It is widely thought that functionalism and the qualia theory are better positioned to accommodate the ‘affective’ aspect of pain phenomenology than representationalism. In this paper, we attempt to overturn this opinion by raising problems for both functionalism and the qualia theory on this score. With regard to functionalism, we argue that it gets the order of explanation wrong: pain experience gives rise to the effects it does because it hurts, and not the other way around. With regard to the (...) qualia theory, we argue that it fails to capture the sense in which pain 's affective phenomenology rationalises various bodily-directed beliefs, desires, and behaviours. Representationalism, in contrast, escapes both of these problems: it gets the order of explanation right and it explains how pain 's affective phenomenology can rationalise bodily-directed beliefs, desires, and behaviours. For this reason, we argue that representationalism has a significant advantage in the debates about pain 's affective phenomenology. We end the paper by examining objections, including the question of what representationalists should say about so-called ‘disassociation cases’, such as pain asymbolia. (shrink)

Abstract: Standing half wave particles at light speed twice in expansion-contraction comprise a static universe where two transverse fields 90° out of phase are the square of distance from each other. The universe has a static concept of time since the infinite universe is a static universe without a beginning or end. The square of distance is a point of reversal in expansion-contraction between the fields as a means to conserve energy. Photons on expansion in the electric field create matter (...) energy while photons on contraction in the magnetic field create light energy and gravitational pull toward the higher frequency energy. Also, the universe with matter has a moving physical concept of time from gravitational pull on expansion-contraction. (shrink)

Abstract: Standing half wave particles at light speed twice in expansion-contraction comprise a static universe where two transverse fields 90° out of phase are the square of distance from each other. The universe has a static concept of time since the infinite universe is a static universe without a beginning or end. The square of distance is a point of reversal in expansion-contraction between the fields as a means to conserve energy. Photons on expansion in the electric field create matter (...) energy while photons on contraction in the magnetic field create light energy and gravitational pull toward the higher frequency energy. Also, the universe with matter has a moving physical concept of time from gravitational pull on expansion-contraction. (shrink)

Abstract: Standing half wave particles at light speed twice in expansion-contraction comprise a static universe where two transverse fields 90° out of phase are the square of distance from each other. The universe has a static concept of time since the infinite universe is a static universe without a beginning or end. The square of distance is a point of reversal in expansion-contraction between the fields as a means to conserve energy. Photons on expansion in the electric field create matter (...) energy while photons on contraction in the magnetic field create light energy and gravitational pull toward the higher frequency energy. Also, the universe with matter has a moving physical concept of time from gravitational pull on expansion-contraction. (shrink)

Abstract: Standing half wave particles at light speed twice in expansion-contraction comprise a static universe where two transverse fields 90° out of phase are the square of distance from each other. The universe has a static concept of time since the infinite universe is a static universe without a beginning or end. The square of distance is a point of reversal in expansion-contraction between the fields as a means to conserve energy. Photons on expansion in the electric field create matter (...) energy while photons on contraction in the magnetic field create light energy and gravitational pull toward the higher frequency energy. Also, the universe with matter has a moving physical concept of time from gravitational pull on expansion-contraction. (shrink)

Decision-making has traditionally been viewed as detached from the neural systems of sensory perception and motor function. Consequently, motor areas have played a relatively minor role in discussions surrounding the control processes and neural origins of decision-making. Empiric evidence, catalysed by technological advances in the past two decades, has proven that motor areas have an integral role in decision-making. They are involved in the generation, modulation, maintenance and execution of decisions and actions. They also take part in a complex hierarchical (...) assessment of multi-modal inputs to ensure that the most appropriate action is generated given the context presented. Clinical conditions such as, alien hand syndrome and utilisation behaviour exemplify the importance of these regulatory controls. This review charts the trajectory of our understanding of the hidden role of motor areas in decision-making and reflects upon the implications of our deepened understanding. The convergence of evidence from multiple modalities underpinning our current knowledge is discussed and the potential applications thereof considered. (shrink)

Within the Computer Science community, many ethical issues have emerged as significant and critical concerns. Computer ethics is an academic field in its own right and there are unique ethical issues associated with information technology. It encompasses a range of issues and concerns including privacy and agency around personal information, Artificial Intelligence and pervasive technology, the Internet of Things and surveillance applications. As computing technology impacts society at an ever growing pace, there are growing calls for more computer ethics content (...) to be included in Computer Science curricula. In this paper we present the results of a survey that polled faculty from Computer Science and related disciplines about teaching practices for computer ethics at their institutions. The survey was completed by respondents from 61 universities across 23 European countries. Participants were surveyed on whether or not computer ethics is taught to Computer Science students at each institution, the reasons why computer ethics is or is not taught, how computer ethics is taught, the background of staff who teach computer ethics and the scope of computer ethics curricula. This paper presents and discusses the results of the survey. (shrink)

This chapter is organized around four central questions about the role of reasons in the epistemology of perception. The 'whether?' question: does perception provide us with reasons for belief about the external world? The 'how?' question: how does perception provide us with reasons for belief about the external world? The 'when?' question: when does perception provide us with reasons for belief about the external world? The 'what?' question: what are the reasons that perception provides us with for belief about the (...) external world? (shrink)

In this chapter, I argue for the thesis that phenomenal consciousness is the basis of epistemic justification. More precisely, I argue for the thesis of phenomenal mentalism, according to which epistemic facts about which doxastic attitudes one has justification to hold are determined by non-epistemic facts about one’s phenomenally individuated mental states. I begin by providing intuitive motivations for phenomenal mentalism and then proceed to sketch a more theoretical line of argument according to which phenomenal mentalism provides the best explanation (...) of the independently motivated thesis of access internalism. The result is a theory of epistemic justification that brings intuition and theory into reflective equilibrium. (shrink)

This chapter is guided by the hypothesis that the point and purpose of using the concept of justification in epistemic evaluation is tied to its role in the practice of critical reflection. In section one, I propose an analysis of justification as the epistemic property in virtue of which a belief has the potential to survive ideal critical reflection. In section two, I use this analysis in arguing for a form of access internalism on which one has justification to believe (...) a proposition if and only if one has higher-order justification to believe that one has justification to believe that proposition. In section three, I distinguish between propositional and doxastic versions of access internalism and argue that the propositional version avoids familiar objections to the doxastic version. In section four, I argue that the propositional version of access internalism also explains and vindicates internalist intuitions about cases. In section five, I conclude with some reflections on the relationship between critical reflection, responsibility and personhood. (shrink)

We argue that the trend toward providing users with feasible and actionable explanations of AI decisions—known as recourse explanations—comes with ethical downsides. Specifically, we argue that recourse explanations face several conceptual pitfalls and can lead to problematic explanation hacking, which undermines their ethical status. As an alternative, we advocate that explanations of AI decisions should aim at understanding.

Does rationality require logical omniscience? Our best formal theories of rationality imply that it does, but our ordinary evaluations of rationality seem to suggest otherwise. This paper aims to resolve the tension by arguing that our ordinary evaluations of rationality are not only consistent with the thesis that rationality requires logical omniscience, but also provide a compelling rationale for accepting this thesis in the first place. This paper also defends an account of apriori justification for logical beliefs that is designed (...) to explain the rational requirement of logical omniscience. On this account, apriori justification for beliefs about logic has its source in logical facts, rather than psychological facts about experience, reasoning, or understanding. This account has important consequences for the epistemic role of experience in the logical domain. In a slogan, the epistemic role of experience in the apriori domain is not a justifying role, but rather an enabling and disabling role. (shrink)

This paper argues that justification is accessible in the sense that one has justification to believe a proposition if and only if one has higher-order justification to believe that one has justification to believe that proposition. I argue that the accessibility of justification is required for explaining what is wrong with believing Moorean conjunctions of the form, ‘p and I do not have justification to believe that p.’.

This chapter has two goals: to motivate the foundationalist solution to the regress problem and to defend it against arguments from Sellars, BonJour and Klein. Both the motivation and the defence of foundationalism raise larger questions about the relationship between foundationalism and access internalism. I argue that foundationalism is not in conflict with access internalism, despite influential arguments to the contrary, and that access internalism in fact supplies a theoretical motivation for foundationalism. I conclude that foundationalism and access internalism form (...) a coherent and well-motivated package. (shrink)

What is involved in making an inference? This chapter argues against what Paul Boghossian calls the Taking Condition: "Inferring necessarily involves the thinker taking his premises to support his conclusion and drawing his conclusion because of that fact" (2014: 5). I won’t argue that the Taking Condition is incoherent: that nothing can coherently play the role that takings are supposed to play in inference. Instead, I’ll argue that it cannot plausibly explain all the inferential knowledge that we ordinarily take ourselves (...) to have. Moreover, I’ll argue that we don’t need it to understand the nature of inference. (shrink)

This chapter defends the thesis that feeling conviction is sufficient for belief: if you feel conviction that p, then you believe that p. I begin with a neutral characterization of belief in terms of its normative profile: belief is a state that is subject to certain distinctive norms of rationality. The main argument of the chapter is that feelings of conviction are beliefs because they are subject to the same norms of rationality that govern our beliefs. Functionalists often deny that (...) feelings of conviction constitute beliefs when they play dysfunctional causal roles, as in cases of mad belief or delusion or implicit bias, but this only serves to obscure the kind of irrationality involved in such cases. These are dysfunctional beliefs, rather than non-doxastic states, or "in-between" cases. (shrink)

Descriptive accounts of the nature of explanation in neuroscience and the global goals of such explanation have recently proliferated in the philosophy of neuroscience and with them new understandings of the experimental practices of neuroscientists have emerged. In this paper, I consider two models of such practices; one that takes them to be reductive; another that takes them to be integrative. I investigate those areas of the neuroscience of learning and memory from which the examples used to substantiate these models (...) are culled, and argue that the multiplicity of experimental protocols used in these research areas presents specific challenges for both models. In my view, these challenges have been overlooked largely because philosophers have hitherto failed to pay sufficient attention to fundamental features of experimental practice. I demonstrate that when we do pay attention to such features, evidence for reduction and integrative unity in neuroscience is simply not borne out. I end by suggesting some new directions for the philosophy of neuroscience that pertain to taking a closer look at the nature of neuroscientific experiments. (shrink)

According to the Rationality Constraint, our concept of belief imposes limits on how much irrationality is compatible with having beliefs at all. We argue that empirical evidence of human irrationality from the psychology of reasoning and the psychopathology of delusion undermines only the most demanding versions of the Rationality Constraint, which require perfect rationality as a condition for having beliefs. The empirical evidence poses no threat to more relaxed versions of the Rationality Constraint, which only require only minimal rationality. Nevertheless, (...) we raise problems for all versions of the Rationality Constraint by appealing to more extreme forms of irrationality that are continuous with actual cases of human irrationality. In particular, we argue that there are conceivable cases of “mad belief” in which populations of Lewisian madmen have beliefs that are not even minimally rational. This undermines Lewis’s claim that our ordinary concept of belief is a theoretical concept that is implicitly defined by its role in folk psychology. We argue that introspection gives us a phenomenal concept of belief that cannot be analyzed by applying Lewis’s semantics for theoretical terms. (shrink)

This chapter argues that attention is a distinctive mode of consciousness, which plays an essential functional role in making information accessible for use in the rational control of thought and action. The main line of argument can be stated quite simply. Attention is what makes information fully accessible for use in the rational control of thought and action. But what makes information fully accessible for use in the rational control of thought and action is a distinctive mode of consciousness. Therefore, (...) attention is a distinctive mode of consciousness. In a slogan: attention is rational-access consciousness. (shrink)

What is the role of affective experience in explaining how our desires provide us with reasons for action? When we desire that p, we are thereby disposed to feel attracted to the prospect that p, or to feel averse to the prospect that not-p. In this paper, we argue that affective experiences – including feelings of attraction and aversion – provide us with reasons for action in virtue of their phenomenal character. Moreover, we argue that desires provide us with reasons (...) for action only insofar as they are dispositions to have affective experiences. On this account, affective experience has a central role to play in explaining how desires provide reasons for action. (shrink)

Questions about the transparency of evidence are central to debates between factive and non-factive versions of mentalism about evidence. If all evidence is transparent, then factive mentalism is false, since no factive mental states are transparent. However, Timothy Williamson has argued that transparency is a myth and that no conditions are transparent except trivial ones. This paper responds by drawing a distinction between doxastic and epistemic notions of transparency. Williamson's argument may show that no conditions are doxastically transparent, but it (...) fails to show that no conditions are epistemically transparent. Moreover, this reinstates the argument from the transparency of evidence against factive mentalism. (shrink)

This is the first in a series of two articles that serve as an introduction to recent debates about cognitive phenomenology. Cognitive phenomenology can be defined as the experience that is associated with cognitive activities, such as thinking, reasoning, and understanding. What is at issue in contemporary debates is not the existence of cognitive phenomenology, so defined, but rather its nature and theoretical role. The first article examines questions about the nature of cognitive phenomenology, while the second article explores the (...) philosophical implications of these questions for the role of consciousness in theories of intentionality, introspective self-knowledge, and knowledge of the external world. (shrink)

In this chapter I investigate the kinds of changes that psychiatric kinds undergo when they become explanatory targets of areas of sciences that are not “mature” and are in the early stages of discovering mechanisms. The two areas of science that are the targets of my analysis are cognitive neuroscience and cognitive neurobiology.

This chapter develops a simple theory of introspection on which a mental state is introspectively accessible just by virtue of the fact that one is in that mental state. This theory raises two questions: first, a generalization question: which mental states are introspectively accessible; and second, an explanatory question: why are some mental states introspectively accessible, rather than others, or none at all? In response to the generalization question, I argue that a mental state is introspectively accessible if and only (...) if it is phenomenally individuated. And in response to the explanatory question, I argue that a mental state is introspectively accessible if and only if it is among the determinants of justification. This provides the basis of an argument for a phenomenal conception of justification, according to which a mental state is among the determinants of justification if and only if it is phenomenally individuated. (shrink)

This paper offers a critique of an account of explanatory integration that claims that explanations of cognitive capacities by functional analyses and mechanistic explanations can be seamlessly integrated. It is shown that achieving such explanatory integration requires that the terms designating cognitive capacities in the two forms of explanation are stable but that experimental practice in the mind-brain sciences currently is not directed at achieving such stability. A positive proposal for changing experimental practice so as to promote such stability is (...) put forward and its implications for explanatory integration are briefly considered. (shrink)

Perception enables us to think demonstrative thoughts about the world around us, but what must perception be like in order to play this role? Does perception enable demonstrative thought only if it is conscious? This paper examines three accounts of the role of consciousness in demonstrative thought, which agree that consciousness is essential for demonstrative thought, but disagree about why it is. First, I consider and reject the accounts proposed by Gareth Evans in The Varieties of Reference and by John (...) Campbell in Reference and Consciousness before offering an alternative proposal of my own. My proposal is that consciousness plays an essential epistemic role in explaining the capacity for demonstrative thought about an object by enabling the subject to form immediately justified beliefs about the object. (shrink)

The aim of this paper is to argue that what I call the simple theory of introspection can be extended to account for our introspective knowledge of what we believe as well as what we consciously experience. In section one, I present the simple theory of introspection and motivate the extension from experience to belief. In section two, I argue that extending the simple theory provides a solution to Moore’s paradox by explaining why believing Moorean conjunctions always involves some degree (...) of irrationality. In section three, I argue that it also solves the puzzle of transparency by explaining why it’s rational to answer the question whether one believes that p by answering the question whether p. Finally, in section four, I defend the simple theory against objections by arguing that self-knowledge constitutes an ideal of rationality. (shrink)

This is the second in a series of two articles that serve as an introduction to recent debates about cognitive phenomenology. Cognitive phenomenology can be defined as the experience that is associated with cognitive activities, such as thinking, reasoning, and understanding. What is at issue in contemporary debates is not the existence of cognitive phenomenology, so defined, but rather its nature and theoretical role. The first article examines questions about the nature of cognitive phenomenology, while the second article explores the (...) philosophical implications of these questions for the role of consciousness in theories of intentionality, introspective self-knowledge, and knowledge of the external world. (shrink)

This chapter provides a critical overview of several influential proposals about the epistemic function of higher-order evidence. I start by criticizing accounts of higher-order evidence that appeal to evidential defeat (§1), epistemic conflicts (§2), and unreasonable knowledge (§3). Next, I propose an alternative account that appeals to a combination of improper basing (§4) and non-ideal rationality (§5). Finally, I conclude by summarizing my reasons for preferring this account of higher-order evidence to the alternatives (§6).

Which beings have moral status? This paper argues that moral status requires some capacity for affective consciousness. David Chalmers rejects this view on the grounds that it denies moral status to Vulcans – namely, conscious creatures with no capacity for affective consciousness. On his more inclusive view, all conscious beings have moral status. Although we agree that consciousness is required for moral status, we disagree about how to explain this. I argue that we cannot explain why unconscious zombies lack moral (...) status without excluding conscious Vulcans too. (shrink)

Could there be a cognitive zombie – that is, a creature with the capacity for cognition, but no capacity for consciousness? Searle argues that there cannot be a cognitive zombie because there cannot be an intentional zombie: on this view, there is a connection between consciousness and cognition that is derived from a more fundamental connection between consciousness and intentionality. However, I argue that there are good empirical reasons for rejecting the proposed connection between consciousness and intentionality. Instead, I argue (...) that there is a connection between consciousness and cognition that is derived from a more fundamental connection between consciousness and rationality. On this view, there cannot be a cognitive zombie because there cannot be a rational zombie. (shrink)

The main goal of this chapter is to argue that accessibilism in epistemology is incompatible with vehicle externalism in philosophy of mind. As we shall see, however, there are strong arguments for both of these positions. On the one hand, there is a compelling argument for vehicle externalism: the parity argument from Clark and Chalmers 1998. On the other hand, there is a compelling argument for accessibilism: the Moorean argument from Smithies 2012. If accessibilism is incompatible with vehicle externalism, then (...) both arguments cannot be sound. I resolve the tension by arguing that while the Moorean argument succeeds, the parity argument fails, and so vehicle externalism should be rejected on broadly epistemological grounds. (shrink)

Neuroscience is a laboratory-based science that spans multiple levels of analysis from molecular genetics to behavior. At every level of analysis experiments are designed in order to answer empirical questions about phenomena of interest. Understanding the nature and structure of experimentation in neuroscience is fundamental for assessing the quality of the evidence produced by such experiments and the kinds of claims that are warranted by the data. This article provides a general conceptual framework for thinking about evidence and experimentation in (...) neuroscience with a particular focus on two research areas: cognitive neuroscience and cognitive neurobiology. (shrink)

How is moral knowledge possible? This paper defends the anti-Humean thesis that we can acquire moral knowledge by deduction from wholly non-moral premises. According to Hume’s Law, as it has become known, we cannot deduce an ‘ought’ from an ‘is’, since it is “altogether inconceivable how this new relation can be a deduction from others, which are entirely different from it” (Hume, 1739, 3.1.1). This paper explores the prospects for a deductive theory of moral knowledge that rejects Hume’s Law.

In this chapter, I argue that scientific practice in the neurosciences of cognition is not conducive to the discovery of natural kinds of cognitive capacities. The “neurosciences of cognition” include cognitive neuroscience and cognitive neurobiology, two research areas that aim to understand how the brain gives rise to cognition and behavior. Some philosophers of neuroscience have claimed that explanatory progress in these research areas ultimately will result in the discovery of the underlying mechanisms of cognitive capacities. Once such mechanistic understanding (...) is achieved, cognitive capacities purportedly will be relegated into natural kind categories that correspond to real divisions in the causal structure of the world. I provide reasons here, however, in support of the claim that the neurosciences of cognition currently are not on a trajectory for discovering natural kinds. As I explain, this has to do with how mechanistic explanations of cognitive capacities are developed. Mechanistic explanations and the kinds they explain are abstract representational byproducts of the conceptual, experimental and integrative practices of neuroscientists. If these practices are not coordinated towards developing mechanistic explanations that mirror the causal structure of the world, then natural kinds of cognitive capacities will not be discovered. I provide reasons to think that such coordination is currently lacking in the neurosciences of cognition and indicate where changes in these practices appropriate to the natural kinds ideal would be required if achieving this ideal is indeed the goal. However, I suggest that an evaluation of current practices in these research areas is suggestive that discovering natural kinds of cognitive capacities is not the goal. (shrink)

In his book, On Reflection, Hilary Kornblith criticizes what he regards as a chronic tendency in philosophy towards inflating the significance of reflection in ways that manifest a combination of philosophical naiveté and scientific ignorance about how reflection actually works. In these comments, I respond to Kornblith's challenge by sketching an account of the philosophical significance of reflection in the theory of epistemic justification.

In his provocative and engaging new book, Perplexities of Consciousness, Eric Schwitzgebel makes a compelling case that introspection is unreliable in the sense that we are prone to ignorance and error in making introspective judgments about our own conscious experience. My aim in this commentary is to argue that Schwitzgebel’s thesis about the unreliability of introspection does not have the damaging implications that he claims it does for the prospects of a broadly Cartesian approach to epistemology.

What is the role of phenomenal consciousness in grounding epistemic justification? This paper explores the prospects for a global version of phenomenal conservatism inspired by the work of Michael Huemer, according to which all epistemic justification is grounded in phenomenal seemings. I’m interested in this view because of its global ambitions: it seeks to explain all epistemic justification in terms of a single epistemic principle, which says that you have epistemic justification to believe whatever seems to you strongly enough on (...) balance to be true. One of the attractions of phenomenal conservatism is that it offers such a simple and unified framework for explaining the epistemic role of phenomenal consciousness. I will argue, however, that the simplicity of phenomenal conservatism is not a theoretical virtue, but a theoretical vice, since it distorts the epistemological phenomena it is supposed to explain. In effect, phenomenal conservatism seeks to explain all epistemic justification on the same model as perception. But this has the predictable effect of distorting the epistemology of other domains, including introspection, inference, and a priori justification. (shrink)

In this paper, I argue that perception justifies belief about the external world in virtue of its phenomenal character together with its relations to the external world. But I argue that perceptual relations to the external world impact on the justifying role of perception only by virtue of their impact on its representational content. Epistemic level-bridging principles provide a principled rationale for avoiding more radically externalist theories of perceptual justification.

One might be inclined to assume, given the mouse donning its cover, that the behavior of interest in Nicole Nelson's book Model Behavior (2018) is that of organisms like mice that are widely used as “stand-ins” for investigating the causes of human behavior. Instead, Nelson's ethnographic study focuses on the strategies adopted by a community of rodent behavioral researchers to identify and respond to epistemic challenges they face in using mice as models to understand the causes of disordered human behaviors (...) associated with mental illness. Although Nelson never explicitly describes the knowledge production activities in which her behavioral geneticist research subjects engage as “exemplary”, the question of whether or not these activities constitute “model behavior(s)”—generalizable norms for engaging in scientific research—is one of the many thought-provoking questions raised by her book. As a philosopher of science interested in this question, I take it up here. (shrink)

What is the connection between justification and truth in moral epistemology? The primary goal of this paper is to argue that you cannot have justified false beliefs about your own moral obligations. The secondary goal is to explain why not. Some epistemologists embrace a global truth-connection in epistemology, according to which epistemic justification is always factive. In contrast, I endorse a local truth-connection in moral epistemology, which says that epistemic justification is factive when it concerns your own moral obligations. To (...) explain this, I appeal to a version of moral rationalism, which says there are necessary truths about morality that everyone has a priori justification to believe. (shrink)

In the quest to discover the neural bases of cognition, rigorous behavioral tools are equally as important as sophisticated tools for neural intervention. This paper evaluates several episodes in the development of a novel behavioral tool for rodent cognitive testing, the rodent touchscreen operant chamber. Using conceptual tools on offer in the philosophical literature on exploratory experimentation and control, I illuminate how optimization of this behavioral tool and an understanding of the causal knowledge it may be used to generate historically (...) has involved dynamic interplay between community-driven exploratory practices operating in parallel with causal hypothesis-driven research. (shrink)

Recent studies have explored the effectiveness of open-label placebos for a variety of conditions, including chronic pain, cancer-related fatigue and irritable bowel syndrome. OLPs are thought to sidestep traditional ethical worries about placebos because they do not involve deception: with an OLP, patients or subjects are told outright that they are not given an active substance. As deception is framed as the primary hurdle to ethical placebo use, the door is ostensibly opened to ethical studies of OLPs. In this article, (...) I suggest that even though OLPs seemingly do not involve deception, there are other ethical considerations in their clinical investigation and subsequent use. Research ethics often focusses on informed consent—of which, deception and honesty are a piece—as a means to justify research practices with human subjects. Yet, it is but one of the ethical considerations that should be taken into account. With research into placebo effects in particular, I argue that the history of clinical placebo use grounds special considerations for OLP research that go beyond respect for the autonomy of individual patients through informed consent and encompass structural concerns about the type of patient for whom a placebo has historically been thought appropriate. (shrink)

Many neurodegenerative and neuropsychiatric diseases and other brain disorders are accompanied by impairments in high-level cognitive functions including memory, attention, motivation, and decision-making. Despite several decades of extensive research, neuroscience is little closer to discovering new treatments. Key impediments include the absence of validated and robust cognitive assessment tools for facilitating translation from animal models to humans. In this review, we describe a state-of-the-art platform poised to overcome these impediments and improve the success of translational research, the Mouse Translational Research (...) Accelerator Platform (MouseTRAP), which is centered on the touchscreen cognitive testing system for rodents. It integrates touchscreen-based tests of high-level cognitive assessment with state-of-the art neurotechnology to record and manipulate molecular and circuit level activity in vivo in animal models during human-relevant cognitive performance. The platform also is integrated with two Open Science platforms designed to facilitate knowledge and data-sharing practices within the rodent touchscreen community, touchscreencognition and mousebytes. Touchscreencognition includes the Wall, showcasing touchscreen news and publications, the Forum, for community discussion, and Training, which includes courses, videos, SOPs, and symposia. To get started, interested researchers simply create user accounts. We describe the origins of the touchscreen testing system, the novel lines of research it has facilitated, and its increasingly widespread use in translational research, which is attributable in part to knowledge-sharing efforts over the past decade. We then identify the unique features of MouseTRAP that stand to potentially revolutionize translational research, and describe new initiatives to partner with similar platforms such as McGill’s M3 platform. (shrink)

This paper argues that the concept of paternalism is currently overextended to include a variety of actions that, while resembling paternalistic actions, are importantly different. I use the example of Japanese physicians’ non-disclosures of cancer diagnoses directly to patients, arguing that the concept of maternalism better captures these actions. To act paternalistically is to substitute one's own judgement for that of another person and decide in place of that person for his/her best interest. By contrast, to act maternalistically is to (...) decide for another person based on a reasonable understanding of that person's own preferences. The concept of maternalism allows for a more thorough assessment of the moral justification of these types of actions. I conclude that it is possible, at least in principle, to justify Japanese physicians’ non-disclosures, and that this justification must be based on an understanding of these actions as maternalistic. (shrink)

David Benatar argues that coming into existence is always a harm, and that – for all of us unfortunate enough to have come into existence – it would be better had we never come to be. We contend that if one accepts Benatar’s arguments for the asymmetry between the presence and absence of pleasure and pain, and the poor quality of life, one must also accept that suicide is preferable to continued existence, and that his view therefore implies both anti-natalism (...) and pro-mortalism . This conclusion has been argued for before by Elizabeth Harman – she takes it that because Benatar claims that our lives are ‘awful’, it follows that ‘we would be better off to kill ourselves’ (Harman 2009: 784). Though we agree with Harman’s conclusion, we think that her argument is too quick, and that Benatar’s arguments for non-pro-mortalism deserve more serious consideration than she gives them. We make our case using a tripartite structure. We start by examining the prima facie case for the claim that pro-mortalism follows from Benatar’s position, presenting his response to the contrary, and furthering the dialectic by showing that Benatar’s position is not just that coming into existence is a harm, but that existence itself is a harm. We then look to Benatar’s treatment of the Epicurean line, which is important for him as it undermines his anti-death argument for non-pro-mortalism. We demonstrate that he fails to address the concern that the Epicurean line raises, and that he cannot therefore use the harm of death as an argument for non-pro-mortalism. Finally, we turn to Benatar’s pro-life argument for non-pro-mortalism, built upon his notion of interests, and argue that while the interest in continued existence may indeed have moral relevance, it is almost always irrational. Given that neither Benatar’s anti-death nor pro-life arguments for non-pro-mortalism work, we conclude that pro-mortalism follows from his anti-natalism, As such, if it is better never to have been, then it is better no longer to be. -/- . (shrink)