Two attitudes are possible: one, that the world is an absolute jungle and that the exercise of coercive power by rulers is only a manifestation of this; and the other, that it is both necessary and right that there should be this exercise of power, that through it the world is much less of a jungle than it could possibly be without it, so that one should in principle be glad of the existence of such power, and only take exception (...) to its unjust exercise. (shrink)

This article addresses the contributions of the literature on the new mechanistic philosophy of science for the scientific practice of model building in ecology. This is reflected in a one-to-one interdisciplinary collaboration between an ecologist and a philosopher of science during science-in-the-making. We argue that the identification, reconstruction and understanding of mechanisms is context-sensitive, and for this case study mechanistic modeling did not present a normative role but a heuristic one. We expect our study to provides useful epistemic tools for (...) the improvement of empirically-riven work in the debates about mechanistic explanation of ecological phenomena. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

As opposed to a ‘one size fits all’ approach, precision medicine uses relevant biological, medical, behavioural and environmental information about a person to further personalize their healthcare. This could mean better prediction of someone’s disease risk and more effective diagnosis and treatment if they have a condition. Big data allows for far more precision and tailoring than was ever before possible by linking together diverse datasets to reveal hitherto-unknown correlations and causal pathways. But it also raises ethical issues relating to (...) the balancing of interests, viability of anonymization, familial and group implications, as well as genetic discrimination. This article analyses these issues in light of the values of public benefit, justice, harm minimization, transparency, engagement and reflexivity and applies the deliberative balancing approach found in theEthical Framework for Big Data in Health and Research to a case study on clinical genomic data sharing. Please refer to that article for an explanation of how this framework is to be used, including a full explanation of the key values involved and the balancing approach used in the case study at the end. Our discussion is meant to be of use to those involved in the practice as well as governance and oversight of precision medicine to address ethical concerns that arise in a coherent and systematic manner. (shrink)

Four studies explore the role of perceptual fluency in attenuating bullshit receptivity, or the tendency for individuals to rate otherwise meaningless statements as “profound”. Across four studies, we presented participants with a sample of pseudoprofound bullshit statements in either a fluent or disfluent font and found that overall, disfluency attenuated bullshit receptivity while also finding little evidence that this effect was moderated by cognitive thinking style. In all studies, we measured participants’ cognitive reflection, need for cognition, faith in intuition, and (...) superstitious beliefs. Superstition strongly predicted bullshit receptivity regardless of fluency. Inconclusive results were found for the remaining scales. Potential links for the role of perceptual disfluency in promoting analytic thinking are discussed. (shrink)

Given the sordid history of injustices linking genetics to race and ethnicity, considerations of justice are central to ensuring the responsible development of precision medicine programmes around the world. While considerations of justice may be in tension with other areas of concern, such as scientific value or privacy, there are also tensions between different aspects of justice. This paper focuses on three particular aspects of justice relevant to this precision medicine: social justice, distributive justice and human rights. We describe the (...) implications of each for the use of race and ethnicity in precision medicine, and also how they intersect and potentially conflict with each another. By attending to these intersections, we aim to enrich and add nuance to debates over how best to proceed with precision medicine initiatives. (shrink)

Ethical decision-making frameworks assist in identifying the issues at stake in a particular setting and thinking through, in a methodical manner, the ethical issues that require consideration as well as the values that need to be considered and promoted. Decisions made about the use, sharing, and re-use of big data are complex and laden with values. This paper sets out an Ethics Framework for Big Data in Health and Research developed by a working group convened by the Science, Health and (...) Policy-relevant Ethics in Singapore Initiative. It presents the aim and rationale for this framework supported by the underlying ethical concerns that relate to all health and research contexts. It also describes a set of substantive and procedural values that can be weighed up in addressing these concerns, and a step-by-step process for identifying, considering, and resolving the ethical issues arising from big data uses in health and research. This Framework is subsequently applied in the papers published in this Special Issue. These papers each address one of six domains where big data is currently employed: openness in big data and data repositories, precision medicine and big data, real-world data to generate evidence about healthcare interventions, AI-assisted decision-making in healthcare, public-private partnerships in healthcare and research, and cross-sectoral big data. (shrink)

G. E. Moore’s critical analysis of right action in utilitarian ethics and his consequentialist concept of right action is a starting point for a theory of moral/right action in ethics of social consequences. The terms right and wrong have different meanings in these theories. The author explores different aspects of right and wrong actions in ethics of social consequences and compares them with Moore’s ideas. He positively evaluates Moore’s contributions to the development his theory of moral/right action.

In this paper, I offer an understanding of G.E. Moore’s epistemology as presented in, “A Defence of Common Sense” and “Proof of an External World”. To frame the discussion, I look to Roderick Chisholm’s essay, The Problem of the Criterion. I begin by looking at two ways that Chisholm believes one can respond to the problem of the criterion, and, referring back to Moore’s essays, explain why it is not unreasonable for Chisholm to believe that he is following a line (...) of reasoning that Moore might take. I then show why I believe Chisholm is actually trying to do something quite different from what Moore was, and thus misses Moore’s actual point. I conclude that Moore is best understood as rejecting traditional epistemological concerns. By forcing Moore to deal with a traditional epistemological problem, it will become clear how bold Moore’s “epistemology” is. (shrink)

Quantum Mechanics is a fundamental physical theory about atomic-scale processes. It was built between 1920 and 1940 by the most distinguished physicists of that time. The accordance between the predictions of the theory and experimental results is remarkable. The physical interpretation of its mathematical constructs, however, raised unprecedented controversies. Ontological, semantic, and epistemic vagueness abound in the orthodox interpretations and have resulted in serious misunderstandings that are often repeated in textbooks and elsewhere. In this work, we identify, criticize, and clarify (...) the most spread ones. (shrink)

This study determined the cognitive skills achievement in mathematics of elementary pre-service teachers as a basis for improving problem-solving and critical thinking which was analyzed using Piaget's seven logical operations namely: classification, seriation, logical multiplication, compensation, ratio and proportional thinking, probability thinking, and correlational thinking. This study utilized an adopted Test on Logical Operations (TLO) and descriptive research design to describe the cognitive skills achievement and to determine the affecting factors. Overall, elementary pre-service teachers performed with sufficient understanding in dealing (...) with the TLO. However, in each logical operation, students were found to have insufficient understanding of probability thinking and correlational thinking. These insufficiencies in other logical operations were attributed to their misconceptions on some mathematical terms, misinterpretation of the problems, poor comprehension skills, poor problem-solving skills, and poor performance in mathematics in general. (shrink)

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.

This article derives from a paper presented at the Philosophy of Religion and Mysticism Conference hosted by the Russian Academy of Sciences in Moscow, May 22-24, 2014. That paper introduced theories and methods drawn from the ”cognitive science of religion’ and suggested future avenues of research connecting CSR and scholarship on mysticism. Towards these same ends, the present article proceeds in three parts. Part I outlines the origins, aims, and basic tenets of CSR research. Part II discusses one specific causal (...) perspective that informs a wide range of CSR research, Sperber’s ”epidemiological’ approach to cultural expression, and connects this perspective to the example of creator deities. Part III discusses some possible future directions for CSR research concerning mysticism and mystical experience. Finally, a coda addresses two common misunderstandings concerning the ”reductionist’ nature of CSR research. (shrink)

Resumo A criação de bezerras está entre as atividades mais importantes da pecuária leiteira, pois reflete a genética e a produção do rebanho. Um bom manejo nutricional de novilhas durante a fase recria é essencial para o desenvolvimento ponderal adequado, pois melhora da função imunológica e precocidade reprodutiva. Este estudo teve como objetivo avaliar a relação do peso de novilhas holandesas com a idade na primeira inseminação artificial, primeiro parto e volume de leite produzido na primeira lactação. Foram utilizados os (...) registros de 200 novilhas holandesas submetidas a inseminação artificial em tempo fixo (IATF) em uma fazenda leiteira na região de Lagoa Formosa, MG, no período de janeiro a dezembro de 2020 a 2023, considerando informações sobre de ganho de peso no período de recria até o primeiro serviço idade na IATF e idade ao primeiro parto, produção de leite (em litros) e tempo de lactação. Os registros com as informações foram tabelados no software Exel® e avaliados. As novilhas foram divididas em três (3) grupos de acordo com o ganho de peso alcançado até a primeira inseminação, sendo: grupo A (GA) acima de 390 kg, grupo B (GB) de 360 a 389 kg e grupo C (GC) abaixo de 359 kg. O GA apresentou menor idade na primeira inseminação e no primeiro parto e maior produção de leite, porém a duração da lactação foi menor em relação aos demais grupos. O escore corporal se mostrou determinante para o bom desempenho na reprodução, na produção e na geração de renda ao produtor. -/- Abstract Raising calves is among the most important activities in dairy farming, as it reflects the genetics and production of the herd. Good nutritional management of heifers during the rearing phase is essential for adequate weight development, as it improves immune function and reproductive precocity. This study aimed to evaluate the relationship between the weight of Holstein heifers and age at first artificial insemination, first calving and volume of milk produced in the first lactation. We used the records of 200 Holstein heifers submitted to fixed-time artificial insemination (FTAI) on a dairy farm in the region of Lagoa Formosa, MG, from January to December 2020 to 2023, considering information on weight gain in the period from rearing to first service age at TAI and age at first calving, milk production (in liters) and lactation time. The records with the information were tabulated in the Exel® software and evaluated. The heifers were divided into three (3) groups according to the weight gain achieved until the first insemination, being: group A (GA) above 390 kg, group B (GB) from 360 to 389 kg and group C (GC) below 359 kg. The GA showed a younger age at first insemination and first birth and higher milk production, but the duration of lactation was shorter compared to the other groups. Body score proved to be decisive for good performance in reproduction, production and income generation for the producer. -/- Resumen La cría de terneros es una de las actividades más importantes en la ganadería lechera, ya que refleja la genética y la producción del rebaño. Un buen manejo nutricional de las novillas durante la fase de cría es esencial para un adecuado desarrollo del peso, ya que mejora la función inmune y la precocidad reproductiva. Este estudio tuvo como objetivo evaluar la relación entre el peso de las vaquillonas Holstein y la edad a la primera inseminación artificial, primer parto y el volumen de leche producida en la primera lactancia. Se utilizaron los registros de 200 novillas Holstein sometidas a inseminación artificial en tiempo fijo (FTAI) en una granja lechera de la región de Lagoa Formosa, MG, de enero a diciembre de 2020 a 2023, considerando información sobre ganancia de peso en el período de recría a primera edad de servicio en TAI y edad al primer parto, producción de leche (en litros) y tiempo de lactancia. Los registros con la información fueron tabulados en el software Exel® y evaluados. Las vaquillonas se dividieron en tres (3) grupos de acuerdo a la ganancia de peso lograda hasta la primera inseminación, siendo: grupo A (GA) por encima de 390 kg, grupo B (GB) de 360 a 389 kg y grupo C (GC) por debajo de 359 kg. El AG mostró una menor edad a la primera inseminación y al primer parto y mayor producción de leche, pero la duración de la lactancia fue menor en comparación con los otros grupos. La puntuación corporal resultó ser determinante para un buen desempeño en la reproducción, la producción y la generación de ingresos para el productor. (shrink)

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

Shortly before G. E. Moore wrote down the formative for the early analytic philosophy lectures on Some Main Problems of Philosophy (1910–1911), he had become acquainted with two books which influenced his thought: (1) a book by Husserl's pupil August Messer and (2) a book by the Greifswald objectivist Dimitri Michaltschew. Central to Michaltschew's book was the concept of the given. In Part I, I argue that Moore elaborated his concept of sense-data in the wake of the Greifswald concept. Carnap (...) did the same when he wrote his Aufbau, the only difference being that he spoke not of sense-data but of Erlebnisse. This means, I argue, that both Moore's sense-data and Carnap'sErlebnisse have little to do with either British empiricists or the neo-Kantians. In Part II, I try to ascertain what made early analytic philosophy different from all those philosophical groups and movements that either exercised influence on it, or were closely related to it: phenomenologists, Greifswald objectivists, Brentanists. For this purpose, I identify the sine qua non practices of the early analytic philosophers: exactness; acceptance of the propositional turn; descriptivism; objectivism. If one of these practices was not explored by a given philosophical school or group, in all probability, it was not truly analytic. (shrink)

In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

The aim of this paper is to provide a conceptual framework that will help in understanding and evaluating, along social and ethical lines, the issue of killing day-old male chicks and two alternative directions of responsible innovations to solve this issue. The following research questions are addressed: Why is the killing of day-old chicks morally problematic? Are the proposed alternatives morally sound? To what extent do the alternatives lead to responsible innovation? The conceptual framework demonstrates clearly that there is a (...) moral “lock-in”, and why the killing of day-old chicks is indeed an issue. Furthermore, it is shown that both alternative directions address some important objections with regard to the killing of day-old chicks, but that they also raise new dilemmas. It also becomes clear that the framework enables and secures anticipation, reflection, deliberation with and responsiveness to stakeholders, the four dimensions of responsible innovation, in a structured way. (shrink)

Purpose Prescription stimulant use as “cognitive enhancers” has been described among undergraduate college students. However, the use of prescription stimulants among future health care professionals is not well characterized. This study was designed to determine the prevalence of prescription stimulant misuse among students at an academic health sciences center. -/- Method Electronic surveys were e-mailed to 621 medical, pharmacy, and respiratory therapy students at East Tennessee State University for four consecutive weeks in fall 2011. Completing the survey was voluntary and (...) anonymous. Surveys asked about reasons for, frequency of, and side effects of nonprescription misuse of prescription stimulants. Given the sensitive material, an opportunity to win one of ten $50 gift cards was used as an incentive. -/- Results Three hundred seventy-two (59.9%) students completed the survey from three disciplines (47.6% medical, 70.5% pharmacy, and 57.6% respiratory therapy). Overall, 11.3% of responders admitted to misusing prescription stimulants. There was more misuse by respiratory therapy students, although this was not statistically significant (10.9% medicine, 9.7% pharmacy, 26.3% respiratory therapy; P = .087). Reasons for prescription stimulant misuse included to enhance alertness/ energy (65.9%), to improve academic performance (56.7%), to experiment (18.2%), and to use recreationally/get high (4.5%). -/- Conclusions Prescription stimulant misuse was prevalent among participating students, but further research is needed to describe prevalence among future health care workers more generally. The implications and consequences of such misuse require further study across professions with emphasis on investigating issues of academic dishonesty (e.g., “cognitive enhancement”), educational quality, and patient safety or health care quality. (shrink)

Editors' introduction to 3rd thematic issue on philosophy of medicine.

The study determined the problem-solving performance and skills of prospective elementary teachers (PETs) in the Northern Philippines. Specifically, it defined the PETs’ level of problem-solving performance in number sense, measurement, geometry, algebra, and probability; significant predictors of their problem-solving performance in terms of sex, socio-economic status, parents’ educational attainment, high school graduated from and subject preference; and their problem-solving skills. The PETs’ problem-solving performance was determined by a problem set consisting of word problems with number sense, measurement, geometry, algebra, and (...) probability. A mixed-method research design was employed. Senior PETs purposively served as a sample where they mostly preferred to teach other subjects than mathematics. PETs who preferred math performed satisfactorily, while prospective teachers who opted for other subjects performed unsatisfactorily. The PETs’ unsatisfactory output indicates the need for remediation to advance the mathematical material skills and enrich the problem-solving abilities of these primary schools' potential teachers. Besides, results showed that subject preference strongly affected and predicted the problem-solving success of the PETs. PETs who preferred to teach mathematics performed significantly better than their counterparts; hence, mathematics as a field of specialization in the Bachelor of Elementary Education program may be considered by teacher education institutions. Further, most PETs displayed lack of problem-solving skills; thus, a Problem-Solving course is recommended for them. (shrink)

The Centre for Society and Genomics (CSG) was established in 2004, funded by NGI (the Netherlands Genomics Initiative). Funding was continued in 2008. This report summarises the basic outcomes of almost a decade of interactive societal research, in close collaboration with the other centres of the NGI network. There are two reasons for presenting these results. First of all, at the end of this year, the CSG Next programme (2008-2013), encompassing more than 50 research projects conducted at 10 Dutch universities, (...) will be completed. Moreover, we are currently preparing ourselves for the years to come. The network of principal investigators, together with the research communities they represent and the societal and international networks they are involved in, have agreed to continue to work together, on the basis of mutual learning, transdisciplinary collaboration and collegial support. Notably, we offer our networks, experiences and expertise to help prepare the ground for promoting Responsible Research and Innovation (RRI) in the context of Horizon2020, together with our European colleagues. This report summarises what our type of research can achieve and how we want to continue our activities in the future. After a concise sketch of the life sciences landscape as it has evolved during the past seven decades or so, we explain how CSG came about and what kind of approach we have developed. Subsequently, we list our main results, notably in the form of project vignettes, so as to make the harvest of the CSG Next programme as tangible and concrete as possible. Finally, we explain how we see our role in the future. As is already indicated by the title: this is not merely a retrospective summary of our results (CSG harvest), but an invitation to readers (from academia, industry, policy and civil society) to reassemble and to optimally prepare ourselves for things to come, by strengthening and broadening our collaborative efforts, building on what we have achieved so far. (shrink)

The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

This work is about current theories concerning the application of the constitutional rules, on the approach of the efficacy and effectiveness of the fundamental rights. It also suggests an alternative way of logical analysis of the problem, mainly taking in account the phenomena of the application-efficacy-effectiveness of the rules. Therefore, it discusses the dogmatic rules and proposes the logical separation between its applicability and its effectiveness, considering the effectiveness as the potential power to realize the fundamental rights.

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...) dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’. (shrink)

Context — Children and adults with psychopathic traits and conduct or oppositional defiant disorder demonstrate poor decision making and are impaired in reversal learning. However, the neural basis of this impairment has not previously been investigated. Furthermore, despite high comorbidity of psychopathic traits and attention deficit/hyperactivity disorder, to our knowledge, no research has attempted to distinguish neural correlates of childhood psychopathic traits and attention-deficit/hyperactivity disorder. Objective—To determine the neural regions that underlie the reversal learning impairments in children with psychopathic traits (...) plus conduct or oppositional defiant disorder. Design — Case-control study. Setting — Government clinical research institute. Participants — Forty-two adolescents aged 10 to 17 years: 14 with psychopathic traits and oppositional defiant disorder or conduct disorder, 14 with attention-deficit/hyperactivity disorder only, and 14 healthy controls. Main Outcome Measure — Blood oxygenation level–dependent signal as measured via functional magnetic resonance imaging during a probabilistic reversal task. Results — Children with psychopathic traits showed abnormal responses within the ventromedial prefrontal cortex (Brodmann area 10) during punished reversal errors compared with children wit hattention deficit/hyperactivity disorder and healthy children (P < .05 corrected for multiple comparisons). Conclusions — To our knowledge, this study provides the first evidence of abnormal ventromedial prefrontal cortex responsiveness in children with psychopathic traits and demonstrates this dysfunction was not attributable to comorbid attention-deficit/hyperactivity disorder. These findings suggest that reversal learning impairments in patients with developmental psychopathic traits relate to abnormal processing of reinforcement information. (shrink)

• Aggregates of previously isolated cells of Hydra are capable, under suitable solvant conditions, of regeneration forming complete animals. In a first stage, ecto- and endodermal cells sort out, producing the bilayered hollow structure characteristic of Hydra tissue; thereafter, heads are formed (even if the original cell preparation contained no head cells), eventually leading to the separation of normal animals with head, body column and foot. Hydra appears to be the highest type of organism that allows for regeneration of the (...) entire structure from random cell aggregates. The system is particularly useful for studying cell interactions, tissue polarity, pattern formation, and cell differentiation. (shrink)

The world of entrepreneurship has historically been linked with taking risks and the potential for significant rewards. However, there persists a notable gender imbalance in the entrepreneurial landscape, wherein women entrepreneurs remain a minority. Women navigating the entrepreneurial path encounter distinct challenges, setting their experiences apart from their male counterparts. In Balayan, Batangas, despite strides towards gender equality, women entrepreneurs continue to face challenges in the entrepreneurial landscape. This qualitative study delves into the experiences of 10 successful female entrepreneurs who (...) met specific criteria. Accordingly, semi-structured interviews are conducted, exploring various aspects of participants' experiences and revealing their motivations, achievements, challenges, and strategies. Thematic analysis reveals the connection between familial, community-driven, and personal motivations that drive these entrepreneurs forward. Despite facing obstacles such as financial constraints and gender biases, they prioritize financial gains and personal growth. With resilience, innovation, and dedication, these women overcome challenges and achieve success, utilizing support networks and online marketing strategies to their advantage. Recommendations include empowering women in entrepreneurship, strengthening support networks, introducing tailored financial literacy programs, and advocating against gender biases. Implement skill development initiatives and provide specialized education in online marketing. Engage in policy advocacy, celebrate success stories, and continuously research challenges and successes. Foster collaborative partnerships between businesses, educational institutions, and communities, and advocate for increased funding opportunities for sustainable growth. This research emphasizes the strength and capabilities of women entrepreneurs in Balayan, Batangas, affirming that "pink doesn't mean weak.". (shrink)

This study investigated the effectiveness of utilizing induced magnetism on the seed germination of radish (Raphanussativus) in terms of growth rate, growth speed, shoot growth, and overall development. This study utilized two groups that consisted of an experimental group where induced magnetism was present one control group where there was an absence of induced magnetism in the seed germination of Radish (Raphanus sativus). Moreover, this study aimed to determine the significant difference between the two in terms growth rate, growth speed, (...) shoot growth, and overall development. Both groups had the same amount of radish (Raphanus sativus) seeds planted in a rectangular wooden container with the same amount of measurement and soil content. This study used an experimental research design by utilizing the functions of an Electromagnetic Induction Device (EID) comprised of a 12v motor battery, light bulb, coiled wire, and switch. The EID was turned on for 10 minutes every day where the electric volts generated by the 12v motor battery were transported through the coiled wire and distributed to the metallic iron screen surrounding the area of the experimental group. The data gathered during the 12-day observation of the growth of radish (Raphanus sativus) were tabulated, analyzed, and evaluated using mean tests, standard deviation, and T-test. Based on the result and analyses of the gathered data, it was found that the experimental group, the one with the presence of induced magnetism, surpassed the control group in terms of growth speed, shoot growth, and overall seed development. However, it was also revealed that in terms of growth rate, there is no significant difference between the control group and experimental group. Therefore, the utilization of Induced Magnetism on the seed germination of radish (Raphanus sativus) is effective in terms of growth speed, shoot growth, and overall development. (shrink)

Several interesting themes emerge from G. E. Moore’s previously unpub­lished review of _The Principles of Mathematics_. These include a worry concerning whether mathematical notions are identical to purely logical ones, even if coextensive logical ones exist. Another involves a conception of infinity based on endless series neglected in the Principles but arguably involved in Zeno’s paradox of Achilles and the Tortoise. Moore also questions the scope of Russell’s notion of material implication, and other aspects of Russell’s claim that mathematics reduces (...) to logic. (shrink)

Die Wittgenstein-Schülerin Elizabeth Anscombe zählt zu den einflussreichsten Philosophinnen des 20. Jahrhunderts. Mit der Monographie Absicht begründete sie die analytische Handlungstheorie, viele ihrer Abhandlungen gelten als Klassiker, aber nur wenige liegen bislang in deutscher Übersetzung vor. Der vorliegende Band füllt diese Lücke: Er versammelt zwölf von Anscombes wichtigsten Aufsätzen, die thematisch von der praktischen Philosophie über die Metaphysik und die Philosophie des Geistes bis hin zu Aristoteles- und Wittgenstein-Interpretationen reichen, also das ganze Spektrum ihres Denkens repräsentieren. Die Anmerkungen und Erläuterungen (...) der Herausgeber sowie das Nachwort von Anselm W. Müller erschließen die Texte und bieten zusätzliche Einblicke in das facettenreiche Werk dieser solitären Denkerin. (shrink)

-- 05.04.2024 -- Intervention held at the Italian Philosophical Society’s national congress’ section entitled "Texts, Words and Images: Philosophical Traditions and Translations", at Catholic University of the Sacred Heart, Milan, Italy -- -/- The aim of this intervention is to briefly advance an interpretation of the post- COVID19 digitalisation processes as to be recognised within the philosophical framework of Vorstellung Metaphysik, “metaphysics of representation”. I would maintain that the formula, firstly indicated by Martin Heidegger, can provide us with a tool (...) to interpret contemporary culture as founded on an “iteration” of individual and collective consciousness into non-existent digital realities. Moreover, I will argue that these concepts are philosophically relatable to those of alienation and reification that come from Marxist traditions. Ultimately, the analysis will try to use the above mentioned tools to delve into an interpretation of remote working and education as potential carriers of alienation. (shrink)

In 2001, W. Carnielli and Marcos considered a 3-valued logic in order to prove that the schema ϕ ∨ (ϕ → ψ) is not a theorem of da Costa’s logic Cω. In 2006, this logic was studied (and baptized) as G'3 by Osorio et al. as a tool to define semantics of logic programming. It is known that the truth-tables of G'3 have the same expressive power than the one of Łukasiewicz 3-valued logic as well as the one of Gödel (...) 3-valued logic G3. From this, the three logics coincide up-to language, taking into acccount that 1 is the only designated truth-value in these logics. -/- From the algebraic point of view, Canals-Frau and Figallo have studied the 3-valued modal implicative semilattices, where the modal operator is the well-known Moisil-Monteiro-Baaz Δ operator, and the supremum is definable from this. We prove that the subvariety obtained from this by adding a bottom element 0 is term-equivalent to the variety generated by the 3-valued algebra of G'3. The algebras of that variety are called G'3-algebras. From this result, we obtain the equations which axiomatize the variety of G'3-algebras. Moreover, we prove that this variety is semisimple, and the 3-element and the 2-element chains are the unique simple algebras of the variety. Finally an extension of G'3 to first-order languages is presented, with an algebraic semantics based on complete G'3-algebras. The corresponding soundness and completeness theorems are obtained. (shrink)

Kant’s critique/doctrine distinction tracks the difference between a canon for the understanding’s proper use and an organon for its dialectical misuse. The latter reflects the dogmatic use of reason to attain a doctrine of knowledge with no antecedent critique. In the 1790s, Fichte collapses Kant’s distinction and redefines dogmatism. He argues that deriving a canon is essentially dialectical and thus yields an organon: critical idealism is properly a doctrine of science or Wissenschaftslehre. Criticism is furthermore said to refute dogmatism, by (...) which Fichte means Spinozism. Schelling repudiates Fichte’s position in his Philosophical Letters by reviving Kant’s distinction. First, ‘critique’ for Schelling names a canon that is valid for all systems—including Spinozism—and thus favours none—not even the Wissenschaftslehre. Second, Schelling coins ‘dogmaticism’ to refer to what Kant calls ‘dogmatism’: reason’s uncritical claim to doctrine. Hence, he says all systems—even Fichte’s—are susceptible to the ‘enthusiasm’ of mistaking themselves for doctrines or ‘objects of knowledge’, instead of subjectively valid ‘objects of freedom’. I reconstruct Schelling’s argument for reviving Kant’s distinction, while noting two consequences for German idealism. First, if criticism favours no system, a system’s origin cannot be an act of knowledge, e.g., intellectual intuition, but only an act of endorsement. Second, if dogmaticism entails enthusiasm, a system’s goal cannot be absolute knowledge, but only infinite striving. Hence, by retrieving Schelling’s notion of dogmaticism, we can both gain a better understanding of the Letters and register the impact of a core Kantian distinction on the German idealist project. (shrink)

This paper focuses on the theme of natural rights, as it emerges from the works of Alasdair MacIntyre. In "After Virtue" he argues that «there are no such rights, and belief in them is one with belief in witches and in unicorns», but in later works he endorsed a thomistic view on natural law, which is compatible with the acknowledgment of universal human rights. MacIntyre’s writings contain the premises for an ontological foundation of natural rights, despite his rejection of any (...) formulation of them. (shrink)

RESUMO Durante o período de 14 de agosto a 25 de outubro de 2023, a empresa ABS Pecplan possibilitou uma visão abrangente das atividades de reprodução assistida em bovinos por meio do estágio realizado. Sob a supervisão do Médico Veterinário Layson Silva de Souza e orientação do Professor Dr. Márcio Gianordoli Teixeira Gomes, a carga horária totalizou 390 horas. A empresa atua nas áreas de inovulação de embriões, aspiração folicular, diagnóstico gestacional e fertilização in vitro em fazendas nos estados do (...) Pará, Tocantins e Maranhão. A introdução de biotecnologias, como a inovulação de embriões e a fertilização in vitro, visa aumentar a eficiência na pecuária, proporcionando melhorias genéticas em curtos períodos. Para tal, ressalta-se a importância do bem-estar animal e manejo sanitário para garantir taxas de prenhez. A equipe de campo, composta por veterinários, executa atividades em diversas fazendas da região. No decorrer do estágio, foram desenvolvidas atividades como aspiração folicular, avaliação de receptoras, inovulação de embriões e diagnóstico gestacional. O número total de animais manejados atingiu 2825, distribuídos em diversas fazendas. Destaca-se a abordagem detalhada das atividades, como a técnica de aspiração folicular, a avaliação das receptoras no protocolo TETF, a inovulação de embriões com uso de anestésico, e o diagnóstico gestacional por ultrassom nos dias 30 e 60 após a inovulação. O estágio proporcionou uma compreensão aprofundada das práticas de reprodução assistida em bovinos, contribuindo para a formação profissional na área veterinária. Neste trabalho abordaremos uma breve revisão de literatura, sobre cistos ovarianos. Os cistos são definidos como anovulatórios, com tamanho superior a 2,5 cm, persistência no ovário por mais de 10 dias, sem a presença de corpo lúteo, é uma patologia frequentemente encontrada em vacas de leite. Os dois cistos mais encontrados são os cistos foliculares e luteínicos, cada um com a sua particularidade. Palavras-chaves: Anestesia epidural. Produção in vitro. Vacina Reprodutiva. -/- ABSTRACT During the period from August 14th to October 25th, 2023, the company ABS Pecplan provided a comprehensive overview of assisted reproduction activities in cattle through the internship carried out. Under the supervision of Veterinarian Layson Silva de Souza and guidance from Professor Dr. Márcio Gianordoli Teixeira Gomes, the workload totaled 390 hours. The company operates in the areas of embryo inovulation, follicular aspiration, gestational diagnosis and in vitro fertilization on farms in the states of Pará, Tocantins and Maranhão. The introduction of biotechnologies, such as embryo inovulation and in vitro fertilization, aims to increase efficiency in livestock farming, providing genetic improvements in short periods. To this end, the importance of animal welfare and health management is highlighted to guarantee pregnancy rates. The field team, made up of veterinarians, carries out activities on several farms in the region. During the internship, activities such as follicular aspiration, recipient evaluation, embryo inovulation and gestational diagnosis were developed. The total number of animals handled reached 2825, distributed across several farms. The detailed approach to activities stands out, such as the follicular aspiration technique, the evaluation of recipients in the TETF protocol, the inovulation of embryos using anesthetic, and gestational diagnosis by ultrasound on days 30 and 60 after inovulation. The internship provided an in-depth understanding of assisted reproduction practices in cattle, contributing to professional training in the veterinary field. In this work we will cover a brief literature review on ovarian cysts. Cysts are defined as anovulatory, measuring more than 2.5 cm, persisting in the ovary for more than 10 days, without the presence of a corpus luteum, and are a pathology frequently found in dairy cows. The two most common cysts are follicular and lutein cysts, each with its own particularities. Keywords: Epidural anesthesia. In vitro production. Reproductive Vaccine. (shrink)

En el debate contemporáneo entre determinismo e indeterminismo, la mecánica cuántica es utilizada por los libertaristas como recurso para escapar al determi-nismo propuesto por la física clásica, y como búsqueda de un fundamento para la posibilidad de la libertad de la voluntad y de la responsabilidad moral. En el presente artículo se mostrará que toda defensa de la libertad que recurra a la mecánica cuántica ha de poder sortear al menos dos problemas: el que plantea el que he decidido llamar (...) el principio de escala, y el que resulta de lo que Robert Kane define como el principio de suerte. Se mostrará, además, que responder al primer problema no implica responder al segundo. Finalmente, a través de un análisis de las más recientes propuestas que desean sortear este último, se mostrará que ninguna de las propuestas ofrece una explicación convincente acerca de cómo la mecánica cuántica puede ayudar a resolver la cuestión de la libertad de la voluntad. Antes bien, parece que la mecánica cuántica contribuye a su complicación. (shrink)

En este artículo presentamos el modelo tradicional (que llamaremos canónico) que se ha usado para explicar el autoengaño y algunos de los problemas que ha de enfrentar. Presentaremos luego el que ha sido conocido como el modelo deflacionista o no intencionalista y defenderemos que es una alternativa mejor para entender este fenómeno que el modelo canónico. Finalmente, presentaremos una limitación o problema que ha de enfrentar el modelo deflacionista y que, al ser tratada, obliga a hacer ciertas consideraciones y a (...) mirarlo bajo una nueva luz que, lejos de ponerlo en duda o debilitarlo, termina por fortalecerlo. Esta limitación se basa en que el modelo ha sido pensado teniendo en mente sólo evidencia perceptual, pero no interacciones sociales. Defenderemos que al incluir las interacciones sociales se hace necesario modificar levemente el modelo para dar cuenta de ellas y del comportamiento que los agentes a quienes adscribimos autoengaño tienen en estas relaciones. En cada una de las secciones de este texto acudiremos a ejemplos de la literatura que sirven para presentar con claridad las características de cada caso. (shrink)

A critical survey of various positions on the nature, use, possession, and analysis of normative concepts. We frame our treatment around G.E. Moore’s Open Question Argument, and the ways metaethicists have responded by departing from a Classical Theory of concepts. In addition to the Classical Theory, we discuss synthetic naturalism, noncognitivism (expressivist and inferentialist), prototype theory, network theory, and empirical linguistic approaches. Although written for a general philosophical audience, we attempt to provide a new perspective and highlight some underappreciated problems (...) about normative concepts. (shrink)

-/- Did the US president who signed the order to use the atomic bomb stain his hands with blood or just ink? Are there cases in which a war is just? In such cases, is any war justifiable? Is ending the life of a terminally ill person different from murder? Do we need to agree on the definition of the embryo as a 'person' to know whether any action on the embryo is prohibited? Is the prohibition of contraception justified even (...) if it is perfectly legitimate to plan births? Anscombe, taking up Wittgenstein, Aristotle and Thomas Aquinas, elaborates a theory of action that places "intention" at the centre, an alternative to the conception of action dominant since Descartes. On this basis, he conducts an indictment against the superficiality of modern moral philosophy, lumping together the Oxford philosophers, utilitarianism and Kantian ethics. And finally, she puts her virtue ethics to work on problems of applied ethics: in the field of public ethics, the just war; in the field of bioethics, questions of the end of life and the beginning of life. This book, edited by Sergio Cremaschi, brings together Anscombe's contributions on ethical issues, allowing for the first time a comprehensive overview of this decisive figure's contribution to twentieth-century philosophy. (shrink)

Rolla (2021) argumentou que a prática de avaliar teorias epistemológicas com base em intuições geradas pela consideração de certos casos, como os cenários hipotéticos envolvendo cérebros encubados, clarividentes e anjos da guarda epistêmicos, é um erro. Um erro que, uma vez reconhecido, faria com que os problemas e métodos que ocupam a epistemologia mudassem significativamente. Neste artigo, defendo que a argumentação de Rolla não se sustenta: há falhas no modo como Rolla caracteriza o uso das intuições, as suposições de Rolla (...) podem gerar consequências implausíveis e há um contraexemplo para as alegações dele. Portanto, epistemólogos podem manter os problemas e a metodologia que Rolla critica. (shrink)

The Warner Books back cover proclaims: In the tradition of Oliver Sachʼs [sic] bestselling *The Man Who Mistook His Wife for a Hat...* The manner and misspellingsignify that Cytowic himself had nothing to do with such publishing hucksterism. However, one thing is clear upon reading this book: Richard Cytowic, M.D., is no Oliver Sacks. Though, as will be seen, there is much in here to recommend itself, his stilted reproduction of conversations which or may not have taken place and his (...) CreativeFiction 100 characterizations (i.e., Dr. Wood's continual inhalation of smoke or food) strike the experienced reader as painfully contrived, as though Cytowic were doing hislevel best to imitate Sacks and reach that always-elusive wider audience. (shrink)