That Kant’s moral thought is invoked by both advocates and opponents of a right to assisted dying attests to both the allure and and the elusiveness of Kant’s moral thought. In particular, the theses that individuals have a right to a ‘death with dignity’ and that assisting someone to die contravenes her dignity appear to gesture at one of Kant’s signature moral notions, dignity. The purposes of this article are to outline Kant’s understanding of dignity and its implications for the (...) ethics of assisted dying. According to Kant, that which has dignity must be treated as an end in itself and may not permissibly be exchanged for that which merely has price. Kant’s reasoning thus seems to preclude acts of self-killing, including voluntary assisted dying, that rest on individual self-interest, since a person’s interests merely have price. However, a recognizably Kantian view of dignity can permit assisted dying under two sets of circumstances: First, it can be permissible for agents who anticipate a degradation of their rational agency due to conditions such as dementia to direct others to end their lives once sufficiently demented. In so doing, such agents in effect exercise a right to impose obligations on others regarding how their bodies, which will at some future point no longer be the vessels of their rational agency, are to be disposed of. Second, Kant errs in supposing that our dignity can stem solely from our moral personality, i.e., from our capacity to abide by universalizable moral principles. Rather, complete dignity also requires the capacity for setting discretionary ends and the means to those ends, i.e., the dignity of humanity. Individuals with prolonged and intense depression, in severe pain, or with serious disability may lack humanity while retaining their moral personality. In such cases, I propose that their opting to end their lives, with or without the assistance of others, does not amount to exchanging their dignified selves for something which merely has price and is therefore not objectionable on Kantian grounds. (shrink)

There is a deeply entrenched view in philosophy and physics, the closed systems view, according to which isolated systems are conceived of as fundamental. On this view, when a system is under the influence of its environment this is described in terms of a coupling between it and a separate system which taken together are isolated. We argue against this view, and in favor of the alternative open systems view, for which systems interacting with their environment are conceived of as (...) fundamental, and the environment's influence is represented via the dynamical equations that govern the system's evolution. Taking quantum theories of closed and open systems as our case study, and considering three alternative notions of fundamentality: (i) ontic fundamentality, (ii) epistemic fundamentality, and (iii) explanatory fundamentality, we argue that the open systems view is fundamental, and that this has important implications for the philosophy of physics, the philosophy of science, and for metaphysics. (shrink)

To what extent can Nietzsche's idea of the Overman be used in connection with transhumanist notions of highly advanced humans and even posthumans?

It is argued that those who defend the Everett, or ‘many-worlds’, interpretation of quantum mechanics should embrace what we call the general quantum theory of open systems (GT) as the proper framework in which to conduct foundational and philosophical investigations in quantum physics. GT is a wider dynamical framework than its alternative, standard quantum theory (ST). This is true even though GT makes no modifications to the quantum formalism. GT rather takes a different view, what we call the open systems (...) view, of the formalism; i.e., in GT, the dynamics of systems whose physical states are fundamentally represented by density operators are represented as fundamentally open as specified by an in general non-unitary dynamical map. This includes, in principle, the dynamics of the universe as a whole. We argue that the more general dynamics describable in GT can be physically motivated, that there is as much prima facie empirical support for GT as there is for ST, and that GT could be fully in the spirit of the Everett interpretation—that there might, in short, be little reason for an Everettian not to embrace the more general theoretical landscape that GT allows one to explore. (shrink)

Wittgenstein did not write very much on the topic of probability. The little we have comes from a few short pages of the Tractatus, some 'remarks' from the 1930s, and the informal conversations which went on during that decade with the Vienna Circle. Nevertheless, Wittgenstein's views were highly influential in the later development of the logical theory of probability. This paper will attempt to clarify and defend Wittgenstein's conception of probability against some oft-cited criticisms that stem from a misunderstanding of (...) his views. Max Black, for instance, criticises Wittgenstein for formulating a theory of probability that is capable of being used only against the backdrop of the ideal language of the Tractatus. I argue that on the contrary, by appealing to the 'hypothetical laws of nature', Wittgenstein is able to make sense of probability statements involving propositions that have not been completely analysed. G.H. von Wright criticises Wittgenstein's characterisation of these very hypothetical laws. He argues that by introducing them Wittgenstein makes what is distinctive about his theory superfluous, for the hypothetical laws are directly inspired by statistical observations and hence these observations indirectly determine the mechanism by which the logical theory of probability operates. I argue that this is not the case at all, and that while statistical observations play a part in the formation of the hypothetical laws, these observations are only necessary, but not sufficient conditions for the introduction of these hypotheses. (shrink)

Recently, there has been a renaissance of study on knowledge by acquaintance. One reason for this is that many writers believe acquaintance holds the key to understanding consciousness and our conscious experience of the world. For this reason, research on acquaintance has been primarily focused on perception and self-knowledge. While these questions are undoubtedly important, I believe being overly focused on these issues has prevented a defensible theory of knowledge by acquaintance from being developed. In particular, two questions have largely (...) been ignored in the literature. First, what kind of knowledge is knowledge by acquaintance? If knowledge by acquaintance is supposed to give us special epistemic access to its objects, what are the central epistemic features of it and how do they differ from other kinds of knowledge? Second, can we have knowledge by acquaintance beyond cases of perception and self-knowledge, and if so, how? In this dissertation, I answer both of these questions. In response to the first question, I argue that knowledge by acquaintance is a form of non-propositional discriminatory knowledge. Roughly, discriminatory knowledge is the exercise of a discriminatory capacity to single out a particular object from other objects of its kind. It is non-propositional because the object of the mental act of discriminating is not a proposition or truth. It is important that we understand knowledge by acquaintance in terms of discriminatory knowledge because it allows us to move beyond perceptual knowledge and self-knowledge. In this dissertation, I show how this is possible by showing that we can be acquainted with the natural numbers. This provides an answer to the second question. There is, in principle, no reason why acquaintance should only exist in sensory perception, provided we understand it in terms of discriminatory knowledge. The upshot of this is that my account of knowledge by acquaintance has a breadth and unity not often found in the acquaintance literature. (shrink)

Mystical Theology and Platonism in the Time of Cusanus engages with the history of mystical theology and Neoplatonic philosophy through the lens of the 15th century philosopher and theologian, Nicholas of Cusa. The volume comprises nineteen essays that break down the barriers between medieval and Renaissance studies, reinterpreting Cusanus’ place in the history of thought by exploring the archive that informed his thinking, while also interrogating his works by exploring them from the standpoint of their later reception by modern philosophers (...) and theologians. The volume also offers tribute to the career of Donald F. Duclow, a leading scholar in the field of Cusanus studies in particular and of the history of mystical theology and Neoplatonic philosophy more generally. (shrink)

For many years there has been a debate about the role of the parietal lobe in the generation of behavior. Does it generate movement plans (intention) or choose objects in the environment for further processing? To answer this, we focus on the lateral intraparietal area (LIP), an area that has been shown to play independent roles in target selection for saccades and the generation of visual attention. Based on results from a variety of tasks, we propose that LIP acts as (...) a priority map in which objects are represented by activity proportional to their behavioral priority. We present evidence to show that the priority map combines bottom-up inputs like a rapid visual response with an array of top-down signals like a saccade plan. The spatial location representing the peak of the map is used by the oculomotor system to target saccades and by the visual system to guide visual attention. (shrink)

In "Frailty Triage: Is Rationing Intensive Medical Treatment on the Grounds of Frailty Ethical?," Wilkinson (2021) argues that the use of frailty scores in ICU triage does not necessarily involve discrimination on the basis of disability. In support of this argument, he claims, “it is not the disability per se that the score is measuring – rather it is the underlying physiological and physical vulnerability." While we appreciate the attention Wilkinson explicitly pays to disability in this piece, we find the (...) distinction between disability and underlying vulnerability untenable both theoretically and practically. In this peer commentary, we begin with a brief overview of research in philosophy of disability concerning the meaning of the concept itself. We argue that this research demonstrates that many forms of disability do not involve underlying vulnerabilities, and, furthermore, that Wilkinson equivocates between "disability" understood as a medical category vs. "disability" understood as a feature of lived experience. We reject Wilkinson’s distinction on these grounds and offer further considerations to avoid disability discrimination in emergency and crisis standards of care contexts. (shrink)

G. A. Cohen’s pathbreaking book, Karl Marx‘s Theory of History: A Defence (1978), prompted extensive reconsideration of historical materialism. This effort recast ongoing debates about Marx‘s theory of history by defending the view that historical materialism embodies a set of substantive claims as appropriately subject to analytical scrutiny as those of any other viable theory. Specifically, Cohen advances one central substantive claim that summarizes his reading of the “Preface” to A Contribution to the Critique of Political Economy. “History is, fundamentally, (...) the growth of productive power, and forms of society rise and fall according as they enable or impede that growth.” This premise affirms that the same set of factors that explain changes societies undergo within a given historical epoch also explain transitions between historical epochs. The theoretical account of intraepochal historical development suffices equally to cover interepochal, revolutionary change. In this paper we reject this premise and argue that even on the most plausible reconstruction of Marx’s theory of history—a reconstruction that employs, among other things, a careful ownership-based criterion of historical epochs and the use of functional explanations—Marx’s theory of history cannot explain social revolutions. -/- . (shrink)

Frege’s rejection of singular reference to concepts is centrally implicated in his notorious paradox of the concept horse. I distinguish a number of claims in which that rejection might consist and detail the dialectical difficulties confronting the defense of several such claims. Arguably the least problematic such claim—that it is simply nonsense to say that a concept can be referred to with a singular term—has recently received a novel defense due to Robert Trueman. I set out Trueman’s argument for this (...) claim, identifying and remedying some omissions and errors of formulation therein. I then develop a response to the argument by showing, pace Trueman, that it is possible—and how it is possible—to express identities between objects and concepts. (shrink)

Predication is an indisputable part of our linguistic behavior. By contrast, the metaphysics of predication has been a matter of dispute ever since antiquity. According to Plato—or at least Platonism, the view that goes by Plato’s name in contemporary philosophy—the truths expressed by predications such as “Socrates is wise” are true because there is a subject of predication (e.g., Socrates), there is an abstract property or universal (e.g., wisdom), and the subject exemplifies the property.1 This view is supposed to be (...) general, applying to all predications, whether the subject of predication is a person, a planet, or a property.2 Despite the controversy surrounding the metaphysics of predication, many theistic philosophers—including the majority of contemporary analytic theists—regard Platonism as extremely attractive. At the same time, however, such philosophers are also commonly attracted to a form of traditional theism that has at its core the thesis that God is an absolutely independent.. (shrink)

_ Source: _Volume 95, Issue 3, pp 368 - 413 Frege famously maintained that concepts are not objects. A key argument of Frege’s for this view is, in outline, as follows: if we are to account for the unity of thought, concepts must be deemed _unsaturated_; since objects are, by contrast, saturated entities, concepts cannot be objects. The author investigates what can be made of this argument and, in particular, of the unsaturated/saturated distinction it invokes. Systematically exploring a range of (...) reconstructions suggested by Frege’s writings, and drawing on contemporary work, the author illustrates that no plausible reconstruction is forthcoming. In essence, it is altogether unclear how to simultaneously substantiate, on the one hand, the claim that unsaturated entities must be recognized in order to account for unity and, on the other, the claim that unsaturatedness is incompatible with objecthood. (shrink)

Editors' introduction to 3rd thematic issue on philosophy of medicine.

Simon Blackburn has not shied away from the use of vivid imagery in developing, over a long and prolific career, a large-scale philosophical vision. Here one might think, for instance, of ‘Practical Tortoise Raising’ or ‘Ramsey's Ladder’ or ‘Frege's Abyss’. Blackburn develops a ‘quasi-realist’ account of many of our philosophical and everyday commitments, both theoretical (e.g., modality and causation) and practical (e.g., moral judgement and normative reasons). Quasi-realism aims to provide a naturalistic treatment of its targeted phenomena while earning the (...) right to deploy all of the ‘trappings’ of realism—i.e., while eschewing any idea that our normal thought and talk about such phenomena are pervasively in error. The quasi-realist project is that of explaining how (as Huw Price puts it here) ‘the folk come to “talk the realist talk” without committing ourselves—us theorists, as it were—to “walking the metaphysical walk”’ (p. 136). Quasi-realism, too, can speak of truth, facts, properties, belief, knowledge, and so on. The imagery in this collection also abounds, though, in capturing a different view of quasi-realism: No fewer than three of the contributors picture Blackburn as wanting to have his cake and eat it too (Louise Antony asking, in addition, ‘Who doesn't? It's cake’ [p. 19]). (shrink)

Risk Management Strategies and Investment Behaviors are considered important factors in the investing activities of the retail investors. This study seeks to determine the relationship between Risk Management Strategies and Investment Behavior of Generation Z retail investors. The study is a correlational research and purposive sampling was used to select the respondents for this study. Cochran’s formula was utilized to determine the total sample size or total number of respondents. Spearman’s Rank-Order Correlation was employed to assess the significant relationship of (...) Risk Management Strategies and Investment Behaviors. Based on the results, it showed that risk management strategies have a significant relationship with one or more of the investment behaviors. Risk avoidance has a significant relationship with confirmation bias. Risk reduction has a significant relationship with all of the investment behaviors such as overconfidence, loss-aversion, recency bias, and confirmation bias. Risk transfer shows a significant relationship with only loss-aversion and confirmation bias. And lastly, risk acceptance also has a significant relationship with all of the investment behaviors. This study recommends exploring other types of behavioral biases under cognitive bias and emotional bias to determine their correlation with risk management strategies. Also, broadening the sample size, demographic scope, and geographic scope of the study can improve the generalizability of the study and provide a more comprehensive understanding of the relationship between investment behavior and risk management strategies. The researchers also recommend to utilize interviews and focus group discussions to gain an in-depth understanding of the underlying values and attitudes concerning investment behavior. (shrink)

The Christian doctrine of the Trinity poses a serious philosophical problem. On the one hand, it seems to imply that there is exactly one divine being; on the other hand, it seems to imply that there are three. There is another well-known philosophical problem that presents us with a similar sort of tension: the problem of material constitution. We argue in this paper that a relatively neglected solution to the problem of material constitution can be developed into a novel solution (...) to the problem of the Trinity. (shrink)

Understanding everyday behavior relies heavily upon understanding our ability to improvise, how we are able to continuously anticipate and adapt in order to coordinate with our environment and others. Here we consider the ability of musicians to improvise, where they must spontaneously coordinate their actions with co-performers in order to produce novel musical expressions. Investigations of this behavior have traditionally focused on describing the organization of cognitive structures. The focus, here, however, is on the ability of the time-evolving patterns of (...) inter-musician movement coordination as revealed by the mathematical tools of complex dynamical systems to provide a new understanding of what potentiates the novelty of spontaneous musical action. We demonstrate this approach through the application of cross wavelet spectral analysis, which isolates the strength and patterning of the behavioral coordination that occurs between improvising musicians across a range of nested time-scales. Revealing the sophistication of the previously unexplored dynamics of movement coordination between improvising musicians is an important step towards understanding how creative musical expressions emerge from the spontaneous coordination of multiple musical bodies. (shrink)

Three recent research reports by Topping and Trickey, by Fair and colleagues, and by Gorard, Siddiqui and Huat See have produced data that support the conclusion that a Philosophy for Children program of one-hour-per-week structured discussions has a marked positive impact on students. This article presents data from a follow up study done three years after the completion of the study reported in Fair et al.. The data show that the positive gains in scores on the Cognitive Abilities Test were (...) still present and had not faded after three years. Given the strength of these confirmations of the positive durable impact of the P4C program of structured discussions and given the relatively low cost of implementing the P4C program, it is recommended that it become a standard part of the school curriculum. (shrink)

Wilfrid Sellars's "Empiricism and the Philosophy of Mind" begins with an argument against sense-datum epistemology. There is some question about the validity of this attack, stemming in part from the assumption that Sellars is concerned with epistemic foundationalism. This paper recontextualizes Sellars's argument in two ways: by showing how the argument of EPM relates to Sellars's 1940s work, which does not concern foundationalism at all; and by considering the view of H.H. Price, Sellars's teacher at Oxford and the only (...) classical datum theorist to receive substantive comment in EPM. Timm Triplett has claimed that Sellars's discussion simply begs the question against Price, but this depends on the mistaken assumption that Sellars's concern is with foundationalism. On the contrary, Sellars's argument concerns the assumption that the innate capacity for sensory experience counts as "thinking in presence" in the way needed for empiricist accounts of content acquisition. Price's distinction between noticing universals and being aware of them encapsulates the tensions empiricists face here. (shrink)

Various approaches have emerged over the last several decades to meet the challenges and complexities of anticipating and responding to the potential impacts of emerging technologies. Although many of the existing approaches share similarities, they each have shortfalls. This paper takes as the object of its study Anticipatory Ethics for Emerging Technologies (ATE) to technology assessment, given that it was formatted to address many of the privations characterising parallel approaches. The ATE approach, also in practice, presents certain areas for retooling, (...) such as how it characterises levels and objects of analysis. This paper results from the work done with the TechEthos Horizon 2020 project in evaluating the ethical, legal, and social impacts of climate engineering, digital extended reality, and neurotechnologies. To meet the challenges these technology families present, this paper aims to enhance the ATE framework to encompass the variety of human processes and material forms, functions, and applications that comprise the socio-technical systems in which these technologies are embedded. (shrink)

Like William James before him, Huw Price has influentially argued that truth has a normative role to play in our thought and talk. I agree. But Price also thinks that we should regard truth-conceived of as property of our beliefs-as something like a metaphysical myth. Here I disagree. In this paper, I argue that reflection on truth's values pushes us in a slightly different direction, one that opens the door to certain metaphysical possibilities that even a Pricean pragmatist (...) can love. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

This three-part paper presents Gordon Pask’s conversation theory (CT) and interaction of actors theory (IA) and outlines ways to apply these cybernetic approaches to designing technologies and scenarios for both formal and informal learning. The first part of the paper covers concepts central to CT and IA, explaining the relationship between conceptual and mechanical operators, and machines mediating informal and formal learning. The second part of the paper applies visual representations of CT and IA to understanding the use of Pask’s (...) course assembly systems (CASTE and THOUGHTSTICKER), created between the late 1960s and the 1980s, and the ThoughtShuffler search interface, created in the 2010s. The third part proposes two pathways for design based on CT and IA: firstly, the potential for designers and observers to reformulate the qualities of tools and learning scenarios to augment human thinking and collective action; and secondly, the possibility to create tools with malleable interfaces that allow users to become intermediaries rather than consumers of knowledge. (shrink)

America and the world are in the process of collapse from excessive population growth, most of it for the last century, and now all of it, due to 3rd world people. Consumption of resources and the addition of 4 billion more ca. 2100 will collapse industrial civilization and bring about starvation, disease, violence and war on a staggering scale. The earth loses at least 1% of its topsoil every year, so as it nears 2100, most of its food growing capacity (...) will be gone. Billions will die and nuclear war is all but certain. In America, this is being hugely accelerated by massive immigration and immigrant reproduction, combined with abuses made possible by democracy. Depraved human nature inexorably turns the dream of democracy and diversity into a nightmare of crime and poverty. China will continue to overwhelm America and the world, as long as it maintains the dictatorship which limits selfishness. The root cause of collapse is the inability of our innate psychology to adapt to the modern world, which leads people to treat unrelated persons as though they had common interests. The idea of human rights is an evil fantasy promoted by leftists to draw attention away from the merciless destruction of the earth by unrestrained 3rd world motherhood. This, plus ignorance of basic biology and psychology, leads to the social engineering delusions of the partially educated who control democratic societies. Few understand that if you help one person you harm someone else—there is no free lunch and every single item anyone consumes destroys the earth beyond repair. Consequently, social policies everywhere are unsustainable and one by one all societies without stringent controls on selfishness will collapse into anarchy or dictatorship. The most basic facts, almost never mentioned, are that there are not enough resources in America or the world to lift a significant percentage of the poor out of poverty and keep them there. The attempt to do this is bankrupting America and destroying the world. The earth’s capacity to produce food decreases daily, as does our genetic quality. And now, as always, by far the greatest enemy of the poor is other poor and not the rich. Without dramatic and immediate changes, there is no hope for preventing the collapse of America, or any country that follows a democratic system. (shrink)

This paper challenges Williamson's "E = K" thesis on the basis of evidential practice. The main point is that most evidence is only approximately true and so cannot be known if knowledge is factive.

Over the last few decades, virtue has become increasingly important in philosophy, psychology, cognitive science, and education. However, as each of these disciplines approaches virtue from a decidedly different perspective, it has proven difficult to come up with an understanding of virtue that satisfies the standards of all four disciplines. In their book, Jennifer Wright, Michael Warren, and Nancy Snow attempt to put forward such an understanding.

Some types of solar radiation management (SRM) research are ethically problematic because they expose persons, animals, and ecosystems to significant risks. In our earlier work, we argued for ethical norms for SRM research based on norms for biomedical research. Biomedical researchers may not conduct research on persons without their consent, but universal consent is impractical for SRM research. We argue that instead of requiring universal consent, ethical norms for SRM research require only political legitimacy in decision-making about global SRM trials. (...) Using Allen Buchanan & Robert Keohane's model of global political legitimacy, we examine several existing global institutions as possible analogues for a politically legitimate SRM decision-making body. (shrink)

The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

Freud proposes that in unconscious processing, logical connections are also (heavily) based upon phonological similarities. Repressed concerns, for example, would also be expressed by way of phonologic ambiguity. In order to investigate a possible unconscious influence of phonological similarity, 31 participants were submitted to a tachistoscopic subliminal priming experiment, with prime and target presented at 1ms. In the experimental condition, the prime and one of the 2 targets were phonological reversed forms of each other, though graphemically dissimilar (e.g., “nice” and (...) “sign”); in the control condition the targets were pseudo-randomly attributed to primes to which they don’t belong. The experimental task was to “blindly” pick the choice most similar to the prime. ERPs were measured with a focus on the N320, which is known to react selectively to phonological mismatch in supraliminal visual word presentations. The N320 amplitude-effects at the electrodes on the midline and at the left of the brain significantly predicted the participants’ net behavioral choices more than half a second later, while their subjective experience is one of arbitrariness. Moreover, the social desirability score (SDS) significantly correlates with both the behavioral and the N320 brain responses of the participants. It is proposed that in participants with low SDS the phonological target induces an expected reduction of N320 and this increases their probability to pick this target. In contrast, high defensive participants have a perplexed brain reaction upon the phonological target, with a negatively peaking N320 as compared to control and this leads them to avoid this target more often. Social desirability, which is understood as reflecting defensiveness, might also manifest itself as a defense against the (energy-consuming) ambiguity of language. The specificity of this study is that all of this is happening totally out of awareness and at the level of very elementary linguistic distinctions. (shrink)

Pria semut terkenal E.O. Wilson selalu menjadi salah satu pahlawan saya-tidak hanya seorang ahli biologi yang luar biasa, tetapi salah satu yang kecil dan menghilang minoritas intelektual yang setidaknya berani untuk petunjuk pada kebenaran tentang sifat kita bahwa orang lain gagal untuk memahami, atau sejauh yang mereka dO pegang, rajin menghindari untuk expedience politik. Sayangnya, ia mengakhiri karirnya yang panjang dalam mode yang paling mesum sebagai pihak yang bodoh dan arogan serangan terhadap sains termotivasi setidaknya sebagian oleh semangat keagamaan dari (...) rekan Harvard. Ini menunjukkan konsekuensi yang keji ketika Universitas menerima uang dari kelompok agama, jurnal Sains begitu terpesona oleh nama besar bahwa mereka menghindari review peer yang tepat, dan ketika ego diizinkan untuk keluar dari kontrol. Hal ini membawa kita ke dalam sifat evolusi, dasar dari metodologi ilmiah, bagaimana matematika berhubungan dengan ilmu pengetahuan, apa yang merupakan teori, dan bahkan apa sikap untuk agama dan kemurahan hati yang sesuai karena kita tak terelakkan pendekatan runtuhnya peradaban industri. -/- Mereka yang ingin komprehensif up to date kerangka perilaku manusia dari dua systems tampilan modern dapat berkonsultasi buku saya 'struktur Logis filsafat, psikologi, mind dan bahasa dalam Ludwig Wittgenstein dan John Searle ' 2nd Ed (2019). Mereka yang tertarik pada tulisan saya lebih mungkin melihat 'berbicara monyet--filsafat, psikologi, ilmu, agama dan politik di planet yang ditakdirkan--artikel dan review 2006-2019 3rd ed (2019) dan bunuh diri utopian delusi di 21st Century 4th Ed (2019) . (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

Ontology is one strategy for promoting interoperability of heterogeneous data through consistent tagging. An ontology is a controlled structured vocabulary consisting of general terms (such as “cell” or “image” or “tissue” or “microscope”) that form the basis for such tagging. These terms are designed to represent the types of entities in the domain of reality that the ontology has been devised to capture; the terms are provided with logical defi nitions thereby also supporting reasoning over the tagged data. Aim: This (...) paper provides a survey of the biomedical imaging ontologies that have been developed thus far. It outlines the challenges, particularly faced by ontologies in the fields of histopathological imaging and image analysis, and suggests a strategy for addressing these challenges in the example domain of quantitative histopathology imaging. The ultimate goal is to support the multiscale understanding of disease that comes from using interoperable ontologies to integrate imaging data with clinical and genomics data. (shrink)

Sceptical theists--e.g., William Alston and Michael Bergmann--have claimed that considerations concerning human cognitive limitations are alone sufficient to undermine evidential arguments from evil. We argue that, if the considerations deployed by sceptical theists are sufficient to undermine evidential arguments from evil, then those considerations are also sufficient to undermine inferences that play a crucial role in ordinary moral reasoning. If cogent, our argument suffices to discredit sceptical theist responses to evidential arguments from evil.

¿Qué tal una toma diferente de los ricos y famosos? Primero lo obvio — las novelas de Harry Potter son supersticiones primitivas que animan a los niños a creer en la fantasía en lugar de asumir la responsabilidad del mundo-la norma por supuesto. JKR es tan despistada sobre sí misma y el mundo como la mayoría de las personas, pero unas 200 veces más destructivas que el estadounidense promedio y unas 800 veces más que el chino promedio. Ella ha sido (...) responsable de la destrucción de tal vez 30.000 hectáreas de bosque para producir estas novelas de basura y toda la erosión subsiguiente (no trivial como es al menos 6 y tal vez 12 toneladas/año de tierra en el océano para todos en la tierra o tal vez 100 toneladas por American, y así alrededor de 5000 toneladas/año para los libros y películas de Rowling y su 3 niños). La tierra pierde al menos el 1% de su tierra vegetal cada año, por lo que se acerca a 2100, la mayor parte de su capacidad de cultivo de alimentos desaparecerá. Luego está la enorme cantidad de combustible quemado y los desechos hechos para hacer y distribuir los libros y películas, muñecas de plástico, etc. Ella muestra su falta de responsabilidad social produciendo niños en lugar de usar sus millones para alentar la planificación familiar o comprar la selva tropical, y promoviendo la estupidez liberal convencional de la 3ª supremacía mundial que está destruyendo Gran Bretaña, Estados Unidos, el mundo y el futuro de su descendiente. Por supuesto, ella no es tan diferente de las otras 7.8 mil millones de - sólo más ruidosas y destructivas. Es el no libre problema de almuerzo escrito grande. La multitud simplemente no puede ver que no hay tal cosa como ayudar a una persona sin dañar a los demás. Los derechos o privilegios dados a los nuevos participantes en un mundo superpoblado sólo pueden disminuir los de los demás. A pesar de los desastres ecológicos masivos que ocurren delante de ellos en todas partes todos los días, no pueden anclar a la maternidad desenfrenada de "lo diverso", que representa la mayor parte del aumento de la población del siglo pasado y todo eso en este. Carecen de una combinación de inteligencia, educación, experiencia y cordura necesaria para extrapolar los asaltos diarios a los recursos y el funcionamiento de la sociedad para el eventual colapso de la civilización industrial. Cada comida, cada viaje en coche o autobús, cada par de zapatos es otro clavo en el ataúd de la tierra. Probablemente nunca ha cruzado su mente que un asiento en un avión de Londres a San Francisco produce alrededor de una tonelada de carbono que derrite unos 3 metros cuadrados de hielo marino y como uno de los privilegiados que probablemente ha volado cientos de tales vuelos. No sólo los ricos y famosos, pero casi cualquier figura pública en absoluto, incluyendo prácticamente todos los profesores, se ven presionados a ser políticamente correcto, que en el las democracias occidentales, ahora significa socialdemócrata (Neomarxista — i. e., comunista diluido), supremacistas del tercer mundo que trabajan por la destrucción de sus propias sociedades y sus propios descendientes. Entonces, aquellos cuya falta of educación, experiencia, inteligencia (y el sentido común básico), que debería prohibirles hacer declaraciones públicas en absoluto, dominar totalmente a todos los medios de comunicación, creando la impresión de que los inteligentes y civilizados deben favorecer la democracia, la diversidad y la igualdad, mientras que la verdad es que estos son los problemas y no las soluciones, y que ellos mismos son los principales enemigos de la civilización. Ver mi suicidio por la democracia 2Nd Ed (2019) y otras obras. (shrink)

If you have ever had to move house, you will know this: the worst part is the sofa. You cannot do it alone. Nor will it be enough for me to just lift one end waiting for you to lift the other. We will have to work together to get the job done. If spaces are tight, we will even have to find a practical solution to a tantalizing mathematical puzzle: the moving sofa problem.Joint actions like that are part and (...) parcel of everyday life. But what exactly is special about acting together? After all, the actions of two strangers also depend on one another when one exits and the other enters through a revolving door, when they happen to walk side-by-side along a forest path, or when they exchange blows in a pub brawl.The problem is that two patterns of social behavior might look identical, even though one is a case of joint action and the other is not. There need not be an observable difference between the movements of old friends taking their morning constitutional together, on the one hand, a .. (shrink)

This paper is about the so-called meta-grounding question, i.e. the question of what grounds grounding facts of the sort ‘φ is grounded in Γ ’. An answer to this question is pressing since some plausible assumptions about grounding and fundamentality entail that grounding facts must be grounded. There are three different accounts on the market which each answer the meta-grounding question differently: Bennett’s and deRosset’s “Straight Forward Account” (SFA), Litland’s “Zero-Grounding Account” (ZGA), and “Grounding Essentialism” (GE). I argue that if (...) grounding is to be regarded as metaphysical explanation (i.e. if unionism is true), (GE) is to be preferred over (ZGA) and (SFA) as only (GE) is compatible with a crucial consequence of the thought that grounding is metaphysical explanation. In this manner the paper contributes not only to discussions about the ground of ground but also to the ongoing debate concerning the relationship between ground, essence, and explanation. (shrink)

Philosophical defenses of parents’ rights typically appeal to the interests of parents, the interests of children, or some combination of these. Here I propose that at least in the case of biological, non-adoptive parents, these rights have a different normative basis: namely, these rights should be accorded to biological parents because of the compensatory duties such parents owe their children by virtue of having brought them into existence. Inspried by Seana Shiffrin, I argue that procreation inevitably encumbers the wills of (...) children in otherwise morally objectionable ways. Such subjection generates duties to compensate children, even if the child’s life is on balance a benefit to her. The right to procreate is thus conditioned on prospective parent’s willingness to compensate for the harms of procreation. And because parents bear such compensatory duties, they must be accorded permissions (i.e., rights) to fulfill these duties. These rights include familiar exclusionary rights to promote children’s welfare, etc. Moreover, because subjecting children to harms or the risks thereof violates their autonomy, parental duties (and rights) include the provision of education and other goods that enable their subsequent autonomy as adults. Grounding parental rights in compensatory procreative duties avoids problems associated with appeals to the interests of children (e.g., that these interests do not seem to generate exclusive parental rights) or to the interests of parents (e.g., that these interests do not appear strong enough to permit the creation of a new, vulnerable human individual). (shrink)

Scholars, journalists, and activists working on climate change often distinguish between “individual” and “structural” approaches to decarbonization. The former concern choices individuals can make to reduce their “personal carbon footprint” (e.g., eating less meat). The latter concern changes to institutions, laws, and other social structures. These two approaches are often framed as oppositional, representing a mutually exclusive forced choice between alternative routes to decarbonization. After presenting representative samples of this oppositional framing of individual and structural approaches in environmental communication, we (...) identify four problems with oppositional thinking and propose five ways to conceive of individual and structural reform as symbiotic and interdependent. (shrink)

Empiezo con algunos comentarios famosos del filósofo (psicólogo) Ludwig Wittgenstein porque Pinker comparte con la mayoría de la gente (debido a la configuración predeterminada de nuestra psicología innata evolucionada) ciertos prejuicios sobre el funcionamiento de la mente, y porque Wittgenstein ofrece una visión única y profunda del funcionamiento del lenguaje, el pensamiento y la realidad (que él consideraba más o menos coextenso) que no se encontraba en ningún otro lugar. Ahí esta sólo referencia a Wittgenstein en este volumen, lo que (...) es más desafortunado teniendo en cuenta que él era el analista más brillante y original del lenguaje. -/- En el último capítulo, usando la famosa metáfora de la cueva de Platón, resume bellamente el libro con una visión general de cómo la mente (lenguaje, pensamiento, psicología intencional)-un producto de egoísmo ciego, moderado sólo ligeramente por el altruismo automatizado para cerca parientes que llevan copias de nuestros genes (Fitness inclusivo)--funciona automáticamente, pero trata de terminar en una nota optimista al darnos la esperanza de que, sin embargo, podemos emplear sus vastas capacidades para cooperar y hacer del mundo un lugar digno para vivir. -/- Pinker es ciertamente consciente de, pero dice poco sobre el hecho de que mucho más sobre nuestra psicología se deja fuera de lo incluido. Entre las ventanas a la naturaleza humana que se dejan fuera o se presta una atención mínima son las matemáticas y la geometría, la música y los sonidos, las imágenes, los eventos y la causalidad, la ontología (clases de cosas o lo que sabemos), la mayor parte de la epistemología (cómo sabemos), disposiciones (creer, pensar, juzgar, pretender, etc.) y el resto de la psicología intencional de la acción, neurotransmisores y entheogens, Estados espirituales (por ejemplo, Satori e iluminación, estimulación y grabación del cerebro, daño cerebral y comportamiento déficits y trastornos, juegos y deportes, teoría de la decisión (incluyendo la teoría del juego y la economía conductual), comportamiento animal (muy poco lenguaje pero mil millones de años de genética compartida). Se han escrito muchos libros sobre cada una de estas áreas de la psicología intencional. Los datos de este libro son descripciones, no explicaciones que muestran por qué nuestro cerebro lo hace de esta manera o cómo se hace. ¿Cómo sabemos usar las oraciones de manera diversa (es decir, conocer todos sus significados)? Esta es la psicología evolutiva que opera a un nivel más básico: el nivel en el que Wittgenstein es más activo. Y hay escasa atención a el Contexto en el que se utilizan palabras = una arena que Wittgenstein fue pionera. -/- Sin embargo, Este es un trabajo clásico y con estas precauciones todavía vale la pena leer. -/- Aquellos que deseen un marco completo hasta la fecha para el comportamiento humano de la moderna dos Sistemas View puede consultar mi libro 'La estructura lógica de la filosofía, la psicología, la mente y lenguaje Een Ludwig Wittgenstein y John Searle ' 2nd ED (2019). Los interesados en más de mis escritos pueden ver 'Monos parlantes--filosofía, psicología, ciencia, religión y política en un planeta condenado--artículos y reseñas 2006-2019 3rd ED (2019) y delirios utópicos suicidas en el 21St Century 4TH Ed (2019) y otras. -/- "Si Dios nos miró a la mente, no sería capaz de ver en quién estábamos pensando." Wittgenstein PI P217 -/- "¿Debe evitarse la palabra" infinito "en las matemáticas? Sí: donde parece conferir un significado sobre el cálculo; en lugar de conseguir uno de él. " Edición revisada de la RFM (1978) P141 -/- "Una y otra vez el intento de usar el lenguaje para limitar el mundo y establecerlo en relieve, pero no se puede hacer. La auto-evidencia del mundo se manifiesta en el mismo hecho de que el lenguaje puede y sólo se refiere a él. Porque el lenguaje sólo deriva la forma en que significa, su significado, del mundo, no hay lenguaje concebible que no represente a este mundo. " Observaciones filosóficas de Wittgenstein S47 . (shrink)

Philosophers often claim that studying philosophy helps people to become better thinkers. Thanks to a grant from the American Philosophical Association, we were able to test this claim empirically, using a large sample of students (N = 122,352) graduating from 369 colleges and universities across the United States between 2010 and 2019. We investigated whether philosophy majors show more growth than non-philosophy majors in intellectual traits like open-mindedness and a tendency to think carefully and thoroughly, as well as more personal (...) forms of growth that might be fostered by philosophical study (e.g., self-understanding). Additionally, although this was not our primary question, we sought to better understand what students who major in philosophy are like. Specifically, we examined the demographics of philosophy majors, the other subjects that they tend to study when they double major, and the patterns of adding and dropping of philosophy majors between freshman and senior year. (shrink)

You can get a quick summary of this book on p 135 or 326. If you are not up to speed on evolutionary psychology you should first read one of the numerous recent texts with this term in the title. One of the best is " The Handbook of Evolutionary Psychology " by Buss, but it is big and expensive. Until about 15 years ago, ´explanations´´of behavior have not really been explanations of mental processes at all, but rather vague and (...) largely useless descriptions of what people did and what they said, with no insight into why. We might say that people gather to commemorate an event, praise god, receive his (or her or their) blessings, etc, but none of this describes the relevant mental processes so we might say they are explanations in much the same way that it explains why an apple drops to the ground if we say its because we released it and it's heavy-there is no mechanism and no explanatory or predictive power. This book continues the elucidation of the genetic basis of human behavior which has been almost univerally ignored and denied by academia, religion, politics and the public(see Pinker´s excellent book``The BlankSlatè`). His statement (p3) that it is meaningless to ask if religion is genetic is mistaken as the percentage of variation due to genes and environment can be studied, just as they are for all other behaviors (see eg. Pinker). The title should be "Preliminary Attempts to Explain Some Aspects of Primitive Religion" since he does not treat higher consciousness at all (e.g., satori, enlightenment etc.) which are by far the most interesting phenomena and the only part of religion of personal interest to intelligent, educated people in the 21st century. Reading this entire book, you would never guess such things exist. Likewise for the immense field of drugs and religion. It lacks a framework for rationality and does not mention the dual systems of thought view which is now so productive. For these I suggest my own recent papers. Nevertheless, the book has much of interest and in spite of being dated is still worth reading. -/- Those wishing a comprehensive up to date account of Wittgenstein, Searle and their analysis of behavior from the modern two systems view may consult my article The Logical Structure of Philosophy, Psychology, Mind and Language as Revealed in Wittgenstein and Searle (2016). Those interested in all my writings in their most recent versions may download from this site my e-book ‘Philosophy, Human Nature and the Collapse of Civilization Michael Starks (2016)- Articles and Reviews 2006-2016’ by Michael Starks First Ed. 662p (2016). -/- All of my papers and books have now been published in revised versions both in ebooks and in printed books. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) https://www.amazon.com/dp/B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B0711R5LGX . (shrink)

If updating with E has the same result across all epistemically possible worlds, then the agent has no uncertainty as to the behavior of the update, and we may call it a transparent update. If an agent is uncertain about the behavior of an update, we may call it opaque. In order to model the uncertainty an agent has about the result of an update, the same update must behave differently across different possible worlds. In this paper, I study opaque (...) updates using a simple system of dynamic epistemic logic suitably modified for that purpose. The paper highlights the connection between opaque updates and the dynamic-epistemic principles Perfect-Recall and No-Miracles. I argue that opaque updates are central to contemporary discussions in epistemology, in particular to externalist theories of knowledge and to the related problem of epistemic bootstrapping, or easy knowledge. Opaque updates allow us to explicitly investigate a dynamic form of uncertainty, using simple and precise logical tools. (shrink)

In Beyond Physicalism, an interdisciplinary group of physical scientists, behavioral and social scientists, and humanists from the Esalen Institute’s Center for Theory and Research argue that physicalism must be replaced by an expanded scientific naturalism that accommodates something spiritual at the heart of nature.

Review of Hegel’s Introduction to the System: Encyclopaedia Phenomenology and Psychology by Robert E. Wood.

著名的蚂蚁人E.O.Wilson一直是我的英雄之一——不仅是一位杰出的生物学家,而且是一小撮正在消失的知识分子,他们至少敢于暗示我们本性的真相,而其他人却无法领会,或者只要他们所掌握的,刻意避免政治权 宜之计。可悲的是,他以最脏的方式结束了他漫长的职业生涯,成为对科学的无知和傲慢攻击的一方,至少部分是出于哈佛同事的宗教热情。它显示了当大学接受宗教团体的钱,科学期刊被大牌们敬畏,以至于他们避免适当的同 行评议,当自我被允许失控时,后果不堪设想。它带我们进入进化的本质,科学方法论的基础,数学如何与科学的关系,什么构成一个理论,甚至什么态度的宗教和慷慨是适当的,因为我们无情地接近工业的崩溃文明。 那些希望从现代两个系统的观点来看为人类行为建立一个全面的最新框架的人,可以查阅我的书《路德维希的哲学、心理学、Min d和语言的逻辑结构》维特根斯坦和约翰·西尔的《第二部》(2019年)。那些对我更多的作品感兴趣的人可能会看到《会说话的猴子——一个末日星球上的哲学、心理学、科学、宗教和政治——文章和评论2006-20 19年第3次(2019年)和自杀乌托邦幻想21篇世纪4日 (2019) .