I believe that the sort of disagreements we encounter in philosophy—disagreements that often take the form that I have elsewhere called system- atic peer disagreements—make it unreasonable to think that there is any knowledge, or even justified belief, when the disagreements themselves are systematic. I readily acknowledge that this skeptical view is quite controversial; I suspect many are unconvinced. However, I will not be defending it here. Rather, I will be exploring a worry, or set of worries, that arise on (...) the assumption that this view is correct. For if it is unreasonable to think that there is justified belief in contexts of systematic philosophical disagreements, by what right do we continue to advance philosophical claims in such contexts? Indeed, by what right do we believe the philosophical claims we advance? And if we don’t believe them, why do we advance them in the first place? An inability to respond to these worries would leave us with the dis- tinct impression that the practice or activity of philosophy is quite suspect: what sort of practice or activity would have us believe unreasonably, assert unwarrantedly, and perhaps exhibit insincerity to boot? (shrink)

This chapter examines modality in the history of analytic philosophy. There were, in this history, two principal types of reductionism or eliminativism about modality, and two corresponding phases in the rejection of anti-modal stances. First, the founders of analytic philosophy, Frege, Moore, and Russell, took necessity and possibility to be reducible to more fundamental logical notions, where logic for these thinkers consists of truths about a mind- and language-independent reality extending beyond the empirical world. Against this reductionism, C. I. Lewis (...) and Wittgenstein argued that logic itself requires modal notions. Second, Carnap advanced a pragmatically motivated account of modal terms as expressing pseudo-object properties, which appear to be properties of objects but can be construed as properties of their designations. Quine criticized this account and proposed a thoroughgoing elimination of modality. Quine’s well-known claim that quantifying into modal contexts is unintelligible without resorting to essentialism cannot be fully understood independently of Carnap’s notion of pseudo-object property. Against Quine, Ruth Marcus and Saul Kripke argued for the coherence of modal concepts and their entrenchment in ordinary language and thought, leading to the now dominant view that modal properties are mind- and language-independent features of the world. (shrink)

Decision theorists widely accept a stochastic dominance principle: roughly, if a risky prospect A is at least as probable as another prospect B to result in something at least as good, then A is at least as good as B. Recently, philosophers have applied this principle even in contexts where the values of possible outcomes do not have the structure of the real numbers: this includes cases of incommensurable values and cases of infinite values. But in these contexts the usual (...) formulation of stochastic dominance is wrong. We show this with several counterexamples. Still, the motivating idea behind stochastic dominance is a good one: it is supposed to provide a way of applying dominance reasoning in the stochastic context of probability distributions. We give two new formulations of stochastic dominance that are more faithful to this guiding idea, and prove that they are equivalent. (shrink)

Should we make significant sacrifices to ever-so-slightly lower the chance of extremely bad outcomes, or to ever-so-slightly raise the chance of extremely good outcomes? *Fanaticism* says yes: for every bad outcome, there is a tiny chance of extreme disaster that is even worse, and for every good outcome, there is a tiny chance of an enormous good that is even better. I consider two related recent arguments for Fanaticism: Beckstead and Thomas's argument from *strange dependence on space and time*, and (...) Wilkinson's *Indology* argument. While both arguments are instructive, neither is persuasive. In fact, the general principles that underwrite the arguments (a *separability* principle in the first case, and a *reflection* principle in the second) are *inconsistent* with Fanaticism. In both cases, though, it is possible to rehabilitate arguments for Fanaticism based on restricted versions of those principles. The situation is unstable: plausible general principles tell *against* Fanaticism, but restrictions of those same principles (with strengthened auxiliary assumptions) *support* Fanaticism. All of the consistent views that emerge are very strange. (shrink)

Sometimes you are unreliable at fulfilling your doxastic plans: for example, if you plan to be fully confident in all truths, probably you will end up being fully confident in some falsehoods by mistake. In some cases, there is information that plays the classical role of evidence—your beliefs are perfectly discriminating with respect to some possible facts about the world—and there is a standard expected‐accuracy‐based justification for planning to conditionalize on this evidence. This planning‐oriented justification extends to some cases where (...) you do not have transparent evidence, in the sense that your beliefs are not perfectly discriminating with respect to any non‐trivial facts. In other cases, accuracy considerations do not tell you to plan to conditionalize on any information at all, but rather to plan to follow a different updating rule. Even in the absence of evidence, accuracy considerations can guide your doxastic plan. (shrink)

“There are no gaps in logical space,” David Lewis writes, giving voice to sentiment shared by many philosophers. But different natural ways of trying to make this sentiment precise turn out to conflict with one another. One is a *pattern* idea: “Any pattern of instantiation is metaphysically possible.” Another is a *cut and paste* idea: “For any objects in any worlds, there exists a world that contains any number of duplicates of all of those objects.” We use resources from model (...) theory to show the inconsistency of certain packages of combinatorial principles and the consistency of others. (shrink)

There are infinitely many ways the world might be, and there may well be infinitely many people in it. These facts raise moral paradoxes. We explore a conflict between two highly attractive principles: a Pareto principle that says that what is better for everyone is better overall, and a statewise dominance principle that says that what is sure to turn out better is better on balance. We refine and generalize this paradox, showing that the problem is faced by many theories (...) of interpersonal aggregation besides utilitarianism, and by many decision theories besides expected value theory. Considering the range of consistent responses, we find all of them to be quite radical. (shrink)

David Lewis holds that a single possible world can provide more than one way things could be. But what are possible worlds good for if they come apart from ways things could be? We can make sense of this if we go in for a metaphysical understanding of what the world is. The world does not include everything that is the case—only the genuine facts. Understood this way, Lewis's “cheap haecceitism” amounts to a kind of metaphysical anti-haecceitism: it says there (...) aren't any genuine facts about individuals over and above their qualitative roles. (shrink)

Some hold that the lesson of Russell’s paradox and its relatives is that mathematical reality does not form a ‘definite totality’ but rather is ‘indefinitely extensible’. There can always be more sets than there ever are. I argue that certain contact puzzles are analogous to Russell’s paradox this way: they similarly motivate a vision of physical reality as iteratively generated. In this picture, the divisions of the continuum into smaller parts are ‘potential’ rather than ‘actual’. Besides the intrinsic interest of (...) this metaphysical picture, it has important consequences for the debate over absolute generality. It is often thought that ‘indefinite extensibility’ arguments at best make trouble for mathematical platonists; but the contact arguments show that nominalists face the same kind of difficulty, if they recognize even the metaphysical possibility of the picture I sketch. (shrink)

“Pragmatic encroachers” about knowledge generally advocate two ideas: (1) you can rationally act on what you know; (2) knowledge is harder to achieve when more is at stake. Charity Anderson and John Hawthorne have recently argued that these two ideas may not fit together so well. I extend their argument by working out what “high stakes” would have to mean for the two ideas to line up, using decision theory.

Could space consist entirely of extended regions, without any regions shaped like points, lines, or surfaces? Peter Forrest and Frank Arntzenius have independently raised a paradox of size for space like this, drawing on a construction of Cantor’s. I present a new version of this argument and explore possible lines of response.

We explore the view that Frege's puzzle is a source of straightforward counterexamples to Leibniz's law. Taking this seriously requires us to revise the classical logic of quantifiers and identity; we work out the options, in the context of higher-order logic. The logics we arrive at provide the resources for a straightforward semantics of attitude reports that is consistent with the Millian thesis that the meaning of a name is just the thing it stands for. We provide models to show (...) that some of these logics are non-degenerate. (shrink)

The counterpart theorist has a problem: there is no obvious way to understand talk about actuality in terms of counterparts. Fara and Williamson have charged that this obstacle cannot be overcome. Here I defend the counterpart theorist by offering systematic interpretations of a quantified modal language that includes an actuality operator. Centrally, I disentangle the counterpart relation from a related notion, a ‘representation relation’. The relation of possible things to the actual things they represent is variable, and an adequate account (...) of modal language must keep track of the way it is systematically shifted by modal operators. I apply my account to resolve several puzzles about counterparts and actuality. In technical appendices, I prove some important logical results about this ‘representational’ counterpart system and its relationship to other modal systems. (shrink)

Many people do not know or believe there is a God, and many experience a sense of divine absence. Are these (and other) “divine hiddenness” facts evidence against the existence of God? Using Bayesian tools, we investigate *evidential arguments from divine hiddenness*, and respond to two objections to such arguments. The first objection says that the problem of hiddenness is just a special case of the problem of evil, and so if one has responded to the problem of evil then (...) hiddenness has no additional bite. The second objection says that, while hiddenness may be evidence against generic theism, it is not evidence against more specific conceptions of God, and thus hiddenness poses no epistemic challenge to a theist who holds one of these more specific conceptions. Our investigation leaves open just how strong the evidence from hiddenness really is, but we aim to clear away some important reasons for thinking hiddenness is of no evidential significance at all. (shrink)

I examine three ‘anti-object’ metaphysical views: nihilism, generalism, and anti-quantificationalism. After setting aside nihilism, I argue that generalists should be anti-quantificationalists. Along the way, I attempt to articulate what a ‘metaphysically perspicuous’ language might even be.

I examine what the mathematical theory of random structures can teach us about the probability of Plenitude, a thesis closely related to David Lewis's modal realism. Given some natural assumptions, Plenitude is reasonably probable a priori, but in principle it can be (and plausibly it has been) empirically disconfirmed—not by any general qualitative evidence, but rather by our de re evidence.

Some philosophers respond to Leibniz’s “shift” argument against absolute space by appealing to antihaecceitism about possible worlds, using David Lewis’s counterpart theory. But separated from Lewis’s distinctive system, it is difficult to understand what this doctrine amounts to or how it bears on the Leibnizian argument. In fact, the best way of making sense of the relevant kind of antihaecceitism concedes the main point of the Leibnizian argument, pressing us to consider alternative spatiotemporal metaphysics.

This paper explores the idea that it is instrumentally valuable to learn normative truths. We consider an argument for "normative hedging" based on this principle, and examine the structure of decision-making under moral uncertainty that arises from it. But it also turns out that the value of normative information is inconsistent with the principle that learning *empirical* truths is instrumentally valuable. We conclude with a brief comment on "metanormative regress.".

People with the kind of preferences that give rise to the St. Petersburg paradox are problematic---but not because there is anything wrong with infinite utilities. Rather, such people cannot assign the St. Petersburg gamble any value that any kind of outcome could possibly have. Their preferences also violate an infinitary generalization of Savage's Sure Thing Principle, which we call the *Countable Sure Thing Principle*, as well as an infinitary generalization of von Neumann and Morgenstern's Independence axiom, which we call *Countable (...) Independence*. In violating these principles, they display foibles like those of people who deviate from standard expected utility theory in more mundane cases: they choose dominated strategies, pay to avoid information, and reject expert advice. We precisely characterize the preference relations that satisfy Countable Independence in several equivalent ways: a structural constraint on preferences, a representation theorem, and the principle we began with, that every prospect has a value that some outcome could have. (shrink)

How should a group with different opinions (but the same values) make decisions? In a Bayesian setting, the natural question is how to aggregate credences: how to use a single credence function to naturally represent a collection of different credence functions. An extension of the standard Dutch-book arguments that apply to individual decision-makers recommends that group credences should be updated by conditionalization. This imposes a constraint on what aggregation rules can be like. Taking conditionalization as a basic constraint, we gather (...) lessons from the established work on credence aggregation, and extend this work with two new impossibility results. We then explore contrasting features of two kinds of rules that satisfy the constraints we articulate: one kind uses fixed prior credences, and the other uses geometric averaging, as opposed to arithmetic averaging. We also prove a new characterisation result for geometric averaging. Finally we consider applications to neighboring philosophical issues, including the epistemology of disagreement. (shrink)

The Epistemic Objection says that certain theories of time imply that it is impossible to know which time is absolutely present. Standard presentations of the Epistemic Objection are elliptical—and some of the most natural premises one might fill in to complete the argument end up leading to radical skepticism. But there is a way of filling in the details which avoids this problem, using epistemic safety. The new version has two interesting upshots. First, while Ross Cameron alleges that the Epistemic (...) Objection applies to presentism as much as to theories like the growing block, the safety version does not overgeneralize this way. Second, the Epistemic Objection does generalize in a different, overlooked way. The safety objection is a serious problem for a widely held combination of views: “propositional temporalism” together with “metaphysical eternalism”. (shrink)

Suppose that all non-qualitative facts are grounded in qualitative facts. I argue that this view naturally comes with a picture in which trans-world identity is indeterminate. But this in turn leads to either pervasive indeterminacy in the non-qualitative, or else contingency in what facts about modality and possible worlds are determinate.

Famous results by David Lewis show that plausible-sounding constraints on the probabilities of conditionals or evaluative claims lead to unacceptable results, by standard probabilistic reasoning. Existing presentations of these results rely on stronger assumptions than they really need. When we strip these arguments down to a minimal core, we can see both how certain replies miss the mark, and also how to devise parallel arguments for other domains, including epistemic “might,” probability claims, claims about comparative value, and so on. A (...) popular reply to Lewis's results is to claim that conditional claims, or claims about subjective value, lack truth conditions. For this strategy to have a chance of success, it needs to give up basic structural principles about how epistemic states can be updated—in a way that is strikingly parallel to the commitments of the project of dynamic semantics. (shrink)

The existence of mereological sums can be derived from an abstraction principle in a way analogous to numbers. I draw lessons for the thesis that “composition is innocent” from neo-Fregeanism in the philosophy of mathematics.

In "Pascal's Mugging" (Bostrom 2009), Pascal gives away his wallet for an extremely tiny chance of an extremely large reward. In this continuation of Bostrom's story, Pascal's friend counsels him to take into account the possibility of making mistakes about his true expected utilities, and they consider to what extent this will help Pascal make plans to avoid future muggings.

We prove a representation theorem for preference relations over countably infinite lotteries that satisfy a generalized form of the Independence axiom, without assuming Continuity. The representing space consists of lexicographically ordered transfinite sequences of bounded real numbers. This result is generalized to preference orders on abstract superconvex spaces.

What degrees of belief does Sleeping Beauty's evidence support? That depends.

It is argued that, given certain reasonable premises, an infinite number of qualitatively identical but numerically distinct minds exist per functioning brain. The three main premises are (1) mental properties supervene on brain properties; (2) the universe is composed of particles with nonzero extension; and (3) each particle is composed of continuum-many point-sized bits of particle-stuff, and these points of particle-stuff persist through time.

Le but de ce texte est de mettre en évidence les équi­valences entre la façon dont le concept de conatus résout, dans l'Éthique, le problème de l'unité modale complexe. en rendant consis­tant le concept de chose singulière en tant que celle-ci doit être consi­dérée comme un légitime sujet d'attribution d'états, et la façon dont ce même concept dessine le rapport cognitif de l'esprit avec lui-même, rapport par lequel l'esprit se saisit comme sujet de ses états et qui ca­ractérise la notion (...) moderne de subjectivité. Ainsi, en éclairant cet as­pect du concept spinoziste de chose singulière. on comprendra aussi, de façon indirecte, l'une des conditions par lesquelles les choses peuvent, dans la doctrine spinoziste, devenir des objets ou des signes pour la connaissance humaine. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Is the fact that our universe contains fine-tuned life evidence that we live in a multiverse? Ian Hacking and Roger White influentially argue that it is not. We approach this question through a systematic framework for self-locating epistemology. As it turns out, leading approaches to self-locating evidence agree that the fact that our own universe contains fine-tuned life indeed confirms the existence of a multiverse. This convergence is no accident: we present two theorems showing that, in this setting, any updating (...) rule that satisfies a few reasonable conditions will have the same feature. The conclusion that fine-tuned life provides evidence for a multiverse is hard to escape. (shrink)

Suppose that, for reasons of animal welfare, it would be better if everyone stopped eating chicken. Does it follow that you should stop eating chicken? Proponents of the “inefficacy objection” argue that, due to the scale and complexity of markets, the expected effects of your chicken purchases are negligible. So the expected effects of eating chicken do not make it wrong. -/- We argue that this objection does not succeed, in two steps. First, empirical data about chicken production tells us (...) that the expected effects of consuming *many* chickens are not negligible. Second, this implies that the expected effect of consuming one chicken is ordinarily not negligible. *Parity* between your purchase and other counterfactual purchases and *uncertainty* about others’ consumption behavior each tend to pull the expected effect of a single purchase toward the average large scale effect. While some purchases do have negligible expected effects, many do not. (shrink)

Forty years have passed since video-games were first made widely available to the public and subsequently playing games has become a favorite past-time for many. Players continuously engage with dynamic visual displays with success contingent on the time-pressured deployment, and flexible allocation, of attention as well as precise bimanual movements. Evidence to date suggests that both brief and extensive exposure to video-game play can result in a broad range of enhancements to various cognitive faculties that generalize beyond the original context. (...) Despite promise, video-game research is host to a number of methodological issues that require addressing before progress can be made in this area. Here an effort is made to consolidate the past 30 years of literature examining the effects of video-game play on cognitive faculties and, more recently, neural systems. Future work is required to identify the mechanism that allows the act of video-game play to generate such a broad range of generalized enhancements. (shrink)

Our approach is based on a tri-partite method of integrating psychodynamic hypotheses, cognitive subliminal processes, and psychophysiological alpha power measures. We present ten social phobic subjects with three individually selected groups of words representing unconscious conflict, conscious symptom experience, and Osgood Semantic negative valence words used as a control word group. The unconscious conflict and conscious symptom words, presented subliminally and supraliminally, act as primes preceding the conscious symptom and control words presented as supraliminal targets. With alpha power as a (...) marker of inhibitory brain activity, we show that unconscious conflict primes, only when presented subliminally, have a unique inhibitory effect on conscious symptom targets. This effect is absent when the unconscious conflict primes are presented supraliminally, or when the target is the control words. Unconscious conflict prime effects were found to correlate with a measure of repressiveness in a similar previous study (Shevrin et al., 1992, 1996). Conscious symptom primes have no inhibitory effect when presented subliminally. Inhibitory effects with conscious symptom primes are present, but only when the primes are supraliminal, and they did not correlate with repressiveness in a previous study (Shevrin et al., 1992, 1996). We conclude that while the inhibition following supraliminal conscious symptom primes is due to conscious threat bias, the inhibition following subliminal unconscious conflict primes provides a neurological blueprint for dynamic repression: it is only activated subliminally by an individual's unconscious conflict and has an inhibitory effect specific only to the conscious symptom. These novel findings constitute neuroscientific evidence for the psychoanalytic concepts of unconscious conflict and repression, while extending neuroscience theory and methods into the realm of personal, psychological meaning. (shrink)

Je cherche à explorer comment l'expérience de la temporalité est multiforme et fortement perturbée à l'époque de la pandémie Covid-19 et des politiques de confinement, générant une expérience d'hétérochronie, qui remet en question notre rapport à la vie.

Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher scores (...) were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

Philosophers of experiment have acknowledged that experiments are often more than mere hypothesis-tests, once thought to be an experiment's exclusive calling. Drawing on examples from contemporary biology, I make an additional amendment to our understanding of experiment by examining the way that `wide' instrumentation can, for reasons of efficiency, lead scientists away from traditional hypothesis-directed methods of experimentation and towards exploratory methods.

The Hoffmann reflex (H-wave) is produced by alpha-motoneuron activation in the spinal cord. A feature of this electromyography response is that it exhibits fluctuations in amplitude even during repetitive stimulation with the same intensity of current. We herein explore the hypothesis that physical training induces plastic changes in the motor system. Such changes are evaluated with the fractal dimension (FD) analysis of the H-wave amplitude-fluctuations (H-wave FD) and the cross-covariance (CCV) between the bilateral H-wave amplitudes. The aim of this study (...) was to compare the H-wave FD as well as the CCV before and after track training in sedentary individuals and athletes. The training modality in all subjects consisted of running three times per week (for 13 weeks) in a concrete road of 5 km. Given the different physical condition of sedentary vs. athletes, the running time between sedentary and athletes was different. After training, the FD was significantly increased in sedentary individuals but significantly reduced in athletes, although there were no changes in spinal excitability in either group of subjects. Moreover, the CCV between bilateral H-waves exhibited a significant increase in athletes but not in sedentary individuals. These differential changes in the FD and CCV indicate that the plastic changes in the complexity of the H-wave amplitude fluctuations as well as the synaptic inputs to the Ia-motoneuron systems of both legs were correlated to the previous fitness history of the subjects. Furthermore, these findings demonstrate that the FD and CCV can be employed as indexes to study plastic changes in the human motor system. (shrink)

The tripartite account of propositional, fallibilist knowledge that p as justified true belief can become adequate only if it can solve the Gettier Problem. However, the latter can be solved only if the problem of a successful coordination of the resources (at least truth and justification) necessary and sufficient to deliver propositional, fallibilist knowledge that p can be solved. In this paper, the coordination problem is proved to be insolvable by showing that it is equivalent to the ''''coordinated attack'''' problem, (...) which is demonstrably insolvable in epistemic logic. It follows that the tripartite account is not merely inadequate as it stands, as proved by Gettier-type counterexamples, but demonstrably irreparable in principle, so that efforts to improve it can never succeed. (shrink)

Philosophical discussions of species have focused on multicellular, sexual animals and have often neglected to consider unicellular organisms like bacteria. This article begins to fill this gap by considering what species concepts, if any, apply neatly to the bacterial world. First, I argue that the biological species concept cannot be applied to bacteria because of the variable rates of genetic transfer between populations, depending in part on which gene type is prioritized. Second, I present a critique of phylogenetic bacterial species, (...) arguing that phylogenetic bacterial classification requires a questionable metaphysical commitment to the existence of essential genes. I conclude by considering how microbiologists have dealt with these biological complexities by using more pragmatic and not exclusively evolutionary accounts of species. I argue that this pragmatism is not borne of laziness but rather of the substantial conceptual problems in classifying bacteria based on any evolutionary standard. (shrink)

The genetic modification of pigs as a source of transplantable organs is one of several possible solutions to the chronic organ shortage. This paper describes existing ethical tensions in xenotransplantation (XTx) that argue against pursuing it. Recommendations for lifelong infectious disease surveillance and notification of close contacts of recipients are in tension with the rights of human research subjects. Parental/guardian consent for pediatric xenograft recipients is in tension with a child’s right to an open future. Individual consent to transplant is (...) in tension with public health threats that include zoonotic diseases. XTx amplifies concerns about justice in organ transplantation and could exacerbate existing inequities. The prevention of infectious disease in source animals is in tension with the best practices of animal care and animal welfare, requiring isolation, ethologically inappropriate housing, and invasive reproductive procedures that would severely impact the well-being of intelligent social creatures like pigs. (shrink)

The question I want to explore is whether experience supports an antireductionist ontology of time, that is, whether we should take it to support an ontology that includes a primitive, monadic property of nowness responsible for the special feel of events in the present, and a relation of passage that events instantiate in virtue of literally passing from the future, to the present, and then into the past.

If you utter sentence (1) ‘Obama was born in 1961’ now, you say something true about the past. Since the past will always be such that the year 1961 has the property of being a time in which Obama was born, it seems impossible that could ever be false in a future context of utterance. We shall consider the case of a sentence about the past exactly like (1), but which was true when uttered a few years ago and is (...) no longer true now. On this basis, we shall conclude that the past has changed. (shrink)

Galileo’s Error is a superlative work of public philosophy, particularly as a way of introducing modern academic panpsychism to a broader audience. In this commentary, I reflect on an issue that is prominent, though often with different background concerns, in both academic and popular discourse: what it means to be ‘scientific’ or ‘unscientific’. Panpsychism is not itself a scientific hypothesis, but neither is it (as critics sometimes claim) in conflict with science. Indeed, Goff argues, and I agree, that panpsychism is (...) an eminently scientific worldview, in the sense of a way of viewing reality that accords with and embraces what science reveals. But what exactly it means to ‘accord with and embrace’ science is disputed; this paper tries to untangle some of the threads. (shrink)

This discussion revises and extends Jonny Anomaly's ‘public goods’ account of public health ethics in light of recent criticism from Richard Dees. Public goods are goods that are both non-rival and non-excludable. What is significant about such goods is that they are not always provided efficiently by the market. Indeed, the state can sometimes realize efficiency gains either by supplying such goods directly or by compelling private purchase. But public goods are not the only goods that the market may fail (...) to provide efficiently. This point to a way of broadening the public goods account of public health to accommodate Dees' counterexamples, without abandoning its distinctive appeal. On the market failures approach to public health ethics, the role of public health is to correct public health-related market failures of all kinds, so far as possible. The underlying moral commitment is to economic efficiency in the sense of Pareto: if we can re-allocate resources in the economy so as to raise the welfare of some without lowering the welfare of any other, we ought to do so. (shrink)

In Mengzi 6A4, Gaozi states that “yì 義 (propriety, rightness) is external, not internal.” In 6A5, Meng Jizi says of yì that “...it is on the external, not from the internal.” Their defenses are met with Mengzi’s resistance. What does he perceive and resist in these statements? Focusing on several key passages, I compare six promising interpretations. 6A4 and a relevant part of 2A2 can be rendered comparably sensible under each of the six. However, what Gaozi says in 6A1 clearly (...) is evidence to Mengzi that, of the six views, Gaozi holds three although he does not convey them in his statement. As for Meng Jiz’s defense of his statement, Meng Jizi cites a special occasion where one is required to act one way even though one would feel a different way. Mengzi’s response has been traditionally interpreted as boiling down to a dissenting opinion about empirical psychology, that the agent on that special occasion would in fact feel the same way as they ought to act. But on a more charitable reading, the point Mengzi makes is conceptual: Though the satisfaction of yì may not require that the feeling and the act align perfectly in this case, cases where the alignment obtains are conceptually prior. This not only refutes Meng Jizi’s statement but also enables a more elegant explanation of why the Mengzi rightly has no record of Mengzi affirming that yì is internal. I conclude that 6A5 itself uniquely favors one interpretation, as far as Meng Jizi’s position is concerned: How one feels is irrelevant to whether one satisfies yì. (shrink)

It seems natural to choose whether to have a child by reflecting on what it would be like to actually have a child. I argue that this natural approach fails. If you choose to become a parent, and your choice is based on projections about what you think it would be like for you to have a child, your choice is not rational. If you choose to remain childless, and your choice is based upon projections about what you think it (...) would be like for you to have a child, your choice is not rational. This suggests we should reject our ordinary conception of how to make this life-changing decision, and raises general questions about how to rationally approach important life choices. (shrink)