Transcranial magnetic stimulation is used to make inferences about relationships between brain areas and their functions because, in contrast to neuroimaging tools, it modulates neuronal activity. The central aim of this article is to critically evaluate to what extent it is possible to draw causal inferences from repetitive TMS data. To that end, we describe the logical limitations of inferences based on rTMS experiments. The presented analysis suggests that rTMS alone does not provide the sort of (...) premises that are sufficient to warrant strong inferences about the direct causal properties of targeted brain structures. Overcoming these limitations demands a close look at the designs of rTMS studies, especially the methodological and theoretical conditions which are necessary for the functional decomposition of the relations between brain areas and cognitive functions. The main points of this article are that TMS-based inferences are limited in that stimulation-related causal effects are not equivalent to structure-related causal effects due to TMS side effects, the electric field distribution, and the sensitivity of neuroimaging and behavioral methods in detecting structure-related effects and disentangling them from confounds. Moreover, the postulated causal effects can be based on indirect effects. A few suggestions on how to manage some of these limitations are presented. We discuss the benefits of combining rTMS with neuroimaging in experimental reasoning and we address the restrictions and requirements of rTMS control conditions. The use of neuroimaging and control conditions allows stronger inferences to be gained, but the strength of the inferences that can be drawn depends on the individual experiment’s designs. Moreover, in some cases, TMS might not be an appropriate method of answering causality-related questions or the hypotheses have to account for the limitations of this technique. We hope this summary and formalization of the reasoning behind rTMS research can be of use not only for scientists and clinicians who intend to interpret rTMS results causally but also for philosophers interested in causal inferences based on brain stimulation research. (shrink)

Epileptogenesis involves an increase in excitatory synaptic strength in the brain in a manner similar to synaptic potentiation. In the present study we investigated the mechanisms of short-term synaptic potentiation in patients with focal epilepsy by using 5 Hz repetitive transcranial magnetic stimulation (rTMS), a non invasive neurophysiological technique able to investigate the mechanisms of synaptic plasticity in humans. Ten patients with focal idiopathic cortical epilepsy were studied. 5 Hz-rTMS (10 stimuli-trains, 120% of motor threshold, RMT) (...) was delivered over the first dorsal interosseus (FDI) motor area of both (affected and unaffected) hemispheres. Changes in the motor evoked potential (MEP) size in the FDI muscle during the trains and the RMT were measured and compared between the hemispheres. 5 Hz-rTMS was also delivered in a group of healthy subjects over both hemispheres. 5 Hz-rTMS in patients elicited a reduced MEP facilitation compared to normal subjects. The reduced MEP amplitude was more evident in the affected hemisphere than in the unaffected hemisphere. RMT in the affected hemisphere was higher than in the unaffected hemisphere and in healthy subjects. Our findings showing a decreased response to 5 Hz-rTMS over the affected hemisphere, differently from the expected results suggest a reduced cortical excitability in epileptic patients. We hypothesize an altered balance between excitatory and inhibitory circuits in epileptic patients under chronic therapy. (shrink)

Background Neuroimaging and lesion studies suggested that the dorsolateral prefrontal and posterior parietal cortices mediate visual metacognitive awareness. The causal evidence provided by non-invasive brain stimulation, however, is inconsistent. -/- Objective/hypothesis Here we revisit a major figure discrimination experiment adding a new Kanizsa figure task trying to resolve whether bilateral continuous theta-burst transcranial magnetic stimulation (cTBS) over these regions affects perceptual metacognition. Specifically, we tested whether subjective visibility ratings and/or metacognitive efficiency are lower when cTBS is (...) applied to these two regions in comparison to an active control region. -/- Methods A within-subjects design including three sessions spaced by one-week intervals was implemented. In each session, every participant was administered bilateral cTBS to either prefrontal, control or parietal cortices. Two concurrent tasks were performed, a real and an illusory figure task, stabilising objective performance with use of an adaptive staircase procedure. -/- Results When performing the replicated task, cTBS was found insufficient to disrupt neither visibility ratings nor metacognitive efficiency. However, with use of Kanizsa style illusory figures, cTBS over the dorsolateral prefrontal, but not over the posterior parietal cortex, was observed to significantly diminish metacognitive efficiency. -/- Conclusion(s) Real and illusory figure tasks demonstrated different cTBS effects. A possible explanation is the involvement of the prefrontal cortex in the creation of expectations, which is necessary for efficient metacognition. Failure to replicate previous findings for the real figure task, however, cannot be said to support, conclusively, the notion that these brain regions have a causal role in metacognitive awareness. This inconsistent finding may result from certain limitations of our study, thereby suggesting the need for yet further investigation. (shrink)

A broad pattern of correlations between mechanisms of brain function impairment and self-transcendence is shown. The pattern includes such mechanisms as cerebral hypoxia, physiological stress, transcranial magnetic stimulation, trance-induced physiological effects, the action of psychoactive substances and even physical trauma to the brain. In all these cases, subjects report self-transcending experiences o en described as ‘mystical’ and ‘awareness-expanding,’ as well as self-transcending skills o en described as ‘savant.’ The idea that these correlations could be rather trivially accounted (...) for on the basis of disruptions to inhibitory neural processes is reviewed and shown to be implausible. Instead, this paper suggests that an as-of-yet unrecognized causal principle underlying the entire pattern might be at work, whose further elucidation through systematic research could hold great promise. (shrink)

Dear editor, we read with interest the article by Gilio et al.. Previous transcranial magnetic stimulation studies in focal epileptic patients brought to controversial results.

Some patients with a lesion to the striate cortex (V1), when assessed through forced-choice paradigms, are able to detect stimuli presented in the blind field, despite reporting a complete lack of visual experience. This phenomenon, known as blindsight, strongly implicates V1 in visual awareness. However, the view that V1 is indispensable for conscious visual perception is challenged by a recent finding that the blindsight subject GY can be aware of visual qualia in his blind field, implying that V1may not be (...) critical under all circumstances. This apparent contradiction raises the following question: if V1 is not always necessary for phenomenal awareness, why do V1 lesions have such a detrimental effect on conscious perception? It is suggested here that this contradiction can be resolved by considering the impact of V1 lesions on the functioning of the whole visual cortex. (shrink)

In their work Gilio et al. investigate the mechanisms involved in the regulation of excitability of the cortex in epileptic subjects, and in particular their epileptogenic threshold.

Traditionally, philosophers have appealed to the phenomenological similarity between visual experience and visual imagery to support the hypothesis that there is significant overlap between the perceptual and imaginative domains. The current evidence, however, is inconclusive: while evidence from transcranial brain stimulation seems to support this conclusion, neurophysiological evidence from brain lesion studies (e.g., from patients with brain lesions resulting in a loss of mental imagery but not a corresponding loss of perception and vice versa) indicates that there are (...) functional and anatomical dissociations between mental imagery and perception. Assuming that the mental imagery and perception do not overlap, at least, to the extent traditionally assumed, then the question arises as to what exactly mental imagery is and whether it parallels perception by proceeding via several functionally distinct mechanisms. In this review, we argue that even though there may not be a shared mechanism underlying vision for perception and conscious imagery, there is an overlap between the mechanisms underlying vision for action and unconscious visual imagery. On the basis of these findings, we propose a modification of Kosslyn’s model of imagery that accommodates unconscious imagination and explore possible explanations of the quasi-pictorial phenomenology of conscious visual imagery in light of the fact that its underlying neural substrates and mechanisms typically are distinct from those of visual experience. (shrink)

This chapter sets the scene for the subsequent philosophical discussions by surveying a number of biological interventions that have been used, or might in the future be used, for the purposes of crime prevention. These interventions are pharmaceutical interventions intended to suppress libido, treat substance abuse or attention deficit-hyperactivity disorder (ADHD), or modulate serotonin activity; nutritional interventions; and electrical and magnetic brain stimulation. Where applicable, we briefly comment on the historical use of these interventions, and in each case (...) we discuss the evidence that they are effective, or might become so with further refinement. The chapter concludes with a comment on some potentially significant differences between the varieties of intervention that we canvass. (shrink)

Although religious belief is often claimed to help with physical ailments including pain, it is unclear what psychological and neural mechanisms underlie the influence of religious belief on pain. By analogy to other top-down processes of pain modulation we hypothesized that religious belief helps believers reinterpret the emotional significance of pain, leading to emotional detachment from it. Recent findings on emotion regulation support a role for the right ventrolateral prefrontal cortex, a region also important for driving top-down pain inhibitory circuits. (...) Using functional magnetic resonance imaging in practicing Catholics and avowed atheists and agnostics during painful stimulation, here we show the existence of a context-dependent form of analgesia that was triggered by the presentation of an image with a religious content but not by the presentation of a non-religious image. As confirmed by behavioral data, contemplation of the religious image eneabled the religious group to detach themselves from the experience of pain. Critically, this context-dependent modulation of pain specifically engaged the right VLPFC, whereas group-specific preferential liking of one of the pictures was associated with activation in the ventral midbrain. We suggest that religious belief might provide a framework that allows individuals to engage known pain-regulatory brain processes. (shrink)

The Hoffmann reflex (H-wave) is produced by alpha-motoneuron activation in the spinal cord. A feature of this electromyography response is that it exhibits fluctuations in amplitude even during repetitive stimulation with the same intensity of current. We herein explore the hypothesis that physical training induces plastic changes in the motor system. Such changes are evaluated with the fractal dimension (FD) analysis of the H-wave amplitude-fluctuations (H-wave FD) and the cross-covariance (CCV) between the bilateral H-wave amplitudes. The aim of (...) this study was to compare the H-wave FD as well as the CCV before and after track training in sedentary individuals and athletes. The training modality in all subjects consisted of running three times per week (for 13 weeks) in a concrete road of 5 km. Given the different physical condition of sedentary vs. athletes, the running time between sedentary and athletes was different. After training, the FD was significantly increased in sedentary individuals but significantly reduced in athletes, although there were no changes in spinal excitability in either group of subjects. Moreover, the CCV between bilateral H-waves exhibited a significant increase in athletes but not in sedentary individuals. These differential changes in the FD and CCV indicate that the plastic changes in the complexity of the H-wave amplitude fluctuations as well as the synaptic inputs to the Ia-motoneuron systems of both legs were correlated to the previous fitness history of the subjects. Furthermore, these findings demonstrate that the FD and CCV can be employed as indexes to study plastic changes in the human motor system. (shrink)

Introduction: This article discusses the brain hierarchical organization/evolution as a consequence of the information-induced brain development, from the perspective of the Informational Model of Consciousness. Analysis: In the frame of the Informational Model of Consciousness, a detailed info-neural analysis ispresented, concerning the specific properties/functions of the informational system of the human body composed by the Center of Acquisition and Storing of Information, Center of Decision and Command, Info-Emotional Center, Maintenance Informational System, Genetic Transmission System, Info Genetic Generator and Info- Connection (...) center, in relation with the neuro-connected brain areas, with a special attention to the Info-Connection and its specific properties. Besides a meticulous analysis of the info-connections/neuro-functions of these centers, a special attention was paid to limbic/cingulate cortex activities. Defined as a trust/confidence center, additional features are highlighted in correlation with the activity of the anterior cingulate cortex, consisting in the intervention/moderation of amygdala emotional signals, conflicting opposite YES/NO data and error elimination in the favor of the organism adaptation/survival, the intervention in the certainty/uncertainty balance to select a suitable pro-life information (antientropic effect), in moderation of pain and in the stimulation of the empathic inter-human relations/communication. Representing the correspondence between the informational subsystems and the brain area map, itis shown that the up/down integration of information by epigenetic mechanisms and the down/ up evolution are correlated. Results: The analysis of the functions of the anterior cingulate opens new gates of investigations concerning the involved intimate mechanisms at the level of cell microstructure, specifically on the compatibility with quantum assisted processes admitted by the Informational Model of Consciousness and the quantum-based models The discussion on the information integration/codification by epigenetic mechanisms shows that this process starts from the superior levels of brain conscious info-processing areas and progressively advances to the automatic/autonomic inferior levels ofthe informational system, under insistent/repetitive cues/stress conditions, pointing out an hierarchical functional/anatomical structure of the brain organization. Additional arguments are discussed, indicating thatthe down/up progressive scale representation is a suggestive illustration of the brain evolution, induced/assisted/determined by information, accelerated at humans by the antientropic functions of the Info-Connection center. Conclusions: The hierarchical organization of the brain is a consequence of the integration process of information, defining its development accordingly to the adaptation requirements for survival during successive evolution stages of the organism, information playing a determinant/key role. (shrink)

During the idea generation phase of the design process, designers often search for inspirations in external sources of information, such as photographs, written descriptions and physical examples. These sources have potential to enhance creative performance. However, they sometimes become too attached to particular ideas of external precedents or various examples. It refers to fixation which is identified as inadequate adoption of features from existing examples. Influence of the existing examples on creativity and fixation, specifically textual examples, have been discussed in (...) this research. -/- For the nature of design, researchers highlighted the restructuring process of design problem by new sources because the capabilities and boundaries of design problems are not defined very well. Further, the design problem is not knowable at any specific point. Design knowledge identifies itself by its ambiguity. Many models have been developed for design process. The various numbers of divided phases of the models can be seen as having two main areas: (1) idea generation phase (or “ideation”); (2) later phase for details. Idea generation plays an important role in the design process. It is the area of new and creative configurations on design. -/- Creativity is an integral part of the design process. Designers purpose to achieve original ideas to demonstrate their ability and unique designs. External stimuli or inspirational inputs play important roles to increase creativity. They can support moments of stimulation. Associations between information from memory and external stimuli can contribute to the creation of new meanings. Designers are widely influenced by their surroundings in daily lives. However, each stimulus may not be the part of a more creative result Even if designers want to utilize stimulus as an inspirational source, somehow it may fixate their mind to its surface features and they may lose potential creative contributions of the source. It is called fixation. There is much research that shows significant evidence of conformity effects across the design problems. -/- The given examples to designers may cause higher-level fixation and lower-level creativity or vice versa. Fixation may occur when example solutions are introduced, on the other hand, the designers may create more original ideas as well. There is a need for research to find ways to avoid fixation traps or reduce their adverse impact. Thus, this research focuses on variables of the given example. -/- The following claims show some research areas remained unclear: (1) Some researchers investigated textual examples as - one of the modalities of representation - but did not focus on forms of textual examples. (2) Much research has been conducted with examples which are selected by the researcher. Nevertheless, designers can also choose or produce their own stimuli. There is not much research on this possibility. In this context, my research focuses on the following two variables through two studies (Study 1 and 2): (1) forms of textual examples; (2) self-construction of textual examples. First, most of the studies in the literature have focused on visual presentation and there is not enough research on the content and form of the text. The study of textual examples has still not been awarded enough attention especially as various forms of text. Some forms of text are as follows: keyword, paragraph, sentence, poem. These observations lead me to the following research question: Which forms of textual example increase creativity and reduce fixation more? (Study 1). -/- Second, most of the studies regarding textual examples have used prose or keywords. The poems have been ignored. However, poems imply more meaning with fewer words. The structure of the poems enables more creative narratives than structure of prose. Because unusual organization of words stimulates the readers and draws their attention. This activates the creative performance of the reader. The surrealist poem is the extreme form of this activation. It is random assemblies with headlines and sentences which is cut from newspapers. Thus, novel meaning networks are formed. The method of creating a surrealist poem offers a new way of getting inspiration. It is termed as self-construction practice by this research. Through this method, designers create their own example from the given one. Reconstruction of the text may increase the creative process and prevent fixations from the given text. This suggestion led me to the following research question: If the designers write their own poem instead of a given poem (as a self-construction practice), can they internalize the textual example? In addition, does it produce more creative and less fixated designs? (Study 2). Two experimental studies were planned to partially answer the research questions, in which novice students of architecture were asked to solve two different design problems, under different conditions. All of the experimental sessions were conducted in a design education studio. The participants produced sketches and added a written explanation relating to their designs. Fluency, flexibility and repetition of key attributes were calculated by the researcher. -/- Originality, practicality, understanding of the task and quality were ranked by judges. Study 1 shows us tendencies of using various textual forms. Distinctions of keywords and of poems have appeared among them. This emphasizes the role of keyword and poem in the design process as inspirational sources and provides many tips for their potential use. The keyword also leads to a high degree of fixation. However, a low degree of fixation is observed when poems are presented as inspirational examples. -/- In Study 2, the self-constructed poem seems to support develop more successful design ideas from many perspectives. In the context of the surrealist poem, writing and reading the surrealist poem trigger the designers’ imagination. At first, the words and lines of poems seem unrelated to each other and designers try to relate them and solve the puzzle of meaning. Hence, novel meaning networks are formed. It indicates that surrealist poems are able to activate the creative performance of the designers. Writing their own surrealist poems ,as a self-construction practice, motivated designers to begin to produce by having fun. Motivated designers have stimulated themselves to produce creative ideas. In other words, the self-construction process may be added to the design process models in the earlier part of the idea generation phase which is called as pre-design and warm-up phase. This earlier phase makes designers highly motivated and they internalized the given examples. -/- Following the conclusions, several implications and recommendations for the design process and education are discussed. (shrink)

El filósofo checo Karel Kosík (1926-2003) desempeñó un rol prominente en el seno del movimiento de oposición a los regímenes de Novotný y Husák, contribuyendo tanto a la gestación como a la pervivencia de los anhelos expresados por la población checoslovaca durante la Primavera de Praga. Junto a la contextualización histórica de su obra, se pone también de manifiesto cómo Marx y Heidegger incidieron con igual relevancia en la conformación de su pensamiento. La filosofía de Kosík reviste por ello una (...) singularidad propia que la aleja de las versiones tradicionales del humanismo marxista predominantes a mediados del siglo pasado en el bloque oriental y occidental. (shrink)

El artículo aborda el itinerario biográfico e intelectual del primer Marcuse con el trasfondo del influjo de la Lebensphilosophie diltheyana, la analítica ontológica del Dasein y la hermenéutica de la facticidad heideggerianas en su pensamiento. Hasta su entrada en el Institut für Sozialforschung en 1932, la obra de Marcuse aspira a combinar la ontología fundamental de la historicidad con una antropología filosófica de inspiración marxiana. Sin embargo, Marcuse va a ir abandonando progresivamente cualquier pretensión de fundamentar ontológicamente el materialismo histórico (...) y se orientará hacia el desarrollo de una teoría dialéctica de la sociedad ónticamente situada. (shrink)

El afán de hallar un soporte antropológico u ontológico fundamental capaz de otorgar validez normativa a la crítica de la sociedad devino un recurso filosófico habitual en las contribuciones teóricas de numerosos autores a lo largo de los siglos XIX y XX. En contraste con la crítica inmanente, que se esfuerza por localizar en la propia realidad social los parámetros normativos y las posibilidades históricas para la crítica y la transformación de esa misma realidad, la crítica antropológica tomaba como criterio (...) para la crítica y la transformación social la remisión a parámetros normativos externos, en concreto la referencia a un concepto de esencia o naturaleza humana ubicado en un nivel ontológico o antropológico fundamental. La facticidad histórica del capitalismo se cuestionaba porque invertía la esencia genérica (Gattungswesen) del ser humano, o bien porque obstaculizaba su adecuada plasmación en el plano óntico de la realidad. Se trataba, en definitiva, de crear las condiciones oportunas para una apropiación por parte del ser humano de su propia naturaleza, de su verdadera esencia. (shrink)

El concepto de “maquinación” (Machenschaft) ocupa un lugar central en la obra de Heidegger durante el período comprendido entre 1936 y 1940. En su análisis de la esencia de la época moderna, el filósofo checo de orientación marxista Karel Kosík se apropia de importantes elementos conceptuales procedentes de esta etapa del pensamiento de Heidegger. En concreto, emplea nociones análogas a la de “maquinación”, como “sistema de manipulabilidad”. Ponemos de relieve las semejanzas y puntos de fricción en la descripción de la (...) esencia de la época moderna de ambos pensadores, así como sus respectivas propuestas para poner coto a la primacía técnica y al pensamiento calculador y las resonancias políticas derivadas de sus análisis. (shrink)

En el presente artículo abordamos la confrontación que ciertos autores pertenecientes al llamado marxismo occidental mantuvieron con la concepción de la vida cotidiana de “término medio” (Durchschnittlichkeit) de "Ser y tiempo" (1927). Nos centramos principalmente en la obra del filósofo checo Karel Kosík (1926-2003), quien, a lo largo de su trayectoria intelectual, llevó a cabo una recepción crítica de la analítica existencial heideggeriana, así como también en los aspectos divergentes y convergentes entre la concepción de la cotidianidad de Martin Heidegger (...) y de György Lukács. En la última sección, se apuntan las posibles sendas de encuentro para un develamiento fenomenológico-marxista de la “verdad” de la cotidianidad. (shrink)

Coincidiendo con su entrada como miembro del equipo de trabajo del Institut für Sozialforschung, Herbert Marcuse comienza a desarrollar una teoría materialista de la sociedad alejada del heideggerianismo de su juventud. Durante el período comprendido entre 1933 y 1936, el autor berlinés escribe una serie de artículos cuestionando la deriva política de la filosofía existencial en Alemania. En ellos se confronta con las versiones vulgarizadas de la Lebensphilosophie y de la fenomenología -encabezadas por Heidegger- que proveyeron una suerte de fundamentación (...) filosófica a la “concepción del mundo” (Weltanschauung) del realismo heroico y a las políticas socio-económicas del Estado total-autoritario. (shrink)

Im besonderen philosophischen Kontext des Zwischenkriegsdeutschlands entwickelte der junge Marcuse eine originelle Rezeption in marxistischer Perspektive der existenziellen Phänomenologie und der Lebensphilosophie (I). In seinen ersten Aufsätzen »Beiträge zu einer Phänomenologie des Historischen Materialismus« (1928) und »Über konkrete Philosophie« (1929) orientierte sich diese Rezeption am Projekt der Erarbeitung einer dialektischen Phänomenologie und in Verbindung damit an dem Versuch, die radikale Tat auf den ontologischen Begriff der Geschichtlichkeit zu gründen, ohne eine materielle Komponente zu vernachlässigen (II, III, IV). In der Auseinandersetzung (...) mit dem fundamentalontologisch anmutenden ›Verfall‹ des Daseins entwarf Marcuse überdies die Grundlagen seiner konkreten Philosophie der Praxis (V). (shrink)

Partiendo de un análisis introductorio en torno a las diversas interpretaciones del concepto de historicidad (Geschichtlichkeit) en las obras de W. Dilthey, P. Yorck von Wartenburg y M. Heidegger, se considera seguidamente el modo como esta polémica fue recepcionada por el joven H. Marcuse (1). En discusión con la sociología alemana de su época (K. Mannheim, S. Landshut, H. Freyer), Marcuse pretende continuar el proyecto de inclusión de la historicidad en las ciencias del espíritu iniciado por Dilthey con una orientación (...) ontológica procedente de Heidegger (2). Si primero interpreta a G. W. F. Hegel desde parámetros próximos a la filosofía de la vida (Dilthey) y a la ontología fundamental (Heidegger), a medida que se acerca a la obra de K. Marx el enfoque ontológico y vitalista deja paso a una aproximación materialista, donde conceptos como razón, mediación, libertad y actualidad adquieren un papel preponderante (3). (shrink)

La interpretación de la dialéctica hegeliana que el joven Marcuse lleva a cabo en sus escritos tempranos «Sobre el problema de la dialéctica I y II» (1930-1931) y «Ontología de Hegel y teoría de la historicidad» (1932) contrarresta las críticas de Heidegger a la dialéctica de Hegel. La lectura de ambos autores también diverge en su comprensión acerca del estatuto y el alcance del fenómeno de la temporalidad en la filosofía hegeliana. Sin embargo, cuando dilucida el concepto de historicidad (Geschichtlichkeit) (...) en Hegel, Marcuse advierte la tensión existente en su sistema entre el concepto ontológico de «vida» y la idea del «saber absoluto». A partir de su entrada en el Institut für Sozialforschung, el autor berlinés abandonará la tematización del concepto de historicidad —tarea que había ocupado un lugar central en sus primeros escritos— por considerar que dicho concepto, demasiado distorsionado por la tradición ontológico-existencial, es inconciliable con la dialéctica materialista. (shrink)

El filósofo checo Karel Kosík (1926-2003) llevó a cabo en su obra una recepción crítica del pensamiento de Martin Heidegger. En determinados capítulos de "Dialéctica de lo concreto" (1963), así como en otros ensayos tardíos, elaboró una crítica de la analítica existencial heideggeriana, principalmente a la concepción de la estructura del ser del Dasein como “preocupación” o “cuidado” (Sorge). Nos ocupamos aquí de dilucidar el sentido y el alcance de esta crítica a "Ser y tiempo" (1927).

En el particular contexto filosófico de la Alemania de entreguerras, el joven H. Marcuse llevó a cabo una original recepción en clave marxista de la fenomenología existencial y de la Lebensphilosophie (I). En sus primeros artículos, «Contribuciones a una fenomenología del materialismo histórico» (1928) y «Sobre filosofía concreta» (1929), esa recepción se orientó al proyecto de elaboración de una fenomenología dialéctica y, vinculado con ello, al intento de fundamentar la acción radical en el concepto ontológico de historicidad (Geschichtlichkeit) sin descuidar (...) su componente material (II, III, IV). Asimismo, en la situación de caída (Verfallen) del Dasein, Marcuse va a otorgar una misión primordial a la filosofía concreta (V). (shrink)

Con la obra de los jóvenes hegelianos (Junghegelianer) concluye el período clásico de la filosofía alemana. Bruno Bauer (1809-1882) fue uno de sus máximos exponentes, considerado en muchos aspectos como mentor del movimiento. En el primer apartado del presente artículo, se contextualiza la figura de Bauer en el trasfondo de las disputas generadas en el seno de la escuela hegeliana. A continuación, se analizan con mayor detenimiento dos nociones centrales en su pensamiento, especialmente durante el período comprendido entre 1829 y (...) 1848: su dialéctica de la autoconciencia infinita (unendlichen Selbstbewußtsein) y la forma adoptada por su crítica pura. (shrink)

Standard lore holds that magnetic forces are incapable of doing mechanical work. More precisely, the claim is that whenever it appears that a magnetic force is doing work, the work is actually being done by another force, with the magnetic force serving only as an indirect mediator. However, the most familiar instances of magnetic forces acting in everyday life, such as when bar magnets lift other bar magnets, appear to present manifest evidence of magnetic forces (...) doing work. These sorts of counterexamples are often dismissed as arising from quantum effects that lie outside the classical regime. In this paper, we show that quantum theory is not needed to account for these phenomena, and that classical electromagnetism admits a model of elementary magnetic dipoles on which magnetic forces can indeed do work. In order to develop this model, we revisit the foundational principles of the classical theory of electromagnetism, showcase the importance of constraints from relativity, examine the structure of the multipole expansion, and study the connection between the Lorentz force law and conservation of energy and momentum. (shrink)

This chapter investigates the Institutional Distribution Question for backwards-looking collective moral responsibility for institutional action, namely, the question how blame is to be distributed over members of an institution in virtue of its being collectively to blame for some harm. The distribution of blame over members of an institution for harms that the institution brings about must take into account the different institutional roles of its members. This is the primary difference between the question of distribution of responsibilities in unorganized (...) groups and in institutional groups. A central goal of this chapter is to say how and why this makes a difference. The two central organizing ideas will be that of a role that is a responsibility magnet, that is, one which attracts individual responsibility for blameworthy institutional action and that of a role which is, at least in certain respects, a responsibility shelter. In a responsibility shelter, the occupier of the role is at least provisionally innocent of blame for institutional action that is itself blameworthy, even when the agent in the role makes a contribution to it. What roles are magnets or shelters can be sensitive to the context and type of action the institution undertakes. The central theoretical tool in determining what roles are magnets and what roles are shelters is how collectively accepted proxy agent roles structure trust and responsibility burdens in an institution. (shrink)

In the second lecture of "Naming and Necessity," Saul Kripke presented a new and quite convincing picture of the reference of proper names. At the same time, however, he expressed some skepticism towards the possibility of developing it into a full-blown theory by offering “more exact conditions for reference to take place.” In this paper, after discussing the reasons for his skepticism, I hint at how I think Kripke’s picture could be developed and offer an outline of a theory of (...) reference based on it. One of the key notions my ‘theory’ makes use of is that of repetition, which I take from Kaplan’s “Words.”. (shrink)

Walter Benjamin’s texts on Baudelaire put forward a threefold analogy, surprising at first glance, between the experience of the crowd, typical of modern metropolises, mechanized work and games of chance. While exploring gambling and the gambler in Benjamin’s analysis, this article explores the inner ambiguity of the concept of repetition: firstly conceived as belonging to the «time of hell» of the ever-new, it can also be understood as a gateway for understanding the processes of experimentation, which are crucial to modern (...) and contemporary aesthetic experiences. In this sense, urban space can also be conceived as a room for play, vulnerable to and enriched by chance and playful mechanisms encompassing aesthetic and political dimensions. (shrink)

Deep Brain Stimulation (DBS) is a relatively new, experimental treatment for patients suffering from treatment-refractory Obsessive Compulsive Disorder (OCD). The effects of treatment are typically assessed with psychopathological scales that measure the amount of symptoms. However, clinical experience indicates that the effects of DBS are not limited to symptoms only: patients for instance report changes in perception, feeling stronger and more confident, and doing things unreflectively. Our aim is to get a better overview of the whole variety of changes (...) that OCD patients experience during DBS treatment. For that purpose we conducted in-depth, semi-structured interviews with 18 OCD patients. In this paper, we present the results from this qualitative study.We list the changes grouped in four domains: with regard to (a) person, (b) (social) world, (c)characteristics of person-world interactions, and (d) existential stance. We subsequently provide an interpretation of these results. In particular, we suggest that many of these changes can be seen as different expressions of the same process; namely that the experience of anxiety and tension gives way to an increased basic trust and increased reliance on one’s abilities. We then discuss the clinical implications of our findings, especially with regard to properly informing patients of what they can expect from treatment, the usefulness of including CBT in treatment, and the limitations of current measures of treatment success. We end by making several concrete suggestions for further research. (shrink)

One striking feature of the contemporary modeling practice is its interdisciplinarity: the same function forms and equations, and mathematical and computational methods are being transferred across disciplinary boundaries. Within philosophy of science this interdisciplinary dimension of modeling has been addressed by both analogy and template-based approaches that have proceeded separately from each other. We argue that a more fully-blown account of model transfer needs both perspectives. We examine analogical reasoning and template application through a detailed case study on the transfer (...) of the Ising model from physics into neuroscience. Our account combines the analogy and template-based approaches through the notion of a model template that highlights the conceptual side of model transfer. (shrink)

We address a long-standing debate over whether classical magnetic forces can do work, ultimately answering the question in the affirmative. In detail, we couple a classical particle with intrinsic spin and elementary dipole moments to the electromagnetic field, derive the appropriate generalization of the Lorentz force law, show that the particle's dipole moments must be collinear with its spin axis, and argue that the magnetic field does mechanical work on the particle's elementary magnetic dipole moment. As consistency (...) checks, we calculate the overall system's energy-momentum and angular momentum, and show that their local conservation equations lead to the same force law and therefore the same conclusions about magnetic forces and work. We also compute the system's Belinfante-Rosenfeld energy-momentum tensor. (shrink)

One of the most conspicuous features of contemporary modeling practices is the dissemination of mathematical and computational methods across disciplinary boundaries. We study this process through two applications of the Ising model: the Sherrington-Kirkpatrick model of spin glasses and the Hopfield model of associative memory. The Hopfield model successfully transferred some basic ideas and mathematical methods originally developed within the study of magnetic systems to the field of neuroscience. As an analytical resource we use Paul Humphreys's discussion of computational (...) and theoretical templates. We argue that model templates are crucial for the intra- and interdisciplinary theoretical transfer. A model template is an abstract conceptual idea associated with particular mathematical forms and computational methods. (shrink)

The classical rule of Repetition says that if you take any sentence as a premise, and repeat it as a conclusion, you have a valid argument. It's a very basic rule of logic, and many other rules depend on the guarantee that repeating a sentence, or really, any expression, guarantees sameness of referent, or semantic value. However, Repetition fails for token-reflexive expressions. In this paper, I offer three ways that one might replace Repetition, and still keep an interesting notion of (...) validity. Each is a fine way to go for certain purposes, but I argue that one in particular is to be preferred by the semanticist who thinks that there are token-reflexive expressions in natural languages. (shrink)

Under the current Mental Health Act of England and Wales, it is lawful to perform deep brain stimulation in the absence of consent and independent approval. We argue against the Care Quality Commission's preferred strategy of addressing this problematic issue, and offer recommendations for deep brain stimulation-specific provisions in a revised Mental Health Act.

After severe brain injury, one of the key challenges for medical doctors is to determine the patient’s prognosis. Who will do well? Who will not do well? Physicians need to know this, and families need to do this too, to address choices regarding the continuation of life supporting therapies. However, current prognostication methods are insufficient to provide a reliable prognosis. -/- Functional Magnetic Resonance Imaging (MRI) holds considerable promise for improving the accuracy of prognosis in acute brain injury patients. (...) Nonetheless, research on functional MRI in the intensive care unit context is ethically challenging. These studies raise several ethical issues that have not been addressed so far. In this article, Prof. Charles Weijer and his co-workers provide a framework for researchers and ethics committees to design and review these studies in an ethically sound way. (shrink)

A growing literature has recognized the importance of mental simulation (e.g., imagining alternatives to reality) in sparking creativity. In this chapter, we examine how counterfactual thinking, or imagining alternatives to past outcomes, affects group creativity. We explore these effects by articulating a model that considers the influence of counterfactual thinking on both the cognitive and social processes known to impact group creative performance. With this framework, we aim to stimulate research on group creativity from a counterfactual perspective.

Deep brain stimulation has been of considerable interest to bioethicists, in large part because of the effects that the intervention can occasionally have on central features of the recipient’s personality. These effects raise questions regarding the philosophical concept of authenticity. In this article, we expand on our earlier work on the concept of authenticity in the context of deep brain stimulation by developing a diachronic, value-based account of authenticity. Our account draws on both existentialist and essentialist approaches to (...) authenticity, and Laura Waddell Ekstrom’s coherentist approach to personal autonomy. In developing our account, we respond to Sven Nyholm and Elizabeth O’Neill’s synchronic approach to authenticity, and explain how the diachronic approach we defend can have practical utility, contrary to Alexandre Erler and Tony Hope’s criticism of autonomy-based approaches to authenticity. Having drawn a distinction between the authenticity of an individual’s traits and the authenticity of that person’s values, we consider how our conception of authenticity applies to the context of anorexia nervosa in comparison to other prominent accounts of authenticity. We conclude with some reflections on the prudential value of authenticity, and by highlighting how the language of authenticity can be invoked to justify covert forms of paternalism that run contrary to the value of individuality that seems to be at the heart of authenticity. (shrink)

We whole-heartedly agree with Mecacci and Haselager(2014) on the need to investigate the psychosocial effects of deep brain stimulation (DBS), and particularly to find out how to prevent adverse psychosocial effects. We also agree with the authors on the value of an embodied, embedded, enactive approach (EEC) to the self and the mind–brain problem. However, we do not think this value primarily lies in dissolving a so-called “maladaptation” of patients to their DBS device. In this comment, we challenge three (...) central claims of the authors on the basis of our direct experience with psychosocial effects of DBS in 45 obsessive- compulsive disorder (OCD) patients treated at the AMC in Amsterdam, The Netherlands, and our indepth qualitative interviews with 18 of them (de Haan et al. 2013). We end our comment by sketching out our perspective on the practical merits of an EEC approach to DBS. (shrink)

Stimulants have been shown to be safe and effective for reduction of the symptoms of attention deficit hyperactivity disorder. Despite much debate, however, there has been little empirical evidence as to whether stimulants affect authenticity and moral agency in children. Singh presents evidence that stimulants do not undercut children's' sense of self and increase their experience of agency. These findings are consistent with laboratory evidence that stimulant drugs in therapeutic doses improve cognitive control over thought and behavior.

The concept of moral wrongness, many think, has a distinctive kind of referential stability, brought out by moral twin earth cases. This article offers a new account of the source of this stability, deriving it from a metaphysics of content: “substantive” radical interpretation, and first-order normative assumptions. This story is distinguished from extant “reference magnetic” explanations of the phenomenon, and objections and replies are considered.

Davis called for “extreme caution” in the use of non-invasive brain stimulation to treat neurological disorders in children, due to gaps in scientific knowledge. We are sympathetic to his position. However, we must also address the ethical implications of applying this technology to minors. Compensatory trade-offs associated with NIBS present a challenge to its use in children, insofar as these trade-offs have the effect of limiting the child’s future options. The distinction between treatment and enhancement has some normative force (...) here. As the intervention moves away from being a treatment toward being an enhancement—and thus toward a more uncertain weighing of the benefits, risks, and costs—considerations of the child’s best interests diminish, and the need to protect the child’s autonomy looms larger. NIBS for enhancement involving trade-offs should therefore be delayed, if possible, until the child reaches a state of maturity and can make an informed, personal decision. NIBS for treatment, by contrast, is permissible insofar as it can be shown to be at least as safe and effective as currently approved treatments, which are themselves justified on a best interests standard. (shrink)

In this paper, we engage in dialogue with Jonathan Pugh, Hannah Maslen, and Julian Savulescu about how to best interpret the potential impacts of deep brain stimulation on the self. We consider whether ordinary people’s convictions about the true self should be interpreted in essentialist or existentialist ways. Like Pugh et al., we argue that it is useful to understand the notion of the true self as having both essentialist and existentialist components. We also consider two ideas from existentialist (...) philosophy – Jean-Paul Sartre and Simone de Beauvoir’s ideas about “bad faith” and “ambiguity” – to argue that there can be value to patients in regarding themselves as having a certain amount of freedom to choose what aspects of themselves should be considered representative of their true selves. Lastly, we consider the case of an anorexia nervosa-patient who shifts between conflicting mind-sets. We argue that mind-sets in which it is easier for the patient and his or her family to share values can plausibly be considered to be more representative of the patient’s true self, if this promotes a well-functioning relationship between the patient and the family. However, we also argue that families are well-advised to give patients room to figure out what such shared values mean to them, since it can be alienating for patients if they feel that others try to impose values on them from the outside. (shrink)

There are many controversial theses about intrinsicness and duplication. The first aim of this paper is to introduce a puzzle that shows that two of the uncontroversial sounding ones can’t both be true. The second aim is to suggest that the best way out of the puzzle requires sharpening some distinctions that are too frequently blurred, and adopting a fairly radical reconception of the ways things are.

In this paper, a Magnetic Levitation (MAGLEV) train is designed with a first degree of freedom electromagnetbased totally system that permits to levitate vertically up and down. Fuzzy logic, PID and MRAS controllers are used to improve the Magnetic Levitation train passenger comfort and road handling. A Matlab Simulink model is used to compare the performance of the three controllers using step input signals. The stability of the Magnetic Levitation train is analyzed using root locus technique. Controller (...) output response for different time period and change of air gap with different time period is analyzed for the three controllers. Finally the comparative simulation and experimental results demonstrate the effectiveness of the presented fuzzy logic controller. (shrink)

A set D subset of V(G) is a dominating set of a graph G if for all x ϵ V(G)\D, for some y ϵ D such that xy ϵ E(G). A dominating set D subset of V(G) is called a connected dominating set of a graph G if the subgraph <D> induced by D is connected. A connected domination number of G, denoted by γ_c(G), is the minimum cardinality of a connected dominating set D. The triple repetition sequence denoted by (...) {S_n:n ϵ Z+} is a sequence of positive integers which is repeated thrice, i.e., {S_n}={1,1,1,2,2,2,3,3,3, ...}. In this paper, we construct a combinatorial explicit formula for the triple repetition sequence of connected domination numbers of a triangular grid graph. (shrink)

This article tries to make sense of the concept of repetition in Søren Kierkegaard’s works. According to Kierkegaard repetition is a temporal movement of existence. What is repetition and what is its meaning for human existence? In answering this question the Danish philosopher depicts repetition by comparing three different approaches to life. Throughout the article I try to develop a coherent argument on ‘the new philosophical category’by analysing the three types of repetition and their corresponding human prototypes. I consider repetition (...) a key concept in summarizing Kierkegaard’s theory of existence, where existence pictures the becoming of the human-self that follows several stages. Constantin Constantius’s repetition is an unsuccessful attempt, an aesthetic expression of human-life. The young lover’s repetition is spiritual, albeit not yet authentic, religious, but more poetic, even if he regains his self. Only Job’s repetition is an authentic movement of existence, an expression of a spiritual trial and of genuine faith. (shrink)

Abstract: Samples of LaxSr1-xMnO3 (x = 0.5, 0.55, 0.6, 0.66, and 0.7) were prepared by the citrate-nitrate autocombustion method. The prepared nano-particles were investigated and characterized using X-Ray diffraction (XRD) and Transmission Electron Microscopy (TEM) to confirm the formation of the samples in single phase without any impurities and to calculate the particle size. The magnetic susceptibility χM was measured as a function of temperature and magnetic field intensity. From χM(T) and M(H) the saturation magnetization (Ms), remanent magnetization (...) (Mr) and coercivity (Hc) of the samples were estimated. The correlation among physical properties and the ratio of divalent cation substitution was discussed and reported to shed more light on technological applications of the investigated samples. (shrink)

This study investigates how e-business capabilities and digital marketing strategies jointly influence business performance in the e-commerce industry, which has experienced unprecedented growth driven by technological advancements and changing consumer behavior. E-business capabilities encompass the use of technology and digital infrastructure, while digital marketing strategies are employed to attract and retain online customers. The study examines the effect of e-business capabilities through digital marketing strategies on the customer satisfaction and loyalty of UAE e-commerce industry. The research is descriptive and explanatory, (...) and uses a structured 5-scale Likert questionnaire to collect data from the HR managers of 135 e-commerce companies based in UAE. The statistical analysis is performed using structural equation modeling. The findings highlight the significant relationship of the study variables. Consequently, the results of this study provide valuable insights for e-commerce businesses, elucidating the need to invest in robust e-business capabilities to support effective digital marketing efforts. Additionally, the research underscores the significance of tailoring digital marketing strategies to align with specific business objectives and customer segments. The study also contributes to the literature on digital transformation, by demonstrating how e-business capabilities and digital marketing strategies can enable e-commerce firms to adapt and thrive in the dynamic and competitive digital environment. (shrink)