The COVID-19 pandemic prompted immense work on the investigation of the SARS-CoV-2 virus. Rapid, accurate, and consistent interpretation of generated data is thereby of fundamental concern. Ontologies––structured, controlled, vocabularies––are designed to support consistency of interpretation, and thereby to prevent the development of data silos. This paper describes how ontologies are serving this purpose in the COVID-19 research domain, by following principles of the Open Biological and Biomedical Ontology (OBO) Foundry and by reusing existing ontologies such as the Infectious Disease Ontology (...) (IDO) Core, which provides terminological content common to investigations of all infectious diseases. We report here on the development of an IDO extension, the Virus Infectious Disease Ontology (VIDO), a reference ontology covering viral infectious diseases. We motivate term and definition choices, showcase reuse of terms from existing OBO ontologies, illustrate how ontological decisions were motivated by relevant life science research, and connect VIDO to the Coronavirus Infectious Disease Ontology (CIDO). We next use terms from these ontologies to annotate selections from life science research on SARS-CoV-2, highlighting how ontologies employing a common upper-level vocabulary may be seamlessly interwoven. Finally, we outline future work, including bacteria and fungus infectious disease reference ontologies currently under development, then cite uses of VIDO and CIDO in host-pathogen data analytics, electronic health record annotation, and ontology conflict-resolution projects. (shrink)

The COVID-19 pandemic prompted immense work on the investigation of the SARS-CoV-2 virus. Ontologies – structured, controlled, vocabularies – are designed to support consistency of interpretation, and thereby to prevent the development of data silos. This paper describes how ontologies are serving this purpose in the virus research domain, following the principles of the Open Biological and Biomedical Ontology (OBO) Foundry and drawing on the resources of the Infectious Disease Ontology (IDO) Core. We report the development of the Virus Infectious (...) Disease Ontology (VIDO), a reference ontology extending IDO Core covering viral infectious diseases. We examine newly minted terms, showcase ontology term reuse, and illustrate the use of VIDO by annotating selections from recent life science research on SAR-CoV-2, in the interest of supporting machine learning projects. (shrink)

‘‘COGNITIVE ECOLOGY’’ is a fruitful model for Shakespearian studies, early modern literary and cultural history, and theatrical history more widely. Cognitive ecologies are the multidimensional contexts in which we remember, feel, think, sense, communicate, imagine, and act, often collaboratively, on the fly, and in rich ongoing interaction with our environments. Along with the anthropologist Edwin Hutchins,1 we use the term ‘‘cognitive ecology’’ to integrate a number of recent approaches to cultural cognition: we believe these approaches offer productive lines of engagement (...) with early modern literary and historical studies.2 The framework arises out of our work in extended mind and distributed cognition.3 The extended mind hypothesis arose from a post-connectionist philosophy of cognitive science. This approach was articulated in Andy Clark’s Being There: Putting Brain, Body, and World Together Again, and further developed by Susan Hurley and Mark Rowlands, among others.4 The distributed cognition approach arose independently, from work in cognitive anthropology, HCI (Human-Computer Interaction), the sociology of education and work, and science studies. The principles of distributed cognition were articulated in Hutchins’s ethnography of navigation, Cogni- tion in the Wild,5 and developed by theorists such as David Kirsh and Lucy Suchman.6 These models share an anti-individualist approach to cognition. In all these views, mental activities spread or smear across the boundaries of skull and skin to include parts of the social and material world. In remembering, decision making, and acting, whether individually or in small groups, our complex and structured activities involve many distinctive dimensions: neural, affective, kines-. (shrink)

This introductory chapter provides an overview of the recent debate about responsibility and distributive justice. It traces the recent philosophical focus on distributive justice to John Rawls and examines two arguments in his work which might be taken to contain the seeds of the focus on responsibility in later theories of distributive justice. It examines Ronald Dworkin's ‘equality of resources’, the ‘luck egalitarianism’ of Richard Arneson and G. A. Cohen, as well as the criticisms of their work put forward (...) by Elizabeth Anderson, Marc Fleurbaey, Susan Hurley, and Jonathan Wolff. Key concepts such as responsibility (individual and collective), luck (thin and thick; brute and option), control, desert, and equality of opportunity are delineated, and the implementation of responsibility-sensitive accounts of justice is considered. The chapters of this book are positioned in relation to the wider literature on responsibility and distributive justice, and a brief outline of the chapters is provided. (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE OS TRANSTORNOS DO CICLO ESTRAL DE VACAS -/- Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 -/- •__6. Transtornos do ciclo estral -/- Qualquer alteração na frequência, duração ou intensidade do ciclo estral é considerada uma perturbação do ciclo, cujas origens variam etiologicamente. As perturbações do ciclo podem originar-se em qualquer das partes do eixo hipotálamo-hipófise-ovário (FRAZER, 2005; GORDON, 1996). Pode ou não ser do tipo (...) permanente e pode depender de sua origem, momento e intensidade cursar com outras alterações reprodutivas, por exemplo uma retenção do corpo lúteo, dá lugar a prolongamento da fase lútea, altos níveis de progesterona circulante e pode, finalmente, desencadear em um cisto luteal ou em uma metrite. Entre os fatores desencadeadores da falha do ciclo estral estão os fatores de origem nutricional, dentre eles: 6.1 Minerais 6.1.1 Relação Na:K (Sódio: Potássio) A deficiência de sódio pode causar distúrbios do ciclo estral, isto porque as células animais intracelularmente possuem uma alta concentração de K e uma baixa concentração de Na, esta relação pode chegar a 10:1 ou mais, em relação ao meio externo. Com esta relação, as concentrações intracelulares estão em equilíbrio com o meio externo. A absorção e secreção de cátions pela célula para conseguir o equilíbrio é simultânea, gerada por um sistema de transporte específico chamado "bomba Na-K". Se a nível celular não existe um balanço iônico de K:Na, a maior prioridade das células tubulares do rim é a de conseguir novamente um equilíbrio, o mecanismo destas células é o da reabsorção do íon que se encontre em excesso de água, diminuindo a quantidade deste no líquido para manter as funções em equilíbrio dinâmico. Os desequilíbrios não compensados a nível celular ou renal, levam a alterações na condutividade nervosa por alteração da bomba de transmissão elétrica. O ciclo estral é alterado por diminuir a expressividade dos sinais comportamentais de estro, que são produzidos por concentrações crescentes de estrogênio mas com alta necessidade de adequação nervosa para a exposição corporal do cio e a aceitação da monta. O potássio, em particular, desempenha um papel fundamental como coator em certas interações enzimáticas, incluindo a transferência de energia, a síntese de proteínas e o metabolismo de hidratos de carbono, em especial nos sistemas em que o ADP está envolvido, as hexoquinases e a anidrase carbônica. O sódio, por sua vez, é o principal cátion extracelular, regula o equilíbrio hídrico no organismo e a mecânica de fluidos, desta forma regula a pressão osmótica e a troca aquosa nos tecidos. Devido a esta função, um dos fatores importantes do fluxo Na:K é o rim, que é controlado pela aldosterona, a principal hormona reguladora da absorção de sódio e excreção de potássio. Qualquer desequilíbrio na relação Na:K, afetará o ciclo estral, de maneira direta e indireta, através da alteração na síntese de proteínas e da perda da regulação hídrica, fator importante pelas secreções que devem acompanhar as manifestações de cio/estro. 6.1.2 Relação Cobalto (Co) A deficiência de cobalto gera um efeito biológico determinado pela sua presença na molécula da vitamina B12, a qual regula a hematopoese (Ativa a síntese de protoporfirina) e afeta o metabolismo do nitrogênio e dos carboidratos. A vitamina B12 atua como uma coenzima da transmetilação (síntese do glutamato mutase, metilmalonil-CoA-Mutase, diol-dehidratase e redução dos ribonucleótidos a desoxirribonucleótidos, isomerização da a-lisina, etc.). Especialmente em ruminantes, a reação mutase da metilmalonina-CoA está relacionada com o metabolismo do ácido propiônico e, portanto, com a síntese de glicose e o equilíbrio energético. O cobalto também está envolvido na carboxilação da propionil-CoA à metilmalonil-CoA e na isomerização deste último para succinil-CoA. O metabolismo do ácido propiônico ocorre no fígado e é reduzido pelo fato do metilmalonil não poder ser convertido em succinil-CoA, impedindo a sua passagem para oxalacetato e glicose, gerando uma relação inversa entre os níveis de energia e proteína; causando uma diminuição de GnRH que afeta negativamente a liberação de LH que, por sua vez, cria um aumento na FSH. Isso produz uma anulação da ovulação e, consequentemente, ausência de um ciclo estral verdadeiro. Vale reforçar que, para prevenção da deficiência do cobalto, o criador pode optar pelo fornecimento de volumosos que dispõem de quantidades de cobalto que suprem as exigências dos animais, ou pela inserção de sais de cobalto à mistura da ração, sempre no intervalo sugerido de 0,07 e 0,11 mg/kg para cada animal, suprindo a necessidade do mesmo e garantindo assim a prevenção dos transtornos do ciclo estral ou outras afecções do sistema reprodutivo. 6.1.3 Relação Cobre (Cu) e Molibdênio (Mo) A deficiência de cobre gera, indiretamente, molibdênio, durante esse processo, tanto o macho como a fêmea são inférteis ou sub-férteis, mas, em geral, os transtornos surgem não por molibdeniose mas por hipocuprose condicionada por excesso de molibdênio nas pastagens e pelos sulfatos presentes na água de bebida (BREM, 2016). Isso leva à formação de tiomolibdato no rúmen, que por sua vez combina com o cobre para formar tiomolibdato de cobre, sal muito insolúvel. O tiomolibdato presente, formado em excesso e que não encontra cobre suficiente, contribuirá para produzir a diarreia, limitando ainda mais a absorção de cobre. A interferência mais importante do molibdênio ocorre no processo metabólico do cobre, interferindo sua atividade enzimática. O molibdênio atua sobre o complexo sulfeto-oxidase hepático. A enzima que está envolvida na oxidação de metabolitos sulfurados, reduz a sua atividade na presença de altos teores de molibdênio, especialmente quando a quantidade de cobre é baixa. Daqui resulta a formação de sulfureto de cobre, muito insolúvel e, portanto, pouco ou nada utilizável pelas células e/ou tecidos (QUIROZ-ROCHA & BOUDA, 2001). O excesso de molibdênio nas pastagens ou na água de bebida reduz a quantidade de cobre no fígado, mas para uma dada dose de molibdênio, esta redução é diretamente proporcional ao aumento dos sulfatos na ingestão, porque só na presença de sulfatos o molibdênio exerce sua ação limitante. O melhor modo de tratar o molibdênio e a ação dos sulfatos sobre o cobre, é aumentar a quantidade de cobre disponível pelos animais, seja por via bucal ou parenteral. Desta forma, há aumentos na cupremia e no ganho de peso. É conveniente, para o efeito, efetuar um controle dos resultados mediante a observação clínica, pesagem dos animais e análise de cobre no sangue. Isso permitirá estabelecer as doses ideais e adequadas para cada estabelecimento e efetuar um estudo econômico da suplementação (BAVERA, 2002). Como já foi tratado o requerimento do cobre para evitar os problemas reprodutivos das vacas, falemos do molibdênio (Mo). O Mo é um elemento primordial para bovinos leiteiros, uma vez que é componente de uma enzima presente no leite (xantina oxidasse). A deficiência de Mo a nível prático não foi relatada, porém casos podem acontecer. Para ovinos, que é uma espécie ruminante, a concentração exigida pelo animal em Mo presente na MS é de 5 a 10 mg/kg, porém deve levar em consideração a relação crítica entre o Mo e o Cu que deve ser no máximo 20 e nunca superior. O nível crítico de toxidade de Mo nos alimentos volumosos (forrageiras, gramíneas e leguminosas) não pode ultrapassar os 6% por kg de MS. Através de todos esses cuidados, o criador poderá obter sucesso tanto na prevenção contra os distúrbios do ciclo estral das vacas, quanto de outras complicações como toxidade, desnutrição, etc. 6.2 Relação energia:proteína Em relação ao aumento do consumo de proteína crua ou de deficiência de energia, aumenta-se a quantidade de ureia no sangue e produz-se uma toxicidade tecidular, afetando o endométrio e diminuindo a produção de prostaglandinas, que são as encarregadas de manter o corpo lúteo, caso não se mantenha acaba provocando um ciclo estral longo. A situação pode ser explicada a nível do eixo hipotálamo-hipófise, no qual os baixos níveis de glicose inibem a secreção de GnRH e resultam na diminuição da pulsatilidade da LH, seja por ação direta ou mediada através das ß-endorfinas. Outro fator que afeta o crescimento folicular é a nutrição, especificamente a perda da condição corporal, quando o animal não se alimenta direito ou quando se alimenta não tem uma condição balanceada que supra suas exigências nutricionais e que tenha um aceitável ganho de peso diário (GPD), acaba perdendo massa muscular ou de gordura, em outras palavras altera-se a condição corporal do mesmo, e se a perda for de 22 a 24 % de peso corporal (PC), os animais que perdem essa condição entram em anestro o que acaba tornando um animal inviável para a reprodução e também para o abate, uma vez que encontra-se fora do peso ideal. Tanto as proteínas quanto a energia foram tratados em trabalhos anteriores, porém nunca é tarde para salientar que ambas devem ser fornecidas em qualidade e quantidade que consiga favorecer ao desenvolvimento do animal e aos mecanismos fisiológicos do mesmo. 6.3 Fito-toxidade Finalmente, um fator adicional que induz a alteração da ciclicidade estral são os fitoestrógenos, plantas com altos teores de isoflavonas que possuem, no organismo animal, uma ação estrogênica. Os fitoestrógenos estão amplamente difundidos, nos trevos, alfafa, milho e nas pastagens de cultivo intensivo. Os fitoestrogênios são diferentes dos estrogênios produzidos pelo animal, mas a sua ação é idêntica nos receptores do trato reprodutivo; o seu metabolismo e excreção é diferente (por exemplo, desmetilização) e a sua excreção renal através dos glicoronosidos, assim mesmo a formação de ésteres sulfatos no tecido hepático é menor, acumulando-se em circulação e alterando a duração da fase estrogênica do ciclo, isso leva à ninfomania das vacas e com ela a perda da função reprodutiva. Deve-se estar atento ao pasto que se cultiva e ao solo em que se implanta o pasto, uma vez que o solo pode ter excessos de minerais prejudiciais ao animal e que o coloque em uma situação de toxidade, já que a planta absorve do solo o excesso e da planta vai para o animal por meio direto ou pela silagem. Um exemplo é o teor de molibdênio na planta que não pode ser maior que 6%, se for ocorrerá inúmeras transformações fisiológicas maléficas ao animal, que acabará sendo descartado do objetivo que seria a reprodução na fazenda. -/- Apoio -/- Realização -/- REFERÊNCIAS BIBLIOGRÁFICAS BAVERA, Guillermo Alejandro. Aguas y aguadas para el ganado. Rio Cuarto: Inter-Medica Editorial, 2009. BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. BREM, J. J. et al. Alteraciones del ciclo estral provocadas por un alto ingreso de molibdeno en vaquillonas Brangus y respuesta a la suplementación con cobre. Revista Veterinaria, v. 12, n. 1 y 2, p. 28-33, 2016. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. GRAHAM, Thomas W. Trace element deficiencies in cattle. Veterinary clinics of North America: food animal practice, v. 7, n. 1, p. 153-215, 1991. GUEDES, Luciana Freitas et al. A importância do cobre, molibdênio e enxofre na alimentação de ovinos. Nucleus Animalium, v. 10, n. 2, p. 7-22, 2018. HURLEY, W. L.; DOANE, R. M. Recent developments in the roles of vitamins and minerals in reproduction. Journal of Dairy Science, v. 72, n. 3, p. 784-804, 1989. KUMAR, Sudhir et al. Importance of micro minerals in reproductive performance of livestock. Veterinary world, v. 4, n. 5, p. 230, 2011. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. MILLS, C. F. Cobalt deficiency and cobalt requirements of ruminants. Recent advances in animal nutrition, p. 129-141, 1981. NICODEMO, M. L. F.; SERENO, J. R. B.; AMARAL, T. B. Minerais na eficiência reprodutiva de bovinos. Embrapa Pecuária Sudeste-Documentos (INFOTECA-E), São Carlos, 2008. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. QUIROZ-ROCHA, Gerardo F.; BOUDA, Jan. Fisiopatología de las deficiencias de cobre en rumiantes y su diagnóstico. Vet. Méx, v. 32, n. 4, p. 289, 2001. SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. YASOTHAI, R. Importance of minerals on reproduction in dairy cattle. International Journal of Science, Environment and Technology, v. 3, n. 6, p. 2051-2057, 2014. Emanuel Isaque Cordeiro da Silva Belo Jardim, 29 de março de 2020. (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE AS ALTERAÇÕES DO CORPO LÚTEO EM VACAS -/- Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 -/- •__7. ALTERAÇÕES DO CORPO LÚTEO -/- A estrutura funcional desenvolve-se a partir da cavidade folicular após a ovulação. O corpo lúteo é constituído pelas células da teca interna (pequenas e ativas na primeira fase do seu desenvolvimento) e células da granulosa (grandes e ativas na segunda metade do seu (...) desenvolvimento). As principais características de cada tipo de célula podem resumir-se da seguinte forma: As células pequenas são mais sensíveis à ação da LH porque possui uma quantidade maior de receptores biologicamente ativos para esta hormona e a resposta é mediada pelo sistema AMPc-adelinato ciclase. As grandes células lúteas têm menos receptores para a LH (a maior quantidade são para a PGF2α e a PGE2), e são as responsáveis pela produção da oxitocina luteal (BAH, et al. 2006; CAMPO, 2003). Contrariamente às pequenas células lúteas, a produção de progesterona (P4) é parcialmente controlada pelo sistema Ca+2 - Fosfatil inositol-quinase C (CAMPO, 2003). A regulação da função do corpo lúteo é um mecanismo complexo. Nela intervêm fatores tróficos e líticos que estão presentes em forma simultânea durante todo o ciclo estral, e portanto a estimulação ou inibição da síntese e secreção de P4 depende do balanço entre estes fatores. (CAMPO, 2003). Dentro dos fatores tróficos, os nutrientes desempenham um papel relevante sobre a luteólise e as funções luteotrópicas, entre estas pode-se citar a ação das seguintes: -/- 7.1 Vitaminas Deficiência em betacarotenos. Vitamina A é um termo genérico que designa qualquer composto com atividade de retinol, o trans-retinol, é o composto base, sua forma aldeído e ácido são chamados de retinol e ácido retinóico, respectivamente. Por outro lado, a forma ativa da Vitamina A participa no mecanismo da visão, como 11-cis-retinal. Adicionalmente, o betacaroteno, considerado uma provitamina A é a única forma em que esta encontra nas plantas. Em sentido nutricional, a família da Vitamina A compreende todos os compostos que possuem atividade de retinol, incluindo cerca de cinquenta carotenoides que possuem atividade de provitamina A, aceitando-se que o mais ativo é o trans-betacaroteno (TORRES, et al. 2002). As vitaminas que são necessárias para o crescimento e a produção, também são essenciais para a reprodução. As recomendações atuais de vitamina A são de 75.000 UI/dia durante a lactação e 80.000 UI/dia (nota: 1 mg de Vitamina A = 400 UI) durante o período seco nas vacas leiteiras. A suplementação com vitamina A tem pouco risco de toxicidade, enquanto a sua deficiência pode retardar o aparecimento do primeiro cio/estro, induzir cios/estros silenciosos, aumentar o número de quistos ováricos, reduzir os índices de concepção, causar abortos, mortes embrionárias e ocasionar o nascimento de bezerros debilitados e fracos, uma vez que não irão nascer com os índices e requerimentos ideais de nutrientes passados da mãe para o feto pela placenta, e que, já que a mãe possui deficiência nutricional, o colostro não terá o efeito completo para passar a imunidade essencial ao neonato. Embora os mecanismos de ação não sejam claros, foram notificadas maiores secreções de esteroides ováricos quando as concentrações de β-carotenos no fluido folicular foram elevadas; logo, foram observadas maiores concentrações elevadas de β- estradiol e vitamina A nos folículos que terminaram em ovulação do que naqueles que terminaram em atresia. Para evitar as perdas reprodutivas por deficiência de vitamina A, pode-se optar pela administração oral ou injetável desta ao animal, mediante dois métodos: o primeiro consiste em adicionar 1 a 2,5 kg de premix vitamínico em 1 tonelada de grãos o que supre de 4 a 6.000 UI o que é desejável; o segundo é a administração via injetável em quantidades vide bula do fármaco. 7.2 Minerais O excesso de fósforo é absorvido principalmente no intestino delgado dos mamíferos através de um mecanismo de transporte ativo dependente do sódio, que é estimulado pela pró-hormona 1,25- hidroxivitamina D3. Os ruminantes são capazes de absorver o fósforo dietético em proporção direta às quantidades presentes na ração. Estima-se que aproximadamente 1% do corpo animal é composto de fósforo, do qual 85% está presente nos dentes e no tecido ósseo. Os tecidos moles são capazes de conter entre 0,15-0,20% de fósforo sob a forma de fosfoproteínas, nucleoproteínas, fosfolipídios, fosfato creatinina, adenosintrifosfato, glicose-6-fosfato, etc. Ao nível do plasma sanguíneo, o fósforo apresenta valores de 12,09 mg/dl. Os valores plasmáticos de fósforo são regulados principalmente pelo rim, sendo observado um aumento na excreção urinária do elemento inorgânico quando este excede a capacidade de transporte (REBOLLAR & MATEOS, 1999). O fósforo faz parte dos fosfolipídios, que são importantes no transporte de lipídios e seu metabolismo, como componente das membranas celulares. O fosfato faz parte do RNA e do DNA, componentes celulares vitais, e são essenciais para a síntese proteica. O fosfato faz parte de sistemas enzimáticos como a cocarboxilase e NAD, portanto está envolvido em todos os processos de síntese e regulação energética, dado que o corpo lúteo requer altas quantidades de energia para a síntese celular e hormonal, um excesso de fósforo pode bloquear a capacidade renal da sua regulação gerando um desequilíbrio catiônico que descompensa a relação Na:K, já que deverão ser excretados íons fosfato para regular o equilíbrio ácido-básico, desta forma, os processos celulares em tecidos de alta sensibilidade como o ovário serão afetados em sua função. A situação para prevenção de problemas relacionados ao fósforo (P) já foi tratada em assuntos anteriores, porém, sempre vale frisar para o leitor fiel que me lê que as exigências de P presentes na matéria seca (MS) variam entre 0,17 e 0,59% de P por kg/MS para bovinos de corte e em 0,32 a 0,44% por kg/MS para o gado leiteiro. Dessa forma, dados obtidos por pesquisas, ditam que para a mantença de uma vaca ou quaisquer outra categoria bovina o ideal é o consumo de 1.43 g/100 kg de peso vivo (PV), garantindo assim a prevenção de possíveis afecções reprodutivas como as alterações do corpo lúteo. Gramíneas, forragens, leguminosas e os concentrados fornecem muito bem os requerimentos de fósforo para os animais, todavia deve-se estar atento as relações e dependências do P com outros elementos como o Ca e a relação Na:K (10-15:1 idealmente). 7.3 Compostos estrogênicos Os fitoestrogênios afetam repetidamente a estabilidade do corpo lúteo. Os compostos estrogênicos encontrados principalmente em leguminosas pertencem principalmente a três grupos: isoflavanos, isoflavonas, presentes no gênero Trifolium e praticamente restritos às leguminosas, e cumestanos, que foram estudados na alfafa (Medicago sativa) e na Melilotus alba. Todas as isoflavonas sofrem algum grau de transformação no rúmen, sendo o Isoflavonoide formononetina, na realidade um pró-estrógeno, o único que se ativa no ecossistema ruminal ao ser convertido em equol, enquanto que as demais são degradadas a produtos inativos (RAMOS, et al. 1998). Por fim, a alta concentração no sangue do equol retarda a retroalimentação sobre a hipófise mediante a qual se reduzem os níveis de FSH para dar lugar à onda ovulatória de LH, se esta não ocorrer, o corpo lúteo obviamente não se formará. O conhecimento acerca dos estrogênios na alimentação animal é defasado nos livros sobre o tema, no entanto, o criador pode ficar tranquilo no que tange o tema na prática da sua fazenda e dos seus animais, uma vez que tal elemento é muito bem fornecido naturalmente por meio dos alimentos volumosos presentes no seu pasto. -/- Apoio -/- Realização -/- REFERÊNCIAS BIBLIOGRÁFICAS BAH, Mamadou M. et al. Role of intraluteal prostaglandin F2α, progesterone and oxytocin in basal and pulsatile progesterone release from developing bovine corpus luteum. Prostaglandins & other lipid mediators, v. 79, n. 3-4, p. 218-229, 2006. BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. CAMPO, E. Comportamiento reproductivo del ganado Bovino y Bufalino. 2003. Universidad Agraria de la Habana. Havana, 2003. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. HURLEY, W. L.; DOANE, R. M. Recent developments in the roles of vitamins and minerals in reproduction. Journal of Dairy Science, v. 72, n. 3, p. 784-804, 1989. KUMAR, Sudhir et al. Importance of micro minerals in reproductive performance of livestock. Veterinary world, v. 4, n. 5, p. 230, 2011. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. RAMOS, Graciano et al. Los compuestos secundarios de las plantas en la nutrición de los herbívoros. Archivos de Zootecnia. 47: 597-620, 1998. REBOLLAR, Paloma García; MATEOS, Gonzalo González. El fósforo en nutrición animal. Necesidades, valoración de materias primas y mejora de la disponibilidad. CURSO DE ESPECIALIZACIÓN FEDNA. Avances en nutrición y alimentaciín animal, XV, p. 19-64, 1999. SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. TEIXEIRA, J. C. Nutrição de ruminantes. Lavras: FAEPE, 1992. TORRES, M. et al. Aspectos Farmacológicos relevantes de las Vitaminas Antioxidantes (E, A y C). Archivos Venezolanos de Farmacología y Terapéutica, v. 21, n. 1, p. 22-27, 2002. YASOTHAI, R. Importance of minerals on reproduction in dairy cattle. International Journal of Science, Environment and Technology, v. 3, n. 6, p. 2051-2057, 2014. -/- Emanuel Isaque Cordeiro da Silva Belo Jardim, 29 de março de 2020. (shrink)

This paper is an essay in what Austin (_Proc Aristotel Soc_ 57: 1–30, 1956–1957) called "linguistic phenomenology". Its focus is on showing how the grammatical features of ordinary causal verbs, as revealed in the kinds of linguistic constructions they can figure in, can shed light on the nature of the processes that these verbs are used to describe. Specifically, drawing on the comprehensive classification of English verbs founds in Levin (_English verb classes and alternations: a preliminary investigation_, University of Chicago (...) Press, Chicago, 1993), I divide the forms of productive causal processes into five classes, corresponding to Aristotle's ontological categories: there are processes that cause change in location, in state, and in quantity; and that lead to the creation and destruction of substances. These broader categories are then subdivided into other ones, corresponding to different Levin classes, according to further differences in the causal processes they involve. I conclude by discussing the relevance of this argument to research in metaphysics and experimental philosophy. (shrink)

This paper proposes a novel experimental approach that would help to determine whether perspectival shapes, such as the elliptical profile of a tilted plate or coin, are part of perceptual experience. If they are part of perceptual experience, then it should be possible to identify these shapes simply by attending appropriately to them. Otherwise, in order to identify perspectival shapes they must first be constructed in the visual imagination. We propose that these accounts of perspectival identification can be tested by (...) measuring the interference between visual and verbal working memory load, respectively, and the identification of perspectival shapes in the appearance of a 3D object. (shrink)

The A-theory and the B-theory advance competing claims about how time is grounded. The A-theory says that A-facts are more fundamental in grounding time than are B-facts, and the B-theory says the reverse. We argue that whichever theory is true of the actual world is also true of all possible worlds containing time. We do this by arguing that time is uniquely groundable: however time is actually grounded, it is necessarily grounded in that way. It follows that if either the (...) A-theory or the B-theory is actually false, then it is necessarily false. (shrink)

Research on the human microbiome has gen- erated a staggering amount of sequence data, revealing variation in microbial diversity at the community, species (or phylotype), and genomic levels. In order to make this complexity more manageable and easier to interpret, new units—the metagenome, core microbiome, and entero- type—have been introduced in the scientific literature. Here, I argue that analytical tools and exploratory statisti- cal methods, coupled with a translational imperative, are the primary drivers of this new ontology. By reducing the (...) dimensionality of variation in the human microbiome, these new units render it more tractable and easier to interpret, and hence serve an important heuristic role. Nonetheless, there are several reasons to be cautious about these new categories prematurely ‘‘hardening’’ into natural units: a lack of constraints on what can be sequenced metagenomically, freedom of choice in taxonomic level in defining a ‘‘core microbiome,’’ typological framing of some of the concepts, and possible reification of statistical constructs. Finally, lessons from the Human Genome Project have led to a translational imperative: a drive to derive results from the exploration of microbiome variation that can help to articulate the emerging paradigm of per- sonalized genomic medicine (PGM). There is a tension between the typologizing inherent in much of this research and the personal in PGM. (shrink)

Consequentializing involves both a strategy and conditions for its successful implementation. The strategy takes the features a target theory holds to be relevant to deontic evaluation of actions, and builds them into a counterpart ranking of outcomes. It succeeds if the result is 1) a substantive version of consequentialism that 2) yields the same deontic verdicts as the target theory. Consequentializers typically claim and their critics allow that all plausible alternative theories can be consequentialized. I demonstrate that even standard alternatives (...) such as Aristotelean virtue ethics and Kantian ethics cannot be. The strategy either leaves out features relevant to deontic evaluation on such target theories, resulting in failure of deontic equivalence, or, if it is altered to include these features, fails to produce a substantive version of consequentialism. The consequentializing strategy thus demonstrates not that we are all consequentialists now, but why so many of us are not, that it is misguided to impose a consequentialist account of deontic evaluation upon alternative theories, that it is the commitment to a constraint on value rationales that distinguishes consequentialist theories, and that the plausibility of this distinctive constraint should be the focus of the debate going forward. -/- . (shrink)

Procedural justifications of democracy emphasize inclusiveness and respect and by doing so come into conflict with instrumental justifications that depend on voters’ competence. This conflict raises questions about jury theorems and makes their standing in democratic theory contested. We show that a type of no-regret learning called meta-induction can help to satisfy the competence assumption without excluding voters or diverse opinion leaders on an a priori basis. Meta-induction assigns weights to opinion leaders based on their past predictive performance to determine (...) the level of their inclusion in recommendations for voters. The weighting minimizes the difference between the performance of meta-induction and the best opinion leader in hindsight. The difference represents the regret of meta-induction whose minimization ensures that the recommendations are optimal in supporting voters’ competence. Meta-induction has optimal truth-tracking properties that support voters’ competence even if it is targeted by mis/disinformation and should be considered a tool for supporting democracy in hyper-plurality. (shrink)

In the Tractatus Theologico-Politicus (TTP), Spinoza argues that an individual’s natural right extends as far as their power. Subsequently, in the Tractatus Politicus (TP), he offers a revised argument for the same conclusion. Here I offer an account of the reasons for the revision. In both arguments, an individual’s natural right derives from God’s natural right. However, the TTP argument hinges on the claim that each individual is part of the whole of nature (totius naturae), and for this reason inherits (...) part of the natural right of that whole. Using several analogous cases from the Ethics, I show that this form of argument from division is not compatible with Spinoza’s considered metaphysical views. The revised argument, by contrast, avoids the pitfalls of his earlier efforts. It also better reveals the deep roots by which the monistic metaphysics of the Ethics feeds into Spinoza’s conception of natural right. (shrink)

In Western political philosophy, democracy is generally the dominant view regarding what the best form of government is, and this holds even in respect to promoting minority rights. However, I argue that there is a better theory for satisfying minority interests and rights. I amass numerous studies from the social sciences demonstrating how democracy does poorly in accounting for minority interests. I then contend that a particular hybrid view that fuses a meritocracy with democracy can do a better job than (...) democracy in accounting for minority interests and in having more equal rights and fair policies coming from the legislative and executive branches. Finally, I defend this thesis from numerous counters. (shrink)

This chapter treats Hubert Dreyfus’ account of skilled coping as part of his wider project of demonstrating the sovereignty of practical intelligence over all other forms of intelligence. In contrast to the standard picture of human beings as essentially rational, individual agents, Dreyfus argued powerfully on phenomenological and empirical grounds that humans are fundamentally embedded, absorbed, and embodied. These commitments are present throughout Dreyfus’ philosophical writings, from his critique of Artificial Intelligence research in the 1970s and 1980s to his rejection (...) of John McDowell’s conceptualism in his 2005 APA Presidential Address. The present chapter articulates Dreyfus’ proposal for a contentless, non-mentalistic form of intentionality by contrasting his position with that of his U.C. Berkeley colleague John Searle and defending it as a plausible alternative to the so-called “Standard Story” of intentional action as the effect of an agent’s mental states. (shrink)

William James wrote that the life of religion “consists of the belief that there is an unseen order, and that our supreme good lies in harmoniously adjusting ourselves thereto.” Naturalism organizes our experiences of the universe within a science-grounded philosophical and/or religious framework aligning it with what is supremely good for our lives. This article describes a science-grounded specific “Framework of Spirituality” identifying part of this unseen order that opens a “spiritual core” within persons as a source of healing and (...) happiness. A cognitive behavioral therapy (CBT) expanded process shows how experiences of human worth and dignity are keys to this new awareness and provides speculation for a brain function and evolutionary explanation. Details of this knowledge are related to various perspectives and authors of naturalism—scientific, religious, ecstatic, and ecological—to contribute to a future direction for the understanding, development, and further expression of naturalism. (shrink)

The purpose of the study was to determine the demographic profiles in terms of age, sex, years in teaching, type of school and ethnicity, SOGIE, perception about the workplace climate in terms of the different gender prejudices faced by secondary science teachers at City of Dasmariñas, Cavite; the study aims to identify if there is a significant difference between perceptions of the participants about the gender prejudices when grouped according to demographic profile; determine if there is a substantial relationship between (...) SOGIE and perceptions about the gender prejudices. This study developed an action plan to promote awareness and make schools SOGIE-sensitive; the research design was quantitative, and an online questionnaire was the data-gathering tool. Descriptive statistics used were mean, median, and standard error; the second level was for relational statistics using Chi-square statistics, Mann-Whitney statistics, and Kruskal-Walli’s statistics. The study revealed that most science teachers in Dasmariñas City, Cavite, were female and young professionals. Science teachers at the secondary level have a diverse SOGIE; in addition, there is zero visibility for transgender people and intersex people. Generally, the secondary schools in the City of Dasmariñas, Cavite, are unsafe for people with diverse SOGIE, especially for transgender and intersex people. The study suggests that the action plan proposed in this study should be adopted by schools to address the issues of gender prejudices and to promote awareness of SOGIE. (shrink)

In this paper, I discuss several temporal aspects of paleontology from a philosophical perspective. I begin by presenting the general problem of “taming” deep time to make it comprehensible at a human scale, starting with the traditional geologic time scale: an event-based, relative time scale consisting of a hierarchy of chronological units. Not only does the relative timescale provide a basis for reconstructing many of the general features of the history of life, but it is also consonant with the cognitive (...) processes humans use to think about time. Absolute dating of rocks, fossils, and evolutionary events (such as branching events on the tree of life) can be accomplished through the use of radiometric dating, chronological signals extractable from fossil growth patterns, and the “molecular clock.” Sometimes these different methods of absolute dating, which start from largely independent assumptions and evidentiary bases, converge in their temporal estimates, resulting in a consilience of inductions. At other times they fail to agree, either because fossils and molecules are giving temporal information about different aspects of nature and should not be expected to agree, or because of flawed assumptions that give rise to an inaccurate estimate. I argue that in general, despite the fact that it can be difficult to integrate disparate kinds of evidence, the principle of total evidence should be applied to the dating of evolutionary events. As a historical science, paleontology studies past events we cannot observe directly. This raises questions of epistemic access, meaning that due to the fragmentary nature of the fossil record we may find ourselves without access to the relevant traces to adjudicate between rival hypotheses about the past. The problems and prospects of epistemic access are explored through a case study of the reconstruction of the colors of dinosaurs. The paper closes with a reflection on the Darwin- Lyell metaphor of the fossil record as a highly fragmentary history book, and a call for a reconsideration of the book metaphor in favor of a systems view of the geologic and fossil records. (shrink)

In Plato’s Statesman, the Eleatic Stranger applies a specialized method of inquiry—the “method of collection and division”, or “method of division”—in order to discover the nature of statecraft. This paper articulates some consequences of the fact that the method is both a tool for identifying natural kinds—that is, a tool for carving the world by its joints (Phaedrus 265b-d)—and social kinds—that is, the kinds depending on human beings for their existence and explanation. A central goal of the paper is to (...) illuminate the extent to which this use of the method of division allows us to identify Plato as an early historical forerunner of racialism, which is an ideology according to which humanity divides into races differentiated by heritable physiological, cultural, and intellectual traits, as a way of vindicating oppressive and exploitative social, political, and economic systems. -/- I defend an interpretation of the Stranger’s claim, much discussed in the literature, that the division of humankind into Greek and barbarian is unnatural (Politicus 262c-263a). I argue that, in the Stranger’s view, this division reflects subjective illusion and prejudice, rather than the fundamental, and teleological, structure of human social organization, which concerns how human beings rationally cooperate to self-produce as a species. Nonetheless, the Stranger’s alternative theory of the natural structure of human society, I suggest, is proto-racial in another way. Through a brief consideration of the Stranger’s affirmative and complex division of kinds in the city, I argue that he re-introduces naturalistic foundations for unjust human hierarchies through his alternative theory of natural kinds and human social teleology. (shrink)

ABSTRACT. This essay addresses the interpretation of Descartes’ understanding of the mind-body relationship as a substantial union in light of a statement he makes in the Passions de l’âme regarding the role of the blood and vital heat. Here, it seems Descartes cites these corporeal properties as the essential dispositions responsible for accommodating the soul into the human fetus. I argue that this statement should be read in the context of certain medical texts with which Descartes was familiar, namely those (...) of Jean Fernel and William Harvey. Reviewing Fernel’s comments on substantial union, one finds that the soul joins the body on the basis of a celestial spirit that not only bears the vital heat, it also directs the generation of the body. Similar to Harvey, Descartes locates these properties in the blood itself, although, in contrast to Harvey, Descartes reduces these processes to matter and motion. Finally, I highlight the role this heat plays in Descartes’ embryological writing, contrasting it with that of Fernel. I conclude that although Descartes makes various comments supporting a reading of the mind-body relation as a substantial union, his physiological writings on generation and his idea of ‘life’ contradict this interpretation. -/- . (shrink)

This essay consists of two parts. Part I offers an explanation of Berkeley's understanding of the relationship between materialism and evil. Berkeley regards materialism as the chief instrumental cause of evil in the world. It is the belief in matter that encourages us to believe that God is not immediately, intimately present in every aspect of our life. Immaterialism, by contrast, makes God's immediate presence vivid and thereby serves to undermine the motivation to vice. Part II locates Berkeley's view on (...) matter and evil within the Christian Neoplatonic tradition. I compare Plotinus' minimalist approach to matter and his identification of matter with evil to Berkeley's eliminitivism about matter and his corresponding identification of materialism as the chief source of evil. (shrink)

Purpose A mixed-method study was performed to determine the impact of integrating systems thinking (ST) into an electronic learning module for junior high school teachers in the Philippines. The study aims to assess how an ST approach to pedagogy compared against a conventional approach in terms of contribution to the participants’ global climate change content knowledge, holistic thinking and depth and accuracy of knowledge and reasoning. -/- Design/methodology/approach The study implemented e-learning modules using an ST approach versus a conventional approach (...) in teaching climate science to junior high school teachers. The paper presents quantitative data obtained from pre and posttests results of the 20 teacher-participants and qualitative data obtained during the focus-group discussion (FGD) after the implementation of the study. -/- Findings The results from the statistical analysis indicated that the ST group obtained a significant increase in their assessment scores compared to the non-ST group, according to predetermined criteria. Content knowledge, depth and accuracy of knowledge and reasoning increased the most. The participants mentioned during the FGD that the module helped deepen their understanding of climate change. -/- Research limitations/implications The study was limited to 20 teacher-participants, but it has relevance for public school teachers in the country given that participants had raised concerns regarding the lack of training in their schools for teaching climate science. They admitted that they lacked critical information to include in climate change topics in their classes. -/- Originality/value This paper shows how the ST approach can be used to teach climate change to junior high students. The e-learning module can provide teachers with better understanding, knowledge and reasoning to teach climate change to high school students more effectively. (shrink)

Beauty is truth, truth beauty.If this epigraph only rarely escapes English class, something like it has fascinated philosophers for a long time. Iris Murdoch remembers that "Kant said that beauty was an analogon of good, Plato said it was the nearest clue."2 I want to go further and posit that our means of perception of the aesthetic and the ethical share an organic connection, an understanding of which will help elucidate moral perception, a critical component of moral education.Or moral education (...) as it should be. But what currently counts as such is, directly or almost directly, simple instruction. I ask why this does not work. I ask why Jane Austen said, "We all love to instruct, though we can teach only what is... (shrink)

What minimal role—if any—must consciousness of morally significant information play in an account of moral worth? According to one popular view, a right action is morally worthy only if the agent is conscious (in some sense) of the facts that make it right. I argue against this consciousness condition and close cousins of it. As I show, consciousness of such facts requires much more sophistication than writers typically suggest—this condition would bar from moral worth most ordinary, intuitively morally worthy agents. (...) Moreover, I show that the attraction to this flavor of consciousness condition rests on mistaken assumptions about what is required for a right act to be non-accidentally right and attributable to the agent. Drawing some lessons from the discussion, I defend a Value-Secured Reliability Theory of Moral Worth and show how a minimal yet indispensable role for consciousness falls out from it. On this independently plausible theory, an action can be morally worthy even when the agent is unaware of the right-making features of her action. (shrink)

I challenge the common picture of the “Standard Story” of Action as a neutral account of action within which debates in normative ethics can take place. I unpack three commitments that are implicit in the Standard Story, and demonstrate that these commitments together entail a teleological conception of reasons, upon which all reasons to act are reasons to bring about states of affairs. Such a conception of reasons, in turn, supports a consequentialist framework for the evaluation of action, upon which (...) the normative status of actions is properly determined through appeal to rankings of states of affairs as better and worse. This covert support for consequentialism from the theory of action, I argue, has had a distorting effect on debates in normative ethics. I then present challenges to each of these three commitments, a challenge to the first commitment by T.M. Scanlon, a challenge to the second by recent interpreters of Anscombe, and a new challenge to the third commitment that requires only minimal and prima facie plausible modifications to the Standard Story. The success of any one of the challenges, I demonstrate, is sufficient to block support from the theory of action for the teleological conception of reasons and the consequentialist evaluative framework. I close by demonstrating the pivotal role that such arguments grounded in the theory of action play in the current debate between evaluator-relative consequentialists and their critics. (shrink)

My objective is to offer at least a rough sketch of a new model for understanding time. Since many people are quite content with the model they have, I will try to show why a new model might be desirable or necessary. The exposition will be broken down into three parts. In the first part, I’ll try to show that no one has ever experienced time as such. In the second part, I shall argue that one good reason for this (...) is that there is no such thing as time as such. Finally, in the third part, I’ll try to reassemble what’s left of the conception of time after all this demolition, and I’ll offer a positive model (albeit rather vague) of what I prefer to call “temporality”. The exposition will follow lines familiar to contemporary students of time, but will, I hope, lead to conclusions that are at least modestly novel. (shrink)

Many consequentialists take their theory to be anchored by a deeply intuitive idea, the “Compelling Idea” that it is always permissible to promote the best outcome. I demonstrate that this Idea is not, in fact, intuitive at all either in its agent-neutral or its evaluator-relative form. There are deeply intuitive ideas concerning the relationship of deontic to telic evaluation, but the Compelling Idea is at best a controversial interpretation of such ideas, not itself one of them. Because there is no (...) Compelling Idea at the heart of consequentialism, there is no initial burden of proof to be discharged nor any air of paradox to be cleared away by its opponents. (shrink)

This paper delves into the philosophical debate surrounding determinism and free will, exploring the compatibility of these two concepts in light of contemporary understanding in physics, psychology, and philosophy. The author critiques Ayer's perspective on free will and determinism, employing examples from quantum mechanics and neuroscience to argue for a deterministic framework of understanding human choices and actions. The paper introduces the concept of "Soft Free Will" as a reconciliation between determinism and the human experience of making choices, positing that (...) free will exists not as an ontological reality, but as a psychological phenomenon rooted in our limited understanding of the complexities involved in decision-making. Through a comprehensive analysis, the paper underscores the importance of acknowledging the deterministic nature of human behavior while also appreciating the subjective experience of choice, ultimately arguing that the progression of scientific understanding will continue to reveal the mechanics of choice without negating our experience of free will. (shrink)

The purpose of this study was to assess the determinants of successful implementation of Early Childhood Development Education (ECDE) by County Governments in Kenya from the implementing partners‟ perspective. This study was guided by the following specific objectives: to determine the influence of the capacities of the County Government staff on the implementation of early childhood development education by County Governments in Kenya, to determine the how management of early childhood development education affects its implementation by County Governments in Kenya, (...) to assess how availability of physical facilities affect the implementation of early childhood development education by County Governments in Kenya and to examine how policies affect the implementation of early childhood development education by County Governments in Kenya. Decentralization theory and organization learning theory were used to explain the relationship between the study variables. Descriptive research design was used in the study. The population for the study was implementing partners working with County Governments in Kenya to support ECDE. Purposive sampling technique was used to select the respondents to participate in the study. A total of 100 respondents were targeted from the 10 organizations studied out of which 70 participated giving a response rate of 70%. Questionnaire was used as instrument for data collection. Both qualitative and quantitative data analysis techniques were used to analyze the data. The study found that the implementation of ECDE by County governments in Kenya was generally successful from the implementing partners‟ perspective and indicated by 56.8%. It is also worth noting that beside the general success, there were myriads of challenges facing the implementation of the program by county governments. Findings from regression analysis showed that the coefficient of determination indicated that 63.5% of the variations on the implementation of ECDE by county governments can be explained by staff capacity, management of ECDE, availability of physical facilities and ECDE policies. The remaining 36.5% can be explained by other variables not included in the study. R square and adjusted R is above average an implication that an above average variation can be explained by the model. The study recommended that county governments should allocate more funds for the renovation and construction of more ECDE centres, allocate adequate funds for the implementation of ECDE and that they should organize consistent in-service training for ECDE teachers and at the same time employ more ECDE staff to cater for the large number of children in ECDE centres.. (shrink)

I distinguish two different senses in which philosophers speak of moral verdicts, senses that in turn invite two different senses of moral overridingness. Although one of these senses, that upon which moral verdicts are taken to reflect decisive reasons from a distinctively moral standpoint, currently dominates the moral overridingness debate, my focus is the other sense, upon which moral verdicts are taken to reflect decisive reasons that are distinctively moral. I demonstrate that the recent tendency to emphasize the now dominant (...) sense to the exclusion of the alternative, couple with the failure to disambiguate the two senses, has fundamentally skewed central debates in moral theory. (shrink)

Robert Myers’ interpretation of Davidson’s practical philosophy gets Davidson right in many fundamental respects. He rightly argues that Davidson avoids inconsistencies among internalism, ethical objectivity, and the belief-desire theory by modifying central elements of the Humean belief-desire theory, and that Davidson’s alternative legitimizes the extension of his interpretation and triangulation arguments into the practical sphere. But at a crucial fork in the interpretive road Myers loses his way. Davidson follows Anscombe down a different path, one that takes individual desires to (...) be constituted in part by evaluative judgements. (shrink)

This report is a compilation of three papers designed to stimulate discussion among those who are focused on North Korean decisionmaking. The first paper describes the experiences of North Korea and three similar authoritarian regimes — China, Vietnam, and Cuba — and provides a forecast of why and how North Korea might adopt a new economic model. The second paper describes decisions that the North Korean leadership might face in two scenarios in which conventional deterrence on the Korean Peninsula breaks (...) down. The final paper provides an assessment of North Korean leadership decisionmaking about nuclear weapons doctrine. Despite the many unknowns surrounding the North Korean leadership decisionmaking process, these papers constructively outline the parameters of the North Korean decisionmaking "trade space" and the historical examples from which North Korean leaders might draw. (shrink)

Teleological theories of reason and value, upon which all reasons are fundamentally reasons to realize states of affairs that are in some respect best, cannot account for the intuition that victims in non-identity cases have been wronged. Many philosophers, however, reject such theories in favor of alternatives that recognize fundamentally non-teleological reasons, second-personal reasons that reflect a moral significance each person has that is not grounded in the teleologist’s appeal to outcomes. Such deontological accounts appear to be better positioned to (...) identify the wrong committed against non-identity victims because a person wrongs another on such accounts if she violates his second-personal claims -- overall benefit to victims presents no obstacle to the identification of second-personal wrongdoing. Derek Parfit argues that non-identity is a problem for these deontological theories as well because the alleged victims are properly understood as consenting to the action in question, thereby waiving any such second-personal claim. But his arguments misrepresent the role of consent on such theories by articulating it through appeal to the very teleological theory of reasons that their advocates dismiss as inadequate. Properly understood, Parfit’s appeal to consent understood as retroactive endorsement only provides the answer on such deontological accounts to the question of whether, given that the non-identity victim is second-personally wronged, he is nonetheless better off existing. Indeed, it becomes clear that it is teleological theories for which non-identity poses a particular problem: they cannot -- while their deontological counterparts can – account for the intuition that non-identity victims have been wronged. (shrink)

This paper explores relationships between environment and education after the Covid-19 pandemic through the lens of philosophy of education in a new key developed by Michael Peters and the Philosophy of Education Society of Australasia. The paper is collectively written by 15 authors who responded to the question: Who remembers Greta Thunberg? Their answers are classified into four main themes and corresponding sections. The first section, ‘As we bake the earth, let's try and bake it from scratch’, gathers wider philosophical (...) considerations about the intersection between environment, education, and the pandemic. The second section, ‘Bump in the road or a catalyst for structural change?’, looks more closely into issues pertaining to education. The third section, ‘If you choose to fail us, we will never forgive you’, focuses to Greta Thunberg’s messages and their responses. The last section, ‘Towards a new normal’, explores future scenarios and develops recommendations for critical emancipatory action. The concluding part brings these insights together, showing that resulting synergy between the answers offers much more then the sum of articles’ parts. With its ethos of collectivity, interconnectedness, and solidarity, philosophy of education in a new key is a crucial tool for development of post-pandemic education. (shrink)

This article is a review of David Hummel’s The Rise and Fall of Dispensationalism, a book that questions whether the academic debate around dispensationalism is truly dead. By exploring through the lens of metaphorical theology, we look at how commercialization caused academic dispensationalism to self-cannibalize. Applying analysis to both the ouroboros and butterfly metaphors we can examine whether dispensationalism is dead or if there is a potential for a newer, stronger version of academic debate on the topic to resurface once (...) again. Equally as plausible, is the notion that dispensationalism has changed its meaning through the metamorphosis process of changing from academic dispensationalism to pop-dispensationalism. By looking at the meaning change that occurs at the point of transaction, we see that the biography of dispensationalism shows a significant shift in meaning as it becomes a commercial hit. (shrink)

Consequentialism is a state of affairs centered moral theory that finds support in state of affairs centered views of value, reason, action, and desire/preference. Together these views form a mutually reinforcing circle. I map an exit route out of this circle by distinguishing between two different senses in which actions can be understood as bringing about states of affairs. All actions, reasons, desires, and values involve bringing about in the first, deflationary sense, but only some appear to involve bringing about (...) in a second, rationalizing sense. I demonstrate that the views making up this circle hold, implausibly, that all reasons, values, desires, and actions involve bringing about in both senses, and that failure to distinguish these senses obscures the implausibility of these views as a set. I demonstrate, in addition, that the distinction blocks two common arguments that otherwise threaten to leverage us back in to the consequentialist circle. (shrink)

Many real-world agents recognise that they impose harms by choosing to emit carbon, e.g., by flying. Yet many do so anyway, and then attempt to make things right by offsetting those harms. Such offsetters typically believe that, by offsetting, they change the deontic status of their behaviour, making an otherwise impermissible action permissible. Do they succeed in practice? Some philosophers have argued that they do, since their offsets appear to reverse the adverse effects of their emissions. But we show that (...) they do not. In practice, standard carbon offsetting does not reverse the harms of the original action, nor does it even benefit the same group as was harmed. Standard moral theories hence deny that such offsetting succeeds. Indeed, we show that any moral theory that allows offsetting in this setting faces a dilemma between allowing any wrong to be offset, no matter how grievous, and recognising an implausibly sharp discontinuity between offsettable actions and non-offsettable actions. The most plausible response is to accept that carbon offsetting fails to right our climate wrongs. (shrink)

That many values can be consequentialized – incorporated into a ranking of states of affairs – is often taken to support the view that apparent alternatives to consequentialism are in fact forms of consequentialism. Such consequentializing arguments take two very different forms. The first is concerned with the relationship between morally right action and states of affairs evaluated evaluator-neutrally, the second with the relationship between what agents ought to do and outcomes evaluated evaluator-relatively. I challenge the consequentializing arguments for both (...) forms of consequentialism. The plausibility of the evaluator-neutral consequentializing of certain values, I argue, in fact establishes the implausibility of an evaluator-neutral consequentialist account of such values. The problems that beset this evaluator-neutral consequentializing argument do not beset its evaluator-relative counterpart. But I demonstrate that evaluator-relatively consequentialized theories can also readily be ‘deontologized’, located within an alternative evaluative framework that is congenial to the articulation of nonconsequentialist moral theories. Such an alternative framework can accommodate what is compelling in consequentialists’ ‘Compelling Idea,’ and what is attractive in their Explanatory Thought. This alternative, moreover, can function as a shared evaluative framework within which the merits of consequentialist and nonconsequentialist alternatives can be considered without begging the question either way. (shrink)

Does Anne Conway (1631–79) hold that the created world consists of a single underlying substance? Some have argued that she does; others have argued that she is a priority monist and so holds that there are many created substances, but the whole created world is ontologically prior to each particular creature. Against both of these proposals, this article makes the case for a substance pluralist interpretation of Conway: individual creatures are distinct substances, and the whole created world is not ontologically (...) prior to the individual creatures that compose it. The basic argument for such a view draws on Conway's claims about the freedom and moral responsibility of individual creatures. The pluralist reading is straightforwardly compatible with these claims, while the monistic readings are not. (shrink)

Evaluator-relative consequentialists frequently endorse the traditional doing-allowing distinction. Yet their endorsement of this traditional distinction only serves to clear the way for their argument against a more fundamental doing-allowing distinction, an argument that one never ought to do something when this will allow something worse to happen. Unlike the case against its more traditional counterpart, the case against this deeper doing-allowing distinction can draw for support upon widely held “state of affairs centered” accounts of attitudes, actions, reasons and value, accounts (...) upon which desires are (all) attitudes towards states of affairs, practical reasons are all reasons to promote states of affairs, and to act is to make something happen -- to promote, produce, or bring about some states of affairs. Moreover, to reject this deeper distinction is to accept the centerpiece of consequentialism – that the evaluation of actions is determined through appeal to the evaluation of states of affairs. Only once the nature of the deep doing-allowing distinction, and these grounds for its rejection, come into view, does it also become clear both what an adequate response to such arguments for its rejection will look like, and that many elements of such a response have already been proposed. (shrink)

The main aims in this article are to discuss and criticize the core thesis of a position that has become known as phenomenal conservatism. According to this thesis, its seeming to one that p provides enough justification for a belief in p to be prima facie justified. This thesis captures the special kind of epistemic import that seemings are claimed to have. To get clearer on this thesis, the article embeds it, first, in a probabilistic framework in which updating on (...) new evidence happens by Bayesian conditionalization, and second, a framework in which updating happens by Jeffrey conditionalization. The article spells out problems for both views, and then generalizes some of these to nonprobabilistic frameworks. The main theme of the discussion is that the epistemic import of a seeming should depend on its content in a plethora of ways that phenomenal conservatism is insensitive to. (shrink)

Van Gordon et al. outline the classification of their Ontological Addiction Theory (OAT), including its aetiology and treatment. In this review article I will from an appreciative perspective question some of its fundamental assumptions by presenting an alternative view on the ontology of ‘the person’, as distinct from its presently assumed conventional conflation with a contracted separate egoic self. I will propose this view as structurally and ethically significant for the ‘embodied’ experience of a reconstructed “dynamic and non-dual self”, as (...) cultivated in their treatment. Rather than this reconstructed self simply being socially desirable for functional purposes, I will underscore the meaning-generative case for ontological status, in the absence of which, a pervasive ‘sense of lack’ is evident, with all attendant individual, psychological, social, ecological and ethical implications. This article brings a developmental psychology perspective to bear in appreciating ‘personhood’ as an emergent, progressively realised and is thus similarly aligned with the intent of OAT in overcoming egoic addictive suffering. This mapping of the territory however populates a blind spot in OAT’s diagnosis by affirming unique personhood, a quality of ‘integrative presence’, meaningfully understood as a psycho-spiritual ontological reality. It offers, as with OAT’s stated intent, the merit of avoiding attendant mental health and developmental pitfalls, which can beset what we may discern as an implicit transcendental reductionist assumption operative in OAT, where ‘the many’ are reduced to ‘the One’ and there are, it is assumed, no real many. This framing is resonant with the lived experience of healthy ‘individuation’, a process distinct from the problematic phenomenon of ‘individualism’, evidenced by the empirical data on post-conventional human development, which potentially provides diagnostic markers for any optimal treatment discernment. It is also attuned to what many recognise as a contemporary Fourth Turning in Buddhism, in its conscious evolutionary recognition of the emergence in non-dual states of a ‘unique personal perspective’, and/or a relative individuation within the whole. This differentiation has formerly been interpreted through an ‘impersonal’ lens as an egoic holdover, and potentially inhibits ethical action in the world, as distinct from the ethical import and potential fruits stemming from the ontological affirmation of the person. Keywords: ego; unique personhood; ontology; epistemology; contemplative traditions; Western Enlightenment; developmental psychology; transcendental reductionism; Fourth Turning in Buddhism. (shrink)

In general we think of reasoning as a way of moving from some body of evidence to a belief that is drawn as a conclusion from it. But is it possible for reasoning to conclude in action, i.e., in a person’s intentionally doing one thing or another? In PRACTICAL SHAPE Jonathan Dancy answers 'Yes', on the grounds that "when an agent deliberates well and then acts accordingly, the action done is of the sort most favoured by the considerations rehearsed, taken (...) as a whole—just as when an agent reasons well and then believes accordingly, the belief formed ... is of the sort most favoured by the considerations rehearsed, again taken as a whole" (Dancy 2018, p. 29). I critique this supposed parallelism between reasoning to action and reasoning to belief, arguing in two ways that in practical reasoning the action that is one’s conclusion need not be meant to be, or to be of a sort, that is most favored by the considerations that one reasons from. I then go on to explain why this should be: that in practical reasoning the correct conclusion to draw is not supposed to have been determined in advance, because this is a form of reasoning by which we create truth through acting rather than reflecting a truth that is independently so. (shrink)