Results for 'molecular pathways'

267 found
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  1. Ontologies of Cellular Networks.Arp Robert & Barry Smith - 2008 - Science Signalling 1 (50):1--3.
    A comparison of six alternative definitions of the term 'cellular pathway' against the background of ontological realism.
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  2. Is the Cell Really a Machine?Daniel J. Nicholson - 2019 - Journal of Theoretical Biology 477:108–126.
    It has become customary to conceptualize the living cell as an intricate piece of machinery, different to a man-made machine only in terms of its superior complexity. This familiar understanding grounds the conviction that a cell's organization can be explained reductionistically, as well as the idea that its molecular pathways can be construed as deterministic circuits. The machine conception of the cell owes a great deal of its success to the methods traditionally used in molecular biology. However, (...)
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  3. A Tale of Two Crocoducks: Creationist Misuses of Molecular Evolution.James R. Hofmann - 2014 - Science & Education 23 (10):2095-2117.
    Although some creationist objections to evolutionary biology are simplistic and thus are easily refuted, when more technical arguments become widespread it is important for science educators to explain the relevant science in a straightforward manner. An interesting case study is provided by misguided allegations about how cytochrome c data pertain to molecular evolution. The most common of these misrepresentations bears a striking similarity to a particularly glaring misunderstanding of what should be expected of a transitional form in a fossil (...)
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  4.  71
    Heads and Tails: Molecular Imagination and the Lipid Bilayer, 1917–1941.Daniel Liu - 2018 - In Karl Matlin, Jane Maienschein & Manfred Laubichler (eds.), Visions of Cell Biology: Reflections Inspired by Cowdry's General Cytology. Chicago: University of Chicago Press. pp. 209-245.
    Today, the lipid bilayer structure is nearly ubiquitous, taken for granted in even the most rudimentary introductions to cell biology. Yet the image of the lipid bilayer, built out of with lipids with heads and tails, went from having obscure origins deep in colloid chemical theory in 1924 to being “obvious to any competent physical chemist” by 1935. This chapter examines how this schematic, strictly heuristic explanation of the idea of molecular orientation was developed within colloid physical chemistry, and (...)
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  5.  12
    Chemical Arbitrariness and the Causal Role of Molecular Adapters.Oliver M. Lean - 2019 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 78:101180.
    Jacques Monod (1971) argued that certain molecular processes rely critically on the property of chemical arbitrariness, which he claimed allows those processes to “transcend the laws of chemistry”. It seems natural, as some philosophers have done, to interpret this in modal terms: a biological relationship is chemically arbitrary if it is possible, within the constraints of chemical “law”, for that relationship to have been otherwise than it is. But while modality is certainly important for understanding chemical arbitrariness, understanding its (...)
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  6.  76
    Bovine Prospection, the Mesocorticolimbic Pathways, and Neuroethics: Is a Cow's Future Like Ours?Gary Comstock - 2020 - In L. Syd M. Johnson, Andrew Fenton & Adam Shriver (eds.), Neuroethics and Nonhuman Animals. Cham, Switzerland: Springer. pp. 73-97.
    What can neuroscience tell us, if anything, about the capacities of cows to think about the future? The question is important if having the right to a future requires the ability to think about one’s future. To think about one’s future involves the mental state of prospection, in which we direct our attention to things yet to come. I distinguish several kinds of prospection, identify the behavioral markers of future thinking, and survey what is known about the neuroanatomy of future-directed (...)
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  7. Rate Variation During Molecular Evolution: Creationism and the Cytochrome C Molecular Clock.R. Hofmann James - 2017 - Evolution: Education and Outreach 10 (1).
    Molecular clocks based upon amino acid sequences in proteins have played a major role in the clarification of evolutionary phylogenies. Creationist criticisms of these methods sometimes rely upon data that might initially seem to be paradoxical. For example, human cytochrome c differs from that of an alligator by 13 amino acids but differs by 14 amino acids from a much more closely related primate, Otolemur garnettii. The apparent anomaly is resolved by taking into consideration the variable substitution rate of (...)
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  8. The Molecular Sememe: A Model for Literary Interpretation.T. Price Caldwell - 2000 - Meisei Review 15:155-162.
    In this paper I propose to describe, in brief, a semiotic paradigm which results from the redefinition of the linguistic sign as a molecular sememe. Borrowing a tactic from Wittgenstein, I wish to use the game of chess as an analogy for the sake of describing what a molecular sememe is. Then I hope to use it further to sketch several implications of this semiotic paradigm for literary criticism and critical theory.
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  9. Differential Activation of ER Stress Signal Pathway s Contributes to Palmitate-Induced Hepatocyte Lipoapoptosis.Xiaofang Zhao - 2016 - Cell Biology 4 (1):128.
    Saturated free fatty acids-induced hepatocyte lipoapoptosis plays a pivotal role in non-alcoholic steatohepatitis. Theactivation of endoplasmic reticulum (ER) stress isinvolved in hepatocyte lipoapoptosis induced by thesaturated free fatty acidpalmitate (PA). However, the underlying mechanismsof the role of ER stress in hepatocyte lipoapoptosis remain largely unclear.In this study, we showed that PA and tunicamycin (Tun), a classic ER stress inducer, resulted in differential activation of ERstress pathways. Our data revealed that PA inducedchronic and persistent ER stress response, but Tuninduced acute (...)
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  10. Developmental Phenotypic Plasticity: Where Ecology and Evolution Meet Molecular Biology.Hilary S. Callahan, Massimo Pigliucci & Carl D. Schlichting - 1997 - Bioessays 19 (6):519-525.
    An exploration of the nexus between ecology, evolutionary biology and molecular biology, via the concept of phenotypic plasticity.
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  11.  49
    From the "'Logic of Molecular Syntax' to Molecular Pragmatism. Explanatory Deficits in Manfred Eigen's Concept of Language and Communication.Guenther Witzany - 1995 - Evolution and Cognition 2 (1):148-168.
    Manfred Eigen employs the terms language and communication to explain key recombination processes of DNA as well as to explain the self-organization of human language and communication: Life processes as well as language and communication processes are governed by the logic of a molecular syntax, which is the exact depiction of a principally formalizable reality. The author of the present contribution demonstrates that this view of Manfred Eigen’s cannot be sufficiently substantiated and that it must be supplemented by an (...)
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  12. Pathways to Pluralism About Biological Individuality.Beckett Sterner - 2015 - Biology and Philosophy 30 (5):609-628.
    What are the prospects for a monistic view of biological individuality given the multiple epistemic roles the concept must satisfy? In this paper, I examine the epistemic adequacy of two recent accounts based on the capacity to undergo natural selection. One is from Ellen Clarke, and the other is by Peter Godfrey-Smith. Clarke’s position reflects a strong monism, in that she aims to characterize individuality in purely functional terms and refrains from privileging any specific material properties as important in their (...)
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  13. The Pathways of Politogenesis and Models of the Early State Formation.Leonid Grinin - 2009 - Social Evolution and History 8 (1):92-132.
    This article considers concrete manifestations of the politogenesis multilinearity and the variation of its forms; it analyzes the main causes that determined the politogenetic pathway of a given society. The respective factors include the polity's size, its ecological and social environment. The politogenesis should be never reduced to the only one evolutionary pathway leading to the statehood. The early state formation was only one of many versions of development of complex late archaic social systems. The author designates various complex non-state (...)
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  14. Molecular Interactions. On the Ambiguity of Ordinary Statements in Biomedical Literature.Stefan Schulz & Ludger Jansen - 2009 - Applied Ontology (4):21-34.
    Statements about the behavior of biochemical entities (e.g., about the interaction between two proteins) abound in the literature on molecular biology and are increasingly becoming the targets of information extraction and text mining techniques. We show that an accurate analysis of the semantics of such statements reveals a number of ambiguities that have to be taken into account in the practice of biomedical ontology engineering: Such statements can not only be understood as event reporting statements, but also as ascriptions (...)
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  15.  73
    Los límites del reduccionismo molecular.Armando Aranda-Anzaldo - 1994 - Ciencia y Desarrollo 20 (116):18-25.
    Existen inconsistencias fundamentales entre el paradigma de la biología molecular y el paradigma de la física contemporánea y, por lo tanto, el marco conceptual vigente en la biología molecular resulta insuficiente para abordar las cuestiones del origen y desarrollo de la forma y organización biológicas.
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  16. Back to the Future: Aristotle and Molecular Biology.Armando Aranda Anzaldo - 2007 - Ludus Vitalis 15 (28):195-198.
    The Aristotelian axiom that function follows form was beautifully instantiated in molecular biology by the discovery of DNA’s structure that immediately suggested how DNA might work as depository and vehicle for genetic information. However, later on molecular biology became infatuated with the gene that became the center of the universe. This gene-centered viewpoint is an obstacle for the emerging field of evo-devo aiming at finding the causal connections between evolution and biological development. Here it is argued that (...) biology must reject the narrow-minded causality associated with the gene-centered view and so it must recover to the spirit of Aristotelian natural history and its four types of causation in order to foster the evo-devo field of research. (shrink)
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  17.  78
    Revamping Molecular Biology for the Twentieth First Century, or Putting Back the Theoretical Horse Ahead of the Technological Cart.Armando Aranda-Anzaldo - 2010 - Ludus Vitalis 18 (33):267-270.
    Molecular biology is a relatively new and very successful branch of science but currently it faces challenges posed by very complex issues that cannot be addressed by a traditional reductionist approach. However, despite its origins in the providential shift of some theoretical physicists to biology, currently molecular biology is immersed in a blind trend in which high-throughput technology, able to generate trillions of data, is becoming the leading edge of a discipline that has traded rational and critical thinking (...)
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  18.  88
    Molecular Analysis and Expression of Bap Gene in Biofilm-Forming Multi-Drug-Resistant Acinetobacter Baumannii.Omid Azizi, Mohammad Reza Shakibaie & Fereshteh Shahcherghi - 2016 - Reports of Biochemistry and Molecular Biology 5 (1):1-8.
    Acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. In this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap) in development of biofilm among multi-drug-resistant A. baumannii (MDRAB). Sixty-five MDRAB isolates from clinical samples were collected. Molecular typing was carried out by random amplified polymorphism DNA polymerase chain reaction (RAPD-PCR). (...)
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  19. Considering Quality of Life While Repudiating Disability Injustice: A Pathways Approach to Setting Priorities.Govind Persad - 2019 - Journal of Law, Medicine and Ethics 47 (2):294-303.
    This article proposes a novel strategy, one that draws on insights from antidiscrimination law, for addressing a persistent challenge in medical ethics and the philosophy of disability: whether health systems can consider quality of life without unjustly discriminating against individuals with disabilities. It argues that rather than uniformly considering or ignoring quality of life, health systems should take a more nuanced approach. Under the article's proposal, health systems should treat cases where quality of life suffers because of disability-focused exclusion or (...)
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  20.  38
    The Promise and Perils of Biotech in Personalised Healthcare. Can New Regulatory Pathways Protect the Vulnerable?Giovanni De Grandis - 2018 - Risk and Regulation Magazine 32 (Winter 2018):20-23.
    The paper discusses some of the implications of regulatory innovation in the area of advanced biological therapies and personalised medicine. Benefits, risks and trade-offs are highlighted.
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  21.  54
    Molekulare Theorie der Mikroreibung - Molecular theory of microfriction.Alfred Gierer & Karl Wirtz - 1953 - Zeitschrift Für Naturforschung Section A 8:532-538.
    The layers of a solvent liquid flowing around a moving molecule have a finite thickness corresponding to the finite dimensions of the solvent molecules. Taking this feature into account leads to a modification of Stokes’ laws of the relation between friction and viscosity in continuous media. We derive the observed order of magnitude of the microfriction, for rotation as well as translation, and its approximately correct dependence on the radii of moving and solvent molecules.
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  22.  28
    Zinc Deficiency Induces Apoptosis Via Mitochondrial P53- and Caspase-Dependent Pathways in Human Neuronal Precursor Cells. James - 2014 - Journal of Trace Elements in Medicine and Biology 59 (65).
    Previous studies have shown that zinc deficiency leads to apoptosis of neuronal precursor cells in vivo and in vitro. In addition to the role of p53 as a nuclear transcription factor in zinc deficient cultured human neuronal precursors (NT-2), we have now identified the translocation of phosphorylated p53 to the mitochondria and p53-dependent increases in the pro-apoptotic mitochondrial protein BAX leading to a loss of mitochondrial membrane potential as demonstrated by a 25% decrease in JC-1 red:green fluorescence ratio. Disruption of (...)
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  23. Reducing the Dauer Larva: Molecular Models of Biological Phenomena in Caenorhabditis Elegans Research.Arciszewski Michal - manuscript
    One important aspect of biological explanation is detailed causal modeling of particular phenomena in limited experimental background conditions. Recognising this allows a new avenue for intertheoretic reduction to be seen. Reductions in biology are possible, when one fully recognises that a sufficient condition for a reduction in biology is a molecular model of 1) only the demonstrated causal parameters of a biological model and 2) only within a replicable experimental background. These intertheoretic identifications –which are ubiquitous in biology and (...)
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  24. Memory and Food in Philippine Literature: A Molecular ‘Re-Siting’ of the Filipino Kitchen.Lawdenmarc Decamora - 2017 - Mabini Review 6:22-36.
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  25.  12
    Molecular Characterization of Polystyrene/ Waste Tires Composites.Mahmoud Abdel-Halim Abdel-Goad - 2018 - International Journal of Engineering and Information Systems (IJEAIS) 4 (2):33-36.
    In this work, polystyrene/waste tires composites were prepared using the melt-mixing method.. The effect of the preparation conditions of the PS/waste tires composite is investigated in this work by using Gel permeation chromatography (GPC) technique. Stability at elevated temperatures were found to increase with the addition of waste tires to PS as confirmed by the results. GPC results indicate that the preparation conditions of the PS/waste tires composite has no effect on the Ps chains as indicated by GPC technique. The (...)
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  26. Molecular Characterization of Aerobic Heterohophic Bacteria Isolated From Petroleum Hydrocarbon Polluted Brackish Waters of Bodo Creeks, Rivers State Nigeria.Tersagh Ichor - 2014 - Open Journal of Ecology 4:715-722.
    Surface water sources in the oil producing Niger Delta region of Nigeria are highly susceptible to pollution by petroleum hydrocarbons and so it is important to understand the microbial diversity of such ecosystems. Water and sediment samples were collected between April-August, 2013 from Bodo creeks and taken to Environmental Microbiology laboratory of University of Portharcourt for analysis. A total of thirty aerobic heterotrophic bacterial strains isolated ranged from 3.0 - 7.0 × 104 cfu for surface water and 1.6 - 5.6 (...)
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  27. Playing with Molecules.Adam Toon - 2011 - Studies in History and Philosophy of Science Part A 42 (4):580-589.
    Recent philosophy of science has seen a number of attempts to understand scientific models by looking to theories of fiction. In previous work, I have offered an account of models that draws on Kendall Walton’s ‘make-believe’ theory of art. According to this account, models function as ‘props’ in games of make-believe, like children’s dolls or toy trucks. In this paper, I assess the make-believe view through an empirical study of molecular models. I suggest that the view gains support when (...)
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  28. The Return of the Organism as a Fundamental Explanatory Concept in Biology.Daniel J. Nicholson - 2014 - Philosophy Compass 9 (5):347-359.
    Although it may seem like a truism to assert that biology is the science that studies organisms, during the second half of the twentieth century the organism category disappeared from biological theory. Over the past decade, however, biology has begun to witness the return of the organism as a fundamental explanatory concept. There are three major causes: (a) the realization that the Modern Synthesis does not provide a fully satisfactory understanding of evolution; (b) the growing awareness of the limits of (...)
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  29. Ontologies for the Life Sciences.Steffen Schulze-Kremer & Barry Smith - 2005 - In Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, vol. 4. Wiley.
    Where humans can manipulate and integrate the information they receive in subtle and ever-changing ways from context to context, computers need structured and context-free background information of a sort which ontologies can help to provide. A domain ontology captures the stable, highly general and commonly accepted core knowledge for an application domain. The domain at issue here is that of the life sciences, in particular molecular biology and bioinformatics. Contemporary life science research includes components drawn from physics, chemistry, mathematics, (...)
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  30. The Fact of Evolution: Implications for Science Education.James R. Hofmann & Bruce H. Weber - 2003 - Science & Education 12 (8):729-760.
    Creationists who object to evolution in the science curriculum of public schools often cite Jonathan Well’s book Icons of Evolution in their support (Wells 2000). In the third chapter of his book Wells claims that neither paleontological nor molecular evidence supports the thesis that the history of life is an evolutionary process of descent from preexisting ancestors. We argue that Wells inappropriately relies upon ambiguities inherent in the term ‘Darwinian’ and the phrase ‘Darwin’s theory’. Furthermore, he does not accurately (...)
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  31.  22
    Binding Specificity and Causal Selection in Drug Design.Oliver M. Lean - 2020 - Philosophy of Science 87 (1):70-90.
    Binding specificity is a centrally important concept in molecular biology, yet it has received little philosophical attention. Here I aim to remedy this by analyzing binding specificity as a causal property. I focus on the concept’s role in drug design, where it is highly prized and hence directly studied. From a causal perspective, understanding why binding specificity is a valuable property of drugs contributes to an understanding of causal selection—of how and why scientists distinguish between causes, not just causes (...)
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  32. Language and Logic in Wittgenstein’s Tractatus.Daniele Mezzadri - 2013 - Nordic Wittgenstein Review 2 (1):57-80.
    This paper investigates Wittgenstein’s account of the relation between elementary and molecular propositions (and thus, also, the propositions of logic) in the Tractatus Logico-Philosophicus. I start by sketching a natural reading of that relation – which I call the “bipartite reading” – holding that the Tractatus gives an account of elementary propositions, based on the so-called picture theory, and a different account of molecular ones, based on the principle of truth- functionality. I then show that such a reading (...)
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  33. The Human Aspect of Christ Between Classic and Quantum Consciousness: Gethsemane - Anxiety & Depression Between Biochemistry & Anthropology.Massimo Cocchi, Lucio Tonello & Fabio Gabrielli - 2012 - Scientific GOD Journal:432-439.
    The studies carried out in recent years on the molecular dynamics of consciousness, especially in relation to diseases such as major depression and bipolar disorder, on man considered as a synthesis of nature and culture, in their interdisciplinary and transdisciplinary expression, prompted us to carry out the molecular logic involving the human component of Christ (Christ-Man). On the basis of evidence presented in the Holy Scriptures, regarding the hours that preceded his death, we tend, in the light of (...)
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  34.  40
    The Challenges of Purely Mechanistic Models in Biology and the Minimum Need for a 'Mechanism-Plus-X' Framework.Sepehr Ehsani - 2018 - Dissertation, University College London
    Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical sciences, where, barring some exceptions, notable new feats of understanding have arguably not been achieved in normal and disease biology, including neurodegenerative disease and cancer pathobiology. I argue for a "mechanism-plus-X" paradigm, where mainstay elements of mechanistic models such (...)
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  35. Philosophy of Experimental Biology.Jacob Stegenga - 2009 - Erkenntnis 71 (3):431-436.
    Philosophers have committed sins while studying science, it is said – philosophy of science focused on physics to the detriment of biology, reconstructed idealizations of scientific episodes rather than attending to historical details, and focused on theories and concepts to the detriment of experiments. Recent generations of philosophers of science have tried to atone for these sins, and by the 1980s the exculpation was in full swing. Marcel Weber’s Philosophy of Experimental Biology is a zenith mea culpa for philosophy of (...)
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  36. What is Life?Guenther Witzany - 2020 - Frontiers in Astronomy and Space Sciences 7:1-13.
    In searching for life in extraterrestrial space, it is essential to act based on an unequivocal definition of life. In the twentieth century, life was defined as cells that self-replicate, metabolize, and are open for mutations, without which genetic information would remain unchangeable, and evolution would be impossible. Current definitions of life derive from statistical mechanics, physics, and chemistry of the twentieth century in which life is considered to function machine like, ignoring a central role of communication. Recent observations show (...)
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  37. Mechanism Schemas and the Relationship Between Biological Theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
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  38. Generation of Biological Patterns and Form: Some Physical, Mathematical and Logical Aspects.Alfred Gierer - 1981 - Progress in Biophysics and Molecular Biology 37 (1):1-48.
    While many different mechanisms contribute to the generation of spatial order in biological development, the formation of morphogenetic fields which in turn direct cell responses giving rise to pattern and form are of major importance and essential for embryogenesis and regeneration. Most likely the fields represent concentration patterns of substances produced by molecular kinetics. Short range autocatalytic activation in conjunction with longer range “lateral” inhibition or depletion effects is capable of generating such patterns (Gierer and Meinhardt, 1972). Non-linear reactions (...)
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  39. The Western and Eastern Thought Traditions for Exploring the Nature of Mind and Life.Plamen L. Simeonov, Arran Gare, Koichiro Matsuno, Abir U. Igamberdiev & Denis Noble - 2017 - Progress in Biophysics and Molecular Biology 131:1-11.
    This is the editorial to the special edition of Progress in Biophysics and Molecular Biology on the role engagement with Eastern traditions of thought could play in the advancement of science generally and biology and the science of mind in particular.
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  40. Harvesting the Promise of AOPs: An Assessment and Recommendations.Annamaria Carusi, Mark R. Davies, Giovanni De De Grandis, Beate I. Escher, Geoff Hodges, Kenneth M. Y. Leung, Maurice Wheelan, Catherine Willet & Gerald T. Ankley - 2018 - Science of the Total Environment 628:1542-1556.
    The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we (...)
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  41. Thought Experiments in Biology.Guillaume Schlaepfer & Marcel Weber - 2018 - In Michael T. Stuart, Yiftach J. H. Fehige & James Robert Brown (eds.), The Routledge Companion to Thought Experiments. London: Routledge. pp. 243-256.
    Unlike in physics, the category of thought experiment is not very common in biology. At least there are no classic examples that are as important and as well-known as the most famous thought experiments in physics, such as Galileo’s, Maxwell’s or Einstein’s. The reasons for this are far from obvious; maybe it has to do with the fact that modern biology for the most part sees itself as a thoroughly empirical discipline that engages either in real natural history or in (...)
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  42. Scientific Revolutions, Specialization and the Discovery of the Structure of DNA: Toward a New Picture of the Development of the Sciences.Politi Vincenzo - 2018 - Synthese 195 (5):2267-2293.
    In his late years, Thomas Kuhn became interested in the process of scientific specialization, which does not seem to possess the destructive element that is characteristic of scientific revolutions. It therefore makes sense to investigate whether and how Kuhn’s insights about specialization are consistent with, and actually fit, his model of scientific progress through revolutions. In this paper, I argue that the transition toward a new specialty corresponds to a revolutionary change for the group of scientists involved in such a (...)
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  43. Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework.Cecilia Arighi, Veronica Shamovsky, Anna Maria Masci, Alan Ruttenberg, Barry Smith, Darren Natale, Cathy Wu & Peter D’Eustachio - 2015 - PLoS ONE 10 (4):e0122978.
    The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation of experimentally known forms and annotations thereof is expected to expose discrepancies, differences, and gaps in our knowledge. We have annotated the early events of innate immune signaling mediated by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting ontology and annotation data set (...)
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  44. Novel Sequence Feature Variant Type Analysis of the HLA Genetic Association in Systemic Sclerosis.R. Karp David, Marthandan Nishanth, G. E. Marsh Steven, Ahn Chul, C. Arnett Frank, S. DeLuca David, D. Diehl Alexander, Dunivin Raymond, Eilbeck Karen, Feolo Michael & Barry Smith - 2009 - Human Molecular Genetics 19 (4):707-719.
    Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...)
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  45. The Origin of Cellular Life and Biosemiotics.Attila Grandpierre - 2013 - Biosemiotics (3):1-15.
    Recent successes of systems biology clarified that biological functionality is multilevel. We point out that this fact makes it necessary to revise popular views about macromolecular functions and distinguish between local, physico-chemical and global, biological functions. Our analysis shows that physico-chemical functions are merely tools of biological functionality. This result sheds new light on the origin of cellular life, indicating that in evolutionary history, assignment of biological functions to cellular ingredients plays a crucial role. In this wider picture, even if (...)
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  46. Holistic Biology: Back on Stage? Comments on Post-Genomics in Historical Perspective.Alfred Gierer - 2002 - Philosophia Naturalis 39 (1):25-44.
    A strong motivation for the human genome project was to relate biological features to the structure and function of small sets of genes, and ideally to individual genes. However, it is now increasingly realized that many problems require a "systems" approach emphasizing the interplay of large numbers of genes, and the involvement of complex networks of gene regulation. This implies a new emphasis on integrative, systems theoretical approaches. It may be called 'holistic' if the term is used without irrational overtones, (...)
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  47. Nature Via Nurture:. [REVIEW]Massimo Pigliucci - 2003 - Nature Genetics 35 (3):199-200.
    On the nature-nurture debate and the complexities of what make us human.
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  48.  61
    Assuming in Biology the Reality of Real Virtuality (a Come Back for Entelechy?).Armando Aranda-Anzaldo - 2011 - Ludus Vitalis 19 (36):333-342.
    Since Aristotle the central question in biology was the origin of organic form; a question put in the backyard by neo-Darwinism that considers organic form as a side effect of the interactions between genes and their products. On the other hand, the fashionable notion of self-organization also fails to provide a true causal explanation for organic form. For Aristotle form is both a cause and the principle of intelligibility and this coupled to the classical concepts of potentiality and actuality provides (...)
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  49. Analytic Philosophy for Biomedical Research: The Imperative of Applying Yesterday's Timeless Messages to Today's Impasses.Sepehr Ehsani - forthcoming - In P. Glauner & P. Plugmann (eds.), Innovative Technologies for Market Leadership - Investing in the Future. Springer.
    The mantra that "the best way to predict the future is to invent it" (attributed to the computer scientist Alan Kay) exemplifies some of the expectations from the technical and innovative sides of biomedical research at present. However, for technical advancements to make real impacts both on patient health and genuine scientific understanding, quite a number of lingering challenges facing the entire spectrum from protein biology all the way to randomized controlled trials should start to be overcome. The proposal in (...)
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  50. On the Possibility of Constructive Neutral Evolution.Arlin Stoltzfus - 1999 - Journal of Molecular Evolution 49 (2):169-181.
    The neutral theory often is presented as a theory of "noise" or silent changes at an isolated "molecular level", relevant to marking the steady pace of divergence, but not to the origin of biological structure, function, or complexity. Nevertheless, precisely these issues can be addressed in neutral models, such as those elaborated here in regard to scrambled ciliate genes, gRNA-mediated RNA editing, the transition from self-splicing to spliceosomal splicing, and the retention of duplicate genes. All of these are instances (...)
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