The right to withdraw from participation in research is recognized in virtually all national and international guidelines for research on human subjects. It is therefore surprising that there has been little justification for that right in the literature. We argue that the right to withdraw should protect research participants from information imbalance, inability to hedge, inherent uncertainty, and untoward bodily invasion, and it serves to bolster public trust in the research enterprise. Although this argument is not radical, it provides a (...) useful way to determine how the right should be applied in various cases. (shrink)

The prospect of consumable meat produced in a laboratory setting without the need to raise and slaughter animals is both realistic and exciting. Not only could such in vitro meat become popular due to potential cost savings, but it also avoids many of the ethical and environmental problems with traditional meat productions. However, as with any new technology, in vitro meat is likely to face some detractors. We examine in detail three potential objections: 1) in vitro meat is disrespectful, either (...) to nature or to animals; 2) it will reduce the number of happy animals in the world; and 3) it will open the door to cannibalism. While each objection has some attraction, we ultimately find that all can be overcome. The upshot is that in vitro meat production is generally permissible and, especially for ethical vegetarians, worth promoting. (shrink)

Husserl’s theory of fulfilment conceives of empty acts, such as symbolic thought, and fulfilling acts, such as sensory perceptions, in a strict parallel. This parallelism is the basis for Husserl’s semantics, epistemology, and conception of truth. It also entails that any true proposition can be known in principle, which Church and Fitch have shown to explode into the claim that every proposition is _actually_ known. I assess this logical challenge and discuss a recent response by James Kinkaid. While Kinkaid’s proposal (...) saves one direction of the parallel for semantics, it gives up the parallelism for truth. I spell out a different response which meshes naturally with Husserl’s account of meaning. If the parallelism is restricted to a class of basic propositions, the truth of non-basic propositions can be defined inductively, without leading to the paradox. I then discuss objections that have been raised against a similar proposal by Dummett. The result is that exegetically plausible and popular interpretations of Husserl’s correlationism are indeed challenged by Church and Fitch. But when taking into account the ‘logical adumbration’ of propositional blindspots, truth and possible fulfilment can be connected without paradox. (shrink)

The aim of this paper is to develop and defend an Attentional View of bodily awareness, on which attention is necessary for bodily awareness. The original formulation of the Attentional View is due to Marcel Kinsbourne. First, I will show that the Attentional View of bodily awareness as formulated by Kinsbourne is superior to other accounts in the literature for characterizing the relationship between attention and bodily awareness. Kinsbourne’s account is the only account in the literature so far which can (...) accommodate key neurological diseases such as personal neglect. Second, when I consider Kinsbourne’s view in more detail, I will argue that Kinsbourne’s Attentional View faces problems because it is too reductive. Kinsbourne deviates from the standard taxonomy on which there is a body schema and a body image. Instead he reduces the body image to the neural representation of the body in the somatosensory cortex, the body schema and attentional shifts. I will present two challenges to Kinsbourne’s view which demonstrate that Kinsbourne’s reduction of the body image is unsuccessful. Finally, I will present a revised version of the Attentional View that is both empirically adequate and philosophically satisfactory. (shrink)

The predominant view is that a study using health data is observational research and should require individual consent unless it can be shown that gaining consent is impractical. But recent arguments have been made that citizens have an ethical obligation to share their health information for research purposes. In our view, this obligation is sufficient ground to expand the circumstances where secondary use research with identifiable health information is permitted without explicit subject consent. As such, for some studies the Institutional (...) Review Board/Research Ethics Committee review process should not assess the practicality of gaining consent for data use. Instead the review process should focus on assessing the public good of the research, public engagement and transparency. (shrink)

This commentary challenges Railton’s claim that the affective system is the key source of control of action. Whilst the affective system is important for understanding how acting for a reason is possible, we argue that there are many levels of control of action and adaptive behaviour and that the affective system is only one source of control. Such a model seems to be more in line with the emerging picture from affective and movement neuroscience.

Ethical decision-making frameworks assist in identifying the issues at stake in a particular setting and thinking through, in a methodical manner, the ethical issues that require consideration as well as the values that need to be considered and promoted. Decisions made about the use, sharing, and re-use of big data are complex and laden with values. This paper sets out an Ethics Framework for Big Data in Health and Research developed by a working group convened by the Science, Health and (...) Policy-relevant Ethics in Singapore Initiative. It presents the aim and rationale for this framework supported by the underlying ethical concerns that relate to all health and research contexts. It also describes a set of substantive and procedural values that can be weighed up in addressing these concerns, and a step-by-step process for identifying, considering, and resolving the ethical issues arising from big data uses in health and research. This Framework is subsequently applied in the papers published in this Special Issue. These papers each address one of six domains where big data is currently employed: openness in big data and data repositories, precision medicine and big data, real-world data to generate evidence about healthcare interventions, AI-assisted decision-making in healthcare, public-private partnerships in healthcare and research, and cross-sectoral big data. (shrink)

Some have objected to human enhancement on the grounds that it violates the autonomy of the enhanced. These objections, however, overlook the interesting possibility that autonomy itself could be enhanced. How, exactly, to enhance autonomy is a difficult problem due to the numerous and diverse accounts of autonomy in the literature. Existing accounts of autonomy enhancement rely on narrow and controversial conceptions of autonomy. However, we identify one feature of autonomy common to many mainstream accounts: reasoning ability. Autonomy can then (...) be enhanced by improving people’s reasoning ability, in particular through cognitive enhancement; given how valuable autonomy is usually taken to be, this gives us extra reason to pursue such cognitive enhancements. Moreover, autonomy-based objections will be especially weak against such enhancements. As we will argue, those who are worried that enhancements will inhibit people’s autonomy should actually embrace those enhancements that will improve autonomy. (shrink)

Moral enhancement is an ostensibly laudable project. Who wouldn’t want people to become more moral? Still, the project’s approach is crucial. We can distinguish between two approaches for moral enhancement: direct and indirect. Direct moral enhancements aim at bringing about particular ideas, motives or behaviors. Indirect moral enhancements, by contrast, aim at making people more reliably produce the morally correct ideas, motives or behaviors without committing to the content of those ideas, motives and/or actions. I will argue, on Millian grounds, (...) that the value of disagreement puts serious pressure on proposals for relatively widespread direct moral enhancement. A more acceptable path would be to focus instead on indirect moral enhancements while staying neutral, for the most part, on a wide range of substantive moral claims. I will outline what such indirect moral enhancement might look like, and why we should expect it to lead to general moral improvement. (shrink)

The current prevailing view is that participation in biomedical research is above and beyond the call of duty. While some commentators have offered reasons against this, we propose a novel public goods argument for an obligation to participate in biomedical research. Biomedical knowledge is a public good, available to any individual even if that individual does not contribute to it. Participation in research is a critical way to support an important public good. Consequently, all have a duty to participate. The (...) current social norm is that individuals participate only if they have a good reason to do so. The public goods argument implies that individuals should participate unless they have a good reason not to. Such a shift would be of great aid to the progress of biomedical research, eventually making society significantly healthier and longer lived. (shrink)

The future of health research will be characterised by three continuing trends: rising demand for health data; increasing impracticability of obtaining specific consent for secondary research; and decreasing capacity to effectively anonymise data. In this context, governments, clinicians and the research community must demonstrate that they can be responsible stewards of health data. IRBs and RECs sit at heart of this process because in many jurisdictions they have the capacity to grant consent waivers when research is judged to be of (...) particular value. However, several different terms are used to refer to this value, indicating a lack of conceptual clarity regarding the appropriate test for access to health data for research without consent. In this paper we do three things. First we describe the current confusion and instability in terminology relating to public interest in the context of consent waivers. Second we argue for harmonisation of terminology on the grounds of clarity, transparency and consistency. Third we argue that the term ‘public interest’ best reflects the normative work required to justify consent waivers because it is the broadest of the competing terms. ‘Public interest’ contains within its scope positive and negative implications of a study, as well as welfare, justice and rights considerations. In making this argument, we explain the normative basis for consent waivers, and provide a starting place for further discussion about the precise conditions in which a given study can be said to advance the public interest. Ipsos MORI study found that: … the public would be broadly happy with administrative data linking for research projects provided Those projects have social value, broadly defined. Data are de-identified. Data are kept secure. Businesses are not able to access the data for profit. (shrink)

While philosophers are often concerned with the conditions for moral knowledge or justification, in practice something arguably less demanding is just as, if not more, important – reliably making correct moral judgments. Judges and juries should hand down fair sentences, government officials should decide on just laws, members of ethics committees should make sound recommendations, and so on. We want such agents, more often than not and as often as possible, to make the right decisions. The purpose of this paper (...) is to propose a method of enhancing the moral reliability of such agents. In particular, we advocate for a procedural approach; certain internal processes generally contribute to people’s moral reliability. Building on the early work of Rawls, we identify several particular factors related to moral reasoning that are specific enough to be the target of practical intervention: logical competence, conceptual understanding, empirical competence, openness, empathy and bias. Improving on these processes can in turn make people more morally reliable in a variety of contexts and has implications for recent debates over moral enhancement. (shrink)

Gregor Schiemann verteidigt die Aktualität des aristotelischen und cartesianischen Naturbegriffes, die Natur in Gegensatz zu Nichtnatürlichem definieren. Als gültig könnnen sich diese traditionellen Naturbegriffe jedoch nur noch innerhalb begrenzter Kontexte erweisen. -/- Im ersten Teil seines Buches zeigt der Autor, dass Aristoteles' Bestimmung der Natur als Gegenbegriff zur Technik in der Lebenswelt sowie Descartes' Dualismus von Natur und Geist für das eigene Bewusstseinserleben orientierungsleitend geblieben sind. Dass die Begriffspaare nicht nur in gesonderten Kontexten vorkommen, sondern sich ihre Anwendungen auch (...) wechselseitig durchdringen, führt er im zweiten Teil am Beispiel von Aristoteles' Seelenlehre und Descartes' Mechanismus aus. Die naturphilosophische und erkenntnistheoretische Untersuchung verbindet Elemente der analytischen Philosophie mit Ansätzen der Phänomenologie. Sie will zu einem pluralen Verständnis der Natur beitragen, das universelle Geltungsansprüche verabschiedet. (shrink)

It has recently been argued that reproductive genetic manipulation technologies like mitochondrial replacement and germline CRISPR modifications cannot be said to save anyone’s life because, counterfactually, no one would suffer more or die sooner absent the intervention. The present article argues that, on the contrary, reproductive genetic manipulations may be life-saving (and, from this, have therapeutic value) under an appropriate population health perspective. As such, popular reports of reproductive genetic manipulations potentially saving lives or preventing disease are not necessarily mistaken, (...) though such terminology still requires further empirical validation. (shrink)

The paper deals with the question of the structure of knowledge and the precise relationship between propositional "knowledge that" and dispositional "knowledge how." In the first part of my essay, I provide an analysis of the term 'knowing how' and argue that the usual alternatives in the recent epistemological debate – knowing how is either a form of propositional or dispositional knowledge – are misleading. In fact it depends on the semantic and pragmatic context of the usage of this term (...) whether 'knowing how' refers to a type of dispositional knowledge, to propositional knowledge, or to a hybrid form of both. Only in the first case, can one say that dispositional know how cannot be reduced to any form of propositional knowledge. Yet, this case is the most interesting one to consider in the investigation of the nature of knowledge, if one assumes that knowing that p presupposes "having found out that p." Having found something out, however, presupposes certain acts of epistemic inquiry and corresponding epistemic abilities. Examined more carefully, it is shown that the dispositional knowledge-how is a necessary condition for propositional knowledge-that, hence propositional knowledge-that is a species of the dispositional knowledge-how. Accordingly, dispositional knowledge has to be understood as being at the very core of our notion of knowledge, including propositional knowledge. (shrink)

Forms of justification. On the structure and scope of self-refutation arguments in Plato, Cicero and Apel. - In this essay, the structure and scope of transcendental types of argumentation are analyzed, compared and criticized on the basis of the reception of two antiskeptical types of reasoning in ancient philosophy (Plato, Parmenides 135b-c; Cicero, Lucullus § 28) by a contemporary philosophical author (Karl-Otto Apel). Plato puts forward a transcendental argument for the inevitability of a final knowledge. Cicero argues that a principle (...) of fallibilism occurring with universal claim contradicts itself. In Karl-Otto Apel's transcendental pragmatic variant of philosophy, the two types of self-refutation arguments developed in Plato's and Cicero's dialogues are brought together into a single argumentation. (shrink)

Two seemingly contradictory tendencies have accompanied the development of the natural sciences in the past 150 years. On the one hand, the natural sciences have been instrumental in effecting a thoroughgoing transformation of social structures and have made a permanent impact on the conceptual world of human beings. This historical period has, on the other hand, also brought to light the merely hypothetical validity of scientific knowledge. As late as the middle of the 19th century the truth-pathos in the natural (...) sciences was still unbroken. Yet in the succeeding years these claims to certain knowledge underwent a fundamental crisis. For scientists today, of course, the fact that their knowledge can possess only relative validity is a matter of self-evidence. The present analysis investigates the early phase of this fundamental change in the concept of science through an examination of Hermann von Helmholtz's conception of science and his mechanistic interpretation of nature. Helmholtz (1821-1894) was one of the most important natural scientists in Germany. The development of this thoughts offers an impressive but, until now, relatively little considered report from the field of the experimental sciences chronicling the erosion of certainty. (shrink)

The so-called ”argument from religious experience’ plays a prominent role in today’s analytical philosophy of religion. It is also of considerable importance to richard Swinburne’s apologetic project. However, rather than joining the polyphonic debate around this argument, the present paper examines the fundamental concept of religious experience. The upshot is that Swinburne neither develops a convincing concept of experience nor explains what makes a religious experience religious. The first section examines some problems resulting mainly from terminology, specifically Swinburne’s use of (...) appear-words as success-verbs. While these problems might be resolved by a recurrence to the observer, the second and third part of our paper present problems not so easily resolved: namely, that Swinburne’s concept of experience as conscious mental events is too broad and inaccurate for its role in the argument given ; and that Swinburne does not even attempt to figure out which features of an experience, when present, turn an experience simpliciter into a distinctly religious experience. Section 4, in conclusion, outlines possible reasons for this unusual and remarkable inaccuracy in conceptualisation. (shrink)

As opposed to a ‘one size fits all’ approach, precision medicine uses relevant biological, medical, behavioural and environmental information about a person to further personalize their healthcare. This could mean better prediction of someone’s disease risk and more effective diagnosis and treatment if they have a condition. Big data allows for far more precision and tailoring than was ever before possible by linking together diverse datasets to reveal hitherto-unknown correlations and causal pathways. But it also raises ethical issues relating to (...) the balancing of interests, viability of anonymization, familial and group implications, as well as genetic discrimination. This article analyses these issues in light of the values of public benefit, justice, harm minimization, transparency, engagement and reflexivity and applies the deliberative balancing approach found in theEthical Framework for Big Data in Health and Research to a case study on clinical genomic data sharing. Please refer to that article for an explanation of how this framework is to be used, including a full explanation of the key values involved and the balancing approach used in the case study at the end. Our discussion is meant to be of use to those involved in the practice as well as governance and oversight of precision medicine to address ethical concerns that arise in a coherent and systematic manner. (shrink)

Ordinary language and scientific discourse are filled with linguistic expressions for dispositional properties such as “soluble,” “elastic,” “reliable,” and “humorous.” We characterize objects in all domains – physical objects as well as human persons – with the help of dispositional expressions. Hence, the concept of a disposition has historically and systematically played a central role in different areas of philosophy ranging from metaphysics to ethics. The contributions of this volume analyze the ancient foundations of the discussion about disposition, examine the (...) problem of disposition within the context of the foundation of modern science, and analyze this dispute up to the 20th century. Furthermore, articles explore the contemporary theories of dispositions. (shrink)

Indem dieser Band sich auf das Verhältnis von Naturerkennen und Natursein konzentriert, thematisiert er einen wesentlichen Ausschnitt aus dem weiten Spektrum von Böhmes philosophischer Arbeit. Um die Naturthematik möglichst breit zu entfalten und für Querverbindungen offenzuhalten, ist der vorliegende Band in drei Abschnitte gegliedert. Im ersten Abschnitt stehen Charakter und Reichweite der wissenschaftlichen Erkenntnis von Natur im Mittelpunkt. Der zweite Teil des Bandes stellt alternative Perspektiven auf Natur vor. Im dritten Teil schließlich stehen der Mensch und sein Verhältnis zu sich (...) selbst im Mittelpunkt der Untersuchungen. Inhaltsverzeichnis Krohn, Wolfgang: Wissenschaftsentwicklung zwischen Dezentrierung und Dekonstruktion. Stehr, Nico: Von den Grenzen der Macht wissenschaftlicher Erkenntnis. Schäfer, Wolf: Zweifel am Ende des Baconschen Zeitalters. Kamper, Dietmar: Wissen ist Ohnmacht. Macht ist Unwissen. Gamm, der Technik. Janich, Peter: Zeit und Natur. Kimmerle, Heinz: »Es ist Zeit, daß es Zeit wird«. Wie kann Zeit Zeit werden? Schiemann, Gregor: Natur auf dem Rückzug. Zur Relevanz der aristotelischen Unterscheidung von Natur und Technik. Hauskeller, Michael: Ist Schönheit eine Atmosphäre?. Zur Bestimmung des landschaftlich Schönen. Schmitz, Hermann: Situationen und Atmosphären. Zur Ästhetik und Onthologie bei Gernot Böhme. Rehmann-Sutter, Christoph: Über Relationalität. Was ist das »Ökologische« in der Naturästhetik? Meyer-Abich, Klaus Michael: Erinnerung an die natürliche Mitwelt. Andreas-Griesebach, Manon: Idee plus Erfahrung. Goethes Begründung eines neuen Typs von Naturwissenschaft. Engelhardt, Dietrich von: Madame de Stael über Naturphilosophie, Naturwissenschaft und Medizin in De l'Allemagne. Deneke, Michael: Schramm, Engelbert: »Soziale Naturwissenschaft«. Zwischen Sozialwissenschaften und Naturwissenschaften. Böhme, Hartmut: Enthüllen und Verhüllen des Körpers. Biblische, mythische und künstlerische Deutungen des Nackten. Lippe, Rudolf zur: Eine Logik des gestischen Wissens. Müller, Rudolf Wolfgang: Gernot Böhme - Anima naturaliter japonica. Hoffmann, Gisbert: Das menschliche Sein als mediales. Martens, Ekkehard: »Natürlich« denken?. Heideggers Pseudosokratismus als Irrationalismus. Fleischer, Helmut: Naturalität ohne Naturalismus. Zum lebensweltlichen Fundus jeder höheren Erkenntnis-Artistik. Gerhard: Technik als Medium. Grundlinien einer Philosophie. (shrink)

Limits of the Conversation about Forms. Types of Knowledge and Necessity of Forms in Plato's "Parmenides". - Forms (ideas) are among the things that Plato is serious about. But about these things he says in his "Seventh Letter": "There neither is nor ever will be a treatise of mine on the subject." (341c, transl. J. Harward). Plato's statement suggests the question, why one does not and never can do justice to the Platonic forms by means of a written text about (...) the forms. Another big question of Plato research is whether the conversations documented in the Platonic dialogues are also affected by this verdict. This paper aims to provide, as far as possible, newly substantiated answers to these two questions. To this end, the systematic limits of the discussion about forms, which are particularly evident in Plato's dialogue "Parmenides", are examined in eight steps: First, two types of knowledge are presented that play an important systematic role in Plato's philosophy with regard to the limits of conversation: knowledge-how (practical knowledge) and knowledge-that (propositional knowledge) (I). Then the Socratic model of these two types of knowledge is interpreted, which is drafted in the tenth book of the "Republic". This model uses the example of bridle, bridlemaker and rider to explain the primacy of practical knowledge and the limits of propositional knowledge (II). Subsequently, it will be shown how the dialogues "Republic" and "Parmenides" are connected with each other in content and form (III). The gradation of the two types of knowledge, which is indicated by the motifs of the bridle and the horse on the image level of the "Parmenides", proves to be the structure that systematically underlies the structure of the entire dialogue (IV). It also makes clear why the conversation about the forms in the first part of the "Parmenides" has to fail (V). The assumption that the two parts of the "Parmenides" express two different types of knowledge in dealing with forms is supported by the results of a logical analysis of the last defence of the acceptance of forms (135b-c). This analysis shows why, for reasons of principle, it is impossible to speak adequately about forms (VI). Forms have the function of being presuppositions of 'talking about something'. Thus forms are always presupposed in conversation when one talks about them, and thus elude appropriate discussion in conversation (VII). That this is not only a methodical insight of the Platonic Parmenides, but can also be attributed to Plato himself, is demonstrated by the concluding reinterpretation of the central sentence of the critique of writing in Plato's "Seventh Letter". It will become apparent that, contrary to the now widespread view of the representatives of the Tübingen school, philosophical and also good philological reasons speak for the fact that Plato related his criticism only to the communicability of forms through treatises, i.e. tract-like writings (VIII). (shrink)

What role should legislation or policy play in avoiding the complications of in-vitro fertilization? In this article, we focus on single versus double embryo transfer, and assess three arguments in favour of mandatory single embryo transfer: risks to the mother, risks to resultant children, and costs to society. We highlight significant ethical concerns about each of these. Reproductive autonomy and non-paternalism are strong enough to outweigh the health concerns for the woman. Complications due to non-identity cast doubt on the extent (...) to which children are harmed. Twinning may offer an overall benefit rather than burden to society. Finally, including the future health costs for children in reproductive policy is inconsistent with other decisions. We conclude that mandatory single embryo transfer is not justified and that a number of countries should reconsider their current embryo transfer policy. (shrink)

"Language and its Public Features: Reorganizing the Trivium in Locke's Essay and Port-Royal Logic" The new theory of language in the 17th century coincides with the end the traditional order of disciplines in the trivium (grammar, logic and rhetoric), which in the mediaeval times provided a comprehensive view of the problems of discourse. The article focuses on some key passages in Port-Royal Logic and Locke's Essay that provide us with a typical early modern scheme of linguistic representation, characterised by heavily (...) emphasized dualism of ideas and words. Since ideas are also the meanings of words and are ontologically essentially private, one can raise the question, where in this analysis of language is it even possible to locate its public features. The article tries to show that private language is not only possible for Locke and the Port-Royalists, but that it is even a necessary and primary character of language. Language becomes a public medium of communication only on the junctures of private meanings constituted by the “common use” of words. The article then focuses on almost complete marginalisation in the two works of the theory of public speech. Rhetoric, in the 17th century often reduced to mere eloquence, has no place in philosophy, and the duties of making speeches persuasive are taken over by reason alone. To show how the domains of jurisdiction of the trivial disciplines had been transformed in the linguistic theories proposed by the Port-Royal Logic and Locke, one can construct a hypothetical early modern trivium in the light of the following order: idea – word – figure, or, logic – grammar – rhetoric. Rhetoric is found to have kept its structural place only to be singled out as dangerous. (shrink)

The COVID-19 pandemic revealed numerous weaknesses in pandemic preparedness and response, including underfunding, inadequate surveillance, and inequitable distribution of countermeasures. To overcome these weaknesses for future pandemics, WHO released a zero draft of a pandemic treaty in February, 2023, and subsequently a revised bureau's text in May, 2023. COVID-19 made clear that pandemic prevention, preparedness, and response reflect choices and value judgements. These decisions are therefore not a purely scientific or technical exercise, but are fundamentally grounded in ethics. The latest (...) treaty draft reflects these ethical considerations by including a section entitled Guiding Principles and Approaches. Most of these principles are ethical—they establish core values that undergird the treaty. Unfortunately, the treaty draft's set of principles are numerous, overlapping, and show inadequate coherence and consistency. We propose two improvements to this section of the draft pandemic treaty. First, key guiding ethical principles should be clearer and more precise than they currently are. Second, the link between ethical principles and policy implementation should be clearly established and define boundaries on acceptable interpretation, ensuring that signatories abide by these principles. (shrink)

Suppose a fire broke out in a fertility clinic. One had time to save either a young girl, or a tray of ten human embryos. Would it be wrong to save the girl? According to Michael Sandel, the moral intuition is to save the girl; what is more, one ought to do so, and this demonstrates that human embryos do not possess full personhood, and hence deserve only limited respect and may be killed for medical research. We will argue, however, (...) that no relevant ethical implications can be drawn from the thought experiment. It demonstrates neither that one always ought to let the embryos die, nor does it allow for any general conclusion concerning the moral status of human embryos. (shrink)

Introduction to Debating Dispositions. Issues in Metaphysics, Epistemology, and Philosophy of Mind, ed. by Gregor Damschen, Robert Schnepf, and Karsten R. Stueber, Berlin/New York: de Gruyter 2009.

Gregor Schiemann führt allgemeinverständlich in das Denken dieses Physikers ein. Thema sind die Erfahrungen und Überlegungen, die Heisenberg zu seinen theoretischen Erkenntnissen geführt haben, die wesentlichen Inhalte dieser Erkenntnisse sowie die Konsequenzen, die er daraus für die Geschichte der Physik und das wissenschaftliche Weltbild gezogen hat. Heisenbergs Vorstellungswelt durchzieht durch ein Spannungsverhältnis, das heute noch das Denken vieler Wissenschaftlerinnen und Wissenschaftler bewegt. Er ist um ein umfassendes Verständnis der Naturprozesse bemüht, zugleich aber von der Berechenbarkeit und Beherrschbarkeit von Phänomenen (...) auch dann schon fasziniert, wenn die zugrunde liegenden Prozesse erst teilweise verstanden sind. Aus der Geschichte der Physik zieht er die wirkungsreiche Lehre, daß sich die naturwissenschaftliche Erkenntnis nicht kontinuierlich, sondern sprunghaft in Form von Revolutionen entwickelt. Die Reichweite des physikalischen Wissens begrenzt er in einer Schichtentheorie der Welt, nach der die komplexen Phänomene des Lebens nicht allein durch die Wechselwirkungen zwischen ihren Bestandteilen erklärt werden können. Der zunehmenden Technisierung der Welt steht Heisenberg kritisch gegenüber. Seiner Zeit weit voraus, glaubt er, daß die Technisierung der Welt eine epochal neue Stufe erreicht habe, in der der Mensch „nur noch sich selbst“ gegenüberstehe. (shrink)

It can be said that Rousseau is one of the most acute thinkers of the corruption of civilisation. In fact, the Second Discourse and the Essay on the Origins of Languages could be read as elaborate analyses of advancing social and cultural decline inasmuch as mankind is continually moving away from the original state of natural innocence. But Rousseau’s idea of corruption is not straightforward. I try to show that in the Essay, Rousseau emphasizes the natural causes for corruption. I (...) argue that an opposition between necessity and contingency, which more accurately represents the two modes operating in Rousseau’s doctrine, should replace the standard nature/culture divide. The contingency of natural catastrophes is found to be ultimately responsible for the corruption in the social realm, which is therefore largely driven by natural causes. (shrink)

Descartes and Architecture -/- The article analyses the architectural metaphor in Descartes' Discourse on Method and The Seventh replies. The idea of Descartes' project, introduced to the reader as a construction of a building and planning of a city, is much more indebted to its architectural imagery than, or so its critics say, is "sound" for a philosophical theory. Architecture is an analogon of philosophy in Descartes' texts. By producing a figure of philosopher-architect, Descartes tries to legitimate his philosophical theory (...) using architectural discourse. Descartes always uses the examples of architecture and urban planning when he intends to introduce his great project of a new beginning in philosophy. This new beginning is manifest in two levels: first, as a denial of traditional metaphysics of the Schools in the Discourse, and second, as a denial of one’s own beliefs in the Meditations using methodical doubt. In the conclusion, the article emphasises through Derrida's analysis of metaphor that, given the metaphysical nature of any metaphor, Descartes’ metaphor also cannot appear as a mere rhetorical figure. (shrink)

"Dieu fainéant? God and Bodies in Descartes, Malebranche, and Leibniz" Conservation, concurrence with secondary causes, and occasionalism are the three attitudes that God can have towards the created universe in early modern philosophy. The aim of this article is to show how and in what forms these three originally mediaeval theories had survived the seventeenth century in Descartes, Malebranche, and Leibniz. I argue that although it cannot always be unequivocally determined which of the three doctrines each of the thinkers is (...) indebted to, Descartes should nevertheless be interpreted as a concurrentist, Malebranche as an occasionalist, and Leibniz can be read as a mere conservationist. The conservation of substances in existence being nothing but a continual creation, we claim (against the famous thesis of Alexandre Koyré) that Leibniz’s God can be called neither Dieu fainéant nor God of the Sabbath day. (shrink)

When in doubt, for the embryo. New arguments on the moral status of human embryos. - In the first part of our essay we distinguish the philosophical from the legal and political level of the embryo debate and describe our indirect justification strategy. It consists in renouncing a determination of the dignity-giving φ-properties and instead starting from premises that are undoubted by all discussion partners. In the second part we reconstruct and criticize the species, continuum, identity and potentiality arguments. The (...) species argument only has a certain plausibility, if at all, as a critical argument. From the continuum argument and identity argument we take over the idea of numerical identity (NI) and link it with the core idea of the potentiality argument (P). So we come to the NIP argument: -/- (NIP) -/- (1) Every living human body that is the bearer of (or has) potential φ-properties has dignity. (2) Every viable human embryo is a living human body that is the bearer of (or has) potential φ properties. Therefore, (3) Every viable human embryo has dignity. -/- Reversibly comatose people and newborns are protected because they have the potential to have actual personal characteristics in the future; our thesis is that embryos that are capable of development also have the same potential in moral terms. The basic idea of numerical identity, with which we support the second premise, is that every human being, from embryonic existence to adulthood, forms a physical unity. In a detailed part, we deal with the crown princess, gametes, parthenogenesis, somatic cell, pronuclear stage, biological heteronome early embryo, multiple, fusion, Siamese twin, hydatidiform mole and finally trophoblast problems. In a third part, the indirect argument is supplemented by a metatheoretical cautionary argument. It states that in situations where there is doubt as to whether a being falls within the scope of a moral norm, but there are sufficiently strong reasons for this subsumption, it must be assumed that this is the case if the contrary assumption and the positive effects it may have are in no acceptable proportion to the moral harm that would result if that subsumption were not made. The main result of our considerations is therefore: When in doubt, for the embryo. (shrink)

Mitochondrial replacement therapy requires oocytes of women whose mitochondrial DNA will be transmitted to resultant children. These techniques are scientifically, ethically and socially controversial; it is likely that some women who donate their oocytes for general in vitro fertilisation usage would nevertheless oppose their genetic material being used in MRT. The possibility of oocytes being used in MRT is therefore relevant to oocyte donation and should be included in the consent process when applicable. In present circumstances, specific consent should be (...) obtained. However, once MRT becomes more routine, such consent could be incorporated into the general consent process for oocyte donation. The reported lack of proper consent for MRT from the oocyte donor in the first baby born via the technique is an ethical failing and should be corrected in any future practice of MRT. (shrink)

Background Several jurisdictions, including Singapore, Australia, New Zealand and most recently Ireland, have a public interest or public good criterion for granting waivers of consent in biomedical research using secondary health data or tissue. However, the concept of the public interest is not well defined in this context, which creates difficulties for institutions, institutional review boards and regulators trying to implement the criterion. Main text This paper clarifies how the public interest criterion can be defensibly deployed. We first explain the (...) ethical basis for requiring waivers to only be granted to studies meeting the public interest criterion, then explore how further criteria may be set to determine the extent to which a given study can legitimately claim to be in the public interest. We propose an approach that does not attempt to measure magnitude of benefit directly, but rather takes into account metrics that are more straightforward to apply. To ensure consistent and justifiable interpretation, research institutions and IRBs should also incorporate procedural features such as transparency and public engagement in determining which studies satisfy the public interest requirement. Conclusion The requirement of public interest for consent waivers in secondary biomedical research should be guided by well-defined criteria for systematic evaluation. Such a criteria and its application need to be periodically subject to intra-committee and intra-institution review, reflection, deliberation and amendment. (shrink)

It is generally unquestioned that human subjects research review boards should assess the ethical acceptability of protocols. It says so right on the tin, after all: they are explicitly called research ethics committees in the UK. But it is precisely those sorts of unchallenged assumptions that should, from time to time, be assessed and critiqued, in case they are in fact unfounded. John Stuart Mill's objection to suppressers of dissent is instructive here: “If the opinion is right, they are deprived (...) of the opportunity of exchanging error for truth: if wrong, they lose, what is almost as great a benefit, the clearer perception and livelier impression of truth, produced by its collision with error”.1 Andrew Moore and Andrew Donnelly's compelling article, “The job of ‘ethics committees’”, is just this sort of challenge to conventional wisdom, a rejection of the notion that review boards should be considering ethical matters at all.2 If true, we should be substantially reforming our research ethics policies. And if false, rebuttals would help strengthen and ground the otherwise unquestioned assumption of the role of ethics committees. As it happens, I will argue that their critiques fall into the second category. While mistaken, they present a valuable opportunity to clarify the role of ethics committees and their relationship to relevant codes. In particular, I will defend a hybrid account where codes have strict primacy, but leave significant room for review boards …. (shrink)

Soweit Engels' Position zum Geltungsanspruch der Naturwissenschaften seiner Zeit aus diesen Texten hervorgeht, kann man sie kaum als konsistent bezeichnen. Erkenntnisse, an deren Gewissheit in der Naturforschung der zweiten Hälfte des 19. Jahrhunderts nicht ernsthaft gezweifelt wurde, werden von ihm teils umstandslos übernommen, teils aber auch einer geltungskrltischen Analyse unterzogen. In weitgehender Unahängigkeit von seinen weltanschaulichen Ambitionen kommt Engels über die Untersuchung der Struktur naturwissenschaftlicher Erkenntnisprozesse zu einer bisher erst wenig beachteten und seiner Zeit vorauseilenden Einsicht in die relativen Geltungsbedingungen (...) des experimentell erzeugten Wissens. Die widersprüchliche Form,in der er seine heute noch sehr aktuelle Kritik am Wahrheitsanspruch der Naturwissenschaften vorträgt, ist der damaligen Umbruchssituation dieser Disziplinen geschuldet und gibt seinem Werk ein hohes Mass an Authentizität. In Anlehnung an Engels' Klassifizierung der Wissenschaften sollen hier die wichtigsten geltungskritischen Ansätze rekonstruiert werden. In dieser Perspektive, die seine Skepsis gegenüber den naturwissenschaftlichen Erkenntnisleistungen hervortreten lässt, erscheint die von ihm behauptete ausgezeichnete Geltung der Dialektik in einem neuen Licht: Sie ist nicht mehr die immer schon vorausgesetzte Grundannahme seiner wissenschafts- und naturtheoretischen Auffassungen, sondern Reaktion auf einen Relativismus, der aus der Reflexion über die Entwicklung der Naturforschung unabweisbar zu folgen scheint und jedes Streben nach einem wissenschaftlich fundierten, einheitlichen Naturbild zunichte macht. (shrink)

Volume 19, Issue 7, July 2019, Page 28-30.

With the recent report of a live birth after use of Mitochondrial replacement therapy, sometimes called ‘Three-parent IVF’, the clinical application of the technique is fast becoming a reality. While the United Kingdom allows the procedure under regulatory scrutiny, it remains effectively outlawed in many other countries. We argue that such prohibitions may violate individuals’ procreative rights, grounded in individuals’ interest in genetic affinity. The interest in genetic affinity was recently endorsed by Singapore’s highest court, reflecting an emphasis on the (...) importance of biological ties found across the globe. We apply that reasoning to make the case for a right to ‘Three-parent IVF’. (shrink)

This commentary examines the role of sustainability in the latest draft of the WHO pandemic accord, highlighting its notable absence from the official list of guiding principles despite being mentioned frequently throughout the text. It argues that sustainability should be explicitly acknowledged as a core principle and given a clear definition tailored to pandemic preparedness, and proposes defining sustainability as ensuring that immediate emergency responses don't compromise future pandemic preparedness and response capabilities. Including sustainability as a guiding principle would serve (...) two key purposes: validating the relevance of ethical principles in the accord's provisions and emphasizing the importance of long-term planning in pandemic preparedness. The commentary notes that while humans naturally discount future consequences, sustainable pandemic planning requires considering impacts beyond the next pandemic. It recommends coupling any reforms, such as intellectual property changes, with alternative innovation incentives to maintain a balanced approach to pandemic preparedness and response. (shrink)

How does microbiota research impact our understanding of biological individuality? We summarize the interdisciplinary summer school on "Microbiota, Symbiosis and Individuality: Conceptual and Philosophical Issues" (July 2019), which was supported by a European Research Council starting grant project "Immunity, DEvelopment, and the Microbiota" (IDEM). The summer school centered around interdisciplinary group work on four facets of microbiota research: holobionts, individuality, causation, and human health. The conceptual discussion of cutting-edge empirical research provided new insights into microbiota and highlights the value of (...) incorporating into meetings experts from other disciplines, such as philosophy and history of science. (shrink)

Do the changes that have taken place in the structures and methods of the production of scientific knowledge and in our understanding of science over the past fifty years justify speaking of an epochal break in the development of science? Gregor Schiemann addresses this issues through the notion of a scientific revolution and claims that at present we are not witnessing a new scientific revolution. Instead, Schiemann argues that after the so-called Scientific Revolution in the sixteenth and seventeenth centuries, (...) a caesura occurred in the course of the nineteenth century that constituted a departure from the early modern origins of science. This change was characterized by the loss of certainty on the part of the scientists, by the steadily increasing importance of scientific communities (rather than individuals), and by the systematic intertwinement of scientific and societal development. As to present science, Schiemann admits that important changes have occurred, but he denies the conflation of nature and culture: even the OncoMouse is a natural organism, though a seriously damaged one. (shrink)

The principle of performative contradiction. On the epistemological significance of the dialogue form in Plato's "Euthydemus". - In this study, an analysis of the section 285d-288a of Plato's "Euthydemus" shall show two things: (1) The sophistic model of a world in which there is no contradiction, in which every linguistic utterance is true and every action correct, has no semantic inconsistencies, but can only be rejected with the help of the principle of performative contradictions. (2) It is precisely these performative (...) contradictions that make it necessary for Plato to philosophize not in treatises but in dialogues; in other words, that the philosophical relevance of the Platonic form of dialogue can be seen, among other things, in the fact that - in contrast to philosophical forms of representation such as the treatise, the essay, and a henology as reconstructed and represented by the Tübingen School - it permits the representation of performative reflections and performative contradictions. (shrink)

The Contingency Postulate of Truth. - Is there a statement that cannot be false under any contingent conditions? Two well-known philosophical schools have given contradictory answers to this question about the existence of a necessarily true statement: Fallibilists (Albert, Keuth) have denied its existence, transcendental pragmatists (Apel, Kuhlmann) and objective idealists (Wandschneider, Hösle) have affirmed it. Dieter Wandschneider has (following Vittorio Hösle) translated the principle of fallibilism, according to which every statement is fallible, into a thesis which he calls the (...) contingency postulate of truth (CPT). It says: <For every true statement there are contingent conditions.> If this postulate were true, it would mark an insurmountable boundary of knowledge: a final epistemic justification would then not be possible. Wandschneider has therefore developed a counterargument to show that the contingency postulate of truth cannot be formulated without contradiction and implies the thesis that there is at least one necessarily true statement. This essay deals with the systematic question whether the contingency postulate of truth really cannot be presented without contradiction. To this end I will first present the contingency postulate and the associated problems (I.). Then I will analyze Wandschneider's argument against the consistency of the contingency postulate (II.) and finally reject it with the help of some considerations from the field of epistemic logic (III.). (shrink)

In his "Ontological proof", Kurt Gödel introduces the notion of a second-order value property, the positive property P. The second axiom of the proof states that for any property φ: If φ is positive, its negation is not positive, and vice versa. I put forward that this concept of positiveness leads into a paradox when we apply it to the following self-reflexive sentences: (A) The truth value of A is not positive; (B) The truth value of B is positive. Given (...) axiom 2, sentences A and B paradoxically cannot be both true or both false, and it is also impossible that one of the sentences is true whereas the other is false. (shrink)

Definition, conditions and bearers of being a person - three philosophical aporias. -/- In this article I examine the philosophical question of how to define the concept of the person in a non-arbitrary way, how to find out the determining conditions of being a person and how to enumerate the bearers of being a person. I come to the conclusion that the question of a non-arbitrary definition, of the essential conditions and of the bearers of being a person has not (...) yet been clarified; it is not sufficiently clear what we actually mean or should mean by "person" - beyond conventions, disciplinary boundaries and doctrines. This results in three philosophical aporias of the concept of the person. (shrink)

God's necessary existence makes sense. Attempt at a transcendental modal proof. - In this essay I outline a novel three-stage proof of God's necessary existence using transcendental and deductive methods. In the first step of the proof, by retorsion, it is proved that there is at least one sentence that is necessary and inescapable. In the second step, the inescapability of the modal logic supposed in the proof is shown. This step also contains a new argument in favour of epistemic (...) anti-realism. The third step finally proves the necessary existence of the person who proves. The proof thus refers to the subject, the object, and the method of this proof itself. (shrink)

Autologos. A dialogue on fundamental logic. - In this dialogue of three dialogue partners, an attempt is made to prove the logical prerequisites of any meaningful dialogue by using transcendental arguments. Among these inescapable logical premises are a semantics as strong as that of modal logic S5, and an epistemic anti-realism.

Can we find propositions that cannot rationally be denied in any possible world without assuming the existence of that same proposition, and so involving ourselves in a contradiction? In other words, can we find transworld propositions needing no further foundation or justification? Basically, three differing positions can be imagined: firstly, a relativist position, according to which ultimately founded propositions are impossible; secondly, a meta-relativist position, according to which ultimately founded propositions are possible but unnecessary; and thirdly, an absolute position, according (...) to which such propositions are necessary. In this short essay I show that under the premise of modal logic S5 with constant domain there are ultimately founded propositions and that their existence is even necessary, and I will give some reasons for the superiority of S5 over other logics. (shrink)

Is knowledge-that a species of knowledge-how? - How is knowledge-how related to knowledge-that? Three possible answers are: (A1) intellectualism: knowledge-how is a subspecies of knowledge-that. (A2) Rylean account: knowledge-how and knowledge-that are completely distinct. (A3) anti-intellectualism: knowledge-that is a subspecies of knowledge-how. In this essay I present a new anti-intellectualist reductio argument that shows that answer A3 is true: knowledge-that is a subspecies of knowledge-how.