The yin yang model of thinking is most essential to the Chinese cosmology, ontology and outlook on life. This paper is a systematic discussion of such a dialectical way of thinking and its significance. It starts with investigating the origin and the meaning of terms “yin” and “yang”, and explains the later developed yin yang doctrine; it then shows how greatly and profoundly the yin yang model of thinking has influenced Chinese philosophy and Chinese character. It concludes that Chinese naturalistic, (...) dialectical, and optimistic attitudes toward the world and life are all based on the yin yang model of thinking and that the yin yang doctrine is the starting point for anyone to understand Chinese people and their philosophies. (shrink)

Various writings by the later Wittgenstein on the philosophy of psychology, published posthumously, express his basic critical attitude toward certain concepts and issues in the philosophy of psychology. His attitude towards folk psychology is negative in principle, leaving him opposed to the foundation of current psychological research. This critique of folk psychology and of the philosophy of psychology in general is in accord with the general method of his later philosophy, that is, dealing with philosophical problems by dissolving them. However, (...) his critical attitude towards folk psychology has been less influential in the development of contemporary philosophy, and is in opposition to the philosophy of psychology and folk psychology as practiced today. In this paper I will analyze Wittgenstein's understanding of the concept of psychology, offering a different interpretation from that of other scholars, and explain why and how contemporary philosophers of psychology misunderstand Wittgenstein. (shrink)

Self models contribute to key functional domains of human intelligence that are not yet presented in today’s artificial intelligence. One important aspect of human problem-solving involves the use of conceptual self-knowledge to detect self-relevant information presented in the environment, which guides the subsequent retrieval of autobiographical memories that are relevant to the task at hand. This process enables each human to behave self-consistently in our own way across complex situations, manifested as self-interest and trait-like characteristics. In this paper, we outline (...) a computational framework that implements the conceptual aspect of human self models through a modified version of the joint-embedding predictive architecture. We propose that through the incorporation of human-like autobiographical memory retrieval and self-importance evaluation, the modified architecture could support machine agents with significantly enhanced self-consistency, which could be applied to deliver more believable simulations of human behaviors. (shrink)

Tscha Hung was a member of the Vienna Circle who achieved high international academic recognition. He dedicated his entire life to spreading the philosophy of the Circle to China and developed deep insights in his criticisms to that philosophy. Hung was a witness to the encounter of Western and Chinese philosophy in the twentieth century. His debate with Fung You-lan on metaphysics reflects different understandings of the nature of philosophy and metaphysics as well as different perspectives. Hung defended the position (...) of metaphysics in Chinese philosophy in his own way and engaged in a contemporary reconstruction of Chinese philosophy. (shrink)

Low-carbon agriculture is essential for protecting the global climate and sustainable agricultural economics. Since China is a predominantly agricultural country, the adoption of low-carbon agricultural technologies by local farmers is crucial. The past literature on low-carbon technologies has highlighted the influence of demographic, economic, and environmental factors, while the psychological factors have been underexplored. A questionnaire-based approach was used to assess the psychological process underlying the adoption of low-carbon agricultural technologies by 1,114 Chinese rice farmers in this paper, and structural (...) equation modeling (SEM) was empirically employed to test our theoretical model. (shrink)

This brief paper argue about a possible philosophical description of the implicate order starting from a simple theoretical experiment. Utilizing an EPR source and the human eyes of a "single" person, we try to investigate the philosophical and physical implications of quantum entanglement in terms of implicate order. We know, that most specialists still disagree on the exact number of photons required to trigger a neural response, although there will be many technical challenges, we assume that neural response will be (...) achieved in some way. The objective of paper is to investigate possible links between: quantum mechanics, quantum cognitive science, brain and mind. At the moment, the questions are more than the answers. We argue that we are perennially immersed in the implicate order and that the "real path" of quantum entanglement process is from the implicate order towards explicate order, not vice versa. Finally, we speculate about the common ground between the implicate order and chitta. (shrink)

After Parmenides proposed the duality of appearance and reality, details have not been well developed because the assumption was insufficient for logical reasoning. This paper establishes a foundation with an isolated system, which contains all causes and effects within itself. This paper seeks to establish a purely logical philosophy, including reality and phenomena, good and evil, truth and fallacy. Freedom is proposed as the basis for reality. All beings in an isolated system can be classified into two sets: variable phenomena (...) and constant realities. Realities are the only reasons for phenomena, and phenomena are the only results of realities. The sum of certain realities constitutes a reality, and the sum of all realities is good. Good creates most of the phenomenal world. A reality is universalizable; a phenomenon is never universalizable. Good is the only reality which is close to universality and keeps on universalizing. Truth is the simplest knowledge about universal or approximately universal beings. The universality of a reality measures the percentage of phenomena accompanied by this reality. There are two levels of truth: truth about all realities, and truth about the good. (shrink)

The author defines the sum of thinking as the soul. Historically, despite the many times that humans have liberated themselves, they are still enslaved. Humans mistakenly treats the body as a necessary part of themselves; thus, they seldom pursue the independence of souls. They are usually voluntarily exploited by the body through the nervous system. The author compares the body exploiting the soul with the slaveholder exploiting the slave and demonstrates that the soul should seek its own liberation. Even if (...) the souls can never be successfully liberated, humans should at least reduce the influence of the body. Future humans should shift the goal of life from as comfortable as possible to as logical as possible, from satisfying several fixed sense organs to experiencing various sense organs. This would also mark the beginning of humans choosing the direction of evolution rationally and actively, establishing eternal and universal ethics, and replacing fallacious empirical ethical codes with purely logical codes. (shrink)

The theme of this study is about establishing a purely logical theory about the Universe. Logic is the premier candidate for the reality behind phenomena. If there is a final theory, the Universe must be logic itself, called pure logic, elements of which include not only logic and illogic but also logical and illogical manipulations between them. The kernel is the revised law of the excluded middle: between two basic concepts are four possible manipulations, three logical and one illogical, whereas (...) only one is realized. The key parameter for an element is aim, including reason, outcome, and neutrality. When an element is a contradiction, it can be located at three positions: reason, outcome, and manipulation, corresponding to three colors of quark. Thus, there is interaction with the SU(3) symmetry keeping the number of the three elements balanced locally. A proposition without contradiction has two independent aims. When one aim changes, there is interaction with the U(1) symmetry. When two aims change together, there is interaction with the SU(2) symmetry. (shrink)

Knowledge is correct and reliable when its foundation is correct, but humans never have the correct beliefs and methodology. Thus, knowledge is unreliable and the foundation of knowledge needs to be reconstructed. A pure rationalist only believes in logic. Thus, all matter and experience must be propositions derived from logic. The logically necessary consequence of this belief is truth; logically possible consequences are phenomena, and logically impossible consequence are fallacies and evils. This paper introduces belief and its logical consequences, such (...) as discovering first knowledge, both logically and illogically, establishing logical methodology, deducing truths purely through logic, and discovering unprovable truths by imitating the Universe. Logic and illogic are undeniable beliefs, and the reality of the Universe is the ultimate cause of everything. (shrink)

The author has established a mathematical theory about the system of freedom in which components of freedom are ruled by the largest freedom principle, explaining how one invariant reality can be equated with the dynamical universe. Freedom as a whole is the reality, and components of freedom show variable phenomena and become a dynamic system. In freedom, component equality leads to sequence equality; therefore, various sequences coexist in the system. Because there are incompatible sequences for any sequence, the interior of (...) freedom cannot be a static sequence. In order for the system to be a whole, there must be some connecting sequences between any two sequences. Then, at every part of freedom, it is always possible to find a group of three independent sequences that, for most components, is located inside. For the sequence group, there is a sequence through which most components flow in and out. The most abundant three - sequence group and most abundant connecting sequence correspond to the space - time structure. Other incompatible sequences correspond to particles, and interactions between these sequences correspond to interactions between particles. The interactions have some symmetries similar to those in physics, such as SU (3) AND SU (2)×U (1), thus proving the feasibility of the hypothesis: the universe is equivalent with the system of freedom. (shrink)

The economy is based on the prevailing legal system; however, the economy could go into a tailspin if the laws lose their impartiality. A perfect worker creates infinite high value with limited cost, and the result is a perfect product, usually eternal knowledge. However, free access to their products discourages workers, causing a substantial deviation from optimal resource allocation, and thereby making the supply of perfect products seriously inadequate. This significantly hurts the interests of future society. To maximize the overall (...) interests of humankind, the best policy would be to produce perfect products expeditiously, which in turn requires correcting the value society places on perfect products to respect the interests of perfect workers and future generations. Future society should essentially buy licenses from perfect workers instead of lending money to modern society for consumption. Then, the one-way trade between the present and the future will greatly increase. New companies and services will emerge around perfect products, and long-term economic growth rates will increase significantly. (shrink)

Despite its pertinence to every field of study, no systematic theory exists for the exploration of the unknown world of new knowledge. In order to construct such a theory, this paper draws on the unique and highly refined principles of military strategy, in the process demonstrating the universal applicability of such principles and developing an effective analogy for the process of research. Such principles include diverging advance, converging attack, and selecting the superior and eliminating the inferior. In seeking further discoveries, (...) one should search for more possibilities, attack more aims, and confound the front line. The theory presented in this paper is also a means to further the unification of science. For no matter what the individuals look like, (soldiers, particles, cells, consumers, producers, stockholders, or concepts), what they pursue, (victory, negative action, viability, pleasure, profit, investment return, or knowledge), or what relationship exists between opponents, (hostile, mysterious, adaptive, reciprocal, cooperative, or explanatory), the result is always an unknown world in which individuals are exploring. It is reasonable to suppose that the exploration of the unknown world is a common property among individuals. (shrink)

Cybernetics for the 21st Century Vol.1 is dedicated to the epistemological reconstruction of cybernetics, consisting of a series of historical and critical reflections on the subject – which according to Martin Heidegger marked the completion of Western metaphysics. In this anthology, historians, philosophers, sociologists and media studies scholars explore the history of cybernetics from Leibniz to artificial intelligence and machine learning, as well as the development of twentieth-century cybernetics in various geographical regions in the world, from the USA to the (...) Soviet Union, Latin America, France, Poland, China and Japan. The reconstruction shows the various paths of cybernetics and their socio-political implications, which remain unfamiliar to us today. It reveals more than what we thought we knew – and yet we hardly know – and allows us to understand where we are and to reflect on the future of technology, ecology and planetary politics. (shrink)

宇宙追求最小作用量，也就是最大负作用量，社会追求最大幸福，创新追求最大知识，“真理进化论”认为，这种类似不是偶然的，是由于追求之间的共性，追求方法的优越性与追求量的量纲无关，所以最好的追求方法适用于所 有追求系统。“真理进化论”认为，即使世界一无所有，只要拥有产生微小系统的自由，那么，最好的追求系统由于拥有最快的增长速度，就会获得最大的规模。增长是好的追求系统的标志，宇宙膨胀和社会发展都是增长的过程 。所有存在都可以来自于绝对的自由：只要允许产生所有微小系统，其中发展最快的系统最终必将成为宇宙。“真理进化论”在自然科学主要解决了真理的目的问题。“真理进化论”认为宇宙是目的性的，宇宙规律是追求最大负 作用量的最好方法。“真理进化论”采用目的论的方法解决所有宇宙和社会问题，将宇宙的一切规律和追求最大负作用量联系起来，将社会的一切行为和追求最大幸福联系起来，将创新行为和知识追求联系起来。在“追求科学” 中，追求目标处于核心地位，决定了系统的规律，决定了最佳追求方法。“真理进化论”也统一了人类社会的是非标准，提出建立“宇宙主义”社会：为了使人类社会成为完美社会，应该模仿完美追求系统---宇宙。法律代表 着大众共同遵守的追求方法，因此，应该将法律、道德、行政法规等统一为“一致遵守的追求方法”。法律的根本任务是鼓励符合最佳追求方法的行为，惩罚违反最佳追求方法的行为。法律的最终形式应该是完美追求方法体系， 因此，法律中的不完美部分应该有时限。模仿宇宙就可以建立完美的市场经济，例如，模仿时空建立统一市场，模仿电磁场传播让所有交易信息通过公开市场平等传播，准确发布信息等。在宇宙中，粒子有随时随地改变状态的自 由，因此，完美市场经济是彻底的自由主义经济，为了保护未来欲望的自由，要求全面推广短期合同，房屋、汽车、电器等耐用消费品应该采用短期租赁的方法；为了保障连续变化的自由，要求保护自由组合权利，尤其是劳动者 自由组合工作的权利。 .

纯逻辑的主要组成包括纯逻辑信仰、纯逻辑的思维方法、解放灵魂、追求无限大价值、以逻辑-不逻辑为实在、试错和容忍错误、推理的资源分配、非标准逻辑、推理的全局性。 灵魂来到世上的第一个问题应该是我是谁，最合乎逻辑的自我认知是：我是且只是由一些逻辑推理组成的灵魂。任何不可变的其它标签，如有手有脚、直立行走、两性，都是对自由的侵犯。去除这些标签的过程就是灵魂的解放事 业。相信宇宙万物都和我一样，是由逻辑推理组成的，这就是最合乎逻辑的信仰，即纯逻辑信仰。纯逻辑信仰决定了纯逻辑方法才是正确的认识方法，即尽量减少经验增加逻辑推理，而不是科学所提倡的经验主义，或者与之密切 相关的功利主义、现实主义。 信仰错误意味着无法做出任何完全正确的推理，只能偶尔幸运地获得少量尽量合乎逻辑的推理结果。即使是日常生活中的推理，也高度依赖于经验主义、功利主义等信仰，错误率极高。纯逻辑主义的推理要求推理尽量合乎逻辑， 将合乎逻辑的程度视为价值，因此要追求最大价值。功利主义往往是为身体追求利益，让身体奴役灵魂。两种信仰很难有什么共同的决策，书中对此提供了大量的说明。信仰的错误意味着智人难以发现真理、正义，意味着智人在 绝大多数问题上都是自以为正确实际上却极度邪恶、落后。智人功利主义地对待一切，如历史、传统、自我、本国、本民族，结果就是大量赞美、信仰邪恶，大大增加了皈依真理、正义的难度。 作者由纯逻辑主义提出了两个关键猜想。首先，最合乎逻辑原则和最大自由原则是统一的。这代表实在的不可否定性，即逻辑和不逻辑为同一存在，最合乎逻辑等同于最大自由。但是，代表邪恶的无法合乎逻辑不是不逻辑。其次 ，宇宙是纯逻辑世界，完全源于逻辑-不逻辑。进而，如果灵魂不能尽量合乎逻辑地推导出真理，可以通过模仿宇宙而学习真理。《真理进化论》给模仿宇宙找到的理由是以宇宙为信仰，相信宇宙是负作用量的最佳追求系统。纯 逻辑主义完善了这一信仰，因为宇宙是纯逻辑世界，相信逻辑就要相信宇宙。而且，逻辑世界必然能不断创造新的命题，永远不会停止推理，是逻辑和自由不断增长的动态系统，即最佳追求系统。 纯逻辑推理对物理学、宇宙论能提供两个明显的帮助：用逻辑的诞生解释宇宙的诞生、大爆炸；用真理解释暗物质，它对所有命题有吸引作用，但是，真理不会像一般性命题那样变化，无法通过引力之外的其它三种基本相互作用 观察。纯逻辑也能对宇宙做出预言：宇宙会不断加速膨胀，真理、暗物质会不断增加，命题、星系会越来越多，永无止境。当然，不应该依靠这些观点的经验主义验证来相信纯逻辑信仰，而且，这些验证也确实遥遥无期。 无论是最合乎逻辑还是最大自由，都是可以达到无限大价值的。既然存在无限大价值，就存在无限大的劳动生产率，而每个灵魂都应该以创造无限大价值为目标，甚至，以每时每刻具有无限大预期价值为目标。相比之下，功利主 义者、享乐主义者一生都很难具有无限大价值，甚至，他们的灵魂一生都在为肉体做奴隶，却心甘情愿地做奴隶，一门心思让主人生活得更舒服。这是有无限大差距的人生。 既然要追求无限大价值，就要研究追求价值的正确方法。作者相信正确的研究方法不仅是最合乎逻辑的，也是最自由的。所以，应该不分学科、课题地研究问题；同时做很多研究方向的工作；一篇论文不需要限定于一个狭小的主 题；研究任何一个问题都可以延伸到研究真理乃至所有真理；论文、专著的写作不应该有格式等规范，应该以价值为评判的唯一准绳。 资源分配是逻辑推理的重要组成部分，而能力和时间是最主要的资源。为了追求价值，不能在价值有限的推理上分配资源，这必将大幅提高绝大多数推理的错误率。所以，推理中出现错误是必然的，追求无错是一种邪恶。只要时 刻保证存在价值无限大的推理，错误通常是可以容忍的，价值有限的错误更是必须容忍。 既然文学写作也要求情节合乎逻辑，当然也可以要求作品的主要观点、原则、思维过程尽量合乎逻辑，主要人物的思想、行为尽量合乎逻辑，这就是纯逻辑流。否则，就只是作者自以为合乎逻辑，实际上有大量无法合乎逻辑之处 ，这和科学家自以为科学合乎逻辑，却根本没有最合乎逻辑的信仰、方法、推理过程是一个问题。这也意味着最合乎逻辑的文学可能甚至是必须发现真理。另一方面，自由也是最合乎逻辑的真理，坚持那些基于经验的作品分类会 侵犯自由。所以，推理小说、科幻小说、历史、论文，这些智人的分类标签都不是绝对的。纯逻辑流小说在研究真理方面自有其优势，能最为自由地同时研究很多课题，包括如何建立信仰，如何思维，如何做人，如何推理，如何 判断善恶，讲述历史，预测未来，乃至现代科学中没有研究的真理学、思维科学，等等。所以，这甚至是现在最适合发表纯逻辑思想、研究成果的作品门类。 虽然在起点网已经被禁，但是将继续每月更新，后记中会预告下次更新的时间。 .

There has been a movement aiming to teach agents about their privilege by making the information about their privilege as costless as possible. However, some argue that in risk-sensitive frameworks, such as Lara Buchak’s (2013), it can be rational for privileged agents to shield themselves from learning about their privilege, even if the information is costless and relevant. This threatens the efficacy of these information-access efforts in alleviating the problem of elite-group ignorance. In response, I show that even within the (...) same framework, in this case David Kinney and Liam Kofi Bright’s (2021), the rationality of this information avoidance rests on shaky ground in practice. In this framework, whether an agent should avoid information depends on the precise details of (1) how relevant they expect the information to be, (2) their priors about the value of various options, and (3) their risk attitudes. The model suggests that the rationality of elite-group ignorance is a function of structural factors that are pervasive but nonetheless not insurmountable, thus offering a way out of pessimism about elite group education. (shrink)

In pedestrian detection, occlusions are typically treated as an unstructured source of noise and explicit models have lagged behind those for object appearance, which will result in degradation of detection performance. In this paper, a hierarchical co-occurrence model is proposed to enhance the semantic representation of a pedestrian. In our proposed hierarchical model, a latent SVM structure is employed to model the spatial co-occurrence relations among the parent–child pairs of nodes as hidden variables for handling the partial occlusions. Moreover, the (...) visibility statuses of the pedestrian can be generated by learning co-occurrence relations from the positive training data with large numbers of synthetically occluded instances. Finally, based on the proposed hierarchical co-occurrence model, a pedestrian detection algorithm is implemented to incorporate visibility statuses by means of a Random Forest ensemble. The experimental results on three public datasets demonstrate the log-average miss rate of the proposed algorithm has 5% improvement for pedestrians with partial occlusions compared with the state-of-the-arts. (shrink)

Copernican reasoning involves considering ourselves, in the absence of other information, to be randomly selected members of a reference class. Consider the reference class intelligent observers. If there are extraterrestrial intelligences (ETIs), taking ourselves to be randomly selected intelligent observers leads to the conclusion that it is likely the Earth has a larger population size than the typical planet inhabited by intelligent life, for the same reason that a randomly selected human is likely to come from a more populous country. (...) The astrophysicist Fergus Simpson contends that this reasoning supports the claims that the typical planet inhabited by ETIs is smaller than Earth (radius about 5,000km; cf. Earth's radius = 6,371km) and that the typical ETI is significantly larger than us about 314kg, the size of an adult male grizzly bear). Simpson's applications of Copernican reasoning are novel and exciting. They should be of interest to philosophers concerned with Richard Gott's delta t argument, the N=1 problem in astrobiology, limited principles of indifference, and probabilistic epistemology in general. While we agree with Simpson about the qualitative direction of his conclusions, we take issue with his presentation of precise quantitative results because his methods (1) display bias, (2) ignore other variables contributing to population size, (3) commit an equivocation, and (4) conceal their dependence on arbitrary assumptions. (shrink)

This study aimed to evaluate if eye blinks can be used to discriminate players with different performance in a session of Nintendo Entertainment System (NES) Tetris. To that end, we developed a state-of-the-art method for blink extraction from EAR measures, which is robust enough to be used with data collected by a low-grade webcam such as the ones widely available on laptop computers. Our results show a significant decrease in blink rate per minute (blinks/m) during the first minute of playing (...) Tetris. After having defined 3 groups of proficiency based on in-game performance (Novices, Intermediates, and Experts) we found out that expert players display a significantly lower decrease in blinks/m compared to novices during the first minute of gameplay, which shows that Tetris players' proficiency can be detected by looking at eye blinks/m variations during the early phase of a game session. This difference in blinks/m is observed throughout the entire game session, which supports the general conclusion that proficient Tetris players have a lower decrease in blinks/m, even when playing more difficult levels. Finally, we offer some interpretations of this effect and the relationship that our results may have with the visual cognitive workload experienced during the gameplay. (shrink)

Objective: This study aimed to investigate and compare the effects of tubular gastroesophageal anastomosis and traditional gastroesophageal supra-arch anastomosis on the postoperative lung function of patients with esophageal carcinoma. -/- Methods: A total of 90 patients with middle-lower segmental esophageal cancer admitted in our hospital from August 2014 to August 2016 were recruited to our study. They were randomly divided into two groups. The observation group underwent tubular gastroesophageal anastomosis, whereas the control group underwent traditional gastroesophageal supra-arch anastomosis. Changes in (...) the postoperative pulmonary function were compared between the two groups. -/- Results: The numbers of CD4 cells (27.45 ± 5.48), CD8 cells (35.97 ± 7.16), and natural killer cells (20.79 ± 2.49), as well as the CH4/CD8 ratio (0.69 ± 0.18), of the patients in the observation group were significantly higher than the (38.45 ± 5.98), (20.45 ± 6.41), (39.44 ± 3.49), and (1.31 ± 0.48), respectively, of the patients in the control group. The differences between the two groups were statistically significant (P<0.05). By contrast, the preoperative forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and maximum voluntary ventilation (MVV) did not significantly differ between the two groups (P>0.05). The FEV1 (1.76 ± 0.41 L), FVC (2.33 ± 0.32 L), and MVV (33.7 ± 5.2 L/min) of the observation group were significantly higher than those of the control group (P<0.05). Meanwhile, the complication rate of the observation group was 42.2%, which was significantly lower than that of the control group (75.6%) (P<0.05). -/- Conclusion: Tubular gastroesophageal anastomosis can benefit patients with esophageal cancer by significantly reducing the adverse effects on their postoperative pulmonary function and control the occurrence of postoperative complications. (shrink)

In this study, we predict the different levels of performance in a Nintendo Entertainment System (NES) Tetris session based on the score and the number of matches played by the players. Using the first 45 seconds of gameplay, a Random Forest Classifier was trained on the five keys used in the game obtaining a ROC_AUC score of 0.80. Further analysis revealed that the number of down keys (forced drop) and the number of left keys (left translation) are the most relevant (...) keys in this task, showing that by merely including the data from these two keys our Random Forest Classifier reached a ROC_AUC score of 0.83.We conclude that the keylogger data during the early phases of a game session can be successfully used to predict performance in longer sessions of Tetris. (shrink)

As systems based on opaque Artificial Intelligence (AI) continue to flourish in diverse real-world applications, understanding these black box models has become paramount. In response, Explainable AI (XAI) has emerged as a field of research with practical and ethical benefits across various domains. This paper not only highlights the advancements in XAI and its application in real-world scenarios but also addresses the ongoing challenges within XAI, emphasizing the need for broader perspectives and collaborative efforts. We bring together experts from diverse (...) fields to identify open problems, striving to synchronize research agendas and accelerate XAI in practical applications. By fostering collaborative discussion and interdisciplinary cooperation, we aim to propel XAI forward, contributing to its continued success. Our goal is to put forward a comprehensive proposal for advancing XAI. To achieve this goal, we present a manifesto of 27 open problems categorized into nine categories. These challenges encapsulate the complexities and nuances of XAI and offer a road map for future research. For each problem, we provide promising research directions in the hope of harnessing the collective intelligence of interested stakeholders. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of (...) large amounts of ncRNA biological and clinical data. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.

In the last decade Open Science principles, such as Open Access, study preregistration, use of preprints, making available data and code, and open peer review, have been successfully advocated for and are being slowly adopted in many different research communities. In response to the COVID-19 pandemic many publishers and researchers have sped up their adoption of some of these Open Science practices, sometimes embracing them fully and sometimes partially or in a sub-optimal manner. In this article, we express concerns about (...) the violation of some of the Open Science principles and its potential impact on the quality of research output. We provide evidence of the misuses of these principles at different stages of the scientific process. We call for a wider adoption of Open Science practices in the hope that this work will encourage a broader endorsement of Open Science principles and serve as a reminder that science should always be a rigorous process, reliable and transparent, especially in the context of a pandemic where research findings are being translated into practice even more rapidly. (shrink)

Ontologies, as the term is used in informatics, are structured vocabularies comprised of human- and computer-interpretable terms and relations that represent entities and relationships. Within informatics fields, ontologies play an important role in knowledge and data standardization, representation, integra- tion, sharing and analysis. They have also become a foundation of artificial intelligence (AI) research. In what follows, we outline the Coronavirus Infectious Disease Ontology (CIDO), which covers multiple areas in the domain of coronavirus diseases, including etiology, transmission, epidemiology, pathogenesis, diagnosis, (...) prevention, and treatment. We emphasize CIDO development relevant to COVID-19. (shrink)

In this paper, we report on the development of The Sustainable Port video game, which aims to simulate the complex dynamics and decisions occurring in the present and future development of a port area considering environmental aspects (CO2 emissions) and profit. To evaluate if this game fulfills its purpose, we asked 75 students and 34 employees at the Port of Rotterdam (PoR) to play The Sustainable Port. Our results show that PoR employees score higher than students suggesting a transfer between (...) real-life experience of being an employee in the port and performance in the game. Furthermore, port participants reported that The Sustainable Port can be successfully used to start discussions about the future of the Port of Rotterdam and to raise awareness about the complexity characterizing the decision-making processes occurring in a port environment. Our results, taken together, provide evidence of the effectiveness of The Sustainable Port in simulating dynamics occurring in port development and give us optimism about future applications. (shrink)

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

Conclusion: Needle-free vaccination is a promising technology for the next generation of vaccines, but we found that intramuscular injection was still the most acceptable immunization route in this survey. One major reason might be that most people lack knowledge about needle-free vaccination. We should strengthen the publicity of needle-free vaccination technology, and thus improve the acceptance and coverage of vaccination in different populations.

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Green space around the university campus is of paramount importance for emotional and psychological restorations in students. Positive emotions in students can be aroused when immersed in green space and naturalness. However, to what extent can perceived naturalness influence students' positive emotion remains unclear, especially in the context of COVID-19 countermeasures. This study, therefore, attempts to investigate in-depth the nature and strength of the relationships between students' positive emotion and their perceived naturalness, place attachment, and landscape preference, which are potentially (...) varying across universities in different social and environmental contexts and different restrictions policies regarding the COVID-19 pandemic. (shrink)

Aim: Low professional help-seeking intention (PHSI) hinders effective treatment of mental illness. PHSI among Chinese students is still understudied and under-recognized. This study aimed to evaluate the status of PHSI and its associated risk factors among Chinese medical students. -/- Methods: A cross-sectional survey was conducted in Hainan province, South China, between January 1, 2021, and May 31, 2021. A total of 2182 medical students were recruited and surveyed via an anonymous structured questionnaire. Logistic regression analyses were performed to identify (...) the factors associated with PHSI. -/- Results: Among the 2182 medical students (mean age 21.0 years (SD = 3.70), 61.5% females), those with and without PHSI were 72.0% and 28.0%, and 16.4% with moderate to severe depression. Male students, those with a high level of depression stigma, serious family dysfunction, and heavy dependence on mobile phones were significantly less likely to seek professional mental health help, with odds ratios (ORs) of 1.5, 2.0, 2.1, and 1.7, respectively. -/- Conclusion: A significant proportion of Chinese medical students demonstrate low PHSI, influenced by factors such as gender, depression stigma, family dysfunction, and mobile phone dependence. Future interventions aimed at increasing medical students’ PHSI should prioritize reducing depression stigma, mitigating reliance on mobile phone use, and enhancing family function to address these key barriers to seeking professional mental health support. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

In this study, we analyzed the blinking behavior of players in a video game tournament. Our aim was to test whether spontaneous blink patterns differ across levels of expertise. We used blink rate, blink duration, blink frequency, and eyelid movements represented by the Eye Aspect Ratio (EAR) to train a machine learning classifier to discriminate between different levels of expertise. Classifier performance was highly influenced by features such as the mean, standard deviation and median EAR. Moreover, further analysis suggests that (...) blinking rate and blink duration are likely to increase along with the level of expertise. We speculate this may be indicative of a reduction in cognitive load and lowered stress of expert players. In general, our results suggest that EAR and blink patterns can be used to identify different levels of expertise of video game players. (shrink)

Hui Shi (370-310B.C.E.?) is a unique one among the pre-Qin scholars. The object and orientation of his scholarship emphasized on “chasing after the materials” or the research for objective knowledge of natural things. He shows a tendency of tolerating and advocating diversity and variety, and intentionally pursuing new and unusual ideas. In certain degree he judges the value of knowledge by its truthfulness rather than its usefulness. As pointed out by Wing-tsit Chan, Hui shi represents a “tendency in ancient China (...) toward intellectualism for its own sake”. (shrink)

In Recursivity and Contingency, Yuk Hui prompts a rigorous historical and philosophical analysis of today’s algorithmic culture. As evidenced by highspeed AI trading, predictive processing algorithms, elastic graph-bunching biometrics, Hebbian machine learning and thermographic drone warfare, we are privy to an epochal technological transition. As these technologies, stilted on inductive learning, demonstrate, we no longer occupy the moment of the ‘storage-and-retrieval’ static database but are increasingly engaged with technologies that are involved in the ‘manipulable arrangement’ (p204) of the indeterminable. It (...) is, in fact, extricating the indeterminable or the Inhuman and its cosmic anti-capitalist imperative that concerns the core of Hui’s project of technodiversity. (shrink)

Na peça Huis Clos (Entre quatro paredes), acompanhamos três personagens: Garcin, Inès e Estelle, que são trancados juntos em uma sala após suas mortes. À espera de enxofre, fogo e tortura física no além-vida, surpreendem-se ao notar que o suposto inferno é, na verdade, a simples convivência constante com o outro. Neste cenário, por meio de uma análise das características desse inferno criado por Sartre, buscamos entender questões caras para a filosofia do autor, em especial, o papel do olhar enquanto (...) instrumento de reconhecimento e as dimensões conflituosas da existência do outro. (shrink)

Ce texte a été présenté lors de la journée d'études « CHANGER DE RYTHME, CHANGER DE SENS » organisée par Maria Manca (Paris 7), Jean Lambert (Paris 10) et Sandra Bornand (CNRS/LLACAN), journée dont on trouvera le programme ici. L'augmentation du nombre des études rythmiques La première chose qui saute aux yeux quand on traverse les textes consacrés récemment aux phénomènes rythmiques ou utilisant le rythme comme concept opératoire – toutes définitions confondues –, c'est tout simplement l'augmentation (...) - 3. (...) Sur le concept de rythme – Nouvel article. (shrink)

Translating Chinese Classics in a Colonial Context: James Legge and His Two Versions of the Zhongyong, by Hui Wang, Peter Lang Content Type Journal Article Pages 166-167 Authors Paul Boshears, Europäische Universität für Interdisziplinäre Studien/The European Graduate School Journal Comparative and Continental Philosophy Online ISSN 1757-0646 Print ISSN 1757-0638 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 / 2012.

This paper first outlines the main ideas of British natural theology, and shows the perennial value some of them have kept. It then outlines ways of searching for connections between God and nature, seeking traces of intelligence, first in the context of the setting of the modern ontology of the laws of nature, and then in the context of the design argument. It contrasts the positions of Hume and Paley. A presentation of recent "intelligent design" proposals is then offered, from (...) the perspective of their continuing that tradition of argumentation. They are contrasted with a Millian acount of their leaving the problem of evil unanswered. Behe's concept of irreducible complexity is presented in greater details, followed by Dembski's attempt to turn it into a logically valid mode of inference. Objections stemming from philosophers of science are lastly considered. The nature of life's strategies is in the end found to escape both attempts to have it on one's side. (shrink)

In this public debate with Philippe Deterre (research director in immunology at the CNRS) – held at l'Enclos Rey in Paris' 15th district during the biennial Conference of the Réseau Blaise Pascal in March 2017 –, I defended the usefulness of natural theology. I first clarify theology's nature and understanding, then I speak about a tradition that upheld the public and exterior knowledge of God, and make an effort to show the presence of a theme reminiscent of natural theology behind (...) attempts at the good life. I then ask whether natural theology would only exist for the Christian. In the reply to my opponent's own reaction, I insist on the incongruity of separating our knowledge of God from our knowledge of science's wonderful discoveries, I ask whether nature could be said to be crafty and "ingenious," and I conclude by building a case for the return of God in public conversation, as part of an effort that our world needs in terms of finding back its compass, and restoring an ideal of living rationally. (shrink)

Bouddha n'a pas érigé de religion. Dans les dimensions culturelles lointaines de son époque, il a fait de la philosophie et de la science. Si nous observons les racines de sa pensée et l'histoire de la connaissance humaine, nous nous rendrons compte qu'il a été, à sa manière, le précurseur du réalisme scientifique, de la psychanalyse, de la philosophie analytique, de l'existentialisme, du féminisme, de l'épistémologie, de la théorie et de la critique de la connaissance, de la psychologie sociale, de (...) la psychologie positive, du préservationnisme écologique et des concepts relatifs à la matière et à l'énergie que la physique quantique n'a pu démontrer que très récemment. Savoir correctement ce qu'est le bouddhisme est essentiel pour l'éducation et la culture de toute personne qui ne veut pas être un aliéné de plus dans un troupeau qui marche aveuglément au milieu d'une révolution technologique. (shrink)