In the last few decades the role played by models and modeling activities has become a central topic in the scientific enterprise. In particular, it has been highlighted both that the development of models constitutes a crucial step for understanding the world and that the developed models operate as mediators between theories and the world. Such perspective is exploited here to cope with the issue as to whether error-based and uncertainty-based modeling of measurement are incompatible, and thus alternative with one (...) another, as sometimes claimed nowadays. The crucial problem is whether assuming this standpoint implies definitely renouncing to maintain a role for truth and the related concepts, particularly accuracy, in measurement. It is argued here that the well known objections against true values in measurement, which would lead to refuse the concept of accuracy as non-operational, or to maintain it as only qualitative, derive from a not clear distinction between three distinct processes: the metrological characterization of measuring systems, their calibration, and finally measurement. Under the hypotheses that (1) the concept of true value is related to the model of a measurement process, (2) the concept of uncertainty is related to the connection between such model and the world, and (3) accuracy is a property of measuring systems (and not of measurement results) and uncertainty is a property of measurement results (and not of measuring systems), not only the compatibility but actually the conjoint need of error-based and uncertainty-based modeling emerges. (shrink)

The common account of the analog vs digital distinction is based on features of physical systems, being related to the usage of continuous vs discrete supports respectively. It is proposed here to alternatively characterize the concepts of analog and digital as related to coding systems, of which a formal definition is given, by suggesting that the distinction refers to the strategy adopted to define the coding function: extensional in digital systems, isomorphic intensional in analog systems. This thesis is supported by (...) examples, in particular of analog systems exploiting discrete supports, and is discussed to explain why digital coding is currently so widespread in technological and social practice. (shrink)

Frank Jackson’s knowledge argument (KA) aims to prove, by means of a thought experiment concerning the hypothetical scientist Mary, that conscious experiences have non-physical properties, called qualia. Mary has complete scientific knowledge of colours and colour vision without having had any colour experience. The central intuition in the KA is that, by seeing colours, Mary will learn what it is like to have colour experiences. Therefore, her scientific knowledge is incomplete, and conscious experiences have qualia. In this paper I consider (...) an objection to the KA raised by Daniel Dennett. He maintains that the KA is vitiated by Jackson’s account of Mary’s scientific knowledge. While endorsing this criticism, I will defend the plausibility and relevance of the type of strategy involved in the KA by offering an account of Mary’s scientific knowledge. This account involves formulating a reasonable and not immediately false version of the physicalist thesis with regard to colour experiences. Whether this version of the KA is successful against this type of physicalism is not investigated here. (shrink)

In this review, we describe some of the central philosophical issues facing origins-of-life research and provide a targeted history of the developments that have led to the multidisciplinary field of origins-of-life studies. We outline these issues and developments to guide researchers and students from all fields. With respect to philosophy, we provide brief summaries of debates with respect to (1) definitions (or theories) of life, what life is and how research should be conducted in the absence of an accepted theory (...) of life, (2) the distinctions between synthetic, historical, and universal projects in origins-of-life studies, issues with strategies for inferring the origins of life, such as (3) the nature of the first living entities (the “bottom up” approach) and (4) how to infer the nature of the last universal common ancestor (the “top down” approach), and (5) the status of origins of life as a science. Each of these debates influences the others. Although there are clusters of researchers that agree on some answers to these issues, each of these debates is still open. With respect to history, we outline several independent paths that have led to some of the approaches now prevalent in origins-of-life studies. These include one path from early views of life through the scientific revolutions brought about by Linnaeus (von Linn.), Wöhler, Miller, and others. In this approach, new theories, tools, and evidence guide new thoughts about the nature of life and its origin.We also describe another family of paths motivated by a” circularity” approach to life, which is guided by such thinkers as Maturana & Varela, Gánti, Rosen, and others. These views echo ideas developed by Kant and Aristotle, though they do so using modern science in ways that produce exciting avenues of investigation. By exploring the history of these ideas, we can see how many of the issues that currently interest us have been guided by the contexts in which the ideas were developed. The disciplinary backgrounds of each of these scholars has influenced the questions they sought to answer, the experiments they envisioned, and the kinds of data they collected. We conclude by encouraging scientists and scholars in the humanities and social sciences to explore ways in which they can interact to provide a deeper understanding of the conceptual assumptions, structure, and history of origins-of-life research. This may be useful to help frame future research agendas and bring awareness to the multifaceted issues facing this challenging scientific question. (shrink)

PRINCÍPIOS DA DIGESTÃO DOS ALIMENTOS NOS BEZERROS -/- -/- E. I. C. da Silva -/- Departamento de Agropecuária – IFPE Campus Belo Jardim -/- Departamento de Zootecnia – UFRPE sede -/- -/- PRINCÍPIOS DA DIGESTÃO DOS ALIMENTOS NOS BEZERROS -/- -/- INTRODUÇÃO -/- Se todos os bezerros pudessem ser criados por suas mães, haveria pouca necessidade de inúmeros livros, artigos e trabalhos, como esse, sobre a criação e o manejo básico desses animais. A maioria das vacas desempenha um ótimo papel (...) na criação dos seus descendentes, desde que sejam tomados os devidos cuidados com relação a alimentação, saúde e a outros aspectos relativos à criação desses neonatos. A essência da pecuária bovina relativa à criação de bezerros é manter esses animais vivos e aptos o suficiente para desempenhar atividades produtivas de grande importância na propriedade. Para tanto, os criadores necessitam entender o desenvolvimento do trato digestivo do bezerro e os conceitos básicos da digestão dos alimentos por ele, e é isso que pretendo aclarar de forma clara e concisa com esse trabalho. -/- -/- 1.1 O TRATO DIGESTIVO DO BEZERRO -/- Um animal adulto necessita de quatro estômagos funcionais para dar-lhe a capacidade de utilizar a ampla gama de alimentos disponíveis. -/- O retículo e o rúmen abrigam milhões de micróbios que fermentam e digerem o material vegetal, em especial às presentes nas forragens. O omaso permite a absorção de água do conteúdo do intestino. O abomaso, ou quarto estômago, é o verdadeiro estômago, comparável ao dos humanos, e permite a digestão ácida dos alimentos. -/- O bezerro muito jovem não desenvolve a capacidade de digerir o pasto, sendo assim o abomaso é o único estômago funcional ao nascer. Tanto os animais recém-nascidos como os adultos têm um intestino delgado funcional que permite a digestão alcalina dos alimentos. -/- A figura 1 ilustra a anatomia dos estômagos e intestino delgado de um bezerro recém-nascido. Esse diagrama esquemático mostra as dimensões relativas dos quatro estômagos, o sulco esofágico, que vai do esôfago até o abomaso, e o esfíncter pilórico ou válvula no fundo do abomaso, que controla a velocidade de movimento do conteúdo do intestino no duodeno. -/- O omaso e o abomaso representam cerca de 70% da capacidade total do estômago no bezerro recém-nascido. Por outro lado, nas vacas adultas, eles compõem apenas 30% da capacidade total do estômago (figura 2). -/- A digestão dos alimentos é auxiliada pela secreção de certos produtos químicos denominados enzimas, que estão presentes nas várias partes do intestino. Por exemplo, os bezerros produzem a enzima renina na parede do abomasal para auxiliar na digestão das proteínas do leite, enquanto a lactase é produzida na parede do duodeno para a digestão do açúcar do leite (lactose). Estas enzimas operam mais eficazmente em diferentes níveis de acidez no conteúdo do intestino, ácido no abomaso e alcalino no duodeno. Para conseguir isso, o bezerro segrega eletrólitos, ou sais minerais, com as enzimas, para mudar o conteúdo do intestino de um tipo para outro. -/- Os produtos finais da digestão dos diferentes componentes dos alimentos são absorvidos através da parede do intestino, mediante as vilosidades intestinais, para a corrente sanguínea, onde são levados para as diferentes partes do corpo para o crescimento e desenvolvimento do animal. -/- -/- 1.2 O BEZERRO ALIMENTADO COM LEITE -/- O Leite ou substituto do leite, quer seja apreendido através de uma teta ou bebido de um balde, é canalizado do esôfago através do sulco esofágico para o abomaso. Este sulco é um pequeno canal na parede do rúmen que é controlado por músculos que permitem que os líquidos sejam diretamente enviados para o abomaso e que não entrem no rúmen. O sulco é ativado em resposta a diferentes estímulos. Funciona bem quando os bezerros amamentam-se através das tetas das mães, mas às vezes não funciona quando bebem de um balde. Essa parece ser uma condição psicológica em resposta aos bezerros separados de suas mães. A maioria dos bezerros podem ser treinados pelo tratador para beber o leite do balde rapidamente e bem, a metodologia empregada é a da persuasão do animal, ao qual o mesmo possa responder positivamente à nova rotina diária e à mãe substituta na forma do criador do bezerro. Quando o leite ou o substituto do leite entra no abomaso, forma um coágulo firme dentro de alguns minutos sob a influência das enzimas renina e pepsina. Este é o mesmo processo envolvido na fabricação de queijo ou junket, usando renina para coagular a proteína do leite. A coagulação do leite retarda a taxa em que flui para fora do abomaso, permitindo assim uma liberação constante de nutrientes alimentares em todo o intestino e, eventualmente, para a corrente sanguínea. Pode levar de 12 a 18 horas para que a coalhada de leite seja totalmente digerida. -/- As enzimas que atuam nas proteínas do leite requerem um ambiente ácido e esse é fornecido pela secreção do ácido clorídrico no abomaso. No entanto, até que a digestão ácida esteja operando de forma eficiente, e isso pode levar até sete dias, a única forma de proteína que pode ser digerida é a caseína. Não há substituto para a caseína no bezerro muito jovem. Os substitutos do leite que contêm outras formas de proteína não podem ser devidamente digeridos até que os bezerros sejam mais velhos. Logo, é necessário muito cuidado para não fornecer substitutos ou sucedâneos que contenham fontes proteicas que não possam ser digeridas pelo estômago do animal, para que não ocasione complicações gastrintestinais. -/- A digestão do leite pode ser melhorada com a inclusão de coalho, que pode ser obtido a partir de fábricas de queijo ou aditivos comerciais de leite de bezerro para a primeira semana ou mais. Esses produtos comerciais podem fornecer ácidos adicionais para reduzir o pH abomasal e incrementar a quantidade de enzimas e bactérias específicas para aumentar a taxa de degradação da coalhada de leite. Tais aditivos são chamados probióticos, na medida em que ajudam nos processos digestivos normais. A pesquisa nem sempre os encontrou para melhorar o desempenho e a saúde dos bezerros, e eles são mais propensos a ser benéficos quando os bezerros estão sofrendo de problemas de saúde. Além disso, a sua eficácia, em termos de custo-benefício é, por vezes, questionada. -/- Qualquer leite de uma alimentação anterior está envolvido neste coágulo recém-formado. As proteínas líquidas de soro de leite e a lactose são rapidamente separadas da coalhada de leite e passam para o abomaso. A gordura do leite contida na coalhada de leite é decomposta por outra enzima, a lipase. Esta é secretado na boca pela saliva e incorporada quando o leite é engolido. A alimentação pelas tetas em vez da alimentação através do balde parece produzir mais saliva e, portanto, mais lipase. A digestão adicional da proteína do leite e da gordura ocorre no duodeno com a ajuda das enzimas produzidas no pâncreas. -/- A lactose, que é rapidamente liberada da coalhada de leite no abomaso, é dividida em glicose e galactose e estas são absorvidas na corrente sanguínea para formar a principal fonte de energia para os bezerros jovens. -/- As gorduras são divididas em ácidos graxos e glicerol para absorção e uso como energia, enquanto as proteínas são divididas em aminoácidos e peptídeos para absorção e uso como fontes de proteína corporal. -/- O amido de cereais, por exemplo, é uma importante fonte de energia em bezerros mais velhos, mas esses animais, nas suas primeiras semanas de vida, não conseguem digerir o amido. -/- O abomaso não é ácido até que o bezerro tenha 1-2 dias de idade e isso apresenta vantagens e desvantagens. A principal vantagem é que as proteínas imunes no colostro não podem ser digeridas nesse compartimento estomacal, por isso são absorvidas na corrente sanguínea na mesma forma quando produzidas pela vaca. Isso garante o seu papel como anticorpos para proteger contra as doenças e infecções. A baixa acidez do conteúdo abomasal no bezerro recém-nascido constitui um risco potencial das bactérias (e provavelmente vírus) tomadas através da boca. Estes não serão mortos pela digestão ácida, sendo assim podem passar para os intestinos, onde podem fazer mal ao bezerro recém-nascido. -/- Todos os bezerros pegam bactérias nos primeiros dias de vida e isso é essencial para o desenvolvimento normal do rúmen (flora microbiana). No entanto, a primeira bactéria a colonizar o intestino também pode causar danos. Desde que o bezerro tenha bebido colostro, os anticorpos maternos podem controlar a propagação dessas bactérias mais nocivas. -/- O bezerro alimentado com leite deve, então, produzir uma digestão ácida no abomaso e uma digestão alcalina no duodeno. Isto é conseguido pela produção de eletrólitos na parede do intestino. -/- Bezerros que sofrem de escoriações devido a distúrbios nutricionais ou infecções bacterianas podem perder grandes quantidades de água e eletrólitos em suas fezes. Estes devem ser reabastecidos como parte do tratamento para as escoriações. -/- O colostro é o primeiro leite produzido por vacas recém-paridas. Além de fornecer nutrientes essenciais para a alimentação animal, fornece anticorpos maternos que permitem a transferência passiva de imunidade contra doenças. As recomendações para a alimentação com colostro serão abordadas brevemente em outro trabalho. -/- -/- 1.3 DESENVOLVIMENTO DO RÚMEN E O PROCESSO DE DESMAME -/- Quando os bezerros são desmamados, o custo da criação diminui acentuadamente. Os custos de alimentação são mais baixos, os insumos de trabalho são reduzidos e a incidência de problemas de saúde é menor. No sentido econômico, faz sentido desmamar os bezerros assim que for razoável. No entanto, o bezerro é forçado a sofrer várias mudanças dramáticas, a saber: -/-  A fonte primária de nutrientes muda de líquido para sólido. -/-  A quantidade de matéria seca que o bezerro recebe é reduzida. -/-  O bezerro deve adaptar-se de um tipo monogástrico a um ruminante de digestão, que inclui a fermentação de alimentos. -/-  Mudanças na habitação e no manejo muitas vezes ocorrem em torno do desmame, o que pode aumentar o estresse. -/- Ao nascer, o rúmen é uma parte pequena e estéril do intestino que, ao desmame deve se tornar o compartimento mais importante dos quatro estômagos. Deve aumentar em tamanho, atividade metabólica interna e fluxo sanguíneo externo. Os cinco requisitos para o desenvolvimento ruminal são: -/-  Estabelecimento de bactérias. -/-  Líquido. -/-  Saída de material (ação muscular). -/-  Capacidade absortiva do tecido. -/-  Substrato para permitir o crescimento bacteriano, tais como minerais reciclados, bem como nutrientes para alimentação. -/- Antes do consumo de alimentos sólidos, as bactérias existentes fermentam o cabelo ingerido, o estrato e o leite que flui do abomaso para o rúmen. A maior parte da água que entra no rúmen provém da água livre (água real não contida no leite ou na solução substituta do leite). O leite contornará o rúmen através do sulco esofágico, enquanto a água livre não. -/- O rúmen se desenvolve a partir de um órgão muito pequeno em bezerros recém-nascidos (1-2 L) para a parte mais importante do intestino (25-30 L) por 3 meses de idade. Ele pode aumentar muito rapidamente durante as primeiras semanas de vida, dado o manejo da alimentação direita. -/- O crescimento do rúmen ocorre apenas sob a influência dos produtos finais da digestão no mesmo, que resultam da fermentação de alimentos sólidos pelos micróbios presentes nesse compartimento. O desenvolvimento ocorre em grande parte através do crescimento das papilas ruminais (figura 5 e 6) na parede ruminal (estruturas semelhantes a folhas na superfície interna), que aumentam a área superficial do rúmen e, portanto, a sua capacidade de absorver estes produtos finais de digestão. Portanto, os concentrados favorecem melhor o desenvolvimento dessas papilas ruminais. Para tanto, é necessário, com um tempo, ir incrementando a dieta sólida gradativamente para que esses animais deixem de consumir o leite das vacas produtoras e possam alimentar-se de ração e pastagens, que é a finalidade da criação de bovinos, ou seja, criar animais com menor custo possível e engordá-los através de ração, mas principalmente de pastagens. -/- A capacidade do rúmen e a ingestão de alimentos sólidos estão intimamente relacionadas. O desenvolvimento do rúmen é muito lento em bezerros alimentados com grandes quantidades de leite. O leite satisfaz seus apetites para que eles não tenham fome suficiente para comer qualquer alimento sólido. Logo, é necessário diminuir paulatinamente o fornecedor do leite para esses animais, favorecendo a ingestão de alimentos sólidos e desenvolvendo o rúmen, estômago que digere as fibras das forragens e que os tona animais peculiares. -/- A ruminação pode ocorrer com cerca de 2 semanas de idade e é uma boa indicação de que o rúmen está se desenvolvendo. Alimentos sólidos, bem como a ruminação, estimulam a produção de saliva e isso fornece nutrientes como ureia e bicarbonato de sódio para produzir os substratos para o crescimento e desenvolvimento da flora bacteriana. -/- No desmame precoce, é importante limitar a quantidade de leite oferecida e a sua disponibilidade durante todo o dia. Também é essencial fornecer alimentos sólidos. Os grosseiros (de baixa ou alta qualidade) devem ser oferecidos em combinação com concentrados de alta qualidade. -/- O criador deve tomar cuidado com o fornecimento de alimentos como a ração farelada, uma vez que essa ração pode entrar pelas vias nasais e ocasionar complicações respiratórias; há alguns relatos de bezerros mortos após a ingestão de ração farelada, na autópsia de um dos casos foi diagnosticada uma morte por esses grãos farelados presentes no pulmão. Portanto, para evitar complicações o ideal é que se forneça uma ração denominada peletizada. -/- Os alimentos grosseiros (volumosos) estimulam o desenvolvimento do rúmen, enquanto os concentrados fornecem nutrientes para a alimentação animal que não são fornecidos pelas quantidades limitadas de leite oferecidas. Sem os concentrados, o crescimento dos bezerros é lento, mas o rúmen ainda se desenvolve, resultando em animais barrigudos. -/- A ureia fornece nitrogênio para os micróbios, enquanto o bicarbonato de sódio atua como um tampão ruminal, ajudando a manter um pH estável no conteúdo do rúmen. Isso é, particularmente, importante quando os bezerros comem grandes quantidades de grãos de cereais na vida adulta, pois os micróbios do rúmen podem produzir muito ácido lático durante a fermentação desse material. -/- Envenenamento por grãos ou acidose ocorre quando os níveis de ácido lático são excessivamente elevados e tornam-se tóxicos para os micróbios do rúmen e, eventualmente, para o animal. Assim como os produtos finais que são absorvidos através da parede do rúmen, a fermentação microbiana produz os gases dióxido de carbono e metano e estes são normalmente exalados. Quando algo impede a fuga destes gases do rúmen, o inchaço pode se manifestar em qualquer fase da vida, diz-se do animal estufado. -/- -/- 1.4 O PAPEL DA FORRAGEM NO PROCESSO DE DESMAME -/- Existem inúmeras controvérsias acerca do papel da forragem no processo de desmame. Pesquisas realizadas na década de 1980 indicaram claramente que a forragem era benéfica, enquanto pesquisas da década de 1990 descobriram que nem sempre era necessário o fornecimento da forragem para que os bezerros fossem desmamados e que não sofresse estresse e nem apresentasse baixa eficiência produtiva e reprodutiva no futuro. Na maioria das pesquisas anteriores, os bezerros eram desmamados com a oferta de concentrados moídos como pellets com ou sem a presença de feno longo ou palha. Porém, a inclusão de forragens na dieta melhorou a ingestão e o desempenho, além de permitir o desmame precoce. -/- Na pesquisa posterior, os bezerros geralmente alimentavam-se de concentrados grosseiramente moídos, além de alguns volumosos, enquanto alguns até incluíam volumosos picados finos na mistura (às vezes chamados de mistura muesli por apresentar o capim e a ração). Nesses estudos, verificou-se que a inclusão de feno ou palha adicional teve pouco efeito no desempenho pré-desmame. -/- Os sistemas de criação de bezerros australianos frequentemente diferem dos demais, especialmente em áreas de parto sazonais. Um número excessivo elevado de bezerros precisam ser criados de uma só vez para lhes fornecer, a todos, currais individuais durante todo o seu período de amamentação. Consequentemente, os bezerros são criados em grupos. Além disso, os ingredientes da maioria dos concentrados para esses animais são finamente moídos. Nessas situações, descobriu-se que a palha limpa é um alimento útil e que deve ser incluso no período pré-desmame. Alguns agricultores preferem feno de boa qualidade, porém estes agricultores geralmente têm bezerros em grupos muito pequenos, muitas vezes um ou dois, por isso possuem maior controle sobre a ingestão de forragem. -/- Figura 7: A alimentação volumosa de bezerros alimentados com leite é uma questão controversa. Imagem cedida pelo IPA -/- É difícil e, portanto, mais caro que os produtores de rações incorporem feno picado nas refeições dos bezerros. Os pellets são muito mais fáceis, pois eles vão fluir para silos. Por fim, os produtores de leite devem incluir o componente volumoso no regime alimentar pré-desmame. A pastagem não é a fonte ideal de forragem volumosa para os bezerros alimentados com leite, uma vez que possui muito pouca fibra e uma baixa densidade de energia alimentar. O seu elevado teor de água limita a sua capacidade de fornecer energia alimentar adequada aos animais em crescimento. Para ingerir a pastagem a capacidade ruminal deveria ser maior, bezerros jovens simplesmente não conseguem comer pasto suficiente, a menos que seja de alta em qualidade. -/- Os bezerros criados com leite e fornecimento gradual de concentrados apresentam uma boa função ruminal às 3 semanas de vida, além de possuírem uma suficiente capacidade ruminal para o desmame entre às 4-6 semanas de idade. No entanto, se a dieta for baseada em leite restrito e pastagem de alta qualidade, a capacidade do rúmen pode não ser suficiente para o desmame até às 8-10 semanas de vida. Mesmo assim, as taxas de crescimento seriam menores em bezerros desmamados com base alimentar somente à pasto, uma vez que a ingestão de energia é insuficiente devido às limitações físicas da capacidade ruminal. -/- Se a qualidade for muito boa e produza apetite, os bezerros preferem volumosos ao invés do concentrado, o que leva a uma ingestão reduzida de nutrientes durante alimentação, tendo como efeito um crescimento mais lento. Quando volumosos e concentrados fornecem apetite no animal, juntamente com o leite limitado, os bezerros podem comer cerca de 10% de palha e 90% de concentrados. Sem o volumoso e a ruminação resultante, o desenvolvimento do rúmen será mais lento devido à falta de saliva e produtos finais da digestão de fibras presentes na parede celular das forragens. -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- BEN ASHER, Aharon. Manual de cría de becerras. Zaragoza: Acribia, 1999. -/- BITTAR, Carla Maris Machado; PORTAL, Rafaela Nunes Sanchez; PEREIRA, Anna Carolina Fett da Cunha. Criação de bezerras leiteiras. Piracicaba: EDUSP, 2018. -/- BLUM, J. W. Nutritional physiology of neonatal calves. Journal of animal physiology and animal nutrition, v. 90, n. 1‐2, p. 1-11, 2006. -/- CAMPOS, OF de. Criação de bezerros até a desmama. Coronel Pacheco: EMBRAPA/CNPGL, 1985. -/- COELHO, S. G. Criação de bezerros. II Simpósio Mineiro de Buiatria, Anais., Belo Horizonte, 2005. -/- DAVIS, Carl L. et al. The development, nutrition, and management of the young calf. Iowa State University Press, 1998. -/- DE OLIVEIRA, Juliana Silva; DE MOURA ZANINE, Anderson; SANTOS, Edson Mauro. Fisiologia, manejo e alimentação de bezerros de corte. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, v. 10, n. 1, 2007. -/- DRACKLEY, James K. Calf nutrition from birth to breeding. Veterinary Clinics of North America: Food Animal Practice, v. 24, n. 1, p. 55-86, 2008. -/- FERREIRA, Lucas Silveira et al. Desempenho animal e desenvolvimento do rúmen de bezerros leiteiros aleitados com leite integral ou sucedâneo. Boletim de Indústria Animal, v. 65, n. 4, p. 337-345, 2008. -/- GUILLOTEAU, P.; ZABIELSKI, R.; BLUM, J. W. Gastrointestinal tract and digestion in the young ruminant: ontogenesis, adaptations, consequences and manipulations. J Physiol Pharmacol, v. 60, n. Suppl 1, p. 37-46, 2009. -/- HUBER, J. T. Development of the digestive and metabolic apparatus of the calf. Journal of Dairy Science, v. 52, n. 8, p. 1303-1315, 1969. -/- LONGENBACH, J. I.; HEINRICHS, Arlyn Judson. A review of the importance and physiological role of curd formation in the abomasum of young calves. Animal feed science and technology, v. 73, n. 1-2, p. 85-97, 1998. -/- LOPES, Marcos Aurélio; VIEIRA, P. de F. Criação de bezerros leiteiros. Jaboticabal: Funep, 1998. -/- LUCCI, Carlos de Sousa. Bovinos leiteiros jovens: nutrição, manejo, doenças. São Paulo: Nobel, 1989. -/- ROY, James Henry Barstow et al. The calf. Boston: Butterworths., 1980. -/- SAVAGE, E. S.; MCCAY, C. M. The nutrition of calves; A review. Journal of Dairy Science, v. 25, n. 7, p. 595-650, 1942. -/- THIVEND, P.; TOULLEC, R.; GUILLOTEAU, P. Digestive adaptation in the preruminant. In: Digestive physiology and metabolism in ruminants. Springer, Dordrecht, 1980. p. 561-585. (shrink)

Translation of Aristotle's Posterior Analytics I into Portuguese, with a few notes, experimental glossary and introduction. The translation, which was made at 2003/4, was preliminary and its publication was intended to provide a didactic tool for courses as well as a provisional resource in research seminars. It needs some revision. I am currently working (slowly...) on the revision of the translation and a new revised one will surely appear at some point.

This paper identifies, develops, and argues for an interpretation of Mary Astell’s understanding of self-government. On this interpretation, what is essential to self-government, according to Astell, is an agent’s responsiveness to her own reasoning. The paper identifies two aspects of her theory of self-government: an ‘authenticity’ criterion of what makes our motives our own and an account of the capacities required for responsiveness to our own reasoning. The authenticity criterion states that when our motives arise from some external source without (...) validation by our own understanding of the reasons supporting them, then they are not our own. The capacities requisite for responsiveness to our own reasoning are those of examining and evaluating our own motives and of resisting the social pressure to conform to others’ opinions. An upshot of this interpretation of Astell’s theory of self-government is that it reveals her insights into the ways ‘custom’ can undermine an individual’s ability to govern oneself. (shrink)

These are commentaries to the translation into Portuguese of Nicomachean Ethics VI, found in the same volume of Dissertatio.

Translation of Aristotle's Physics I-II into Portuguese, with commentaries. Tradução para o português dos livros I e II da Física de Aristóteles, com comentários.

Este livro é um 'ancestral' em pré-print do meu livro de 2006, Introdução à Teoria da Predicação em Aristóteles (ISBN 978-85-268-0716-1), publicado pela Editora da Unicamp (ver https://www.academia.edu/6912408/Introdu%C3%A7%C3%A3o_%C3%A0_teoria_da_predica%C3%A7%C3%A3o_em_Arist %C3%B3teles). O ancestral foi felizmente muito citado, mesmo depois da aparição do livro definitivo em 2006. -/- This is an ancestor (in pré-print) of my 2006 Book, 'Introdução à Teoria da Predicação em Aristóteles' (ISBN 978-85-268-0716-1), published by Editora da Unicamp (see https://www.academia.edu/6912408/Introdu%C3%A7%C3%A3o_%C3%A0_teoria_da_predica%C3%A7%C3%A3o_em_Arist %C3%B3teles). The ancestor was cited by many, even after the definitive book (...) appeared in 2006. (shrink)

Public participation in scientific research has gained prominence in many scientific fields, but the theory of participatory research is still limited. In this paper, we suggest that the divergence of values and goals between academic researchers and public participants in research is key to analyzing the different forms this research takes. We examine two existing characterizations of participatory research: one in terms of public participants' role in the research, the other in terms of the virtues of the research. In our (...) view, each of these captures an important feature of participatory research but is, on its own, limited in what features it takes into account. We introduce an expanded conception of norms of collaboration that extends to both academic researchers and public participants. We suggest that satisfying these norms requires consideration of the two groups' possibly divergent values and goals, and that a broad characterization of participatory research that starts from participants' values and goals can motivate both public participants’ role in the research and the virtues of the research. The resulting framework clarifies the similarities and differences among participatory projects and can help guide the responsible design of such projects. (shrink)

I discuss three kinds of relationship between ends and means (or "things that promote ends") in the Aristotelian ethical theory, in order to clarify how moral virtues and phronesis are related both in adopting ends and in determining means for virtuous actions. Phronesis seems to be mainly charged with determining means for an end given by the moral virtues, but it must involve some conception of ends too. Phronesis cannot be parasitic on moral virtue concerning the conception of ends, for (...) otherwise it will lack intrinsic moral value. I argue that the intrinsic moral value of phronesis can be better understood through a certain kind of relation between means and ends that has not received much attention. (shrink)

John Hardwig has championed the thesis (NE) that evidence that an expert EXP has evidence for a proposition P, constituted by EXP’s testimony that P, is not evidence for P itself, where evidence for P is generally characterized as anything that counts towards establishing the truth of P. In this paper, I first show that (NE) yields tensions within Hardwig’s overall view of epistemic reliance on experts and makes it imply unpalatable consequences. Then, I use Shogenji-Roche’s theorem of transitivity of (...) incremental confirmation to show that (NE) is false if a natural Bayesian formalization of the above notion of evidence is implemented. I concede that Hardwig could resist my Bayesian objection if he re-interpreted (NE) as a more precise thesis that only applies to community-focused evidence. I argue, however, that this precisification, while diminishing the philosophical relevance of (NE), wouldn’t settle the tensions internal to Hardwig’s views. (shrink)

This is an introductory handbook for some of the main themes around the notion of predication in Aristotle. It does not aim at being exhaustive, but only sketches some important lines about the subject; it contains an introductory essay, besides the translation (into Portuguese) and commentary of basic texts (such as Posterior Analytics I-22, Categories 1-5, Interpretation 1-6 etc.).

I discuss in this paper the six requirements Aristotle advances at Posterior Analytics A-2, 71b20-33, for the premisses of a scientific demonstration. I argue that the six requirements give no support for an intepretation in terms of “axiomatization”. Quite on the contrary, the six requirements can be consistently understood in a very different picture, according to which the most basic feature of a scientific demonstration is to explain a given proposition by its appropriate cause.

This paper considers two novel Bayesian responses to a well-known skeptical paradox. The paradox consists of three intuitions: first, given appropriate sense experience, we have justification for accepting the relevant proposition about the external world; second, we have justification for expanding the body of accepted propositions through known entailment; third, we do not have justification for accepting that we are not disembodied souls in an immaterial world deceived by an evil demon. The first response we consider rejects the third intuition (...) and proposes an explanation of why we have a faulty intuition. The second response, which we favor, accommodates all three intuitions; it reconciles the first and the third intuition by the dual component model of justification, and defends the second intuition by distinguishing two principles of epistemic closure. (shrink)

I discuss some of Aristotle’s scattered remarks from which one can construct his conception of matter. Aristotle seems to oscillate between two conceptions: one in which matter is the principle of becoming, another in which matter is a constituent element with no contribution for processes of becoming. Sometimes Aristotle takes matter as a thing independent in itself, and the correlated form is a feature that does not contribute to the matter’s essence, nor is a necessary condition for its existence. But (...) sometimes Aristotle takes matter as a constituent element the existence of which depends on the whole thing it is the matter of. These different approaches to matter seem to suggest an inconsistent theory of matter. However, I argue that, quite to the contrary, Aristotle has a consistent theory about matter. One of my main points is to distinguish contexts in which Aristotle is indeed talking about matter in general from contexts in which he uses the term “matter” to refer to a given thing that was previously taken as matter and to talk about that thing not qua matter, but qua the thing it is. (shrink)

This book discusses Aristotle’s notions of essence and substance as they are developed in Metaphysics ZH. I examine Aristotle's argument at length and defends an unorthodox interpretation according to which his motivation is to provide an answer against a conflation between criteria for existential priority (delivering substances as primary beings) and criteria for explanatory priority (delivering essences as primary principles).

According to Jim Pryor’s dogmatism, when you have an experience with content p, you often have prima facie justification for believing p that doesn’t rest on your independent justification for believing any proposition. Although dogmatism has an intuitive appeal and seems to have an antisceptical bite, it has been targeted by various objections. This paper principally aims to answer the objections by Roger White according to which dogmatism is inconsistent with the Bayesian account of how evidence affects our rational credences. (...) If this were true, the rational acceptability of dogmatism would be seriously questionable. I respond that these objections don’t get off the ground because they assume that our experiences and our introspective beliefs that we have experiences have the same evidential force, whereas the dogmatist is uncommitted to this assumption. I also consider the question whether dogmatism has an antisceptical bite. I suggest that the answer turns on whether or not the Bayesian can determine the priors of hypotheses and conjectures on the grounds of their extra-empirical virtues. If the Bayesian can do so, the thesis that dogmatism has an antisceptical bite is probably false. (shrink)

Este artigo é um 'ancestral' de vários argumentos que desenvolvi depois em múltiplos outros artigos. Defendo que a teoria da ciência dos Segundos Analíticos não é incompatível com as ciências naturais tais como desenvolvidos nos tratados científicos de Aristóteles.

This paper examines Aristotle’s notion of priority with the specific aim of capturing the sort of priority that characterizes the primacy of substances in his metaphysics. I reject the traditional interpretation, which understands the ontological priority of substances in terms of independent existence. But there are rather two sorts of priority: the ontological priority of substances should be understood in terms of completeness, whereas the ontological priority of “substances-of-something” (the essences) is a causal-explanatory priority. Furthermore, an important piece of Aristotle’s (...) argument against Platonism is that these two sorts of priority – namely, the completeness priority and the causal-explanatory priority – should be kept distinct. (shrink)

Constitutivism argues that the source of the categorical force of the norms of rationality and morality lies in the constitutive features of agency. A systematic failure to be guided by these norms would amount to a loss or lack of agency. Since we cannot but be agents, we cannot but be unconditionally guided by these norms. The constitutivist strategy has been challenged by David Enoch. He argues that our participation in agency is optional and thus cannot be a source of (...) categorical demands. In this paper, I defend the viability of constitutivism by showing that agency is indeed a special ‘inescapable’ enterprise. Agency has the largest jurisdiction, and it is closed under rational assessment. This inescapability does not exempt constitutivism from raising the question whether agents have reason to be agents, but this question has to be taken up within agency. If this question is answered affirmatively, then—I argue—the criteria of practical correctness are self-ratifying in a non-circular way. This is sufficient to show the viability of the constitutivist strategy. Whether agents have conclusive reasons to be agents, however, is a matter to be addressed in the terms of particular versions of constitutivism. (shrink)

This PhD thesis is a careful discussion of Aristotle's Metaphysics VII (Zeta) almost line by line (or at least argument by argument). It might be interesting to know that a revised and shortened version of it was published as a book in Portuguese, "As Noções Aristotélicas de Substância e Essência", Campinas: Editora da Unicamp, 2008. Actually, I believe the original version of the PhD thesis has been superseded by the book.

In this paper, I discuss whether there are genuinely *diachronic* constraints of practical rationality, that is, pressures on combinations of practical attitudes over time, which are not reducible to mere synchronic rational pressures. Michael Bratman has recently argued that there is at least one such diachronic rational constraint that governs the stability of intentions over time. *Pace* Bratman, I argue that there are no genuinely diachronic constraints on intentions that meet the stringent desiderata set by him. But I show that (...) there are at least two synchronic rational constraints with distinctive and important, although only indirect, diachronic dimensions. Neither of them, however, supports the practical conservatism in the face of normative underdetermination that, according to Bratman, is part and parcel of the diachronic rationality of intention stability. (shrink)

It is often argued, most recently by Samuel Scheffler, that we should reconcile with our mortality as constitutive of our existence: as essential to its temporal structure, to the nature of deliberation, and to our basic motivations and values. Against this reconciliatory strategy, I argue that there is a kind of immortal existence that is coherently conceivable and potentially desirable. First, I argue against the claim that our existence has a temporal structure with a trajectory that necessarily culminates in an (...) ending. This claim is based on two false assumptions: that a life as a whole calls for narrative structure, and that narratives necessarily require closure as temporal endings. Second, I reject the proposal that temporal finitude is constitutive of the basic elements of diachronic agency, including the nature of deliberation and of our values. I argue that only finitude as scarcity of opportunities is constitutive of these elements. Additionally, scarcity might be present in an endless existence. Therefore, it is not incoherent to conceive of a recognizable and potentially desirable immortality that grounds the core features of diachronic agency. Thus, against the reconciliatory strategy, I conclude that we might never fully reconcile with mortality. Although we might embrace our inescapable mortality as essential to a fuller range of features of our existence, we can still justifiably regret our missing on an immortal existence. (shrink)

I discuss Aristotle's anomalous terminology in Physics A.1 (involving "universals" and "particulars") and its coherence with Aristotle's notion of scientific demonstration.

It is often argued that future-directed decisions are effective at shaping our future conduct because they give rise, at the time of action, to a decisive reason to act as originally decided. In this paper, I argue that standard accounts of decision-based reasons are unsatisfactory. For they focus either on tie-breaking scenarios or cases of self-directed distal manipulation. I argue that future-directed decisions are better understood as tools for the non-manipulative, intrapersonal division of deliberative labor over time. A future-directed decision (...) to ϕ gives rise to a defeasible exclusionary reason to ϕ. This reason is grounded on the default authority that is normally granted to one’s prior self as an “expert” deliberator. I argue that this kind of exclusionary reason is the only one that can account for the effectiveness of future-directed decisions at shaping our diachronic agency without violating our autonomy over time. (shrink)

Paul Guyer is well known for defending the claim that freedom, understood as the capacity to set ends, is Kant’s fundamental value. In contrast, I have developed a reading of Kant’s ethics that places autonomy and community at the heart of Kant’s ethics. At the heart of my account is a conception of autonomy understood as what I call the capacity for sovereignty. I argue that these two positions can be made compatible. To do this involves making a distinction between (...) the concepts of dignity and value and arguing that although autonomy, understood as the capacity for sovereignty, is the source of the dignity of humanity, this is compatible with the claim that the ultimate value for Kant is freedom understood as the capacity to set ends. To explain how this is possible I appeal to Wilfrid Sellars Kantian account of the moral point of view in Science and Metaphysics. (shrink)

If you utter sentence ‘Obama was born in 1961’ now, you say something true about the past. Since the past will always be such that the year 1961 has the property of being a time in which Obama was born, it seems impossible that could ever be false in a future context of utterance. We shall consider the case of a sentence about the past exactly like , but which was true when uttered a few years ago and is no (...) longer true now. On this basis, we shall conclude that the past has changed. (shrink)

We discuss a well-known puzzle about the lexicalization of logical operators in natural language, in particular connectives and quantifiers. Of the many logically possible operators, only few appear in the lexicon of natural languages: the connectives in English, for example, are conjunction _and_, disjunction _or_, and negated disjunction _nor_; the lexical quantifiers are _all, some_ and _no_. The logically possible nand (negated conjunction) and Nall (negated universal) are not expressed by lexical entries in English, nor in any natural language. Moreover, (...) the lexicalized operators are all upward or downward monotone, an observation known as the Monotonicity Universal. We propose a logical explanation of lexical gaps and of the Monotonicity Universal, based on the dynamic behaviour of connectives and quantifiers. We define update potentials for logical operators as procedures to modify the context, under the assumption that an update by \( \phi \) depends on the logical form of \( \phi \) and on the speech act performed: assertion or rejection. We conjecture that the adequacy of update potentials determines the limits of lexicalizability for logical operators in natural language. Finally, we show that on this framework the Monotonicity Universal follows from the logical properties of the updates that correspond to each operator. (shrink)

Translation of Aristotle's Metaphysics Lambda into Portuguese.

In this paper we focus on transmission and failure of transmission of warrant. We identify three individually necessary and jointly sufficient conditions for transmission of warrant, and we show that their satisfaction grounds a number of interesting epistemic phenomena that have not been sufficiently appreciated in the literature. We then scrutinise Wright’s analysis of transmission failure and improve on extant readings of it. Nonetheless, we present a Bayesian counterexample that shows that Wright’s analysis is partially incoherent with our analysis of (...) warrant transmission and prima facie defective. We conclude exploring three alternative lines of reply: developing a more satisfactory account of transmission failure, which we outline; dismissing the Bayesian counterexample by rejecting some of its assumptions; reinterpreting Wright’s analysis to make it immune to the counterexample. (shrink)

Translation of Aristotle's Metaphysics IV and VI, with notes. The translation is preliminary and intended as a provisional teaching tool to be also used in seminars and discussions with peers in order to reach a more elaborated version.

I discuss what Aristotle means when he say that scientific demonstration must proceed from necessary principles. I argue that, for Aristotle, scientific demonstration should not be reduced to sound deduction with necessary premises. Scientific demonstration ultimately depends on the fully appropriate explanatory factor for a given explanandum. This explanatory factor is what makes the explanandum what it is. Consequently, this factor is also unique. When Aristotle says that demonstration must proceed from necessary principles, he means that each demonstration requires the (...) principle that is the necessary one for the fully appropriate explanation of its explanandum. This picture also provides a key to understand Aristotle's thesis that scientific explanation depends on essences: it is the essence of the attribute to be explained that should be stated as the fully appropriate explanatory factor. (shrink)

There are three ways to control our future conduct: by causing it, by manipulating our future selves, or by taking future-directed decisions. I show that the standard accounts of future-directed decisions fail to do justice to their distinctive contribution in intentional diachronic agency. The standard accounts can be divided in two categories: First, those that conflate the operation of decisions with that of devices for either physical constraint or manipulative self-management. Second, accounts that, although they acknowledge the non-manipulative nature of (...) decisions, offer too restrictive a view of source of their effectiveness over time. I argue that a comprehensive view of decisions must acknowledge that there is a variety of ways in which they can be effective, which range from the exercise of rational authority to the reliance on sub-agential psychological propensities. What keeps all of these mechanisms together as possible explanations of the role of decisions in supporting diachronic intentional agency is that these mechanisms operate under a common regulative ideal of diachronic agency: the agent’s reliance on the continuous sense of the stability of the choiceworthiness of the action, regardless of her prior decision to perform it. In light of this regulative ideal, the contribution of effective decisions to diachronic agency is thus in principle dispensable although usually necessary for limited beings like us. (shrink)

I discuss in this paper Aristotle’s definition of nature in Physics 192b 20-23. I intend to prove that this definition has to be taken as a set of three (not only two) conditions: the first condition just establishes that nature is a sort of cause; the second condition concerns the relationship between nature and the natural thing that has it as a cause; the third condition concerns the relationship between nature and the properties that natural things have from nature’s causality.

I have two aims in this paper. First, I argue that, in Aristotle’s theory of the four causes, there is a basic and common feature by which all causes are causes: they all work in a triadic framework in which they explain why a given attribute holds of a given underlying thing. Secondly, I argue against a version of “compatibilism” according to which each kind of cause is complete in its own domain and does not compete with any other kind. (...) I claim that there are priority relations according to which some kinds of cause are subordinated to others, even if these relations do not hold in every cases. (shrink)

In this paper, we develop an impure somatic theory of emotion, according to which emotions are constituted by the integration of bodily perceptions with representations of external objects, events, or states of affairs. We put forward our theory by contrasting it with Prinz's pure somatic theory, according to which emotions are entirely constituted by bodily perceptions. After illustrating Prinz's theory and discussing the evidence in its favor, we show that it is beset by serious problems—i.e., it gets the neural correlates (...) of emotion wrong, it isn't able to distinguish emotions from bodily perceptions that aren't emotions, it cannot account for emotions being directed towards particular objects, and it mischaracterizes emotion phenomenology. We argue that our theory accounts for the empirical evidence considered by Prinz and solves the problems faced by his theory. In particular, we maintain that our theory gives a unified and principled account of the relation between emotions and bodily perceptions, the intentionality of emotions, and emotion phenomenology. (shrink)

We present epistemic multilateral logic, a general logical framework for reasoning involving epistemic modality. Standard bilateral systems use propositional formulae marked with signs for assertion and rejection. Epistemic multilateral logic extends standard bilateral systems with a sign for the speech act of weak assertion (Incurvati and Schlöder 2019) and an operator for epistemic modality. We prove that epistemic multilateral logic is sound and complete with respect to the modal logic S5 modulo an appropriate translation. The logical framework developed provides the (...) basis for a novel, proof-theoretic approach to the study of epistemic modality. To demonstrate the fruitfulness of the approach, we show how the framework allows us to reconcile classical logic with the contradictoriness of so-called Yalcin sentences and to distinguish between various inference patterns on the basis of the epistemic properties they preserve. (shrink)

Tradução preliminar em pré-print. A Tradução definitiva é a de 2009.

I discuss Aristotle's treatment of essence and definition in Metaphysics VII.4. I argue that it is coherent and perfectly in accord with its broader context. His discussion in VII.4 offers, on the one hand, minimal criteria for what counts as definition and essence for whatever kind of object, but also, on the other hand, stronger criteria for a primary sort of definition and essence—and thereby it serves the interest of book VII in pointing to the explanatory power of the essence (...) of composite substances. (shrink)

I examine Aristotle’s definition of scientific knowledge in Posterior Analytics 71b 9-12 and try to understand how it relates to the sophistical way of knowing and to "kata sumbebekos knowledge". I claim that scientific knowledge of p requires knowing p by its appropriate cause, and that this appropriate cause is a universal (katholou) in the restricted sense Aristotle proposes in 73b 26-27 ff., i.e., an attribute coextensive with the subject (an extensional feature) and predicated of the subject in itself (an (...) intensional feature). Kata sumbebekos knowledge, on the other hand, can occur even when the predicate of a conclusion is coextensive with its subject and is proved by a convertible meson which is not the most appropriate from an explanatory standpoint. (shrink)

I discuss the role of translatability in philosophical justification. I begin by discussing and defending Thomas Reid’s account of the role that facts about comparative linguistics can play in philosophical justification. Reid believes that common sense offers a reliable but defeasible form of justification. We cannot know by introspection, however, which of our judgments belong to common sense. Judgments of common sense are universal, and so he argues that the strongest evidence that a judgment is a part of common sense (...) is that it is to be found in all languages. For Reid, then, evidence that a certain distinction is to be found in all languages is evidence that the distinction is part of common sense rather than being a common local prejudice. From such a perspective, empirical work in comparative linguistics can play a defeasible justificatory role in philosophical arguments. I contrast Reid’s position with the more radical position of defenders of the Natural Semantic Metalanguage approach, such as Anna Wierzbicka, who argues that only judgments that are translatable into all natural languages are justifiable. I show how such a position is rooted in an implausible view, although one common among cognitive scientists and linguistics, about the nature of concepts, which does not allow for novel concepts. (shrink)

In Posterior Analytics 71b9 12, we find Aristotle’s definition of scientific knowledge. The definiens is taken to have only two informative parts: scientific knowledge must be knowledge of the cause and its object must be necessary. However, there is also a contrast between the definiendum and a sophistic way of knowing, which is marked by the expression “kata sumbebekos”. Not much attention has been paid to this contrast. In this paper, I discuss Aristotle’s definition paying due attention to this contrast (...) and to the way it interacts with the two conditions presented in the definiens. I claim that the “necessity” condition ammounts to explanatory appropriateness of the cause. (shrink)

Tradução para o Português de Ethica Nicomachea VI.

When people want to identify the causes of an event, assign credit or blame, or learn from their mistakes, they often reflect on how things could have gone differently. In this kind of reasoning, one considers a counterfactual world in which some events are different from their real-world counterparts and considers what else would have changed. Researchers have recently proposed several probabilistic models that aim to capture how people do (or should) reason about counterfactuals. We present a new model and (...) show that it accounts better for human inferences than several alternative models. Our model builds on the work of Pearl (2000), and extends his approach in a way that accommodates backtracking inferences and that acknowledges the difference between counterfactual interventions and counterfactual observations. We present six new experiments and analyze data from four experiments carried out by Rips (2010), and the results suggest that the new model provides an accurate account of both mean human judgments and the judgments of individuals. (shrink)

I review recent work on Phenomenal Conservatism, the position introduced by Michael Huemer according to which if it seems that P to a subject S, in the absence of defeaters S has thereby some degree of justification for believing P.

Translation of Aristotle's Metaphysics I-III into Portuguese, with a few notes and introduction. The translation, which was made at 2007, is preliminary and its publication was intended to provide a didactic tool for courses as well as a provisional resource in research seminars. It needs some revision. I am currently working (slowly...) on the revision of the translation and a new revised one will surely appear at some point.