There is a deeply entrenched view in philosophy and physics, the closed systems view, according to which isolated systems are conceived of as fundamental. On this view, when a system is under the influence of its environment this is described in terms of a coupling between it and a separate system which taken together are isolated. We argue against this view, and in favor of the alternative open systems view, for which systems interacting with their environment are conceived of as (...) fundamental, and the environment's influence is represented via the dynamical equations that govern the system's evolution. Taking quantum theories of closed and open systems as our case study, and considering three alternative notions of fundamentality: (i) ontic fundamentality, (ii) epistemic fundamentality, and (iii) explanatory fundamentality, we argue that the open systems view is fundamental, and that this has important implications for the philosophy of physics, the philosophy of science, and for metaphysics. (shrink)

To what extent can Nietzsche's idea of the Overman be used in connection with transhumanist notions of highly advanced humans and even posthumans?

It is argued that those who defend the Everett, or ‘many-worlds’, interpretation of quantum mechanics should embrace what we call the general quantum theory of open systems (GT) as the proper framework in which to conduct foundational and philosophical investigations in quantum physics. GT is a wider dynamical framework than its alternative, standard quantum theory (ST). This is true even though GT makes no modifications to the quantum formalism. GT rather takes a different view, what we call the open systems (...) view, of the formalism; i.e., in GT, the dynamics of systems whose physical states are fundamentally represented by density operators are represented as fundamentally open as specified by an in general non-unitary dynamical map. This includes, in principle, the dynamics of the universe as a whole. We argue that the more general dynamics describable in GT can be physically motivated, that there is as much prima facie empirical support for GT as there is for ST, and that GT could be fully in the spirit of the Everett interpretation—that there might, in short, be little reason for an Everettian not to embrace the more general theoretical landscape that GT allows one to explore. (shrink)

Wittgenstein did not write very much on the topic of probability. The little we have comes from a few short pages of the Tractatus, some 'remarks' from the 1930s, and the informal conversations which went on during that decade with the Vienna Circle. Nevertheless, Wittgenstein's views were highly influential in the later development of the logical theory of probability. This paper will attempt to clarify and defend Wittgenstein's conception of probability against some oft-cited criticisms that stem from a misunderstanding of (...) his views. Max Black, for instance, criticises Wittgenstein for formulating a theory of probability that is capable of being used only against the backdrop of the ideal language of the Tractatus. I argue that on the contrary, by appealing to the 'hypothetical laws of nature', Wittgenstein is able to make sense of probability statements involving propositions that have not been completely analysed. G.H. von Wright criticises Wittgenstein's characterisation of these very hypothetical laws. He argues that by introducing them Wittgenstein makes what is distinctive about his theory superfluous, for the hypothetical laws are directly inspired by statistical observations and hence these observations indirectly determine the mechanism by which the logical theory of probability operates. I argue that this is not the case at all, and that while statistical observations play a part in the formation of the hypothetical laws, these observations are only necessary, but not sufficient conditions for the introduction of these hypotheses. (shrink)

Recently, there has been a renaissance of study on knowledge by acquaintance. One reason for this is that many writers believe acquaintance holds the key to understanding consciousness and our conscious experience of the world. For this reason, research on acquaintance has been primarily focused on perception and self-knowledge. While these questions are undoubtedly important, I believe being overly focused on these issues has prevented a defensible theory of knowledge by acquaintance from being developed. In particular, two questions have largely (...) been ignored in the literature. First, what kind of knowledge is knowledge by acquaintance? If knowledge by acquaintance is supposed to give us special epistemic access to its objects, what are the central epistemic features of it and how do they differ from other kinds of knowledge? Second, can we have knowledge by acquaintance beyond cases of perception and self-knowledge, and if so, how? In this dissertation, I answer both of these questions. In response to the first question, I argue that knowledge by acquaintance is a form of non-propositional discriminatory knowledge. Roughly, discriminatory knowledge is the exercise of a discriminatory capacity to single out a particular object from other objects of its kind. It is non-propositional because the object of the mental act of discriminating is not a proposition or truth. It is important that we understand knowledge by acquaintance in terms of discriminatory knowledge because it allows us to move beyond perceptual knowledge and self-knowledge. In this dissertation, I show how this is possible by showing that we can be acquainted with the natural numbers. This provides an answer to the second question. There is, in principle, no reason why acquaintance should only exist in sensory perception, provided we understand it in terms of discriminatory knowledge. The upshot of this is that my account of knowledge by acquaintance has a breadth and unity not often found in the acquaintance literature. (shrink)

For many years there has been a debate about the role of the parietal lobe in the generation of behavior. Does it generate movement plans (intention) or choose objects in the environment for further processing? To answer this, we focus on the lateral intraparietal area (LIP), an area that has been shown to play independent roles in target selection for saccades and the generation of visual attention. Based on results from a variety of tasks, we propose that LIP acts as (...) a priority map in which objects are represented by activity proportional to their behavioral priority. We present evidence to show that the priority map combines bottom-up inputs like a rapid visual response with an array of top-down signals like a saccade plan. The spatial location representing the peak of the map is used by the oculomotor system to target saccades and by the visual system to guide visual attention. (shrink)

Mystical Theology and Platonism in the Time of Cusanus engages with the history of mystical theology and Neoplatonic philosophy through the lens of the 15th century philosopher and theologian, Nicholas of Cusa. The volume comprises nineteen essays that break down the barriers between medieval and Renaissance studies, reinterpreting Cusanus’ place in the history of thought by exploring the archive that informed his thinking, while also interrogating his works by exploring them from the standpoint of their later reception by modern philosophers (...) and theologians. The volume also offers tribute to the career of Donald F. Duclow, a leading scholar in the field of Cusanus studies in particular and of the history of mystical theology and Neoplatonic philosophy more generally. (shrink)

In "Frailty Triage: Is Rationing Intensive Medical Treatment on the Grounds of Frailty Ethical?," Wilkinson (2021) argues that the use of frailty scores in ICU triage does not necessarily involve discrimination on the basis of disability. In support of this argument, he claims, “it is not the disability per se that the score is measuring – rather it is the underlying physiological and physical vulnerability." While we appreciate the attention Wilkinson explicitly pays to disability in this piece, we find the (...) distinction between disability and underlying vulnerability untenable both theoretically and practically. In this peer commentary, we begin with a brief overview of research in philosophy of disability concerning the meaning of the concept itself. We argue that this research demonstrates that many forms of disability do not involve underlying vulnerabilities, and, furthermore, that Wilkinson equivocates between "disability" understood as a medical category vs. "disability" understood as a feature of lived experience. We reject Wilkinson’s distinction on these grounds and offer further considerations to avoid disability discrimination in emergency and crisis standards of care contexts. (shrink)

G. A. Cohen’s pathbreaking book, Karl Marx‘s Theory of History: A Defence (1978), prompted extensive reconsideration of historical materialism. This effort recast ongoing debates about Marx‘s theory of history by defending the view that historical materialism embodies a set of substantive claims as appropriately subject to analytical scrutiny as those of any other viable theory. Specifically, Cohen advances one central substantive claim that summarizes his reading of the “Preface” to A Contribution to the Critique of Political Economy. “History is, fundamentally, (...) the growth of productive power, and forms of society rise and fall according as they enable or impede that growth.” This premise affirms that the same set of factors that explain changes societies undergo within a given historical epoch also explain transitions between historical epochs. The theoretical account of intraepochal historical development suffices equally to cover interepochal, revolutionary change. In this paper we reject this premise and argue that even on the most plausible reconstruction of Marx’s theory of history—a reconstruction that employs, among other things, a careful ownership-based criterion of historical epochs and the use of functional explanations—Marx’s theory of history cannot explain social revolutions. -/- . (shrink)

Predication is an indisputable part of our linguistic behavior. By contrast, the metaphysics of predication has been a matter of dispute ever since antiquity. According to Plato—or at least Platonism, the view that goes by Plato’s name in contemporary philosophy—the truths expressed by predications such as “Socrates is wise” are true because there is a subject of predication (e.g., Socrates), there is an abstract property or universal (e.g., wisdom), and the subject exemplifies the property.1 This view is supposed to be (...) general, applying to all predications, whether the subject of predication is a person, a planet, or a property.2 Despite the controversy surrounding the metaphysics of predication, many theistic philosophers—including the majority of contemporary analytic theists—regard Platonism as extremely attractive. At the same time, however, such philosophers are also commonly attracted to a form of traditional theism that has at its core the thesis that God is an absolutely independent.. (shrink)

Understanding everyday behavior relies heavily upon understanding our ability to improvise, how we are able to continuously anticipate and adapt in order to coordinate with our environment and others. Here we consider the ability of musicians to improvise, where they must spontaneously coordinate their actions with co-performers in order to produce novel musical expressions. Investigations of this behavior have traditionally focused on describing the organization of cognitive structures. The focus, here, however, is on the ability of the time-evolving patterns of (...) inter-musician movement coordination as revealed by the mathematical tools of complex dynamical systems to provide a new understanding of what potentiates the novelty of spontaneous musical action. We demonstrate this approach through the application of cross wavelet spectral analysis, which isolates the strength and patterning of the behavioral coordination that occurs between improvising musicians across a range of nested time-scales. Revealing the sophistication of the previously unexplored dynamics of movement coordination between improvising musicians is an important step towards understanding how creative musical expressions emerge from the spontaneous coordination of multiple musical bodies. (shrink)

Editors' introduction to 3rd thematic issue on philosophy of medicine.

Various approaches have emerged over the last several decades to meet the challenges and complexities of anticipating and responding to the potential impacts of emerging technologies. Although many of the existing approaches share similarities, they each have shortfalls. This paper takes as the object of its study Anticipatory Ethics for Emerging Technologies (ATE) to technology assessment, given that it was formatted to address many of the privations characterising parallel approaches. The ATE approach, also in practice, presents certain areas for retooling, (...) such as how it characterises levels and objects of analysis. This paper results from the work done with the TechEthos Horizon 2020 project in evaluating the ethical, legal, and social impacts of climate engineering, digital extended reality, and neurotechnologies. To meet the challenges these technology families present, this paper aims to enhance the ATE framework to encompass the variety of human processes and material forms, functions, and applications that comprise the socio-technical systems in which these technologies are embedded. (shrink)

Risk Management Strategies and Investment Behaviors are considered important factors in the investing activities of the retail investors. This study seeks to determine the relationship between Risk Management Strategies and Investment Behavior of Generation Z retail investors. The study is a correlational research and purposive sampling was used to select the respondents for this study. Cochran’s formula was utilized to determine the total sample size or total number of respondents. Spearman’s Rank-Order Correlation was employed to assess the significant relationship of (...) Risk Management Strategies and Investment Behaviors. Based on the results, it showed that risk management strategies have a significant relationship with one or more of the investment behaviors. Risk avoidance has a significant relationship with confirmation bias. Risk reduction has a significant relationship with all of the investment behaviors such as overconfidence, loss-aversion, recency bias, and confirmation bias. Risk transfer shows a significant relationship with only loss-aversion and confirmation bias. And lastly, risk acceptance also has a significant relationship with all of the investment behaviors. This study recommends exploring other types of behavioral biases under cognitive bias and emotional bias to determine their correlation with risk management strategies. Also, broadening the sample size, demographic scope, and geographic scope of the study can improve the generalizability of the study and provide a more comprehensive understanding of the relationship between investment behavior and risk management strategies. The researchers also recommend to utilize interviews and focus group discussions to gain an in-depth understanding of the underlying values and attitudes concerning investment behavior. (shrink)

The Christian doctrine of the Trinity poses a serious philosophical problem. On the one hand, it seems to imply that there is exactly one divine being; on the other hand, it seems to imply that there are three. There is another well-known philosophical problem that presents us with a similar sort of tension: the problem of material constitution. We argue in this paper that a relatively neglected solution to the problem of material constitution can be developed into a novel solution (...) to the problem of the Trinity. (shrink)

This three-part paper presents Gordon Pask’s conversation theory (CT) and interaction of actors theory (IA) and outlines ways to apply these cybernetic approaches to designing technologies and scenarios for both formal and informal learning. The first part of the paper covers concepts central to CT and IA, explaining the relationship between conceptual and mechanical operators, and machines mediating informal and formal learning. The second part of the paper applies visual representations of CT and IA to understanding the use of Pask’s (...) course assembly systems (CASTE and THOUGHTSTICKER), created between the late 1960s and the 1980s, and the ThoughtShuffler search interface, created in the 2010s. The third part proposes two pathways for design based on CT and IA: firstly, the potential for designers and observers to reformulate the qualities of tools and learning scenarios to augment human thinking and collective action; and secondly, the possibility to create tools with malleable interfaces that allow users to become intermediaries rather than consumers of knowledge. (shrink)

If you have ever had to move house, you will know this: the worst part is the sofa. You cannot do it alone. Nor will it be enough for me to just lift one end waiting for you to lift the other. We will have to work together to get the job done. If spaces are tight, we will even have to find a practical solution to a tantalizing mathematical puzzle: the moving sofa problem.Joint actions like that are part and (...) parcel of everyday life. But what exactly is special about acting together? After all, the actions of two strangers also depend on one another when one exits and the other enters through a revolving door, when they happen to walk side-by-side along a forest path, or when they exchange blows in a pub brawl.The problem is that two patterns of social behavior might look identical, even though one is a case of joint action and the other is not. There need not be an observable difference between the movements of old friends taking their morning constitutional together, on the one hand, a .. (shrink)

This paper challenges Williamson's "E = K" thesis on the basis of evidential practice. The main point is that most evidence is only approximately true and so cannot be known if knowledge is factive.

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

This collection of articles was written over the last 10 years and the most important and longest within the last year. Also I have edited them to bring them up to date (2016). All the articles are about human behavior (as are all articles by anyone about anything), and so about the limitations of having a recent monkey ancestry (8 million years or much less depending on viewpoint) and manifest words and deeds within the framework of our innate psychology as (...) presented in the table of intentionality. As famous evolutionist Richard Leakey says, it is critical to keep in mind not that we evolved from apes, but that in every important way, we are apes. If everyone was given a real understanding of this (i.e., human ecology and psychology) in school, maybe civilization would have a chance. In my view these articles and reviews have many novel and highly useful elements, in that they use my own version of the recently (ca. 1980’s) developed dual systems view of our brain and behavior to lay out a logical system of rationality (personality, psychology, mind, language, behavior, thought, reasoning, reality etc.) that is sorely lacking in the behavioral sciences (psychology, philosophy, literature, politics, anthropology, history, economics, sociology etc.). (shrink)

Ho letto molte recenti discussioni sui limiti del calcolo e dell'universo come computer, sperando di trovare alcuni commenti sull'incredibile lavoro del fisico polimatematico e del teorista delle decisioni David Wolpert, ma non ho trovato una sola citazione e quindi presento questo brevissimo riassunto. Wolpert si dimostrò una straordinaria impossibilità o incompletezza teoremi (1992-2008-see arxiv dot org) sui limiti dell'inferenza (calcolo) che sono così generali che sono indipendenti dal dispositivo che fa il calcolo, e anche indipendenti dalle leggi della fisica, in (...) modo che si applichino tra computer, fisica e comportamento umano. Fanno uso della diagonalizzazione di Cantor, del paradosso bugiardo e delle linee del mondo per fornire quello che potrebbe essere il teorema definitivo nella Teoria delle Macchine di Turing, e apparentemente forniscono intuizioni sull'impossibilità, l'incompletezza, i limiti del calcolo, e l'universo come computer, in tutti gli universi possibili e in tutti gli esseri o meccanismi, generando, tra le altre cose, un principio di incertezza meccanica non quantistica e una prova di monoteismo. Ci sono evidenti connessioni con l'opera classica di Chaitin, Solomonoff, Komolgarov e Wittgenstein e alla nozione che nessun programma (e quindi nessun dispositivo) può generare una sequenza (o dispositivo) con maggiore complessità di quella che possiede. Si potrebbe dire che questo corpo di lavoro implica l'ateismo poiché non può esserci alcuna entità più complessa dell'universo fisico e dal punto di vista della Wittgensteinian, "più complesso" non ha senso (non ha condizioni di soddisfazione, cioè, creatore di verità o test). Anche un 'Dio' (cioè un 'dispositivo'con tempo/spazio illimitato ed energia) non può, determinare se un dato "numero" è 'casuale', né trovare un modo per dimostrare che una determinata "formula", "teorema" o "sentenza" o "dispositivo" (tutti questi sono giochi linguistici complessi) fa parte di un particolare "sistema". Coloro che desiderano un quadro aggiornato completo per il comportamento umano dalla moderna vista a due systems possono consultare il mio libro 'La struttura logica dellafilosofia, psicologia, Mind e il linguaggio in Ludwig Wittgenstein e John Searle' 2nd ed (2019). Coloro che sono interessati a più dei miei scritti possono vedere 'TalkingMonkeys--Filosofia, Psicologia, Scienza, Religione e Politica su un Pianeta Condannato--Articoli e Recensioni 2006-2019nd ed (2019) e Suicidal Utopian Delusions nel 21st Century 4th ed (2019) . (shrink)

Over the last few decades, virtue has become increasingly important in philosophy, psychology, cognitive science, and education. However, as each of these disciplines approaches virtue from a decidedly different perspective, it has proven difficult to come up with an understanding of virtue that satisfies the standards of all four disciplines. In their book, Jennifer Wright, Michael Warren, and Nancy Snow attempt to put forward such an understanding.

Inauguration speech at chair number 18 of the Brasilian Academy of Philosophy.

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

Sceptical theists--e.g., William Alston and Michael Bergmann--have claimed that considerations concerning human cognitive limitations are alone sufficient to undermine evidential arguments from evil. We argue that, if the considerations deployed by sceptical theists are sufficient to undermine evidential arguments from evil, then those considerations are also sufficient to undermine inferences that play a crucial role in ordinary moral reasoning. If cogent, our argument suffices to discredit sceptical theist responses to evidential arguments from evil.

Laboratory science is our only source of knowledge about the world as it is apart from our perceptions of the world. Empiricist philosophy, relying on evidence consisting in human perceptions, can only give us knowledge of phenomena making up the world-perceived, which recent neuroscience tells us is wholly and entirely constructed by our neuron-based human perceptual apparatus. In this light, empiricist philosophy should explicitly and fundamentally be reconceived as a method of thinking critically about phenomena, i.e. as a stripped down, (...) fallibilist, non-foundationalist version of “phenomenology”. I also describe implications of these proposals for thinking critically about and conceptualizing phenomena like the Cartesian “I”-that-thinks, consciousness, mind, personal identity, free will, and causal relationships between the brain and the conscious “I.”. (shrink)

Freud proposes that in unconscious processing, logical connections are also (heavily) based upon phonological similarities. Repressed concerns, for example, would also be expressed by way of phonologic ambiguity. In order to investigate a possible unconscious influence of phonological similarity, 31 participants were submitted to a tachistoscopic subliminal priming experiment, with prime and target presented at 1ms. In the experimental condition, the prime and one of the 2 targets were phonological reversed forms of each other, though graphemically dissimilar (e.g., “nice” and (...) “sign”); in the control condition the targets were pseudo-randomly attributed to primes to which they don’t belong. The experimental task was to “blindly” pick the choice most similar to the prime. ERPs were measured with a focus on the N320, which is known to react selectively to phonological mismatch in supraliminal visual word presentations. The N320 amplitude-effects at the electrodes on the midline and at the left of the brain significantly predicted the participants’ net behavioral choices more than half a second later, while their subjective experience is one of arbitrariness. Moreover, the social desirability score (SDS) significantly correlates with both the behavioral and the N320 brain responses of the participants. It is proposed that in participants with low SDS the phonological target induces an expected reduction of N320 and this increases their probability to pick this target. In contrast, high defensive participants have a perplexed brain reaction upon the phonological target, with a negatively peaking N320 as compared to control and this leads them to avoid this target more often. Social desirability, which is understood as reflecting defensiveness, might also manifest itself as a defense against the (energy-consuming) ambiguity of language. The specificity of this study is that all of this is happening totally out of awareness and at the level of very elementary linguistic distinctions. (shrink)

Some types of solar radiation management (SRM) research are ethically problematic because they expose persons, animals, and ecosystems to significant risks. In our earlier work, we argued for ethical norms for SRM research based on norms for biomedical research. Biomedical researchers may not conduct research on persons without their consent, but universal consent is impractical for SRM research. We argue that instead of requiring universal consent, ethical norms for SRM research require only political legitimacy in decision-making about global SRM trials. (...) Using Allen Buchanan & Robert Keohane's model of global political legitimacy, we examine several existing global institutions as possible analogues for a politically legitimate SRM decision-making body. (shrink)

Empirical evidence from developmental psychology and anthropology points out that the human mind is predisposed to conceptualize the world in particular, species-specific ways. These cognitive predispositions lead to universal human commonsense views, often referred to as folk theories. Nevertheless, humans can transgress these views – i.e. they can contradict them with alternative descriptions, they perceive as more accurate – as exemplified in modern sciences. In this paper, I enquire about the cognitive faculties underlying such transgressions. I claim that there are (...) three faculties enabling us to part with these universal commonsense views of the world imposed by our nature. The first is our ability to represent representations – i.e. to form metarepresentations. The second is our ability to produce alternative representations both by explaining a familiar subject matter in terms of the principles governing different conceptual domains than the one that we are predisposed to apply to the subject matter and by directing our mind to new subject matters (for which we have no predisposed conceptual grasp), understanding them in terms of familiar domains. The third, finally, is our ability to give these representations an epistemic orientation. Key words: Human cognition, Domain-specific knowledge systems, Cognitive predispositions, Folk theories, Cognitive flexibility, Human – nonhuman distinction. (shrink)

Ontology is one strategy for promoting interoperability of heterogeneous data through consistent tagging. An ontology is a controlled structured vocabulary consisting of general terms (such as “cell” or “image” or “tissue” or “microscope”) that form the basis for such tagging. These terms are designed to represent the types of entities in the domain of reality that the ontology has been devised to capture; the terms are provided with logical defi nitions thereby also supporting reasoning over the tagged data. Aim: This (...) paper provides a survey of the biomedical imaging ontologies that have been developed thus far. It outlines the challenges, particularly faced by ontologies in the fields of histopathological imaging and image analysis, and suggests a strategy for addressing these challenges in the example domain of quantitative histopathology imaging. The ultimate goal is to support the multiscale understanding of disease that comes from using interoperable ontologies to integrate imaging data with clinical and genomics data. (shrink)

David E. Cooper proposes that the ”mystery’ of ”reality as it “anyway‘ is, independently of human perspective’ provides measure for the leading of our lives and thus avoids, on the one hand, the hubris of a humanism for which moral life is the product of the human will and has no warrant beyond it, and, on the other, a theism which appears to be at once too remote from and too close to the human world to provide any such warrant. (...) The paper rejects the role this gives to ”mystery’ and locates ”warrant’ in a moral perspective that is not the product of will. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

This paper gives an account of Kant’s concept of self-contentment (Selbstzufriedenheit), i.e. the satisfaction involved in the performance of moral action. This concept is vulnerable to an important objection: if moral action is satisfying, it might only ever be performed for the sake of this satisfaction. I explain Kant’s response to this objection and argue that it is superior to Francis Hutcheson’s response to a similar objection. I conclude by showing that two other notions of moral satisfaction in Kant’s moral (...) philosophy, namely ‘sweet merit’ and the highest good, also avoid the objection. (shrink)

Scholars, journalists, and activists working on climate change often distinguish between “individual” and “structural” approaches to decarbonization. The former concern choices individuals can make to reduce their “personal carbon footprint” (e.g., eating less meat). The latter concern changes to institutions, laws, and other social structures. These two approaches are often framed as oppositional, representing a mutually exclusive forced choice between alternative routes to decarbonization. After presenting representative samples of this oppositional framing of individual and structural approaches in environmental communication, we (...) identify four problems with oppositional thinking and propose five ways to conceive of individual and structural reform as symbiotic and interdependent. (shrink)

유명한 개미맨 E.O. 윌슨은 뛰어난 생물학자일 뿐만 아니라, 적어도 다른 사람들이 이해하지 못하는 우리의 본성에 대한 진실을 감히 암시하기 위해 감히, 또는 정치적 편의를위해 공전적으로 피하는 소수의 지식인 중 한 명입니다. 슬프게도, 그는 적어도 하버드 동료들의 종교적 열정에 의해 동기를 부여 과학에 대한 무지하고 오만한 공격의 당사자로서 가장 끔찍한 방식으로 자신의 긴 경력을 끝내고 종교적 열정 있습니다. 그것은 대학이 종교 단체에서 돈을 받아 들일 때 사악한 결과를 보여줍니다, 과학 저널은 그들이 적절한 동료 검토를 피할 수 있도록 큰 이름에 의해 너무 (...) 경외, 그리고 자아가 통제에서 얻을 수 있을 때. 그것은 진화의 본질, 과학적 방법론의 기초, 수학이 과학과 어떻게 관련되는지, 이론을 구성하는 것이 무엇인지, 그리고 산업 문명의 붕괴에 가차없이 접근할 때 종교와 관대함에 대한 태도가 어떤 적절한지에 대해 설명합니다. 현대 의 두 시스템 보기에서인간의 행동에 대한 포괄적 인 최신 프레임 워크를 원하는 사람들은 내 책을 참조 할 수 있습니다'철학의 논리적 구조, 심리학, 민d와 루드비히 비트겐슈타인과 존 Searle의언어' 2nd ed (2019). 내 글의 더 많은 관심있는 사람들은 '이야기 원숭이를 볼 수 있습니다-철학, 심리학, 과학, 종교와 운명 행성에 정치 - 기사 및 리뷰 2006-2019 3 rd 에드 (2019) 및 21st 세기 4번째 에드 (2019) 및 기타에서 자살 유토피아 망상. (shrink)

Famoso formiga-homem E.O. Wilson sempre foi um dos meus heróis-não só um excelente biólogo, mas um dos minúsculos e desaparecendo minoria de intelectuais que, pelo menos, se atreve a sugerir a verdade sobre a nossa natureza que os outros não conseguem entender, ou na medida em que do agarrar , de forma a evitar a conveniência política. Infelizmente, ele está terminando sua longa carreira em uma moda mais sórdido como um partido para um ataque ignorante e arrogante sobre a ciência (...) motivada pelo menos em parte pelo fervor religioso de seus colegas de Harvard. Mostra as conseqüências vis quando as universidades aceitam o dinheiro dos grupos religiosos, as revistas da ciência são tão impressionado com por nomes grandes que evitam a revisão apropriada do par, e quando os egos são permitidos sair do controle. Leva-nos para a natureza da evolução, os fundamentos da metodologia científica, como a matemática se relaciona com a ciência, o que constitui uma teoria, e até mesmo as atitudes de religião e generosidade são apropriadas como nós inexoravelmente abordar o colapso da indústria da civilização. Aqueles que desejam um quadro até à data detalhado para o comportamento humano da opinião moderna dos dois sistemas consultar meu livros Falando Macacos 3ª Ed (2019), A Estrutura Lógica da Filosofia, Psicologia, Mente e Linguagem em Ludwig Wittgenstein e John Searle 2a Ed (2019), Suicídio Pela Democracia,4aEd(2019), Entendendo as Conexões entre Ciência, Filosofia, Psicologia, Religião, Política e Economia Artigos e Análises 2006-2019 (2019), Ilusões Utópicas Suicidas no 21St século 5a Ed (2019), A Estrutura Lógica do Comportamento Humano (2019), e A Estrutura Lógica da Consciência (2019) e outras. (shrink)

I give a detailed review of 'The Outer Limits of Reason' by Noson Yanofsky 403(2013) from a unified perspective of Wittgenstein and evolutionary psychology. I indicate that the difficulty with such issues as paradox in language and math, incompleteness, undecidability, computability, the brain and the universe as computers etc., all arise from the failure to look carefully at our use of language in the appropriate context and hence the failure to separate issues of scientific fact from issues of how language (...) works. I discuss Wittgenstein's views on incompleteness, paraconsistency and undecidability and the work of Wolpert on the limits to computation. -/- Those wishing a comprehensive up to date account of Wittgenstein, Searle and their analysis of behavior from the modern two systems view may consult my article The Logical Structure of Philosophy, Psychology, Mind and Language as Revealed in Wittgenstein and Searle (2016). Those interested in all my writings in their most recent versions may download from this site my e-book ‘Philosophy, Human Nature and the Collapse of Civilization Michael Starks (2016)- Articles and Reviews 2006-2016’ by Michael Starks First Ed. 662p (2016). -/- All of my papers and books have now been published in revised versions both in ebooks and in printed books. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) https://www.amazon.com/dp/B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B0711R5LGX . (shrink)

Célèbre fourmi-homme E.O. Wilson a toujours été l’un de mes héros - non seulement un biologiste exceptionnel, mais l’une des minorités minuscules et en voie de disparition des intellectuels qui ose au moins faire allusion à la vérité sur notre nature que d’autres ne parviennent pas à saisir, ou dans la mesure osant o saisir, soigneusement éviter pour l’opportunisme politique. Malheureusement, il met fin à sa longue carrière d’une manière très sordide en tant que parti à une attaque ignorante et (...) arrogante sur la science motivée au moins en partie par la ferveur religieuse de ses collègues de Harvard. Il montre les conséquences ignobles lorsque les universités acceptent l’argent de groupes religieux, les revues scientifiques sont tellement impressionnés par les grands noms qu’ils évitent l’examen par les pairs appropriés, et quand les egos sont autorisés à devenir hors de contrôle. Il nous entraîne dans la nature de l’évolution, les bases de la méthodologie scientifique, comment les mathématiques se rapportent à la science, ce qui constitue une théorie, et même quelles attitudes à la religion et la générosité sont appropriées que nous approchons inexorablement l’effondrement de la civilisation industrielle. Ceux qui souhaitent un cadre complet à jour pour le comportement humain de la vue moderne de deux systemes peuvent consulter mon livre 'The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle' 2nd ed (2019). Ceux qui s’intéressent à plus de mes écrits peuvent voir «Talking Monkeys --Philosophie, Psychologie, Science, Religion et Politique sur une planète condamnée --Articles et revues 2006-2019 3e ed (2019) et Suicidal Utopian Delusions in the 21st Century 4th ed (2020) et autres. (shrink)

Eu li muitas discussões recentes sobre os limites da computação e do universo como computador, na esperança de encontrar alguns comentários sobre o trabalho surpreendente do físico polimatemático e teórico da decisão David Wolpert, mas não encontrei uma única citação e assim que eu apresento este muito breve Resumo. Wolpert provou alguma impossibilidade impressionante ou teoremas da incompletude (1992 a 2008-Veja arxiv dot org) nos limites à inferência (computação) que são tão gerais que são independentes do dispositivo que faz a (...) computação, e mesmo independente das leis da física, para que eles se apliquem em computadores, física e comportamento humano. Eles fazem uso da diagonalização de cantor, o paradoxo mentiroso e worldlines (linhas do mundo) para fornecer o que pode ser o teorema final na teoria da máquina de Turing, e, aparentemente, fornecer insights sobre a impossibilidade, incompletude, os limites da computação, e do universo como computador, em todos os universos possíveis e todos os seres ou mecanismos, gerando, entre outras coisas, um princípio de incerteza mecânica não quântica e uma prova de monoteísmo. Há umas conexões óbvias ao trabalho clássico de Chaitin, Solomonoff, Komolgarov e Wittgenstein e à noção que nenhum programa (e assim nenhum dispositivo) pode gerar uma seqüência (ou dispositivo) com maior complexidade do que possui. Pode-se dizer que este corpo de trabalho implica ateísmo, uma vez que não pode haver qualquer entidade mais complexa do que o universo físico e do ponto de vista Wittgensteiniano, ' mais complexo ' é sem sentido (não tem condições de satisfação, ou seja, criador de verdade ou teste). Mesmo um ' Deus ' (ou seja, um ' dispositivo ' com tempo ilimitado/espaço e energia) não pode determinar se um determinado ' número ' é ' aleatório ', nem encontrar uma determinada maneira de mostrar que uma determinada ' fórmula ', ' teorema ' ou ' sentença ' ou ' Device ' (todos estes sendo linguagem complexa jogos) faz parte de um determinado «sistema». Aqueles que desejam um quadro até à data detalhado para o comportamento humano da opinião moderna dos dois sistemas consultar meu livros Falando Macacos 3ª Ed (2019), A Estrutura Lógica da Filosofia, Psicologia, Mente e Linguagem em Ludwig Wittgenstein e John Searle 2a Ed (2019), Suicídio Pela Democracia,4aEd(2019), Entendendo as Conexões entre Ciência, Filosofia, Psicologia, Religião, Política e Economia Artigos e Análises 2006-2019 (2019), Ilusões Utópicas Suicidas no 21St século 5a Ed (2019), A Estrutura Lógica do Comportamento Humano (2019), e A Estrutura Lógica da Consciência (2019) y outras. (shrink)

アメリカと世界は、過去1世紀の人口増加の大部分から崩壊し、今では第3位の世界の人々が原因で崩壊しています。資源の消費と30億人以上のca.2100の追加は、産業文明を崩壊させ、驚異的な規模で飢餓、病気 、暴力、戦争をもたらすでしょう。地球は毎年表土の少なくとも1%を失うので、2100に近づくにつれて、食料の栽培能力のほとんどは失われます。何十億人もの人々が死んでしまい、核戦争は確実です。アメリカでは 、大規模な移民と移民の再生によって、民主主義によって可能になった虐待と組み合わせることで、これは大幅に加速されています。堕落した人間性は、民主主義と多様性の夢を犯罪と貧困の悪夢に変える。中国は利己主義 を制限する独裁政権を維持する限り、アメリカと世界を圧倒し続けるだろう。崩壊の根本的な原因は、私たちの生来の心理学が現代の世界に適応できないことであり、人々は、彼らが共通の利益を持っているかのように無関 係な人を扱うように導きます。人権の考え方は、無制限の第三世界の母性によって地球の無慈悲な破壊から注意を引くために左翼によって促進された邪悪なファンタジーです。これは、基礎生物学と心理学の無知に加えて、 民主主義社会を支配する部分的に教育を受けた人々の社会工学の妄想につながります。一人の人が他人に危害を加えるのを助ければ、無料の昼食はなく、誰もが消費するすべてのアイテムが修理を超えて地球を破壊すること を理解している人はほとんどいません。その結果、どこでも社会政策は持続不可能であり、利己主義に対する厳格な統制なしにすべての社会が一つ一つ無秩序または独裁に崩壊するだろう。最も基本的な事実は、ほとんど言 及されていないが、貧困から貧しい人々のかなりの割合を持ち上げ、そこにそれらを維持するために、アメリカや世界に十分な資源が存在しないことです。これを行おうとする試みは、アメリカを破産させ、世界を破壊して いる。地球の食糧生産能力は、私たちの遺伝的品質と同様に、毎日減少します。そして今、いつものように、貧しい人々の最大の敵は、他の貧しい人々であり、金持ちではない。劇的かつ即時の変化がなければ、アメリカの 崩壊を防ぐ望みはないし、民主主義システムに従う国も存在しない。.

著名的蚂蚁人E.O.Wilson一直是我的英雄之一——不仅是一位杰出的生物学家,而且是一小撮正在消失的知识分子,他们至少敢于暗示我们本性的真相,而其他人却无法领会,或者只要他们所掌握的,刻意避免政治权 宜之计。可悲的是,他以最脏的方式结束了他漫长的职业生涯,成为对科学的无知和傲慢攻击的一方,至少部分是出于哈佛同事的宗教热情。它显示了当大学接受宗教团体的钱,科学期刊被大牌们敬畏,以至于他们避免适当的同 行评议,当自我被允许失控时,后果不堪设想。它带我们进入进化的本质,科学方法论的基础,数学如何与科学的关系,什么构成一个理论,甚至什么态度的宗教和慷慨是适当的,因为我们无情地接近工业的崩溃文明。 那些希望从现代两个系统的观点来看为人类行为建立一个全面的最新框架的人,可以查阅我的书《路德维希的哲学、心理学、Min d和语言的逻辑结构》维特根斯坦和约翰·西尔的《第二部》(2019年)。那些对我更多的作品感兴趣的人可能会看到《会说话的猴子——一个末日星球上的哲学、心理学、科学、宗教和政治——文章和评论2006-20 19年第3次(2019年)和自杀乌托邦幻想21篇世纪4日 (2019) .

Philosophers often claim that studying philosophy helps people to become better thinkers. Thanks to a grant from the American Philosophical Association, we were able to test this claim empirically, using a large sample of students (N = 122,352) graduating from 369 colleges and universities across the United States between 2010 and 2019. We investigated whether philosophy majors show more growth than non-philosophy majors in intellectual traits like open-mindedness and a tendency to think carefully and thoroughly, as well as more personal (...) forms of growth that might be fostered by philosophical study (e.g., self-understanding). Additionally, although this was not our primary question, we sought to better understand what students who major in philosophy are like. Specifically, we examined the demographics of philosophy majors, the other subjects that they tend to study when they double major, and the patterns of adding and dropping of philosophy majors between freshman and senior year. (shrink)

In Beyond Physicalism, an interdisciplinary group of physical scientists, behavioral and social scientists, and humanists from the Esalen Institute’s Center for Theory and Research argue that physicalism must be replaced by an expanded scientific naturalism that accommodates something spiritual at the heart of nature.

This paper is about the so-called meta-grounding question, i.e. the question of what grounds grounding facts of the sort ‘φ is grounded in Γ ’. An answer to this question is pressing since some plausible assumptions about grounding and fundamentality entail that grounding facts must be grounded. There are three different accounts on the market which each answer the meta-grounding question differently: Bennett’s and deRosset’s “Straight Forward Account” (SFA), Litland’s “Zero-Grounding Account” (ZGA), and “Grounding Essentialism” (GE). I argue that if (...) grounding is to be regarded as metaphysical explanation (i.e. if unionism is true), (GE) is to be preferred over (ZGA) and (SFA) as only (GE) is compatible with a crucial consequence of the thought that grounding is metaphysical explanation. In this manner the paper contributes not only to discussions about the ground of ground but also to the ongoing debate concerning the relationship between ground, essence, and explanation. (shrink)

Foundations of Relational Realism presents an intuitive interpretation of quantum mechanics, based on a revised decoherent histories interpretation, structured within a category theoretic topological formalism. -/- If there is a central conceptual framework that has reliably borne the weight of modern physics as it ascends into the twenty-first century, it is the framework of quantum mechanics. Because of its enduring stability in experimental application, physics has today reached heights that not only inspire wonder, but arguably exceed the limits of intuitive (...) vision, if not intuitive comprehension. For many physicists and philosophers, however, the currently fashionable tendency toward exotic interpretation of the theoretical formalism is recognized not as a mark of ascent for the tower of physics, but rather an indicator of sway—one that must be dampened rather than encouraged if practical progress is to continue. -/- In this unique two-part volume, designed to be comprehensible to both specialists and non-specialists, the authors chart out a pathway forward by identifying the central deficiency in most interpretations of quantum mechanics: That in its conventional, metrical depiction of extension, inherited from the Enlightenment, objects are characterized as fundamental to relations—i.e., such that relations presuppose objects but objects do not presuppose relations. The authors, by contrast, argue that quantum mechanics exemplifies the fact that physical extensiveness is fundamentally topological rather than metrical, with its proper logico-mathematical framework being category theoretic rather than set theoretic. -/- By this thesis, extensiveness fundamentally entails not only relations of objects, but also relations of relations. Thus, the fundamental quanta of quantum physics are properly defined as units of logico-physical relation rather than merely units of physical relata as is the current convention. Objects are always understood as relata, and likewise relations are always understood objectively. In this way, objects and relations are coherently defined as mutually implicative. The conventional notion of a history as “a story about fundamental objects” is thereby reversed, such that the classical “objects” become the story by which we understand physical systems that are fundamentally histories of quantum events. -/- These are just a few of the novel critical claims explored in this volume—claims whose exemplification in quantum mechanics will, the authors argue, serve more broadly as foundational principles for the philosophy of nature as it evolves through the twenty-first century and beyond. (shrink)

Basic Emotion Theory, or BET, has dominated the affective sciences for decades (Ekman, 1972, 1992, 1999; Ekman and Davidson, 1994; Griffiths, 2013; Scarantino and Griffiths, 2011). It has been highly influential, driving a number of empirical lines of research (e.g., in the context of facial expression detection, neuroimaging studies and evolutionary psychology). Nevertheless, BET has been criticized by philosophers, leading to calls for it to be jettisoned entirely (Colombetti, 2014; Hufendiek, 2016). This paper defuses those criticisms. In addition, it shows (...) that we have good reason to retain BET. Finally, it reviews and puts to rest worries that BET’s commitment to affect programs renders it outmoded. We propose that, with minor adjustments, BET can avoid such criticisms when conceived under a radically enactive account of emotions. Thus, rather than leaving BET behind, we show how its basic ideas can be revised, refashioned and preserved. Hence, we conclude, our new BET is still a good bet. (shrink)

Este livro é inestimável como uma sinopse de algumas das obras de um dos maiores filósofos dos últimos tempos. Há muito valor em analisar suas respostas às confusões básicas da filosofia, e em tentativas geralmente excelentes de conectar o pensamento clássico chinês com a filosofia moderna. Eu tenho uma visão moderna de Wittgensteiniano para colocá-lo em perspectiva. Aqueles que querem uma estrutura completa até o momento para o comportamento humano do ponto de vista moderno de dois sistemas podem consultar meus (...) livros Talking Monkeys 3rd ed (2019), The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle 2nd ed (2019), Suicídio pela Democracia 4a ed (2019), Estrutura Lógica do Comportamento Humano (2019), A Estrutura Lógica da Consciência (2019), Entendendo as Conexões Entre Ciência, Filosofia, Psicologia, Religião, Política e Economia (2019), Delírios Utópicos Suicidas no século XXI (2019), Observações sobre Impossibilidade, Incompletude, Paraconsistência, Indecidabilidade, Alealeitividade, Computabilidade, Informática, Paradoxo e Incerteza em Chaitin, Wittgenstein, Hofstadter, Wolpert, Doria, Doria, da Costa , Godel, Searle, Rodych Berto, Floyd, Moyal-Sharrock e Yanofsky (2019) e outros. (shrink)

While philosophers hold that it is patently absurd to blame robots or hold them morally responsible [1], a series of recent empirical studies suggest that people do ascribe blame to AI systems and robots in certain contexts [2]. This is disconcerting: Blame might be shifted from the owners, users or designers of AI systems to the systems themselves, leading to the diminished accountability of the responsible human agents [3]. In this paper, we explore one of the potential underlying reasons for (...) robot blame, namely the folk's willingness to ascribe inculpating mental states or "mens rea" to robots. In a vignette-based experiment (N=513), we presented participants with a situation in which an agent knowingly runs the risk of bringing about substantial harm. We manipulated agent type (human v. group agent v. AI-driven robot) and outcome (neutral v. bad), and measured both moral judgment (wrongness of the action and blameworthiness of the agent) and mental states attributed to the agent (recklessness and the desire to inflict harm). We found that (i) judgments of wrongness and blame were relatively similar across agent types, possibly because (ii) attributions of mental states were, as suspected, similar across agent types. This raised the question - also explored in the experiment - whether people attribute knowledge and desire to robots in a merely metaphorical way (e.g., the robot "knew" rather than really knew). However, (iii), according to our data people were unwilling to downgrade to mens rea in a merely metaphorical sense when given the chance. Finally, (iv), we report a surprising and novel finding, which we call the inverse outcome effect on robot blame: People were less willing to blame artificial agents for bad outcomes than for neutral outcomes. This suggests that they are implicitly aware of the dangers of overattributing blame to robots when harm comes to pass, such as inappropriately letting the responsible human agent off the moral hook. (shrink)