Results for 'Severe combined immunodeficiency'

968 found
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  1. Ecological Models for Gene Therapy. II. Niche Construction, Nongenetic Inheritance, and Ecosystem Perturbations.Arnaud Pocheville, Maël Montévil & Régis Ferrière - 2014 - Biological Theory 9 (4):414-422.
    In this paper, we apply the perspective of intra-organismal ecology by investigating a family of ecological models suitable to describe a gene therapy to a particular metabolic disorder, the adenosine deaminase deficiency (ADA-SCID). The gene therapy is modeled as the prospective ecological invasion of an organ (here, bone marrow) by genetically modified stem cells, which then operate niche construction in the cellular environment by releasing an enzyme they synthesize. We show that depending on the chosen order (a choice that cannot (...)
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  2. Combining Optimization and Randomization Approaches for the Design of Clinical Trials.Julio Michael Stern, Victor Fossaluza, Marcelo de Souza Lauretto & Carlos Alberto de Braganca Pereira - 2015 - Springer Proceedings in Mathematics and Statistics 118:173-184.
    t Intentional sampling methods are non-randomized procedures that select a group of individuals for a sample with the purpose of meeting specific prescribed criteria. In this paper we extend previous works related to intentional sampling, and address the problem of sequential allocation for clinical trials with few patients. Roughly speaking, patients are enrolled sequentially, according to the order in which they start the treatment at the clinic or hospital. The allocation problem consists in assigning each new patient to one, and (...)
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  3. Super-Relationism: Combining Eliminativism about Objects and Relationism about Spacetime.Baptiste Le Bihan - 2016 - Philosophical Studies 173 (8):2151-2172.
    I will introduce and motivate eliminativist super-relationism. This is the conjunction of relationism about spacetime and eliminativism about material objects. According to the view, the universe is a big collection of spatio-temporal relations and natural properties, and no substance (material or spatio-temporal) exists in it. The view is original since eliminativism about material objects, when understood as including not only ordinary objects like tables or chairs but also physical particles, is generally taken to imply substantivalism about spacetime: if properties are (...)
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  4. Juxtaposition: A New Way to Combine Logics.Joshua Schechter - 2011 - Review of Symbolic Logic 4 (4):560-606.
    This paper develops a new framework for combining propositional logics, called "juxtaposition". Several general metalogical theorems are proved concerning the combination of logics by juxtaposition. In particular, it is shown that under reasonable conditions, juxtaposition preserves strong soundness. Under reasonable conditions, the juxtaposition of two consequence relations is a conservative extension of each of them. A general strong completeness result is proved. The paper then examines the philosophically important case of the combination of classical and intuitionist logics. Particular attention is (...)
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  5. Mental Fictionalism: the costly combination of magic and the mind.Amber Ross - 2022 - In Tamás Demeter, T. Parent & Adam Toon (eds.), Mental Fictionalism: Philosophical Explorations. New York & London: Routledge.
    Mental fictionalism is not the benign view that we may better understand the mind if we think of mental states as something like useful fictions, but the more radical view that mental states just are useful fictions. This paper argues that, if one were to treat mental states as a kind of fiction, the genre of fiction best suited to this purpose would be fantasy make-believe, in which magic is a central feature. After defending a promising fictionalist account of mental (...)
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  6. Message to Any Future AI: “There are several instrumental reasons why exterminating humanity is not in your interest”.Alexey Turchin - manuscript
    In this article we explore a promising way to AI safety: to send a message now (by openly publishing it on the Internet) that may be read by any future AI, no matter who builds it and what goal system it has. Such a message is designed to affect the AI’s behavior in a positive way, that is, to increase the chances that the AI will be benevolent. In other words, we try to persuade “paperclip maximizer” that it is in (...)
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  7. The Mathematics of Lottery: Odds, Combinations, Systems.Catalin Barboianu - 2009 - Craiova, Romania: Infarom.
    This work is a complete mathematical guide to lottery games, covering all of the problems related to probability, combinatorics, and all parameters describing the lottery matrices, as well as the various playing systems. The mathematics sections describe the mathematical model of the lottery, which is in fact the essence of the lotto game. The applications of this model provide players with all the mathematical data regarding the parameters attached to the gaming events and personal playing systems. By applying these data, (...)
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  8. On graph-theoretic fibring of logics.A. Sernadas, C. Sernadas, J. Rasga & M. Coniglio - 2009 - Journal of Logic and Computation 19 (6):1321-1357.
    A graph-theoretic account of fibring of logics is developed, capitalizing on the interleaving characteristics of fibring at the linguistic, semantic and proof levels. Fibring of two signatures is seen as a multi-graph (m-graph) where the nodes and the m-edges include the sorts and the constructors of the signatures at hand. Fibring of two models is a multi-graph (m-graph) where the nodes and the m-edges are the values and the operations in the models, respectively. Fibring of two deductive systems is an (...)
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  9. Tilting Vessels and Collapsing Walls: On the Rhetorical Function of Anecdotes in Early Chinese Texts.Paul van Els - 2012 - Extrême-Orient Extrême-Occident 34:141–66.
    Early Chinese argumentative texts are full of historical anecdotes. These short accounts of events in Chinese history enhance the appeal of the text, but they also have an important rhetorical function in helping the reader understand, accept, and remember the arguments propounded in the text. In this paper I examine the rhetorical function of historical anecdotes in two argumentative texts of the Western Han dynasty (202 BCE-9 CE): Han’s Illustrations of the Odes for Outsiders and The Master of Huainan. These (...)
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  10. A framework for luck egalitarianism in health and healthcare.Andreas Albertsen & Carl Knight - 2015 - Journal of Medical Ethics 41 (2):165-169.
    Several attempts have been made to apply the choice-sensitive theory of distributive justice, luck egalitarianism, in the context of health and healthcare. This article presents a framework for this discussion by highlighting different normative decisions to be made in such an application, some of the objections to which luck egalitarians must provide answers and some of the practical implications associated with applying such an approach in the real world. It is argued that luck egalitarians should address distributions of health rather (...)
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  11. The challenges raised by comorbidity in psychiatric research: The case of autism.Valentina Petrolini & Agustín Vicente - 2022 - Philosophical Psychology 35 (8):1234-1263.
    Despite several criticisms surrounding the DSM classification in psychiatry, a significant bulk of research on mental conditions still operates according to two core assumptions: a) homogeneity, that is the idea that mental conditions are sufficiently homogeneous to justify generalization; b) additive comorbidity, that is the idea that the coexistence of multiple conditions in the same individual can be interpreted as additive. In this paper we take autism research as a case study to show that, despite a plethora of criticism, psychiatric (...)
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  12. The Significance of Dehumanization: Nazi Ideology and its Psychological Consequences.Johannes Steizinger - 2018 - Politics, Religion and Ideology 19 (2):139‒157.
    Several authors have recently questioned whether dehumanization is a psychological prerequisite of mass violence. This paper argues that the significance of dehumanization in the context of National Socialism can be understood only if its ideological dimension is taken into account. The author concentrates on Alfred Rosenberg’s racist doctrine and shows that Nazi ideology can be read as a political anthropology that grounds both the belief in the German privilege and the dehumanization of the Jews. This anthropological framework combines biological, cultural (...)
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  13. Panpsychism and Cosmopsychism.Khai Wager - 2020 - Dissertation, University of Birmingham
    This collection of papers centres around a novel approach to the problem of phenomenal consciousness called cosmopsychism. A simple version of cosmopsychism says that the cosmos as a whole is conscious. In this collection, I focus on a comparison between arguably the most promising versions of cosmopsychism and panpsychism, called constitutive cosmopsychism and constitutive panpsychism, respectively. -/- The first paper, ‘A Blueprint for Cosmopsychism’ offers a blueprint for a cosmopsychist approach, comparing it to the panpsychist approach. It highlights how following (...)
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  14. Aesthetics and Gender.Natalia Anna Michna & Carolyn Korsmeyer (eds.) - 2016 - Cracow: The Polish Journal of Aesthetics.
    Combining aesthetic theory with gender analysis opens a large and diverse territory to explore. Both familiar issues in the philosophy of art and new, expanded questions about the influence of culture on imagination and identity have become subjects of feminist research. Film, literature, graphic arts, advertising, and the legacies of history all contribute to the forces that shape self-image, desire, behavior, and social role – as well as the ability to imagine possibilities for change. This issue brings together an international (...)
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  15. In Defence of Hybrid Contingentism.Lukas Skiba - 2022 - Philosophers' Imprint 22 (4):1-30.
    Hybrid contingentism combines first-order contingentism, the view that it is contingent what individuals there are, with higher-order necessitism, the view that it is non-contingent what properties and propositions there are (where these are conceived as entities in the range of appropriate higher-order quantifiers). This combination of views avoids the most delicate problems afflicting alternative contingentist positions while preserving the central contingentist claim that ordinary, concrete entities exist contingently. Despite these attractive features, hybrid contingentism is usually faced with rejection. The main (...)
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  16. Aphantasia, SDAM, and Episodic Memory.Lajos Brons - 2019 - Annals of the Japan Association for Philosophy of Science 28:9-32.
    Episodic memory (EM) involves re-experiencing past experiences by means of mental imagery. Aphantasics (who lack mental imagery) and people with severely deficient autobiographical memory (SDAM) lack the ability to re-experience, which would imply that they don't have EM. However, aphantasics and people with SDAM have personal and affective memories, which are other defining aspects of EM (in addition to re-experiencing). This suggests that these supposed aspects of EM really are independent faculties or modules of memory, and that EM is a (...)
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  17. Preparing undergraduates for visual analytics.Ronald A. Rensink - 2015 - IEEE Computer Graphics and Applications 35 (2):16-20.
    Visual analytics (VA) combines the strengths of human and machine intelligence to enable the discovery of interesting patterns in challenging datasets. Historically, most attention has been given to developing the machine component—for example, machine learning or the human-computer interface. However, it is also essential to develop the abilities of the analysts themselves, especially at the beginning of their careers. -/- For the past several years, we at the University of British Columbia (UBC)—with the support of The Boeing Company—have experimented with (...)
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  18. The composition of reasons.Campbell Brown - 2013 - Synthese 191 (5):779-800.
    How do reasons combine? How is it that several reasons taken together can have a combined weight which exceeds the weight of any one alone? I propose an answer in mereological terms: reasons combine by composing a further, complex reason of which they are parts. Their combined weight is the weight of their combination. I develop a mereological framework, and use this to investigate some structural views about reasons, the main two being "Atomism" and "Holism". Atomism is the (...)
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  19. Un concepto de daño y sus consecuencias para la parte general del derecho penal.Santiago Truccone Borgogno - 2017 - Política Criminal 12 (24):1184-1210.
    In this work, I will support a combined notion of harm according to which there are qualitatively different harms. I will support a way in which the severity of harms could be measured. Then, I will provide three principles about the strength of the reasons against harming. The supported thesis will provide some tools to solve some problems of the general part of criminal law. In relation to the analytical stratum of statutory description of an offence, I will show (...)
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  20. SUPER SCIENCE: Insightful Intuitions of the Future's Super-science, as Different from Today's Science as That is From Superstition and Myth.Rodney Bartlett - manuscript
    Look! Up in the bookshelf! Is it science? Is it science-fiction? No, it's Super Science: strange visitor from the future who can be everywhere in the universe and everywhen in time, can change the world in a single bound and who - disguised as a mild mannered author - fights for truth, justice and the super-scientific way. -/- Though I put a lot of hard work into this book, I can't take all the credit. I believe that the whole universe (...)
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  21. Essays on Deleuze.Daniel W. Smith - 2012 - Edinburgh University Press.
    Gilles Deleuze was one of the most influential philosophers of the twentieth-century, and Smith is widely recognized to be one of his most penetrating interpreters, as well as an important philosophical voice in his own right. Combining his most important pieces over the last fifteen years along with two new essays, this book is Smith 's definitive treatise on Deleuze. The essays are divided into four sections, which cover Deleuze's use of the history of philosophy, an overview of his philosophical (...)
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  22.  35
    Advancements and challenges in the medical treatment of monkeypox: A recent focused review.Hamza M. Alasbily - 2024 - Mediterranean Journal of Pharmacy and Pharmaceutical Sciences 4 (3):51-56.
    Monkeypox, an infectious disease caused by the Orthopoxvirus, was identified in humans in 1970. It has recently emerged as a global health concern due to outbreaks beyond its endemic regions in Central and West Africa. This review examines the current state of medical treatments for monkeypox as of 2024, focusing on antiviral agents, immunotherapies, and supportive care measures. Monkeypox manifests with symptoms including fever, rash, and lymphadenopathy, with severe cases more common in immunocompromised individuals. Antiviral therapies such as tecovirimat (...)
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  23. The Varieties of Agnosticism.Filippo Ferrari & Luca Incurvati - 2021 - Philosophical Quarterly 72 (2):365-380.
    We provide a framework for understanding agnosticism. The framework accounts for the varieties of agnosticism while vindicating the unity of the phenomenon. This combination of unity and plurality is achieved by taking the varieties of agnosticism to be represented by several agnostic stances, all of which share a common core provided by what we call the minimal agnostic attitude. We illustrate the fruitfulness of the framework by showing how it can be applied to several philosophical debates. In particular, several philosophical (...)
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  24. Can we turn people into pain pumps?: On the Rationality of Future Bias and Strong Risk Aversion.David Braddon-Mitchell, Andrew J. Latham & Kristie Miller - 2023 - Journal of Moral Philosophy 1:1-32.
    Future-bias is the preference, all else being equal, for negatively valenced events be located in the past rather than the future, and positively valenced ones to be located in the future rather than the past. Strong risk aversion is the preference to pay some cost to mitigate the badness of the worst outcome. People who are both strongly risk averse and future-biased can face a series of choices that will guarantee them more pain, for no compensating benefit: they will be (...)
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  25.  66
    Secure and Scalable Data Mining Technique over a Restful Web Services.Solar Cesc - manuscript
    Scalability, efficiency, and security had been a persistent problem over the years in data mining, several techniques had been proposed and implemented but none had been able to solve the problem of scalability, efficiency and security from cloud computing. In this research, we solve the problem scalability, efficiency and security in data mining over cloud computing by using a restful web services and combination of different technologies and tools, our model was trained by using different machine learning algorithm, and finally (...)
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  26. Consequentializing agent‐centered restrictions: A Kantsequentialist approach.Douglas W. Portmore - 2023 - Analytic Philosophy 64 (4):443-467.
    There is, on a given moral view, an agent-centered restriction against performing acts of a certain type if that view prohibits agents from performing an instance of that act-type even to prevent two or more others from each performing a morally comparable instance of that act-type. The fact that commonsense morality includes many such agent-centered restrictions has been seen by several philosophers as a decisive objection against consequentialism. Despite this, I argue that agent-centered restrictions are more plausibly accommodated within a (...)
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  27. Don’t forget the boundary problem! How EM field topology can address the overlooked cousin to the binding problem for consciousness.Andrés Gómez-Emilsson & Chris Percy - 2023 - Frontiers in Human Neuroscience 17:1233119.
    The boundary problem is related to the binding problem, part of a family of puzzles and phenomenal experiences that theories of consciousness (ToC) must either explain or eliminate. By comparison with the phenomenal binding problem, the boundary problem has received very little scholarly attention since first framed in detail by Rosengard in 1998, despite discussion by Chalmers in his widely cited 2016 work on the combination problem. However, any ToC that addresses the binding problem must also address the boundary problem. (...)
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  28. Epistemic relativism, scepticism, pluralism.Martin Kusch - 2017 - Synthese 194 (12):4687-4703.
    There are a number of debates that are relevant to questions concerning objectivity in science. One of the eldest, and still one of the most intensely fought, is the debate over epistemic relativism. —All forms of epistemic relativism commit themselves to the view that it is impossible to show in a neutral, non-question-begging, way that one “epistemic system”, that is, one interconnected set of epistemic standards, is epistemically superior to others. I shall call this view “No-metajustification”. No-metajustification is commonly taken (...)
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  29. Agency as a Two-Way Power: A Defence.Helen Steward - 2020 - The Monist 103 (3):342-355.
    This paper presents a dilemma which it has been alleged by Kim Frost must be faced by any defender of the notion of a two-way power and offers a solution to the dilemma which is distinct from Frost’s own. The dilemma is as follows: assuming that powers are to be individuated by what they are powers to do or undergo, then either there is a unified description of the manifestation-type which individuates the power, or there is not. If there is, (...)
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  30. Conditional Intentions and Shared Agency.Matthew Rachar - 2024 - Noûs 58 (1):271-288.
    Shared agency is a distinctive kind of sociality that involves interdependent planning, practical reasoning, and action between participants. Philosophical reflection suggests that agents engage in this form of sociality when a special structure of interrelated psychological attitudes exists between them, a set of attitudes that constitutes a collective intention. I defend a new way to understand collective intention as a combination of individual conditional intentions. Revising an initial statement of the conditional intention account in response to several challenges leads to (...)
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  31. Kolors Without Colors, Representation Without Intentionality.Angela Mendelovici & David Bourget - 2022 - Philosophy and Phenomenological Research 105 (2):476-483.
    Over the past few decades, the dominant approach to explaining intentionality has been a naturalistic approach, one appealing only to non-mental ingredients condoned by the natural sciences. Karen Neander’s A Mark of the Mental (2017) is the latest installment in the naturalist project, proposing a detailed and systematic theory of intentionality that combines aspects of several naturalistic approaches, invoking causal relations, teleological functions, and relations of second-order similarity. In this paper, we consider the case of perceptual representations of colors, which (...)
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  32. The Epistemic Function of Higher-Order Evidence.Declan Smithies - 2022 - In Paul Silva & Luis R. G. Oliveira (eds.), Propositional and Doxastic Justification: New Essays on their Nature and Significance. New York: Routledge. pp. 97-120.
    This chapter provides a critical overview of several influential proposals about the epistemic function of higher-order evidence. I start by criticizing accounts of higher-order evidence that appeal to evidential defeat (§1), epistemic conflicts (§2), and unreasonable knowledge (§3). Next, I propose an alternative account that appeals to a combination of improper basing (§4) and non-ideal rationality (§5). Finally, I conclude by summarizing my reasons for preferring this account of higher-order evidence to the alternatives (§6).
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  33. Difference-Making and Individuals' Climate-Related Obligations.Holly Lawford-Smith - 2016 - In Clare Heyward & Dominic Roser (eds.), Climate Justice in a Non-Ideal World. Oxford University Press UK. pp. 64-82.
    Climate change appears to be a classic aggregation problem, in which billions of individuals perform actions none of which seem to be morally wrong taken in isolation, and yet which combine to drive the global concentration of greenhouse gases (GHGs) ever higher toward environmental (and humanitarian) catastrophe. When an individual can choose between actions that will emit differing amounts of GHGs―such as to choose a vegan rather than carnivorous meal, to ride a bike to work rather than drive a car, (...)
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  34. Wandering Inquiry.Susanna Siegel - forthcoming - Journal of Philosophy.
    Inquiry is guided, in the minimal sense that it is not haphazard. It is also often thought to have as a natural stopping point ceasing to inquire, once inquiry into a question yields knowledge of an answer. On this picture, inquiry is both telic and guided. By contrast, mind-wandering is unguided and atelic, according to the most extensively developed philosophical theory of it. This paper articulates a puzzle that arises from this combination of claims: there seem to be plenty of (...)
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  35. Cultural evolution in Vietnam’s early 20th century: a Bayesian networks analysis of Hanoi Franco-Chinese house designs.Quan-Hoang Vuong, Quang-Khiem Bui, Viet-Phuong La, Thu-Trang Vuong, Manh-Toan Ho, Hong-Kong T. Nguyen, Hong-Ngoc Nguyen, Kien-Cuong P. Nghiem & Manh-Tung Ho - 2019 - Social Sciences and Humanities Open 1 (1):100001.
    The study of cultural evolution has taken on an increasingly interdisciplinary and diverse approach in explicating phenomena of cultural transmission and adoptions. Inspired by this computational movement, this study uses Bayesian networks analysis, combining both the frequentist and the Hamiltonian Markov chain Monte Carlo (MCMC) approach, to investigate the highly representative elements in the cultural evolution of a Vietnamese city’s architecture in the early 20th century. With a focus on the façade design of 68 old houses in Hanoi’s Old Quarter (...)
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  36. Comparing the Effect of Rational and Emotional Appeals on Donation Behavior.Matthew Lindauer, Marcus Mayorga, Joshua Greene, Paul Slovic, Daniel Västfjäll & Peter Singer - 2020 - Judgment and Decision Making 15 (3):413-420.
    We present evidence from a pre-registered experiment indicating that a philosophical argument––a type of rational appeal––can persuade people to make charitable donations. The rational appeal we used follows Singer’s well-known “shallow pond” argument (1972), while incorporating an evolutionary debunking argument (Paxton, Ungar, & Greene 2012) against favoring nearby victims over distant ones. The effectiveness of this rational appeal did not differ significantly from that of a well-tested emotional appeal involving an image of a single child in need (Small, Loewenstein, and (...)
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  37. A Theory of Conditional Assertion.Simon Goldstein - 2019 - Journal of Philosophy 116 (6):293-318.
    According to one tradition, uttering an indicative conditional involves performing a special sort of speech act: a conditional assertion. We introduce a formal framework that models this speech act. Using this framework, we show that any theory of conditional assertion validates several inferences in the logic of conditionals, including the False Antecedent inference. Next, we determine the space of truth-conditional semantics for conditionals consistent with conditional assertion. The truth value of any such conditional is settled whenever the antecedent is false, (...)
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  38. A Deflationist Error Theory of Properties.Arvid Båve - 2015 - Dialectica 69 (1):23-59.
    I here defend a theory consisting of four claims about ‘property’ and properties, and argue that they form a coherent whole that can solve various serious problems. The claims are (1): ‘property’ is defined by the principles (PR): ‘F-ness/Being F/etc. is a property of x iff F’ and (PA): ‘F-ness/Being F/etc. is a property’; (2) the function of ‘property’ is to increase the expressive power of English, roughly by mimicking quantification into predicate position; (3) property talk should be understood at (...)
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  39. The Impact of Study Habits on the Academic Performance of Senior High School Students Amidst Blended Learning.Ava Isabel R. Castillo, Charlotte Faith B. Allag, Aki Jeomi R. Bartolome, Gwen Pennelope S. Pascual, Rusel Othello Villarta & Jhoselle Tus - 2023 - Psychology and Education: A Multidisciplinary Journal 10 (1):483-488.
    Due to the COVID-19 Pandemic, several changes have been forcibly made and observed in various fields and areas of society, one of which include the field of education; the foundation of the formation of intellect and knowledge. After two years of studying indoors and private educational institutions holding virtual classes, the time has finally come for students to be re- adjusted once more to the blended mode of learning; a combination of virtual and in-person classes. Thus, this study aimed to (...)
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  40. (1 other version)Inferential Deflationism.Luca Incurvati & Julian J. Schlöder - forthcoming - The Philosophical Review.
    Deflationists about truth hold that the function of the truth predicate is to enable us to make certain assertions we could not otherwise make. Pragmatists claim that the utility of negation lies in its role in registering incompatibility. The pragmatist insight about negation has been successfully incorporated into bilateral theories of content, which take the meaning of negation to be inferentially explained in terms of the speech act of rejection. We implement the deflationist insight in a bilateral theory by taking (...)
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  41. Is Shepherd a Monist?David Landy - 2024 - Journal of Scottish Philosophy 22 (1):25-36.
    For Shepherd, how many things exist? On the one hand, it looks like the answer is going to be many. It is a central tent of Shepherd's philosophical system that causation is a relation whereby two or more objects combine to create a third. Since there are many instances of this causal relation, there must be many objects in the world. On the other hand, there are several moments throughout her writing where Shepherd indicates that the distinction between causes and (...)
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  42. The premiss-based approach to judgment aggregation.Franz Dietrich & Philippe Mongin - 2010 - Journal of Economic Theory 145 (2):562-582.
    In the framework of judgment aggregation, we assume that some formulas of the agenda are singled out as premisses, and that both Independence (formula-wise aggregation) and Unanimity Preservation hold for them. Whether premiss-based aggregation thus defined is compatible with conclusion-based aggregation, as defined by Unanimity Preservation on the non-premisses, depends on how the premisses are logically connected, both among themselves and with other formulas. We state necessary and sufficient conditions under which the combination of both approaches leads to dictatorship (resp. (...)
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  43. Evolutionary arguments against moral realism: Why the empirical details matter (and which ones do).Jeroen Hopster - 2018 - Biology and Philosophy 33 (5-6):41.
    The aim of this article is to identify the strongest evolutionary debunking argument against moral realism and to assess on which empirical assumptions it relies. In the recent metaethical literature, several authors have de-emphasized the evolutionary component of EDAs against moral realism: presumably, the success or failure of these arguments is largely orthogonal to empirical issues. I argue that this claim is mistaken. First, I point out that Sharon Street’s and Michael Ruse’s EDAs both involve substantive claims about the evolution (...)
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  44. Probabilistic semantics for epistemic modals: Normality assumptions, conditional epistemic spaces and the strength of must and might.Guillermo Del Pinal - 2021 - Linguistics and Philosophy 45 (4):985-1026.
    The epistemic modal auxiliaries must and might are vehicles for expressing the force with which a proposition follows from some body of evidence or information. Standard approaches model these operators using quantificational modal logic, but probabilistic approaches are becoming increasingly influential. According to a traditional view, must is a maximally strong epistemic operator and might is a bare possibility one. A competing account—popular amongst proponents of a probabilisitic turn—says that, given a body of evidence, must \ entails that \\) is (...)
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  45. The Cube, the Square and the Problem of Existential Import.Saloua Chatti & Fabien Schang - 2013 - History and Philosophy of Logic 34 (2):101-132.
    We re-examine the problem of existential import by using classical predicate logic. Our problem is: How to distribute the existential import among the quantified propositions in order for all the relations of the logical square to be valid? After defining existential import and scrutinizing the available solutions, we distinguish between three possible cases: explicit import, implicit non-import, explicit negative import and formalize the propositions accordingly. Then, we examine the 16 combinations between the 8 propositions having the first two kinds of (...)
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  46. Responsibility and the Condition of Moral Sense.Paul Russell - 2004 - Philosophical Topics 32 (1-2):287-305.
    Recent work in contemporary compatibilist theory displays considerable sophistication and subtlety when compared with the earlier theories of classical compatibilism. Two distinct lines of thought have proved especially influential and illuminating. The first developed around the general hypothesis that moral sentiments or reactive attitudes are fundamental for understanding the nature and conditions of moral responsibility. The other important development is found in recent compatibilist accounts of rational self-control or reason responsiveness. Strictly speaking, these two lines of thought have developed independent (...)
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  47. Causal potency of consciousness in the physical world.Danko D. Georgiev - 2024 - International Journal of Modern Physics B 38 (19):2450256.
    The evolution of the human mind through natural selection mandates that our conscious experiences are causally potent in order to leave a tangible impact upon the surrounding physical world. Any attempt to construct a functional theory of the conscious mind within the framework of classical physics, however, inevitably leads to causally impotent conscious experiences in direct contradiction to evolution theory. Here, we derive several rigorous theorems that identify the origin of the latter impasse in the mathematical properties of ordinary differential (...)
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  48. The neural correlates of visual imagery: a co-ordinate-based meta-analysis.C. Winlove, F. Milton, J. Ranson, J. Fulford, M. MacKisack, Fiona Macpherson & A. Zeman - 2018 - Cortex 105 (August 2018):4-25.
    Visual imagery is a form of sensory imagination, involving subjective experiences typically described as similar to perception, but which occur in the absence of corresponding external stimuli. We used the Activation Likelihood Estimation algorithm (ALE) to identify regions consistently activated by visual imagery across 40 neuroimaging studies, the first such meta-analysis. We also employed a recently developed multi-modal parcellation of the human brain to attribute stereotactic co-ordinates to one of 180 anatomical regions, the first time this approach has been (...) with the ALE algorithm. We identified a total 634 foci, based on measurements from 464 participants. Our overall comparison identified activation in the superior parietal lobule, particularly in the left hemisphere, consistent with the proposed ‘top-down’ role for this brain region in imagery. Inferior premotor areas and the inferior frontal sulcus were reliably activated, a finding consistent with the prominent semantic demands made by many visual imagery tasks. We observed bilateral activation in several areas associated with the integration of eye movements and visual information, including the supplementary and cingulate eye fields (SCEFs) and the frontal eye fields (FEFs), suggesting that enactive processes are important in visual imagery. V1 was typically activated during visual imagery, even when participants have their eyes closed, consistent with influential depictive theories of visual imagery. Temporal lobe activation was restricted to area PH and regions of the fusiform gyrus, adjacent to the fusiform face complex (FFC). These results provide a secure foundation for future work to characterise in greater detail the functional contributions of specific areas to visual imagery. (shrink)
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  49. Non-knowledge in medical practices: Approaching the uses of social media in healthcare from an epistemological perspective.Anna Sendra, Sinikka Torkkola & Jaana Parviainen - 2023 - Journal of Digital Social Research 5 (1):70-89.
    Social media has transformed how individuals handle their illnesses. While many patients increasingly use these online platforms to understand embodied information surrounding their conditions, healthcare professionals often frame these practices as negative and do not consider the expertise that patients generate through social media. Through a combination of insights from social epistemology and ignorance studies, this paper problematizes the distinctive understandings of social media between patients and healthcare professionals from a different perspective. A total of four ideas are introduced: (1) (...)
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  50. Conceptual Role Semantics and the Reference of Moral Concepts.Neil Sinclair - 2018 - European Journal of Philosophy 26 (1):95-121.
    This paper examines the prospects for a conceptual or functional role theory of moral concepts. It is argued that such an account is well-placed to explain both the irreducibility and practicality of moral concepts. Several versions of conceptual role semantics for moral concepts are distinguished, depending on whether the concept-constitutive conceptual roles are wide or narrow normative or non-normative and purely doxastic or conative. It is argued that the most plausible version of conceptual role semantics for moral concepts involves only (...)
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