show how and why some of the syllogisms do not lead to valid results in Aristotle’s logic. 1) N1: No necessary relation between a fullset and a noset of a set There is no necessary relation between a fullset of a set and its noset. If A is a fullset and C a noset of B, there is no necessary relation inferable between A and C. This rule is in strict contradiction with R7, where the half extension of full exclusion to fullsets is approved, while two moods of the third figure and one mood of the first figure are accepted to result in syllogism. This contradiction is evident in one text where Aristotle both accepts R7 and denies it. (PrA., A, 6, 28a25-31) 2) N2: No necessary relation between two full exclusions No relation can be inferred between two nosets of a set. If A and C are two nosets of B, none of the four relations is necessarily inferable between A and C. 3) N3: No necessary relation between a full and a half inclusion The relation between a fullset of a set and an overlapping set of it can be either of the four kinds of relations and, thus, no syllogism is inferable between them. If A is a fullset and C an overlappimg set of B, there is no necessary relation between A and C. 4) N4: No necessary relation between a demiset and a lowerlapping set of a set The relation between a demiset and a lowerlapping set of a set is not necessarily one of the four kinds of relations. If B is a lowerlapping set of A and at the same time a fullset of C, the relation between A and C is not a necessary relation. 5) N5: No necessary relation between a noset and an overlapping set of a set If A be a noset and C an overlapping set of B, no necessary relation is inferable between A and C. This is in strict contradiction with R4 in which it is necessary to be a half inclusion relation between an overlapping set of a set and its noset: AᶓB, BɜC→AᶔC and AɜB, BᶓC→CᶔA 6) N6: No necessary relation between a noset and a lowerlapping set of a set If C is a noset and A a lowerlapping set of B, there is no necessary relation between A and C. 7) N7: No necessary relation between a fullset and a lowerlapped set of a set If A is a fullset and C a lowerlapped set of B, there is no necessary relation inferable between A and C. 8) N8: No necessary relation between a full and a half exclusion There is no necessary relation between a noset and a lowerlapped set of a set. If A is a noset and C a lowerlapped set of B, there will be no necessary relation between A and C. 9) N9: No necessary relation between two halfly related sets Two halfly related sets, whether two half inclusions, two half exclusions or one half inclusion and one half exclusion, cannot bring about a third necessary relation. None of two overlapping sets, two lowerlapping sets, two lowerlapped sets, one overlapping and the other lowerlapping/lowerlapped set or one lowerlapping and the other lowerlapped set may result in a necessary relation. Thus, if A is an overlapping or a lowerlapping or a lowerlapped set of B, we do not have a syllogism whenever C is an overlapping or a lowerlapping or a lowerlapped set of B. 10) N10: No necessary relation between two demisets of a fullset If B is a fullset of both A and C, there will be no necessary relation between A and C except when one of A and C is the fullset of the other, which leads to a valid syllogism based on R1. 11) N11: No necessary relation between a fullset and a lowerlapped set of a set If A is a fullset and C a lowerlapped set of B, there will be no necessary relation between A and C. This is in strict contradiction with R8 where half inclusion to fullsets is said to be extendable. (PrA., A, 6, 28b15-21) -/- All figures, their moods and the rules applicable to each of them are shown in three tables in the appendix of this paper below. C. Is Aristotle’s Logic a Theory of Classification? There are some commentators who agree that Aristotle’s logic somehow is, or at least contains, a theory of classification. 1. K. J. Spalding thinks that Plato’s Ideas are fundamentally generic and the dialectic is a process of classification. He brings forward two reasons for his claim: i) classification reduces many individuals to a unity which is above them and ii) it does so by overcoming oppositions. He appeals to Philebus (16, V.): ‘The precise question to which the previous discussion requires an answer is how they are one and also many and not at once infinite, and what number of species is to be assigned to them before we allow them to drop into infinity.’ Spalding asserts: ‘If a process such as this was dialectic then, in requiring not merely genera but also species, it was pre-eminently classification.’ 2. Gareth B. Matthews says: ‘Man … is said of the individual man, say Socrates. And what that means is that Socrates is classified basically and fundamentally as a man. Put the other way round, man is said of Socrates means that man classifies Socrates in a fundamental way. … Here one might wonder why we shouldn’t say that Socrates is said of Socrates… The reason seems to be that Socrates does not classify Socrates; it names him.’ 3. Discoll believes that PrA. I, 24b26-30 suggests the interchangeability of talk about universal and classes. 4. Phil Corkum believes that the fact that Aristotle thinks in terms of collectivity does not necessarily mean that he must be thinking of sets because there is an alternative: mereology. A major difference between these two theories is that while set theory differentiates membership from inclusion, mereology does not make such a differentiation and has a unitary part relation. This explains why Aristotle does not distinguish class-membership from class-inclusion, and this objection is based on the wrong assumption that Aristotle’s theory is a set theory. He believes that Aristotle’s theory is a mereology rather than a set theory. ‘A mereology,’ he says, ‘unlike a set theory, typically employs uniting part relation and not distinct membership and inclusion relations.’ The view he ascibes to Aristotle is this: ‘both subjects and predicates refer, while holding that he would deny that a sentence is true just in case the subject and predicate name one and the same thing.’ He thinks that Aristotle’s semantic is not identity but ‘the weaker relation of constitution.’ Based on this view, ‘an ordinary predication such as ‘Man is mortal’ expresses a true thought, in Aristotle’s view, just in case the mereological sum of human is a part of the mereological sum of mortals.’ Nonetheless, he insists that he is not claiming that categorical predications ‘can be reductively analyzed into mereological claims’ but only that ‘certain mereological claims provide informative truth conditions for the thoughts which are expressed by categorical predications.’ 5. K. J. Spalding believes that ‘classification is the real, if implicit, basis of the Aristotelian logic.’ He accepts, however, that there are to be found theories in Aristotle’s logic being emphatically not developments of classification.’ He also admits that classification could not have been the meaning of Aristotle’s logic. What he emphasizes on is that: ‘The most important feature of the Aristotelian logic is perhaps its insistence on universality- on connexion of contents,- on independence of enumeration.’ 6. To resolve Velastos’ objection that Aristotle does not distinguish class-membership from class-inclusion, Daniel W. Graham thinks that it is not clear that taking secondary substances as classes is a valid assumption. (shrink)

REPRODUÇÃO EM NOVILHAS LEITEIRAS -/- INTRODUÇÃO -/- O principal objetivo da criação de substitutos em gado leiteiro é produzir uma novilha que tenha seu parto aos dois anos de idade (23 a 25 meses) e com um peso de 550 a 580 kg. O manejo reprodutivo das novilhas começa quando estas atingem 14 ou 15 meses de idade e um peso de 350 a 370 kg. A produção de novilhas deve ser suficiente para substituir as vacas descartadas anualmente (25 a (...) 35%), e para contribuir com o crescimento do rebanho. Espera-se que em um gado leiteiro deva haver uma população de animais de reposição, desde um dia de vida até à fase de novilha ao parto, correspondendo pelo menos a 70 % do total das vacas (figura 1). -/- Figura 1: A meta do programa de produção de substitutos ou fêmeas de reposição consiste em uma novilha que chegue ao seu primeiro parto aos 24 ou 25 meses de idade, entre um peso de 550 a 580 kg. Elaborado pelo autor. -/- A produção de novilhas depende basicamente de três fatores: da fertilidade das vacas, ou seja, do número de bezerras nascidas anualmente; da mortalidade durante a criação e desenvolvimento; e da eficiência reprodutiva das novilhas. O manejo reprodutivo moderno das novilhas é orientado para a utilização da inseminação artificial, seja em um estro natural ou sincronizado. As novilhas representam a população animal geneticamente mais avançada no rebanho, portanto, o mérito genético de suas crias obtidas por inseminação é maior do que o das crias das vacas adultas. Além disso, as crias das novilhas obtidas mediante a inseminação aceleram o avanço genético, uma vez que contribuem com uma proporção maior de substituições do rebanho em comparação com as crias das vacas de outras faixas etárias. Além disso, as novilhas são as fêmeas mais férteis do rebanho (porcentagem de concepção: 60 a 70% vs 30 a 40% em vacas), pelo que o custo do sêmen por gestação é menor em comparação com as vacas adultas, o que permite investir em melhores touros e em sêmen sexado. -/- 1. PUBERDADE -/- A puberdade é definida como a fase de desenvolvimento em que a fêmea apresenta o seu primeiro estro fértil. Regularmente as novilhas leiteiras, sob condições ótimas de manejo, chegam à puberdade entre 11 e 12 meses de idade, ou seja, antes de alavancar o peso recomendado para receber o primeiro serviço. Vale salientar que as novilhas podem ficar gestantes após a puberdade; no entanto, isto não é conveniente porque ainda não completou-se o seu desenvolvimento. Se ficarem gestantes nos primeiros ciclos estrais, as novilhas poderiam chegar ao parto com pouco desenvolvimento físico, o que provocaria distocias e baixa produção de leite (figura 2). A ativação do sistema neuroendócrino para que a bezerra atinja a puberdade é regulada principalmente pelo estado nutricional (condição corporal). A transição do anestro pré-puberal à ciclicidade puberal coincide com um aumento da condição corporal e das concentrações de insulina, IGF-I e leptina. Estes hormônios agem como sinais metabólicos no hipotálamo e hipófise que modificam a frequência de secreção das gonadotropinas, resultando na maturação folicular e ovulação. O atraso em relação à puberdade está diretamente relacionado com deficiências na alimentação; esta condição verifica-se em criações pouco tecnificadas, principalmente de pequenos e médios produtores. As novilhas que já atingiram o peso para receber o primeiro serviço e não apresentaram estro, devem ser examinadas por via retal para excluir possíveis anormalidades do desenvolvimento, tais como freemartinismo ou hipoplasia genital. -/- Figura 2: O fator mais importante que determina a puberdade é a nutrição. Bezerras bem alimentadas apresentam ciclos estrais aos 11 meses de idade e devem ser inseminadas aos 14 ou 15 meses de idade, com um peso de 350 a 370 kg. Acervo pessoal do autor. -/- 2. DETECÇÃO DE ESTRO E INSEMINAÇÃO ARTIFICIAL -/- A baixa eficiência na detecção de estros é o problema que mais afeta a eficiência reprodutiva das novilhas. De acordo com a duração do estro (8 a 18 horas), a observação das novilhas em períodos de 30 minutos durante a manhã e à tarde, permite detectar em estro até 70% das fêmeas, enquanto a observação contínua (24 horas) aumenta a eficiência na detecção até 95% (figuras 3 e 4). No manejo tradicional dos rebanhos leiteiros, as novilhas recebem pouca atenção por parte dos trabalhadores, o que resulta em baixa eficiência na detecção de estros (50 a 60%). Em diferença das vacas adultas em lactação, as novilhas estão menos expostas a fatores que diminuem a expressão do estro, portanto, com uma rotina de observação, de pelo menos duas horas na manhã (6h a 8h da manhã) e duas horas pela tarde até a noite (17h da tarde a 19h da noite), pode-se detectar até 90% das fêmeas no estro (figura 5). -/- Figura 3: O fator que mais influencia a idade ao primeiro parto é a baixa eficiência na detecção de estros, pelo que é recomendável a observação de estros com pessoal qualificado, em períodos de pelo menos duas horas pela manhã e duas à tarde. Acervo pessoal do autor. -/- Figura 4: Com a observação contínua é possível alcançar de 90 a 95% de eficiência na detecção de estros. Acervo pessoal do autor. -/- Figura 5: A inseminação deve ser realizada durante o período de receptividade sexual. Com boa eficiência na detecção de estros, a inseminação pode ser praticada no programa AM-PM e PM-AM, ou em apenas um turno de inseminação pela manhã (10:00), com bons resultados. -/- 3. TAXA DE PRENHEZ -/- O melhor indicador de eficiência reprodutiva é a taxa de prenhez. Este indicador refere-se à proporção de animais gestantes do total elegível para inseminação, num período equivalente a um ciclo estral. Como já se descreveu no trabalho Fisiologia do Estro e do Serviço na Reprodução Bovina, este indicador considera a eficiência na detecção de estros e a porcentagem de concepção, e reflete com maior objetividade a eficácia do manejo reprodutivo. Este parâmetro pode ser melhorado através de um aumento da proporção de novilhas detectadas em estro, o que se obtém aumentando o tempo de observação e aplicando técnicas de sincronização do estro (figura 6). -/- 4. INSEMINAÇÃO DE NOVILHAS COM SÊMEN SEXADO -/- A utilização de sêmen sexado é uma boa opção para a produção de novilhas de reposição. Com a nova tecnologia disponível para a separação de espermatozoides com o cromossomo x, é possível alcançar até 90% de crias fêmeas; no entanto, o processo de separação de espermatozoides tem baixa eficiência, o que limita o número de espermatozoides por palheta. As palhetas de inseminação com sêmen sexado contém de dois a três milhões de espermatozoides (doses de sêmen não sexado têm de 20 a 30 milhões). De acordo com os dados de fertilidade de gados comerciais, as novilhas inseminadas com sêmen sexado mostram de 10 a 20% menor concepção que novilhas inseminadas com sêmen não sexado, o que desencoraja o seu uso. Causas de baixa fertilidade não são conhecidas, no entanto, estão associadas com a menor concentração espermática e com alguns danos nos espermatozoides provocados pelo processo de separação. No entanto, o uso de sêmen sexado é uma opção viável para aumentar a produção de novilhas no rebanho, e com o melhoramento dos processos de separação espermática em pouco tempo se converterá em uma prática de rotina nos estábulos (figura 7). -/- Figura 6: Uma técnica que aumenta a eficiência na detecção dos estros consiste em pintar a região da grupa. Quando esta pintura desaparece ou se nota que as novilhas estão "talhadas", devem ser apalpadas via retal para determinar se existem sinais genitais de estro. Acervo pessoal do autor. -/- Figura 7: As novilhas são as fêmeas mais férteis do rebanho, por isso o custo do sêmen por gestação é menor em comparação com as vacas adultas, o que permite investir em melhores touros e em sêmen sexado. Acervo pessoal do autor. 5. MONTA DIRIGIDA -/- A monta dirigida ou direta é uma opção prática e eficaz para emprenhar as novilhas. Neste sistema se introduz um touro com um grupo de novilhas, para que ele se encarregue de encontrar as fêmeas em estro e proceder a monta. Em rebanhos comerciais, o ideal é a utilização de um touro para 25 fêmeas. No entanto, com este manejo perde-se a oportunidade de utilizar a inseminação artificial e, com isso, a possibilidade de melhoria genética. -/- 6. PROGRAMAS DE SINCRONIZAÇÃO DE ESTROS -/- Os tratamentos para sincronizar o estro das novilhas possuem os mesmos fundamentos que os utilizados nas vacas. -/- 6.1 Prostaglandina F2a -/- A PGF2α é utilizada para a sincronização de estros em grupos de novilhas, e também é utilizada para a indução do estro individualmente, nas fêmeas que são examinadas por via retal e têm um corpo lúteo. A resposta dos animais tratados é variável; em novilhas pode-se alcançar até 95% de animais em estro. O tempo de manifestação do estro após a injeção é de 48 a 120 horas. -/- 6.1.1 Dupla injeção de PGF2a -/- Além da sincronização dos animais selecionados pela presença de um corpo lúteo diagnosticado por palpação retal, existem dois programas que não incluem a palpação retal. Por exemplo, na segunda-feira, ou no dia preferido, injeta-se PGF2α em todas as novilhas que se deseja inseminar. Cerca de 50% das novilhas manifestarão estro nas próximas 48 a 120 horas. As fêmeas que não mostrarem estro receberão uma segunda injeção na segunda-feira seguinte (intervalo de sete dias). As que apresentaram estro com a primeira injeção teriam um corpo lúteo nesse momento, enquanto as que não o manifestaram estavam em estro ou em metaestro; assim, ao repetir o tratamento sete dias depois, estas últimas novilhas teriam um corpo lúteo e responderiam à PGF2α (figura 8). No outro programa, é administrada duas doses de PGF2α com 11 dias de separação/intervalo. As novilhas podem ser inseminadas no estro observado, após qualquer uma das duas injeções. Este programa oferece uma boa sincroniza- ção após a segunda injeção e é o programa de escolha na sincronização das novilhas receptoras de embriões (figura 9). -/- Figura 8: Sincronização do estro com dupla injeção de PGF2a com 7 dias de diferença/intervalo. Elaborado pelo autor. -/- Figura 9: Sincronização do estro com dupla injeção de PGF2a com 11 dias de diferença/intervalo. Elaborado pelo autor. -/- 6.2 Progestágenos -/- Existe um tratamento que consiste na inserção, na parte externa da orelha, de um implante que contém norgestomet, que permanece na região auricular por nove dias. Além disso, o tratamento é complementado com a injeção intramuscular de valerato de estradiol e norgestomet, no momento da colocação do implante. O tempo de apresentação do estro a partir da remoção do implante é de 48 a 72 horas e a proporção de animais em estro muitas vezes se torna maior do que 80%. Outro tratamento é baseado na inserção intravaginal de dispositivos de liberação de progesterona. O dispositivo pode ser utilizado durante 12 dias ou o período de exposição pode ser encurtado, desde que seja acompanhado da injeção de uma dose luteolítica de PGF2α, um dia antes ou no momento da remoção do dispositivo. A fertilidade global conseguida após o serviço no estro sincronizado é similar à obtida no estro natural; porém, algumas novilhas são menos férteis, o que está associado com alterações no desenvolvimento folicular e alterações na relação temporal entre o estro e a ovulação. Observou-se que o tratamento com implantes de norgestomet combinados com a injeção de valerato de estradiol pode induzir comportamento estral em animais que não estão ciclando normalmente. Isso ocorre porque os níveis de estradiol, administrados no primeiro dia, persistem até o momento da remoção do implante. Assim, ao remover a fonte do progestágeno e ao haver concentrações altas de estradiol se desencadeia o estro, o qual em novilhas anéstricas não é acompanhado de ovulação, enquanto que em novilhas ciclando se altera a relação temporal entre o estro, pico pré-ovulatório de LH e ovulação. Bons resultados são alcançados quando o valerato de estradiol não é administrado e é substituído por uma injeção de PGF2α no momento da remoção do implante. Outro fator que tem sido associado com baixa fertilidade é o dia do ciclo em que o tratamento começa. Observou-se que quando coincide com a presença de um corpo lúteo (diestro), a porcentagem de concepção é maior do que quando não há um corpo lúteo (proestro). Isto ocorre porque a concentração sérica do progestágeno, por si só, não é capaz de suprimir a secreção pulsátil de LH, o que faz com que o folículo dominante presente no momento de iniciar o tratamento não sofra atresia e persista até o dia da retirada do progestágeno, convertendo-se no folículo ovulatório. Com isso, o folículo já envelheceu e o ovócito já sofreu alterações que reduzem o seu potencial para desenvolver um embrião viável. Quando o tratamento coincide com a presença de um corpo lúteo, a secreção de LH é efetivamente suprimida devido ao efeito aditivo da progesterona secretada pelo corpo lúteo e do progestágeno exógeno, inserido na vaca, o que provoca a reposição folicular. Em condições de campo, a seleção das vacas pela presença de um corpo lúteo antes de iniciar o tratamento com progestágenos é impraticável, uma vez que não é possível visualizá-lo, além disso essa prática/seleção não faria sentido, já que seria mais fácil tratar estes animais com dose ou doses de PGF2α. Atualmente existem tratamentos para eliminar folículos dominantes e promover uma nova onda folicular. -/- 6.3 Progestágenos orais -/- O acetato de melengestrol (MGA) é um progestágeno administrado por via oral. Em fêmeas bovinas é utilizado para melhorar a eficiência alimentar nos currais de engorda, o que se consegue através da inibição da apresentação do estro. Como todos os progestágenos, o MGA inibe a secreção de LH, eliminando assim a maturação do folículo e a ovulação. Após a remoção do MGA, o folículo dominante termina o seu desenvolvimento e as fêmeas apresentam estro em forma sincronizada. A dose de MGA por novilha é de 0,5 a 1 mg por dia, em tratamentos que variam de 9 a 14 dias. A apresentação comercial de MGA contém 0,22 mg do hormônio por 1 g do produto. O MGA pode ser facilmente misturado com qualquer concentrado ou grão moído. Após o último dia de tratamento, o estro se apresenta de dois a seis dias. O intervalo de remoção do MGA ao estro é mais longo quando comparado com outros progestágenos. Isto deve-se ao tempo de remoção do MGA, uma vez que enquanto um implante ou dispositivo intravaginal é removido abruptamente, o MGA pode continuar a ser absorvido enquanto é removido do trato gastrointestinal. Com tratamentos de 14 dias podem-se obter porcentagens de concepção menores em comparação com o estro natural, o que se deve em grande parte à ovulação de folículos persistentes. Um tratamento eficaz, que também melhora a fertilidade, consiste na administração de MGA durante 14 dias, seguido de uma injeção de PGF2α 15 ou 17 dias após a remoção do progestágeno. Com este programa, uma alta proporção de fêmeas teriam um corpo lúteo no momento da injeção da PGF2α e apresentariam estro com boa sincronização. Outro tratamento eficaz consiste na administração do MGA durante nove dias, mais uma dose de PGF2α ao nono dia; com este programa também se obtêm bons resultados em sincronização do estro e fertilidade. Este tratamento foi avaliado com novilhas holandesas e a porcentagem de fêmeas sincronizadas é elevada (95%). A porcentagem de concepção é semelhante à obtida no estro natural. Estes resultados são comparáveis aos obtidos com outros programas, como implantes de norgestomet ou dispositivos intravaginais de liberação de progesterona, mas com um custo significativamente menor (figura 10). -/- 6.4 Sincronização da ovulação e inseminação em tempo fixo -/- Em contraste com o observado em vacas em lactação, a resposta das novilhas aos programas de sincronização da ovulação e inseminação a tempo fixo é deficiente, o que se reflete em porcentagens de concepção de 20 a 35% menores que as novilhas inseminadas no estro natural. A causa desta resposta está relacionada com diferenças no desenvolvimento folicular; assim, nas novilhas o tempo de desenvolvimento do folículo dominante é mais rápido e o tempo de domínio é mais curto do que nas vacas em lactação. Desta forma, o folículo da onda folicular sincronizada com a injeção de GnRH sofre atresia antes da injeção de PGF2α, de tal forma que quando se induz a ovulação com a segunda injeção de GnRH, as novilhas têm folículos em diferentes estádios de desenvolvimento, o que provoca assincronia entre a ovulação e a inseminação artificial. -/- Figura 10: Programa de sincronização do estro com Acetato de Melengestrol (MGA). Elaborado pelo autor. -/- 7. MANEJO DO ANESTRO -/- Uma vez que as novilhas atingem a puberdade, apresentam ciclos estrais em intervalos de 21 dias que só são interrompidos pela gestação ou por alguma patologia. O anestro patológico é raro em novilhas; no entanto, surgem casos de piometra e cistos luteinizados, que são tratados com uma dose de PGF2α. Também se observam anormalidades de desenvolvimen- to, tais como freemartinismo e hipoplasia genital, patologias que não têm tratamento; somente 8% das novilhas freemartin são férteis. O anestro funcional (as novilhas manifestam estro, mas não são detectadas) é frequen- te e está diretamente relacionado com a eficiência na detecção de estros. As novilhas com idade e peso para se integrarem no programa reprodutivo e não apresentarem sinais de estro devem ser examinadas retalmente para diagnosticar a causa do anestro. Se, durante a palpação retal, as novilhas tiverem um corpo lúteo são tratadas nesse momento com PGF2α, os animais sem corpo lúteo podem receber uma injeção de PGF2α, sete dias depois. Este programa sincroniza o estro e aumenta a probabilidade de o detectar (figura 11). -/- Figura 11: As novilhas com idade e peso para se integrarem no programa reprodutivo e não mostrarem sinais de estro devem ser verificadas via retal para diagnosticar a causa do anestro. Arquivo pessoal do autor. -/- 8. MANEJO DA NOVILHA INFÉRTIL -/- A fertilidade das vacas leiteiras diminuiu nos últimos 30 anos, enquanto a fertilidade das novilhas não se alterou; após a primeira inseminação, entre 60 e 70% das novilhas emprenham. O objetivo do programa reprodutivo é conseguir que 90% das novilhas gestem nos primeiros três serviços. Desta forma, esta proporção de animais daria à luz antes dos 25 meses de idade. É comum que 10% das novilhas se transformem em animais repetidores, ou seja, novilhas com mais de três serviços inférteis. A causa da falha na concepção de novilhas deve-se principalmente à morte embrionária precoce. Uma causa importante da falha na concepção das novilhas repetidoras são as patologias adquiridas no aparelho reprodutivo; é comum encontrar aderências ovarianas e salpingite. Provavelmente, esses problemas são consequência de alguma infecção adquirida durante a criação. Diversos tratamentos hormonais têm sido testados para resolver o problema de infertilidade em novilhas repetidoras e os resultados obtidos ainda são deficientes. Como estes tratamentos não apresentam resultados consistentes, a melhor forma de mitigar o problema de infertilidade nas novilhas é melhorando as práticas de inseminação, ou seja, o momento da inseminação, o manejo do sêmen e a técnica de inseminação empregada. Além disso, a melhor técnica para aumentar a proporção de novilhas prenhes no rebanho é aumentar a eficiência da detecção de estros. -/- 9. RESUMO -/- As novilhas devem parir aos dois anos de idade (23 a 25 meses). O peso ao parto deve ser de 550 a 580 kg. O manejo reprodutivo começa aos 14 ou 15 meses de idade, com um peso de 350 a 370 kg. As palhetas de sêmen sexado contêm de 2 a 3 milhões de espermatozoides. As doses de sêmen não sexado contêm de 20 a 30 milhões de espermatozoides. A porcentagem de concepção das novilhas inseminadas com sêmen sexado é 10 a 20% menor do que com sêmen não sexado. Com sêmen sexado se obtém entre 90 e 95% de fêmeas. A porcentagem de concepção com programas de IATF é de 20 a 35% menor que nas novilhas inseminadas no estro natural. Cerca de 90% das novilhas devem ficar prenhes nos primeiros três serviços. Devem ser produzidas novilhas para substituir as vacas que são descartadas anualmen- te (25 a 35%). Espera-se que um gado leiteiro tenha ao dispor uma população de animais de reposição, desde um dia de vida até a etapa de novilha ao parto, correspondente a, pelo menos, 70 % do total das vacas. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- AUAD, Alexander Machado et al. Manual de bovinocultura de leite. Brasília: LK Editora, 2010. BRICKELL, J. S.; MCGOWAN, M. M.; WATHES, D. C. Effect of management factors and blood metabolites during the rearing period on growth in dairy heifers on UK farms. Domestic animal endocrinology, v. 36, n. 2, p. 67-81, 2009. DE VRIES, A. et al. Exploring the impact of sexed semen on the structure of the dairy industry. Journal of Dairy Science, v. 91, n. 2, p. 847-856, 2008. Fertilidade em Vacas Leiteiras: Fisiologia e Manejo. Fisiologia do Estro e do Serviço na Reprodução Bovina. FERREIRA, A. M. Manejo reprodutivo de bovinos leiteiros: práticas corretas e incorretas, casos reais, perguntas e respostas. Edição do autor, Juiz de Fora, 2012. FERREIRA, A. de M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns (causas e tratamentos). Juiz de Fora: Minas Gerais–Brasil, p. 422, 2010. GALINA, Carlos; VALENCIA, Javier. Reproducción de los animales domésticos. 2006. GONÇALVES, J. N. Manual do produtor de leite. Viçosa, MG: Aprenda Fácil, 2012. HEINRICHS, A. J. Raising dairy replacements to meet the needs of the 21st century. Journal of dairy science, v. 76, n. 10, p. 3179-3187, 1993. HOFFMAN, P. C. Optimum body size of Holstein replacement heifers. Journal of Animal Science, v. 75, n. 3, p. 836-845, 1997. NEIVA, R. S. Criação eficiente de bezerros e novilhas. Lavras: Autor, 2013. NEIVA, Rogério Santoro. Produção de bovinos leiteiros. Lavras: UFLA, 1998. PEREIRA, E. S. et al. Novilhas leiteiras. Graphiti Gráfica e Editora LTDA, Fortaleza, Ceará, 2010. CARVALHO, B. C. Manejo reprodutivo de novilhas leiteiras. In. SENAR. Curso de reprodução e genética em bovinocultura de leite. Coronel Pacheco: Senar, 2021. YOUNGQUIST, Robert S.; THRELFALL, W. R. Large animal theriogenology. 2007. (shrink)

Der berühmte Ameisenmann E.O. Wilson war schon immer einer meiner Helden - nicht nur ein hervorragender Biologe, sondern eine der winzigen und verschwindenden Minderheit von Intellektuellen, die es zumindest wagt, die Wahrheit über unsere Natur anzudeuten, die andere nicht verstehen oder, soweit sie es verstehen, aus politischen Gründen unermüdlich vermeiden. Leider beendet er seine lange Karriere auf äußerst schäbige Weise als Partei eines ignoranten und arroganten Angriffs auf die Wissenschaft, der zumindest teilweise durch die religiöse Inbrunst seiner Harvard-Kollegenmotiviertist. Es zeigt (...) die abscheulichen Folgen, wenn Universitäten Geld von religiösen Gruppen annehmen, Wissenschaftszeitschriften von großen Namen so bewundert sind, dass sie eine ordnungsgemäße Peer Review vermeiden und wenn Egos außer Kontrolle geraten dürfen. Es führt uns in die Natur der Evolution, die Grundlagen der wissenschaftlichen Methodik, wie Mathematik mit Wissenschaft zusammenhängt, was eine Theorie ausmacht, und sogar, welche Einstellungen zu Religion und Großzügigkeit angemessen sind, wenn wir uns unaufhaltsam dem Zusammenbruch der industriellen Zivilisation nähern. Ich fand Abschnitte in 'Conquest' mit dem üblichen prägnanten Kommentar (obwohl nichts wirklich Neues oder Interessantes, wenn man seine anderen Werke gelesen hat und auf biologie im Allgemeinen ist) in der oftgestylten Prosa, die sein Markenzeichen ist, aber war ziemlich überrascht, dass der Kern des Buches seine Ablehnung inklusiver Fitness (die seit über 50 Jahren ein Standbein der Evolutionsbiologie ist) zugunsten der Gruppenauswahl ist. Man nimmt an, dass von ihm kommen und mit den articles er bezieht sich auf veröffentlicht von sich selbst und Harvard Mathematik Kollege Nowak in großen Peer-Review-Zeitschriften wie Nature, muss es ein wesentlicher Fortschritt sein,, trotz der Tatsache, dass ich wusste, Gruppenauswahl wurde fast überall abgelehnt, da mit jeder großen Rolle in der Evolution. Ich habe zahlreiche Rezensionen im Netz gelesen und viele haben gute Kommentare, aber die, die ich am meisten sehen wollte, war, dass von renommierten Wissenschaftsautor und Evolutionsbiologe Richard Dawkins. Im Gegensatz zu den meisten von Fachleuten, die in Zeitschriften nur für diejenigen mit Zugang zu einer Universität zur Verfügung stehen, ist es leicht im Netz verfügbar, obwohlanscheinend, entschied er sich, es nicht in einer Zeitschrift zu veröffentlichen, da es angemessen abscheulich ist. Leider findet man eine vernichtende Ablehnung des Buches und den acerbic Kommentar über einen wissenschaftlichen Kollegen, den ich je von Dawkins gesehen habe -- über alles in seinem vielen Austausch mit dem verstorbenen und unbeklagten Demagogen und Pseudowissenschaftler Stephan Jay Gould. Obwohl Gould für seine persönlichen Angriffe auf seinen Harvard-Kollegen Wilson berüchtigt war, stellt Dawkins fest, dass ein Großteil von "Conquest" einen unbequem an Goulds häufige Verfehlungen in "bland, unfocussed ecumenicalis" erinnert. Dasselbe gilt mehr oder weniger für Wilsons populäres Schreiben, einschließlich seines jüngsten Buches "The Meaning of Human Existence" – eine weitere schamlose Eigenwerbung seiner diskreditierten Ideen zu Inklusiver Fitness (IF). Dawkins weist darauf hin, dass das berüchtigte 2010-Papier von Nowak, Tarnita und Wilson in Nature von über 140 Biologen, die einen Brief unterzeichnet haben, fast überall abgelehnt wurde und dass es in Wilsons Buch kein Wort darüber gibt. Auch in den folgenden 4 Jahren mit Artikeln, Vorträgen und mehreren Büchern haben sie dies nicht korrigiert. Es gibt keine andere Wahl, als Dawkins trenchant Kommentar zuzustimmen: "Für Wilson nicht zu zugeben, dass er für sich selbst gegen die große Mehrheit seiner professionellen Kollegen spricht - es schmerzt mich, dies von einem lebenslangen Helden zu sagen -- ein Akt mutwilligen Arroganz." Angesichts von Nowaks späterem Verhalten muss man ihn auch einbeziehen. Ich habe das Gefühl, dass einer der fassungslosen Menschen, die man im Fernsehen sieht, interviewt wird, nachdem der nette Mann von nebenan, der seit 30 Jahren alle Kinder babysitten, als Serienmörder entlarvt wird. Dawkins weist auch darauf hin (wie er und andere seit vielen Jahren), dass inklusive Fitness mit dem Neo-Darwinismus (d.h. logischerweise folgt) entsteht und nicht abgelehnt werden kann, ohne die Evolution selbst abzulehnen. Wilson erinnert uns erneut an Gould, der Kreationisten von der einen Seite seines Mundes anprangerte, während er ihnen Trost spendete, indem er endlosen ultraliberalen marxistisch gefärbten Kauderwelsch über Spandrels, unterbrochenes Gleichgewicht und Evolutionspsychologie von der anderen ausspeist. Die Unbestimmtheit und mathematische Opazität (für die meisten von uns) der Mathematik der Gruppen- oder Mehrebenenauswahl ist genau das, was die Sanftmütigen ihnen ermöglichen wollen, dem rationalen Denken in ihren endlosen antiwissenschaftlichen Gerüchten und (in der Wissenschaft) postmodernen Wortsalate zu entkommen. Schlimmer noch, Wilsons "Eroberung" ist ein schlecht durchdachtes und schlampig geschriebenes Durcheinander voller Nonsequiturs, vager Streifzüge, Verwirrungen und Inkohärenz. Eine gute Bewertung, die einige davon im Detail ist, dass von Absolvent Gerry Carter, die Sie im Netz finden können. Wilson hat auch nichts mit unserem gegenwärtigen Verständnis der Evolutionspsychologie (EP) zu tun (siehe z.B. die letzten 300 Seiten von Pinkers 'The Better Angels of our Nature'). Wenn Sie eine seriöse Buchlänge Bericht über die soziale Evolution und einige relevante EP von einem Experten wollen, siehe 'Principles of Social Evolution' von Andrew F.G. Bourke, oder ein nicht ganz so ernster und zugegebenermaßen fehlerhafter und irrender Bericht, aber ein Muss,das Robert Trivers dennoch lesen muss—'The Folly of Fools: The Logic of Deceit and Self-Deception in Human Life' und ältere, aber immer noch aktuelle und durchdringende Werke wie 'The Evolutionof Cooperation':Revised Edition by Robert Axelrod and 'The Biology ofMoral Systems' von Richard Alexander. (shrink)

Bird reveals an important problem at the heart of Armstrong’s theory of laws of nature: to explain how a law necessitates its corresponding regularity, Armstrong is committed to a vicious regress. In his very brief response, Armstrong gestures towards an argument that, as he admits, is more of a “speculation.” Later, Barker and Smart argue that a very similar problem threatens Bird’s dispositional monist theory of laws of nature and he is committed to a similar vicious regress. In this paper, (...) first, I construct Armstrong’s would-be argument in response to Bird. Second, I argue that his response makes his account of laws and natural properties incompatible with science. Finally, I argue that Armstrong’s strategy to address Bird’s criticism can be used, quite ironically, to defuse Barker and Smart’s argument against Bird. (shrink)

The relationship of the author’s intention to the meaning of a literary work has been a persistently controversial topic in aesthetics. Anti-intentionalists Wimsatt and Beardsley, in the 1946 paper that launched the debate, accused critics who fueled their interpretative activity by poring over the author’s private diaries and life story of committing the ‘fallacy’ of equating the work’s meaning, properly determined by context and linguistic convention, with the meaning intended by the author. Hirsch responded that context and convention are not (...) sufficient to determine a unique meaning for a text; to avoid radical ambiguity we must appeal to the author’s intention, which actualizes one of the candidate meanings. Subsequent writers have defended refined versions of these views, and a variety of positions on the spectrum between them, in a debate that remains central to philosophical aesthetics. This Teaching and Learning Guide lists key readings and suggests how they might be incorporated within a syllabus. It also offers focus questions related to the readings. See also the companion article, Sherri Irvin, “Authors, Intentions and Literary Meaning.” Philosophy Compass 1 (2006), 114-128. (shrink)

Professor Morales’ Coss Dialogue Lecture demonstrates the utility of pragmatism for his work as a social scientist across three projects: 1) field research studying the acephalous and heterogenous social order of Chicago’s Maxwell Street Market; 2) nascent research how unseen religious orders animate the lives of im/migrants and their contributions to food systems; and 3) large-scale longitudinal research on farmers markets using the Metrics + Indicators for Impact (MIFI) toolkit. The first two sections of my paper applaud and build upon (...) Morales’ first two projects, and my extremely brief third section raises some questions about positivist specters that may haunt the MIFI project insofar as it is conceptualized, described, and deployed using the terms favored by mainstream social science. (shrink)

According to ontological nihilism there are, fundamentally, no individuals. Both natural languages and standard predicate logic, however, appear to be committed to a picture of the world as containing individual objects. This leads to what I call the \emph{expressibility challenge} for ontological nihilism: what language can the ontological nihilist use to express her account of how matters fundamentally stand? One promising suggestion is for the nihilist to use a form of \emph{predicate functorese}, a language developed by Quine. This proposal faces (...) a difficult objection, according to which any theory in predicate functorese will be a notational variant of the corresponding theory stated in standard predicate logic. Jason Turner (2011) has provided the most detailed and convincing version of this objection. In the present paper, I argue that Turner's case for the notational variance thesis relies on a faulty metasemantic principle and, consequently, that an objection long thought devastating is in fact misguided. (shrink)

Can there be grounding without necessitation? Can a fact obtain wholly in virtue of metaphysically more fundamental facts, even though there are possible worlds at which the latter facts obtain but not the former? It is an orthodoxy in recent literature about the nature of grounding, and in first-order philosophical disputes about what grounds what, that the answer is no. I will argue that the correct answer is yes. I present two novel arguments against grounding necessitarianism, and show that grounding (...) contingentism is fully compatible with the various explanatory roles that grounding is widely thought to play. (shrink)

When people suffer they always suffer as a whole human being. The emotional, cognitive and spiritual suffering of human beings cannot be completely separated from all other kinds of suffering, such as from harmful natural, ecological, political, economic and social conditions. In reality they interact with each other and influence each other. Human beings do not only suffer from somatic illnesses, physical pain, and the lack of decent opportunities to satisfy their basic vital, social and emotional needs. They also suffer (...) when they are not able to experience and grasp any meaning of life even if such suffering is not quite as obvious as most forms of physical, social and emotional suffering. Suffering from the lack for the sense of the meaning of life is a special form of emotional, cognitive, and spiritual suffering. Although all human beings share the same basic human need for some meaning of life, the fulfilment of this need is highly individual and personal. Although all forms of human suffering can be a challenge to the meaning of life, the personal conditions of suffering usually are a stronger challenge for the meaning of life. Among the personal conditions of human suffering, the Grenzsituationen cannot be cancelled or raised at all, but only accepted and coped with as existential aspects of the conditio humana. According to Karl Jaspers these are: death, suffering, struggling, guilt, and failing. The challenge for human beings to cope with these Grenzsituationen is a way to move from the mere Being-there to true human Existence. (shrink)

Samuel Alexander was a central figure of the new wave of realism that swept across the English-speaking world in the early twentieth century. His Space, Time, and Deity (1920a, 1920b) was taken to be the official statement of realism as a metaphysical system. But many historians of philosophy are quick to point out the idealist streak in Alexander’s thought. After all, as a student he was trained at Oxford in the late 1870s and early 1880s as British Idealism (...) was beginning to flourish. This naturally had some effect on his philosophical outlook and it is said that his early work is overtly idealist. In this paper I examine his neglected and understudied reactions to British Idealism in the 1880s. I argue that Alexander was not an idealist during this period and should not be considered as part of the British Idealist tradition, philosophically speaking. (shrink)

ABSTRACT It has become standard to conceive of metalinguistic disagreement as motivated by a form of negotiation, aimed at reaching consensus because of the practical consequences of using a word with one content rather than another. This paper presents an alternative motive for expressing and pursuing metalinguistic disagreement. In using words with given criteria, we betray our location amongst social categories or groups. Because of this, metalinguistic disagreement can be used as a stage upon which to perform a social identity. (...) The ways in which metalinguistic disagreements motivated in this way diverge in character from metalinguistic negotiations are described, as are several consequences of the existence of metalinguistic disagreements motivated in this way. (shrink)

Achieving space situational awareness requires, at a minimum, the identification, characterization, and tracking of space objects. Leveraging the resultant space object data for purposes such as hostile threat assessment, object identification, and conjunction assessment presents major challenges. This is in part because in characterizing space objects we reference a variety of identifiers, components, subsystems, capabilities, vulnerabilities, origins, missions, orbital elements, patterns of life, operational processes, operational statuses, and so forth, which tend to be defined in highly heterogeneous and sometimes inconsistent (...) ways. The Space Domain Ontologies are designed to provide a consensus-based realist framework for formulating such characterizations in a way that is both consistent and computable. Space object data are aligned with classes and relations in a suite of ontologies built around the existing Space Object Ontology. They are stored in a dynamically updated Resource Description Framework triple store, which can be queried to support space situational awareness and the needs of spacecraft operators and analysts. This paper provides an overview of the Space Domain Ontologies and their development and use. It presents the motivation for and advantages of the Space Domain Ontologies, including the benefits they provide for enhancing and maintaining long-term space situational awareness. (shrink)