The new paradigm in the psychology of reasoning draws on Bayesian formal frameworks, and some advocates of the new paradigm think of these formal frameworks as providing a computational-level theory of rational human inference. I argue that Bayesian theories should not be seen as providing a computational-level theory of rational human inference, where by “Bayesian theories” I mean theories that claim that all rational credal states are probabilistically coherent and that rational adjustments of degrees of belief in the light of (...) new evidence must be in accordance with some sort of conditionalization. The problems with the view I am criticizing can best be seen when we look at chains of inferences, rather than single-step inferences. Chains of inferences have been neglected almost entirely within the new paradigm. (shrink)

The prospect of consumable meat produced in a laboratory setting without the need to raise and slaughter animals is both realistic and exciting. Not only could such in vitro meat become popular due to potential cost savings, but it also avoids many of the ethical and environmental problems with traditional meat productions. However, as with any new technology, in vitro meat is likely to face some detractors. We examine in detail three potential objections: 1) in vitro meat is disrespectful, either (...) to nature or to animals; 2) it will reduce the number of happy animals in the world; and 3) it will open the door to cannibalism. While each objection has some attraction, we ultimately find that all can be overcome. The upshot is that in vitro meat production is generally permissible and, especially for ethical vegetarians, worth promoting. (shrink)

In their recent article, Koplin, Gyngell and Savulescu (2019) assess the viability of the precautionary principle as a decision-making tool to determine whether and under what circumstances germline gene editing should proceed. While their survey of different forms of the precautionary principle is illuminating, the most novel contribution is a new account of the precautionary principle, what they dub the Sufficientarian Precautionary Principle (SPP). SPP is meant to avoid several problems with existing accounts, while comporting with at least some of (...) the intuitive force behind the general idea of the precautionary principle. However, as it is only one subsection of a larger paper, SPP is not fully worked out. In this brief response, I will flesh out some problems with SPP as a decision-making tool – particularly that there is a lack of adequate normative justification for adopting it. While this does not constitute a decisive refutation of the approach, SPP needs considerable refinement and clarification before it can be considered viable for use in decision-making. (shrink)

Ethical decision-making frameworks assist in identifying the issues at stake in a particular setting and thinking through, in a methodical manner, the ethical issues that require consideration as well as the values that need to be considered and promoted. Decisions made about the use, sharing, and re-use of big data are complex and laden with values. This paper sets out an Ethics Framework for Big Data in Health and Research developed by a working group convened by the Science, Health and (...) Policy-relevant Ethics in Singapore Initiative. It presents the aim and rationale for this framework supported by the underlying ethical concerns that relate to all health and research contexts. It also describes a set of substantive and procedural values that can be weighed up in addressing these concerns, and a step-by-step process for identifying, considering, and resolving the ethical issues arising from big data uses in health and research. This Framework is subsequently applied in the papers published in this Special Issue. These papers each address one of six domains where big data is currently employed: openness in big data and data repositories, precision medicine and big data, real-world data to generate evidence about healthcare interventions, AI-assisted decision-making in healthcare, public-private partnerships in healthcare and research, and cross-sectoral big data. (shrink)

I argue against abductivism about logic, which is the view that rational theory choice in logic happens by abduction. Abduction cannot serve as a neutral arbiter in many foundational disputes in logic because, in order to use abduction, one must first identify the relevant data. Which data one deems relevant depends on what I call one's conception of logic. One's conception of logic is, however, not independent of one's views regarding many of the foundational disputes that one may hope to (...) solve by abduction. (shrink)

Nontransitive responses to the validity Curry paradox face a dilemma that was recently formulated by Barrio, Rosenblatt and Tajer. It seems that, in the nontransitive logic ST enriched with a validity predicate, either you cannot prove that all derivable metarules preserve validity, or you can prove that instances of Cut that are not admissible in the logic preserve validity. I respond on behalf of the nontransitive approach. The paper argues, first, that we should reject the detachment principle for naive validity. (...) Secondly, I show how to add a validity predicate to ST while avoiding the dilemma. (shrink)

The paper offers an account of inference. The account underwrites the idea that inference requires that the reasoner takes her premises to support her conclusion. I reject views according to which such ‘takings’ are intuitions or beliefs. I sketch an alternative view on which inferring consists in attaching what I call ‘inferential force’ to a structured collection of contents.

I argue that the accounts of inference recently presented (in this journal) by Paul Boghossian, John Broome, and Crispin Wright are unsatisfactory. I proceed in two steps: First, in Sects. 1 and 2, I argue that we should not accept what Boghossian calls the “Taking Condition on inference” as a condition of adequacy for accounts of inference. I present a different condition of adequacy and argue that it is superior to the one offered by Boghossian. More precisely, I point out (...) that there is an analog of Moore’s Paradox for inference; and I suggest that explaining this phenomenon is a condition of adequacy for accounts of inference. Boghossian’s Taking Condition derives its plausibility from the fact that it apparently explains the analog of Moore’s Paradox. Second, in Sect. 3, I show that neither Boghossian’s, nor Broome’s, nor Wright’s account of inference meets my condition of adequacy. I distinguish two kinds of mistake one is likely to make if one does not focus on my condition of adequacy; and I argue that all three—Boghossian, Broome, and Wright—make at least one of these mistakes. (shrink)

I argue that recent attempts to show that meaning and content are not normative fail. The two most important arguments anti-normativists have presented are what I call the ‘argument from constitution’ and the ‘argument from guidance’. Both of these arguments suffer from the same basic problem: they overlook the possibility of focusing on assessability by norms, rather than compliance with norms or guidance by norms. Moreover, I argue that the anti-normativists arguments fail even if we ignore this basic problem. Thus, (...) we have not been given good reasons to think that normativism is false. (shrink)

According to McHugh and Way reasoning is a person-level attitude revision that is regulated by its constitutive aim of getting fitting attitudes. They claim that this account offers an explanation of what is wrong with reasoning in ways one believes to be bad and that this explanation is an alternative to an explanation that appeals to the so-called Taking Condition. I argue that their explanation is unsatisfying.

The paper presents a truth-maker semantics for Strict/Tolerant Logic (ST), which is the currently most popular logic among advocates of the non-transitive approach to paradoxes. Besides being interesting in itself, the truth-maker presentation of ST offers a new perspective on the recently discovered hierarchy of meta-inferences that, according to some, generalizes the idea behind ST. While fascinating from a mathematical perspective, there is no agreement on the philosophical significance of this hierarchy. I aim to show that there is no clear (...) philosophical significance of meta-inferences above the first level. (shrink)

The perhaps most important criticism of the nontransitive approach to semantic paradoxes is that it cannot truthfully express exactly which metarules preserve validity. I argue that this criticism overlooks that the admissibility of metarules cannot be expressed in any logic that allows us to formulate validity-Curry sentences and that is formulated in a classical metalanguage. Hence, the criticism applies to all approaches that do their metatheory in classical logic. If we do the metatheory of nontransitive logics in a nontransitive logic, (...) however, there is no reason to think that the argument behind the criticism goes through. In general, asking a logic to express its own admissible metarules may not be a good idea. (shrink)

In this comprehensive interview with Charles Taylor, the focus is put on the conceptual level. Taylor reflects on the relationship between history, narrativity and social critique, between social imaginaries and social change, and between his own thought and that of Cambridge School history of ideas, Nietzschean genealogy, Frankfurt School critical theory, and agonistic approaches to the political. This interview not only captures the tremendous breadth and range of Taylor’s theoretical interests, it also vindicates his contention that the common thread of (...) his oeuvre is the attempt to work out a non-reductive, non-mechanistic, non-atomistic philosophical anthropology. Still, it offers new insights into Taylor's most recent thinking and his intellectual engagement with the challenges of our time. (shrink)

Some philosophers have recently argued that there are no diachronic norms of epistemic rationality, that is, that there are no norms regarding how you should change your attitudes over time. I argue that this is wrong on the grounds that there are norms governing reasoning.

Abstract The paper explores responses to an inconsistent quartet of theses regarding rule-following. In addressing this inconsistent quartet, two lines of thought pull in opposite directions. On the one hand, it can seem that rule-following cannot require acts that shape or guide themselves or acts that require infinitely many similar acts. On the other hand, rule-following seems to require that we are responsible for our acts of rule-following in a special way. It is difficult to see how these thoughts can (...) be coherently combined. (shrink)

Some think that logic concerns the “laws of truth”; others that logic concerns the “laws of thought.” This paper presents a way to reconcile both views by building a bridge between truth-maker theory, à la Fine, and normative bilateralism, à la Restall and Ripley. The paper suggests a novel way of understanding consequence in truth-maker theory and shows that this allows us to identify a common structure shared by truth-maker theory and normative bilateralism. We can thus transfer ideas from normative (...) bilateralism to truth-maker theory, such as non-transitive solutions to paradox, and vice versa, such as notions of factual equivalence and containment. (shrink)

While we can judge and believe things by merely accepting testimony, we cannot make inferences by merely accepting testimony. A good theory of inference should explain this. The theories that are best suited to explain this fact seem to be theories that accept a so-called intuitional construal of Boghossian’s Taking Condition.

I argue that logic is unlike science in its methodology, thus rejecting anti-exceptionalism about logic. Logic has a mathematical and a philosophical part. In its mathematical part, the methodology of logic is like that of mathematics, and no need to choose between theories arises in that part. In its philosophical part, the methodology of logic is like that of philosophy. Philosophy and mathematics are both unlike the empirical sciences in their methodology. So logic is unlike the empirical sciences in its (...) methodology. I end by looking at disagreements about the liar paradox as an example. (shrink)

I am presenting a sequent calculus that extends a nonmonotonic consequence relation over an atomic language to a logically complex language. The system is in line with two guiding philosophical ideas: (i) logical inferentialism and (ii) logical expressivism. The extension defined by the sequent rules is conservative. The conditional tracks the consequence relation and negation tracks incoherence. Besides the ordinary propositional connectives, the sequent calculus introduces a new kind of modal operator that marks implications that hold monotonically. Transitivity fails, but (...) for good reasons. Intuitionism and classical logic can easily be recovered from the system. (shrink)

Die Wittgenstein-Schülerin Elizabeth Anscombe zählt zu den einflussreichsten Philosophinnen des 20. Jahrhunderts. Mit der Monographie Absicht begründete sie die analytische Handlungstheorie, viele ihrer Abhandlungen gelten als Klassiker, aber nur wenige liegen bislang in deutscher Übersetzung vor. Der vorliegende Band füllt diese Lücke: Er versammelt zwölf von Anscombes wichtigsten Aufsätzen, die thematisch von der praktischen Philosophie über die Metaphysik und die Philosophie des Geistes bis hin zu Aristoteles- und Wittgenstein-Interpretationen reichen, also das ganze Spektrum ihres Denkens repräsentieren. Die Anmerkungen und Erläuterungen (...) der Herausgeber sowie das Nachwort von Anselm W. Müller erschließen die Texte und bieten zusätzliche Einblicke in das facettenreiche Werk dieser solitären Denkerin. (shrink)

The predominant view is that a study using health data is observational research and should require individual consent unless it can be shown that gaining consent is impractical. But recent arguments have been made that citizens have an ethical obligation to share their health information for research purposes. In our view, this obligation is sufficient ground to expand the circumstances where secondary use research with identifiable health information is permitted without explicit subject consent. As such, for some studies the Institutional (...) Review Board/Research Ethics Committee review process should not assess the practicality of gaining consent for data use. Instead the review process should focus on assessing the public good of the research, public engagement and transparency. (shrink)

The paper argues for a version of the Guise of the Good thesis, namely the claim that if someone acts as the result of practical reasoning, then she takes her premises to jointly provide a sufficient and undefeated reason for her action. I argue for this by showing, first, that it is an application of Boghossian's Taking Condition on inference to practical reasoning and, second, that the motivations for the Taking Condition for theoretical reasoning carry over to practical reasoning. I (...) end by arguing that this version of the Guise of the Good withstands standard objections. (shrink)

In Chapter 8 of The Language Animal, Charles Taylor claims that narratives are unsubstitutable for an appropriate understanding of social life and ‘human affairs’ in general. In order to identify open questions in his argumentation as well as unwanted consequences of his outlook, I proceed in three consecutive steps. I first problematize Taylor’s distinction between laws and stories, then go on to address his intentional blurring of stories and histories, and finally suggest that the concept of genealogy might be a (...) promising candidate for describing Taylor’s approach, concluding that he implicitly forms the equation: narrative equals history equals critique. (shrink)

This paper offers an account of deontic normativity in terms of attributive goodness. An action is permissible for S in C just in case there is a good practical inference available to S in C that results in S performing (or intending to perform) the action. The standards of goodness for practical inferences are determined by what is a good or bad exercise of the human capacity of practical reason, which is an attributive (and not a deontic) assessment.

Some have objected to human enhancement on the grounds that it violates the autonomy of the enhanced. These objections, however, overlook the interesting possibility that autonomy itself could be enhanced. How, exactly, to enhance autonomy is a difficult problem due to the numerous and diverse accounts of autonomy in the literature. Existing accounts of autonomy enhancement rely on narrow and controversial conceptions of autonomy. However, we identify one feature of autonomy common to many mainstream accounts: reasoning ability. Autonomy can then (...) be enhanced by improving people’s reasoning ability, in particular through cognitive enhancement; given how valuable autonomy is usually taken to be, this gives us extra reason to pursue such cognitive enhancements. Moreover, autonomy-based objections will be especially weak against such enhancements. As we will argue, those who are worried that enhancements will inhibit people’s autonomy should actually embrace those enhancements that will improve autonomy. (shrink)

The paper presents teleo-inferentialism, which is a novel meta-semantic theory that combines advantages of teleosemantics and normative inferentialism. Like normative inferentialism, teleo-inferentialism holds that contents are individuated by the norms that govern inferences in which they occur. This allows teleo-inferentialism to account for sophisticated concepts. Like teleosemantics, teleo-inferentialism explains conceptual norms in a naturalistically acceptable way by appeal to the broadly biological well-functioning of our innate capacities. As a test-case for teleo-inferentialism, I discuss how the view handles Kripkenstein-style meaning skepticism.

In Kapitel 5 dieses Buches wurde mit dem ontologischen Sextett eine Klassifizierung der Realität vorgestellt, die das klassische Aristotelische Viereck erweitert, indem sie Einzeldinge und Universalien in insgesamt sechs Kategorien umfaßt. Zwischen den Entitäten dieser Kategorien sind bestimmte Beziehungen postuliert worden, wie zum Beispiel Inhärenz, Partizipation, Instantiierung, Exemplifizierung und Charakterisierung. In diesem Kapitel soil der Frage nachgegangen werden, wie eben diese Beziehungen zwischen den Entitäten dieser Kategorien genauer charakterisiert und die sie bezeichnenden relationalen Ausdrücke eindeutig formal definiert werden konnen.

Moral enhancement is an ostensibly laudable project. Who wouldn’t want people to become more moral? Still, the project’s approach is crucial. We can distinguish between two approaches for moral enhancement: direct and indirect. Direct moral enhancements aim at bringing about particular ideas, motives or behaviors. Indirect moral enhancements, by contrast, aim at making people more reliably produce the morally correct ideas, motives or behaviors without committing to the content of those ideas, motives and/or actions. I will argue, on Millian grounds, (...) that the value of disagreement puts serious pressure on proposals for relatively widespread direct moral enhancement. A more acceptable path would be to focus instead on indirect moral enhancements while staying neutral, for the most part, on a wide range of substantive moral claims. I will outline what such indirect moral enhancement might look like, and why we should expect it to lead to general moral improvement. (shrink)

It is often assumed that neo-Aristotelian virtue ethics postulates an obligation to be a good human being and that it derives further obligations from this idea. The paper argues that this assumption is false, at least for Philippa Foot’s view. Our argument blocks a widespread objection to Foot’s view, and it shows how virtue ethics in general can neutralize such worries.

The current prevailing view is that participation in biomedical research is above and beyond the call of duty. While some commentators have offered reasons against this, we propose a novel public goods argument for an obligation to participate in biomedical research. Biomedical knowledge is a public good, available to any individual even if that individual does not contribute to it. Participation in research is a critical way to support an important public good. Consequently, all have a duty to participate. The (...) current social norm is that individuals participate only if they have a good reason to do so. The public goods argument implies that individuals should participate unless they have a good reason not to. Such a shift would be of great aid to the progress of biomedical research, eventually making society significantly healthier and longer lived. (shrink)

We sometimes violate social norms in order to express our views and to trigger public debates. Many extant accounts of social norms don’t give us any insight into this phenomenon. Drawing on Cristina Bicchieri’s work, I am putting forward an empirical hypothesis that helps us to understand such norm violations. The hypothesis says, roughly, that we often adhere to norms because we are systematically blind to norm-violating options. I argue that this hypothesis is independently plausible and has interesting consequences. It (...) implies, e.g., that some experimental paradigms for investigating social norms have hitherto unnoticed shortcomings. (shrink)

The COVID-19 pandemic revealed numerous weaknesses in pandemic preparedness and response, including underfunding, inadequate surveillance, and inequitable distribution of countermeasures. To overcome these weaknesses for future pandemics, WHO released a zero draft of a pandemic treaty in February, 2023, and subsequently a revised bureau's text in May, 2023. COVID-19 made clear that pandemic prevention, preparedness, and response reflect choices and value judgements. These decisions are therefore not a purely scientific or technical exercise, but are fundamentally grounded in ethics. The latest (...) treaty draft reflects these ethical considerations by including a section entitled Guiding Principles and Approaches. Most of these principles are ethical—they establish core values that undergird the treaty. Unfortunately, the treaty draft's set of principles are numerous, overlapping, and show inadequate coherence and consistency. We propose two improvements to this section of the draft pandemic treaty. First, key guiding ethical principles should be clearer and more precise than they currently are. Second, the link between ethical principles and policy implementation should be clearly established and define boundaries on acceptable interpretation, ensuring that signatories abide by these principles. (shrink)

While philosophers are often concerned with the conditions for moral knowledge or justification, in practice something arguably less demanding is just as, if not more, important – reliably making correct moral judgments. Judges and juries should hand down fair sentences, government officials should decide on just laws, members of ethics committees should make sound recommendations, and so on. We want such agents, more often than not and as often as possible, to make the right decisions. The purpose of this paper (...) is to propose a method of enhancing the moral reliability of such agents. In particular, we advocate for a procedural approach; certain internal processes generally contribute to people’s moral reliability. Building on the early work of Rawls, we identify several particular factors related to moral reasoning that are specific enough to be the target of practical intervention: logical competence, conceptual understanding, empirical competence, openness, empathy and bias. Improving on these processes can in turn make people more morally reliable in a variety of contexts and has implications for recent debates over moral enhancement. (shrink)

The future of health research will be characterised by three continuing trends: rising demand for health data; increasing impracticability of obtaining specific consent for secondary research; and decreasing capacity to effectively anonymise data. In this context, governments, clinicians and the research community must demonstrate that they can be responsible stewards of health data. IRBs and RECs sit at heart of this process because in many jurisdictions they have the capacity to grant consent waivers when research is judged to be of (...) particular value. However, several different terms are used to refer to this value, indicating a lack of conceptual clarity regarding the appropriate test for access to health data for research without consent. In this paper we do three things. First we describe the current confusion and instability in terminology relating to public interest in the context of consent waivers. Second we argue for harmonisation of terminology on the grounds of clarity, transparency and consistency. Third we argue that the term ‘public interest’ best reflects the normative work required to justify consent waivers because it is the broadest of the competing terms. ‘Public interest’ contains within its scope positive and negative implications of a study, as well as welfare, justice and rights considerations. In making this argument, we explain the normative basis for consent waivers, and provide a starting place for further discussion about the precise conditions in which a given study can be said to advance the public interest. Ipsos MORI study found that: … the public would be broadly happy with administrative data linking for research projects provided Those projects have social value, broadly defined. Data are de-identified. Data are kept secure. Businesses are not able to access the data for profit. (shrink)

It has recently been argued that reproductive genetic manipulation technologies like mitochondrial replacement and germline CRISPR modifications cannot be said to save anyone’s life because, counterfactually, no one would suffer more or die sooner absent the intervention. The present article argues that, on the contrary, reproductive genetic manipulations may be life-saving (and, from this, have therapeutic value) under an appropriate population health perspective. As such, popular reports of reproductive genetic manipulations potentially saving lives or preventing disease are not necessarily mistaken, (...) though such terminology still requires further empirical validation. (shrink)

As opposed to a ‘one size fits all’ approach, precision medicine uses relevant biological, medical, behavioural and environmental information about a person to further personalize their healthcare. This could mean better prediction of someone’s disease risk and more effective diagnosis and treatment if they have a condition. Big data allows for far more precision and tailoring than was ever before possible by linking together diverse datasets to reveal hitherto-unknown correlations and causal pathways. But it also raises ethical issues relating to (...) the balancing of interests, viability of anonymization, familial and group implications, as well as genetic discrimination. This article analyses these issues in light of the values of public benefit, justice, harm minimization, transparency, engagement and reflexivity and applies the deliberative balancing approach found in theEthical Framework for Big Data in Health and Research to a case study on clinical genomic data sharing. Please refer to that article for an explanation of how this framework is to be used, including a full explanation of the key values involved and the balancing approach used in the case study at the end. Our discussion is meant to be of use to those involved in the practice as well as governance and oversight of precision medicine to address ethical concerns that arise in a coherent and systematic manner. (shrink)

The right to withdraw from participation in research is recognized in virtually all national and international guidelines for research on human subjects. It is therefore surprising that there has been little justification for that right in the literature. We argue that the right to withdraw should protect research participants from information imbalance, inability to hedge, inherent uncertainty, and untoward bodily invasion, and it serves to bolster public trust in the research enterprise. Although this argument is not radical, it provides a (...) useful way to determine how the right should be applied in various cases. (shrink)

Graham Priest has formulated the minimally inconsistent logic of paradox (MiLP), which is paraconsistent like Priest’s logic of paradox (LP), while staying closer to classical logic. We present logics that stand to (the propositional fragments of) strong Kleene logic (K3) and the logic of first-degree entailment (FDE) as MiLP stands to LP. That is, our logics share the paracomplete and the paraconsistent-cum-paracomplete nature of K3 and FDE, respectively, while keeping these features to a minimum in order to stay closer to (...) classical logic. We give semantic and sequent-calculus formulations of these logics, and we highlight some reasons why these logics may be interesting in their own right. (shrink)

For semantic inferentialists, the basic semantic concept is validity. An inferentialist theory of meaning should offer an account of the meaning of "valid." If one tries to add a validity predicate to one's object language, however, one runs into problems like the v-Curry paradox. In previous work, I presented a validity predicate for a non-transitive logic that can adequately capture its own meta-inferences. Unfortunately, in that system, one cannot show of any inference that it is invalid. Here I extend the (...) system so that it can capture invalidities. (shrink)

We suggest a new neo-Aristotelian account of right action: An action A is right for an agent S in a situation C just in case it is possible for A in C to result from a good practical inference. A practical inference is good if people must have a disposition to make such practical inferences where a society is to flourish. One advantage of this account is that it applies to non-ideal agents. It thus blocks the right-but-not-virtuous objection to virtue (...) ethics. Our account furthermore suggests a new way of thinking about the concept of a fully virtuous agent. Ideal agents, we argue, necessarily have certain unmanifested dispositions, and failure is a real possibility for them. (shrink)

What role should legislation or policy play in avoiding the complications of in-vitro fertilization? In this article, we focus on single versus double embryo transfer, and assess three arguments in favour of mandatory single embryo transfer: risks to the mother, risks to resultant children, and costs to society. We highlight significant ethical concerns about each of these. Reproductive autonomy and non-paternalism are strong enough to outweigh the health concerns for the woman. Complications due to non-identity cast doubt on the extent (...) to which children are harmed. Twinning may offer an overall benefit rather than burden to society. Finally, including the future health costs for children in reproductive policy is inconsistent with other decisions. We conclude that mandatory single embryo transfer is not justified and that a number of countries should reconsider their current embryo transfer policy. (shrink)

The paper presents an exhaustive menu of nonmonotonic logics. The options are individuated in terms of the principles they reject. I locate, e.g., cumulative logics and relevance logics on this menu. I highlight some frequently neglected options, and I argue that these neglected options are particularly attractive for inferentialists.

Background Several jurisdictions, including Singapore, Australia, New Zealand and most recently Ireland, have a public interest or public good criterion for granting waivers of consent in biomedical research using secondary health data or tissue. However, the concept of the public interest is not well defined in this context, which creates difficulties for institutions, institutional review boards and regulators trying to implement the criterion. Main text This paper clarifies how the public interest criterion can be defensibly deployed. We first explain the (...) ethical basis for requiring waivers to only be granted to studies meeting the public interest criterion, then explore how further criteria may be set to determine the extent to which a given study can legitimately claim to be in the public interest. We propose an approach that does not attempt to measure magnitude of benefit directly, but rather takes into account metrics that are more straightforward to apply. To ensure consistent and justifiable interpretation, research institutions and IRBs should also incorporate procedural features such as transparency and public engagement in determining which studies satisfy the public interest requirement. Conclusion The requirement of public interest for consent waivers in secondary biomedical research should be guided by well-defined criteria for systematic evaluation. Such a criteria and its application need to be periodically subject to intra-committee and intra-institution review, reflection, deliberation and amendment. (shrink)

The paper aims to clarify the role of the meaning of life in Anselm Müller’s philosophy. Müller says that the ethically good life is the life of acting well, and acting well requires at least a rough conception of the meaning of life, or a conception of what makes a life go well. But why is such a conception required and what does it mean to have such a conception? I argue that such a conception cannot provide us with ultimate (...) ends in our practical deliberations. Nor can its role be merely to provide a standard against which practical reasoning can be assessed. Rather, our conception of the meaning of life is, in the first instance, that which allows us, in our practical reasoning, to see certain considerations as good reasons for certain actions and to weigh reasons for and against different options. One upshot of my interpretation is that Müller should be more optimistic about philosophy’s ability to answer the question of the meaning of life than he allows himself to be. (shrink)

Mitochondrial replacement therapy requires oocytes of women whose mitochondrial DNA will be transmitted to resultant children. These techniques are scientifically, ethically and socially controversial; it is likely that some women who donate their oocytes for general in vitro fertilisation usage would nevertheless oppose their genetic material being used in MRT. The possibility of oocytes being used in MRT is therefore relevant to oocyte donation and should be included in the consent process when applicable. In present circumstances, specific consent should be (...) obtained. However, once MRT becomes more routine, such consent could be incorporated into the general consent process for oocyte donation. The reported lack of proper consent for MRT from the oocyte donor in the first baby born via the technique is an ethical failing and should be corrected in any future practice of MRT. (shrink)

So-called optimists about moral testimony argue, against pessimists, that, ceteris paribus, we ought to accept and act in accordance with trustworthy, pure moral testimony. I argue that even if we grant this, we need to explain why moral testimony cannot make us more virtuous. I offer an explanation that appeals to the fact that we cannot share inferential abilities via testimony. This explanation is compatible with the core commitments of optimism, but it also allows us to see what is right (...) about pessimism. (shrink)

It is generally unquestioned that human subjects research review boards should assess the ethical acceptability of protocols. It says so right on the tin, after all: they are explicitly called research ethics committees in the UK. But it is precisely those sorts of unchallenged assumptions that should, from time to time, be assessed and critiqued, in case they are in fact unfounded. John Stuart Mill's objection to suppressers of dissent is instructive here: “If the opinion is right, they are deprived (...) of the opportunity of exchanging error for truth: if wrong, they lose, what is almost as great a benefit, the clearer perception and livelier impression of truth, produced by its collision with error”.1 Andrew Moore and Andrew Donnelly's compelling article, “The job of ‘ethics committees’”, is just this sort of challenge to conventional wisdom, a rejection of the notion that review boards should be considering ethical matters at all.2 If true, we should be substantially reforming our research ethics policies. And if false, rebuttals would help strengthen and ground the otherwise unquestioned assumption of the role of ethics committees. As it happens, I will argue that their critiques fall into the second category. While mistaken, they present a valuable opportunity to clarify the role of ethics committees and their relationship to relevant codes. In particular, I will defend a hybrid account where codes have strict primacy, but leave significant room for review boards …. (shrink)

Volume 19, Issue 7, July 2019, Page 28-30.

With the recent report of a live birth after use of Mitochondrial replacement therapy, sometimes called ‘Three-parent IVF’, the clinical application of the technique is fast becoming a reality. While the United Kingdom allows the procedure under regulatory scrutiny, it remains effectively outlawed in many other countries. We argue that such prohibitions may violate individuals’ procreative rights, grounded in individuals’ interest in genetic affinity. The interest in genetic affinity was recently endorsed by Singapore’s highest court, reflecting an emphasis on the (...) importance of biological ties found across the globe. We apply that reasoning to make the case for a right to ‘Three-parent IVF’. (shrink)