In this paper, a novel experimental task is developed for testing the highly influential, but experimentally underexplored, possible worlds account of conditionals (Stalnaker, 1968; Lewis, 1973). In Experiment 1, this new task is used to test both indicative and subjunctive conditionals. For indicative conditionals, five competing truth tables are compared, including the previously untested, multi-dimensional possible worlds semantics of Bradley (2012). In Experiment 2, these results are replicated and it is shown that they cannot be accounted for by an (...) alternative hypothesis proposed by our reviewers. In Experiment 3, individual variation in truth assignments of indicative conditionals is investigated via Bayesian mixture models that classify participants as following one of several competing models. As a novelty of this study, it is found that a possible worlds semantics of Lewis and Stalnaker is capable of accounting for participants’ aggregate truth value assignments in this task. Applied to indicative conditionals, we show across three experiments, that the theory both captures participants’ truth values at the aggregate level (Experiments 1 and 2) and that it makes up the largest subgroup in the analysis of individual variation in our experimental paradigm (Experiment 3). (shrink)

In this paper, we argue for a novel three-dimensionalist solution to the problem of persistence, i.e. cross-temporal identity. We restrict the discussion of persistence to simple substances, which do not have other substances as their parts. The account of simple substances employed in the paper is a trope-nominalist strong nuclear theory, which develops Peter Simons' trope nominalism. Regarding the distinction between three dimensionalism and four dimensionalism, we follow Michael Della Rocca's formulation, in which 3D explains persistence in virtue of (...) same entities and 4D in virtue of distinct entities. SNT is a 3D'ist position because it accounts for the persistence of simple substances in virtue of diachronically identical ‘nuclear’ tropes. The nuclear tropes of a simple substance are necessary for it and mutually rigidly dependent but distinct. SNT explains qualitative change by tropes that are contingent to a simple substance. We show that it avoids the standard problems of 3D: temporal relativization of ontic predication, Bradley's regress and coincidence, fission and fusion cases. The temporal relativization is avoided because of the analysis of temporary parts that SNT gives in terms of temporal sub-location, which is atemporal part–whole relation. (shrink)

In this paper, I articulate and argue for a new truthmaker view of ontological commitment, which I call the “General Truthmaker View”: when one affirms a sentence, one is ontologically committed to there being something that makes true the proposition expressed by the sentence. This view comes apart from Quinean orthodoxy in that we are not ontologically committed to the things over which we quantify, and it comes apart from extant truthmaker views of ontological commitment in that we are not (...) ontologically committed to the truthmakers of our sentences. (shrink)

Many philosophers and scientists have claimed that time has an arrow that points in a special direction. The Roman poet Ovid may have referred to this one-way property of time when he said, “Time itself glides on with constant motion, ever as a flowing river.” However, understanding this arrow is not … Continue reading The Arrow of Time →.

In this paper, I offer a new theory of grounding. The theory has it that grounding is a job description that is realized by different properties in different contexts. Those properties play the grounding role contingently, and grounding is the property that plays the grounding role essentially. On this theory, grounding is monistic, but ‘grounding’ refers to different relations in different contexts. First, I argue against Kit Fine’s monist univocalism. Next, I argue against Jessica Wilson’s pluralist multivocalism. Finally, I introduce (...) monist multivocalism, explicate three versions of it (of which the above is one), and show its advantages. (shrink)

Contrary to Block's assertion, “identity-crowding” does not provide an interesting instance of object-seeing without object-attention. The successful judgments and unusual phenomenology of identity-crowding are better explained by unconscious perception and non-perceptual phenomenology associated with cognitive states. In identity-crowding, as in other cases of crowding, subjects see jumbled textures and cannot individuate the items contributing to those textures in the absence of attention. Block presents an attenuated sense in which identity-crowded items are seen, but this is irrelevant to the debate about (...) phenomenal experience of an object in the absence of object-attention. Finally, even unconscious object perception in identity-crowding likely involves an attention-like selective process. (shrink)

Many epistemological problems can be solved by the objective Bayesian view that there are rationality constraints on priors, that is, inductive probabilities. But attempts to work out these constraints have run into such serious problems that many have rejected objective Bayesianism altogether. I argue that the epistemologist should borrow the metaphysician’s concept of naturalness and assign higher priors to more natural hypotheses.

Surprisingly little has been written about hedged assertion. Linguists often focus on semantic or syntactic theorizing about, for example, grammatical evidentials or epistemic modals, but pay far less attention to what hedging does at the level of action. By contrast, philosophers have focused extensively on normative issues regarding what epistemic position is required for proper assertion, yet they have almost exclusively considered unqualified declaratives. This essay considers the linguistic and normative issues side-by-side. We aim to bring some order and clarity (...) to thinking about hedging, so as to illuminate aspects of interest to both linguists and philosophers. In particular, we consider three broad questions. 1) The structural question: when one hedges, what is the speaker’s commitment weakened from? 2) The functional question: what is the best way to understand how a hedge weakens? And 3) the taxonomic question: are hedged assertions genuine assertions, another speech act, or what? (shrink)

Peirce and Dewey were generally more concerned with the process of scientific activity than purely mathematical work. However, their accounts of knowledge production afford some insights into the epistemology of mathematical postulates, especially definition and axioms. Their rejection of rationalist metaphysics and their emphasis on continuity in inquiry provides the pretext for the pragmatic a priori – hypothetical and operational assumptions whose justification relies on their fruitfulness in the long run. This paper focuses on the application of this idea to (...) the epistemology of definitions and an account of progress in mathematics, although it has broader implications for the study of conceptual change and the function and basis of presuppositions in the sciences. (shrink)

Adam Elga takes the Sleeping Beauty example to provide a counter-example to Reflection, since on Sunday Beauty assigns probability 1/2 to H, and she is certain that on Monday she will assign probability 1/3. I will show that there is a natural way for Bas van Fraassen to defend Reflection in the case of Sleeping Beauty, building on van Fraassen’s treatment of forgetting. This will allow me to identify a lacuna in Elga’s argument for 1/3. I will then argue, however, (...) that not all is well with Reflection: there is a problem with van Fraassen’s treatment of forgetting. Ultimately I will agree with Elga’s 1/3 answer. David Lewis maintains that the answer is 1/2; I will argue that cases of forgetting can be used to show that the premiss of Lewis’s argument for 1/2 is false. (shrink)

I argue that the wave function ontology for quantum mechanics is an undesirable ontology. This ontology holds that the fundamental space in which entities evolve is not three-dimensional, but instead 3N-dimensional, where N is the number of particles standardly thought to exist in three-dimensional space. I show that the state of three-dimensional objects does not supervene on the state of objects in 3N-dimensional space. I also show that the only way to guarantee the existence of the appropriate mental states in (...) the wave function ontology has undesirable metaphysical baggage: either mind/body dualism is true, or circumstances which we take to be logically possible turn out to be logically impossible.“While our theory can be extended formally in a logically consistent way by introducing the concept of a wave in a 3N-dimensional space, it is evident that this procedure is not really acceptable in a physical theory... ” (Bohm 1957, 117). (shrink)

The fundamental constants that are involved in the laws of physics which describe our universe are finely-tuned for life, in the sense that if some of the constants had slightly different values life could not exist. Some people hold that this provides evidence for the existence of God. I will present a probabilistic version of this fine-tuning argument which is stronger than all other versions in the literature. Nevertheless, I will show that one can have reasonable opinions such that the (...) fine-tuning argument doesn’t lead to an increase in one’s probability for the existence of God. (shrink)

I argue that space has three dimensions, and quantum mechanics does not show otherwise. Specifically, I argue that the mathematical wave function of quantum mechanics corresponds to a property that an N-particle system has in three-dimensional space.

On Hume’s account of motivation, beliefs and desires are very different kinds of propositional attitudes. Beliefs are cognitive attitudes, desires emotive ones. An agent’s belief in a proposition captures the weight he or she assigns to this proposition in his or her cognitive representation of the world. An agent’s desire for a proposition captures the degree to which he or she prefers its truth, motivating him or her to act accordingly. Although beliefs and desires are sometimes entangled, they play very (...) different roles in rational agency. In two classic papers (Lewis 1988, 1996), David Lewis discusses several challenges to this Humean picture, but ultimately rejects them. We think that his discussion of a central anti-Humean alternative – the desire-as-belief thesis – is in need of refinnement. On this thesis, the desire for proposition p is given by the belief that p is desirable. Lewis claims that ‘[e]xcept in trivial cases, [this thesis] collapses into contradiction’(Lewis 1996, p. 308). The problem, he argues, is that the thesis is inconsistent with the purportedly plausible requirement that one’s desire for a proposition should not change upon learning that the proposition is true; call this the invariance requirement. In this paper, we revisit Lewis’s argument. We show that, if one carefully distinguishes between non-evaluative and evaluative propositions, the desire-asbelief thesis can be rendered consistent with the invariance requirement. Lewis’s conclusion holds only under certain conditions: the desire-as-belief thesis conflicts with the invariance requirement if and only if there are certain correlations between non-evaluative and evaluative propositions. But when there are such correlations, we suggest, the invariance requirement loses its plausibility. Thus Lewis’s argument against the desire-as-belief thesis appears to be valid only in cases in which it is unsound. (shrink)

There is a philosophical tradition of arguing against presentism, the thesis that only presently existing things exist, on the basis of its incompatibility with fundamental physics. I grant that presentism is incompatible with special and general relativity, but argue that presentism is not incompatible with quantum gravity, because there are some theories of quantum gravity that utilize a fixed foliation of spacetime. I reply to various objections to this defense of presentism, and point out a flaw in Gödel's modal argument (...) for the ideality of time. This paper provides an interesting case study of the interplay between physics and philosophy. (shrink)

Nearly all success is due to some mix of ability and luck. But some successes we attribute to the agent’s ability, whereas others we attribute to luck. To better understand the criteria distinguishing credit from luck, we conducted a series of four studies on knowledge attributions. Knowledge is an achievement that involves reaching the truth. But many factors affecting the truth are beyond our control and reaching the truth is often partly due to luck. Which sorts of luck are compatible (...) with knowledge? We find that knowledge attributions are highly sensitive to lucky events that change the explanation for why a belief is true. By contrast, knowledge attributions are surprisingly insensitive to lucky events that threaten but ultimately fail to change the explanation for why a belief is true. These results shed light on our concept of knowledge, help explain apparent inconsistencies in prior work on knowledge attributions, and constitute progress toward a general understanding of the relation between success and luck. (shrink)

Monism about being says that there is one way to be. Pluralism about being says that there are many ways to be. Recently, Trenton Merricks and David Builes have offered arguments against Pluralism. In this paper, I show how Pluralists who appeal to the relative naturalness of quantifiers can respond to these arguments.

In reply to the problem of evil, some suggest that God created an infinite number of universes—for example, that God created every universe that contains more good than evil. I offer two objections to these multiverse theodicies. First, I argue that, for any number of universes God creates, he could have created more, because he could have created duplicates of universes. Next, I argue that multiverse theodicies can’t adequately account for why God would create universes with pointless suffering, and hence (...) they don’t solve the problem of evil. (shrink)

It has sometimes been suggested that backwards time travel always incurs causal loops. I show that this is mistaken, by describing worlds where backwards time travel occurs and yet no causal loops occur. Arguments that backwards time travel can occur without causal loops have been given before in the literature, but I show that those arguments are unconvincing.

Mereological nihilism is the view that no objects have proper parts. Despite how counter‐intuitive it is, it is taken quite seriously, largely because it solves a number of puzzles in the metaphysics of material objects – or so its proponents claim. In this article, I show that for every puzzle that mereological nihilism solves, there is a similar puzzle that (a) it doesn’t solve, and (b) every other solution to the original puzzle does solve. Since the solutions to the new (...) puzzles apply just as well to the old puzzles, the old puzzles provide no motivation to be a mereological nihilist. (shrink)

Some stories of moral exemplars motivate us to emulate their admirable attitudes and behaviors, but why do some exemplars motivate us more than others? We systematically studied how motivation to emulate is influenced by the similarity between a reader and an exemplar in social or cultural background (Relatability) and how personally costly or demanding the exemplar’s actions are (Attainability). Study 1 found that university students reported more inspiration and related feelings after reading true stories about the good deeds of a (...) recent fellow alum, compared to a famous moral exemplar from decades past. Study 2A developed a battery of short moral exemplar stories that more systematically varied Relatability and Attainability, along with a set of non-moral exemplar stories for comparison. Studies 2B and 2C examined the path from the story type to relatively low stakes altruism (donating to charity and intentions to volunteer) through perceived attainability and relatability, as well as elevation and pleasantness. Together, our studies suggest that it is primarily the relatability of the moral exemplars, not the attainability of their actions, that inspires more prosocial motivation, at least regarding acts that help others at a relatively low cost to oneself. (shrink)

Recent research has begun to investigate sensory processing in relation to nonclinical variation in traits associated with the autism spectrum disorders (ASD). We propose that existing accounts of autistic perception can be augmented by considering a role for individual differences in top-down expectations for the precision of sensory input, related to the processing of state-dependent levels of uncertainty. We therefore examined ASD-like traits in relation to the rubber-hand illusion: an experimental paradigm that typically elicits crossmodal integration of visual, tactile, and (...) proprioceptive information in an unusual illusory context. Individuals with higher ASD-like traits showed reduced effects of the rubber-hand illusion on perceived arm position and reach-to-grasp movements, compared to individuals with lower ASD-like traits. These differences occurred despite both groups reporting the typical subjective experience of the illusion concerning visuotactile integration and ownership for the rubber hand. Together these results suggest that the integration of proprioceptive information with cues for arm position derived from the illusory context differs between individuals partly in relation to traits associated with ASD. We suggest that the observed differences in sensory integration can be best explained in terms of differing expectations regarding the precision of sensory estimates in contexts that suggest uncertainty. (shrink)

A morally acceptable course of AI development should avoid two dangers: creating unaligned AI systems that pose a threat to humanity and mistreating AI systems that merit moral consideration in their own right. This paper argues these two dangers interact and that if we create AI systems that merit moral consideration, simultaneously avoiding both of these dangers would be extremely challenging. While our argument is straightforward and supported by a wide range of pretheoretical moral judgments, it has far-reaching moral implications (...) for AI development. Although the most obvious way to avoid the tension between alignment and ethical treatment would be to avoid creating AI systems that merit moral consideration, this option may be unrealistic and is perhaps fleeting. So, we conclude by offering some suggestions for other ways of mitigating mistreatment risks associated with alignment. (shrink)

In recent years, many philosophers of religion have turned their attention to the topic of faith. Given the ubiquity of the word “faith” both in and out of religious contexts, many of them have chosen to begin their forays by offering an analysis of faith. But it seems that there are many kinds of faith: religious faith, non‐religious faith, interpersonal faith, and propositional faith, to name a few. In this article, I discuss analyses of faith that have been offered and (...) point out the dimensions along which they differ. (shrink)

Autism spectrum disorder is characterised by differences in unimodal and multimodal sensory and proprioceptive processing, with complex biases towards local over global processing. Many of these elements are implicated in versions of the rubber hand illusion, which were therefore studied in high-functioning individuals with ASD and a typically developing control group. Both groups experienced the illusion. A number of differences were found, related to proprioception and sensorimotor processes. The ASD group showed reduced sensitivity to visuotactile-proprioceptive discrepancy but more accurate proprioception. (...) This group also differed on acceleration in subsequent reach trials. Results are discussed in terms of weak top-down integration and precision-accuracy trade-offs. The RHI appears to be a useful tool for investigating multisensory processing in ASD. (shrink)

In this paper, I show how a solution to Lewis’ problem of temporary intrinsics is also a response to McTaggart’s argument that the A-series is incoherent. There are three strategies Lewis considers for solving the problem of temporary intrinsics: perdurantism, presentism, and property-indexing. William Lane Craig (Analysis 58(2):122–127, 1998) has examined how the three strategies fare with respect to McTaggart’s argument. The only viable solution Lewis considers to the problem of temporary intrinsics that also succeeds against McTaggart, Craig claims, is (...) presentism. This gives us prima facie reason to be presentists. But there is a strategy Craig does not consider-indexing, or relativizing, the copula. In this paper, I show that to the degree that indexing the copula solves the problem of temporary intrinsics, it also shows the invalidity of McTaggart’s argument. The upshot: the copula-indexer needn’t affirm the unreality of time, nor need she embrace presentism. (shrink)

There is a growing movement towards construing some classic debates in ontology as meaningless, either because the answers seem obvious or the debates seem intractable. In this paper, I respond to this movement. The response has three components: First, the members of the two sides of the ontological debates that dismissivists have targeted are using different quantifiers. Second, the austere ontologist is using a more fundamental quantifier than her opponent. Third, the austere ontologist’s more fundamental quantifier is a restriction of (...) her opponent’s quantifier. This response takes seriously the intuition that there is something wrong with the ontological disputes, but does not entail dismissivism. (shrink)

Metaphysicians sometimes appeal to physics to establish claims about the fundamental nature of the world. But given the current state of inquiry in physics, where there are two most fundamental theories that are incompatible, such arguments of physics-based metaphysics are problematic. I support this line of thought by focussing on two sorts of problematic arguments, special-relativity-based arguments against presentism and big-bang-based arguments in favor of the existence of God. I am not arguing that physics-based metaphysics can’t be done; I am (...) just arguing that extant examples of physics-based metaphysics are flawed. I close by considering various ways that future versions of physics-based metaphysics could potentially be successful. (shrink)

The Carter-Leslie Doomsday argument, as standardly presented, relies on the assumption that you have knowledge of your approximate birth rank. I demonstrate that the Doomsday argument can still be given in a situation where you have no knowledge of your birth rank. This allows one to reply to Bostrom's defense of the Doomsday argument against the refutation based on the idea that your existence makes it more likely that many observers exist.

An important line of response to scepticism appeals to the best explanation. But anti-sceptics have not engaged much with work on explanation in the philosophy of science. I plan to investigate whether plausible assumptions about best explanations really do favour anti-scepticism. I will argue that there are ways of constructing sceptical hypotheses in which the assumptions do favour anti-scepticism, but the size of the support for anti-scepticism is small.

In this paper, I discuss some prominent features of our use of social media and what I think are its harms. My paper has three main parts. In the first part, I use a dialogical framework to argue that much of the discursive activity online is manifested as an ethically impoverished other-directedness and interactivity. In the second part, I identify and discuss several reasons that help explain why so much of the discursive activity on social media is ethically lacking. And (...) in the final part, I mention some of the effects these discursive practices have on us even when offline. Specifically, I suggest that the persistent use of digital communication technologies trains its users to adopt these problematic online discursive attitudes and activities into their experiences offline, making it more difficult for them to engage with themselves and others in more dialogically ethical ways. (shrink)

Nelson et al.(2023) argue that the inclusion of personal experience in bioethical debates has significant benefits and liabilities, illustrating their claim with two examples: unproven medical treatments and disability bioethics. We believe that the benefits of including personal experience in disability bioethics far exceed its liabilities. The absence of participants with relevant experience impoverishes and biases bioethical debates, while the biases risked by their inclusion are hardly unique to personal experiences and are readily mitigated.

I defend Pascal's Wager from a particular way of evading it, the mixed strategy approach. The mixed strategies approach suggests that Pascal's Wager does not obligate one to believe in God, because one can get the same infinite expected utility from other strategies besides the strategy of believing in God. I will show that while there's nothing technically wrong with the mixed strategy approach, rationality requires it to be applied in such a way that Pascal's Wager doesn't lose any force.

What does logic tells us how about we ought to reason? If P entails Q, and I believe P, should I believe Q? I will argue that we should embed the issue in an independently motivated contextualist semantics for ‘ought’, with parameters for a standard and set of propositions. With the contextualist machinery in hand, we can defend a strong principle expressing how agents ought to reason while accommodating conflicting intuitions. I then show how our judgments about blame and guidance (...) can be handled by this machinery. (shrink)

The UK has been ‘following the science’ in response to the COVID-19 pandemic in line with the national framework for the use of scientific advice in assessment of risk. We argue that the way in which it does so is unsatisfactory in two important respects. Firstly, pandemic policy making is not based on a comprehensive assessment of policy impacts. And secondly, the focus on reasonable worst-case scenarios as a way of managing uncertainty results in a loss of decision-relevant information and (...) does not provide a coherent basis for policy making. (shrink)

Experiments in particle physics have hitherto failed to produce any significant evidence for the many explicit models of physics beyond the Standard Model (BSM) that had been proposed over the past decades. As a result, physicists have increasingly turned to model-independent strategies as tools in searching for a wide range of possible BSM effects. In this paper, we describe the Standard Model Effective Field Theory (SM-EFT) and analyse it in the context of the philosophical discussions about models, theories, and (bottom-up) (...) effective field theories. We find that while the SM-EFT is a quantum field theory, assisting experimentalists in searching for deviations from the SM, in its general form it lacks some of the characteristic features of models. Those features only come into play if put in by hand or prompted by empirical evidence for deviations. Employing different philosophical approaches to models, we argue that the case study suggests not to take a view on models that is overly permissive because it blurs the lines between the different stages of the SM-EFT research strategies and glosses over particle physicists' motivations for undertaking this bottom-up approach in the first place. Looking at EFTs from the perspective of modelling does not require taking a stance on some specific brand of realism or taking sides in the debate between reduction and emergence into which EFTs have recently been embedded. (shrink)

The Intergovernmental Panel on Climate Change has developed a novel framework for assessing and communicating uncertainty in the findings published in their periodic assessment reports. But how should these uncertainty assessments inform decisions? We take a formal decision-making perspective to investigate how scientific input formulated in the IPCC’s novel framework might inform decisions in a principled way through a normative decision model.

Self-locating beliefs cause a problem for conditionalization. Miriam Schoenfield offers a solution: that on learning E, agents should update on the fact that they learned E. However, Schoenfield is not explicit about whether the fact that they learned E is self-locating. I will argue that if the fact that they learned E is self-locating then the original problem has not been addressed, and if the fact that they learned E is not self-locating then the theory generates implausible verdicts which Schoenfield (...) explicitly rejects. (shrink)

The current global COVID-19 pandemic has led to a deep and multidimensional crisis across all sectors of society. As countries contemplate their mobility and social-distancing policy restrictions, we have a unique opportunity to re-imagine the deliberative frameworks and value priorities in our food systems. Pre-pandemic food systems at global, national, regional and local scales already needed revision to chart a common vision for sustainable and ethical food futures. Re-orientation is also needed by the relevant sciences, traditionally siloed in their disciplines (...) and without adequate attention paid to how the food system problem is variously framed by diverse stakeholders according to their values. From the transdisciplinary perspective of food ethics, we argue that a post-pandemic scheme focused on bottom-up, regional, cross-sectoral and non-partisan deliberation may provide the re-orientation and benchmarks needed for not only more sustainable, but also more ethical food futures. (shrink)

Having an agreed-upon definition of character education would be useful for both researchers and practitioners in the field. However, even experts in character education disagree on how they would define it. We attempted to achieve greater conceptual clarity on this issue through a prototype analysis in which the features perceived as most central to character education were identified. In Study 1 (N = 77), we asked character education experts to enumerate features of character education. Based on these lists, we identified (...) 30 features. In Study 2 (N = 101), experts assessed which features were central to character education through a categorization task. In Study 3 (N = 166), we assessed the extent of centrality using scalar items. We conclude by offering practical advice for the development of future character education studies and programs rooted in what is deemed central to such programs. (shrink)

According to our folk theory of lying, liars leak observable cues of their insincerity, observable cues that make it easy to catch a liar in real time. Various prominent social epistemologists rely on the correctness of our folk theory as empirically well-confirmed when building their normative accounts of the epistemology of testimony. Deception detection research in communication studies, however, has shown that our folk-theory is mistaken. It is not empirically well-confirmed but empirically refuted. Michaelian (2010) and Shieber (2012) have already (...) discussed some of this literature and its relevance for epistemology, especially for the most worked out reliance on our folk theory by Elizabeth Fricker (1994, 2016, 2017a, 2024). Fricker (2016) raises a reasonable objection to their presentations of the research: is the research ecologically valid? Do the experiments in the lab carry over to real life? This chapter conveys the methodology of the research, defends its ecological validity, and addresses further research on the nature and frequency of lies in ordinary life. Social epistemologists stand to gain from understanding the nuts and bolts of deception detection research and its findings. The chapter concludes with a detailed examination of Fricker’s relilance on folk theory in her “local reductionist” epistemology of testimony. Further areas of research relevant to social epistemology are listed. (shrink)

There is a divide in epistemology between those who think that, for any hypothesis and set of total evidence, there is a unique rational credence in that hypothesis, and those who think that there can be many rational credences. Schultheis offers a novel and potentially devastating objection to Permissivism, on the grounds that Permissivism permits dominated credences. I will argue that Permissivists can plausibly block Schultheis' argument. The issue turns on getting clear about whether we should be certain whether our (...) credences are rational. (shrink)

The Protein Ontology provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation of experimentally known forms and annotations thereof is expected to expose discrepancies, differences, and gaps in our knowledge. We have annotated the early events of innate immune signaling mediated by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting ontology and annotation data set has (...) allowed us to identify species-specific gaps in experimental data and possible functional differences between species, and to employ inferred structural and functional relationships to suggest plausible resolutions of these discrepancies and gaps. (shrink)

A distorted representation of one's own body is a diagnostic criterion and core psychopathology of both anorexia nervosa (AN) and bulimia nervosa (BN). Despite recent technical advances in research, it is still unknown whether this body image disturbance is characterized by body dissatisfaction and a low ideal weight and/or includes a distorted perception or processing of body size. In this article, we provide an update and meta-analysis of 42 articles summarizing measures and results for body size estimation (BSE) from 926 (...) individuals with AN, 536 individuals with BN and 1920 controls. We replicate findings that individuals with AN and BN overestimate their body size as compared to controls (ES= 0.63). Our meta-regression shows that metric methods (BSE by direct or indirect spatial measures) yield larger effect sizes than depictive methods (BSE by evaluating distorted pictures), and that effect sizes are larger for patients with BN than for patients with AN. To interpret these results, we suggest a revised theoretical framework for BSE that accounts for differences between depictive and metric BSE methods regarding the underlying body representations (conceptual vs. perceptual, implicit vs. explicit). We also discuss clinical implications and argue for the importance of multimethod approaches to investigate body image disturbance. (shrink)

It is widely believed that deflationary truth has no explanatory power. I will argue that it does. Specifically, I will consider some objections to deflationary truth having explanatory power, and argue that they fail. The position which will emerge is that the deflationary concept of truth is analogous to the concept of an average. Scientists take averages to be explanatory, and I will argue that the concept of deflationary truth is explanatory in the same way. I then argue that this (...) deflationary _concept_ of truth motivates a theory of the _property_ of truth which is metaphysically disunified, but that this is no obstacle to explanation. This leads to a way of understanding the deflationary/substantive distinction in terms of grounding. (shrink)