Results for 'David Diehl'

962 found
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  1. Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis.R. Karp David, Marthandan Nishanth, G. E. Marsh Steven, Ahn Chul, C. Arnett Frank, S. DeLuca David, D. Diehl Alexander, Dunivin Raymond, Eilbeck Karen, Feolo Michael & Barry Smith - 2009 - Human Molecular Genetics 19 (4):707-719.
    Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...)
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  2. OBO Foundry in 2021: Operationalizing Open Data Principles to Evaluate Ontologies.Rebecca C. Jackson, Nicolas Matentzoglu, James A. Overton, Randi Vita, James P. Balhoff, Pier Luigi Buttigieg, Seth Carbon, Melanie Courtot, Alexander D. Diehl, Damion Dooley, William Duncan, Nomi L. Harris, Melissa A. Haendel, Suzanna E. Lewis, Darren A. Natale, David Osumi-Sutherland, Alan Ruttenberg, Lynn M. Schriml, Barry Smith, Christian J. Stoeckert, Nicole A. Vasilevsky, Ramona L. Walls, Jie Zheng, Christopher J. Mungall & Bjoern Peters - 2021 - BioaRxiv.
    Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...)
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  3.  79
    Political Ethics: Voters, Lobbyists, and Politicians.Emily Crookston, David Killoren & Jonathan Trerise (eds.) - 2016 - New York: Routledge.
    Most research in political philosophy focuses on issues related to states and governments. Only rarely do political philosophers focus on the ethical actions of individuals—voters, lobbyists, politicians, party members—acting within large-scale political systems. _Political Ethics _works against the dominant paradigm, offering twenty-one, never before-published essays on the ethics of non-statist political agents. The chapters cover three major areas of political ethics: The Rights and Obligations of Politicians; The Rights and Obligations of Citizens; and Political Parties. The volume is a ground-breaking (...)
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  4. Eight Arguments for First‐Person Realism.David Builes - 2024 - Philosophy Compass 19 (1):e12959.
    According to First-Person Realism, one's own first-person perspective on the world is metaphysically privileged in some way. After clarifying First-Person Realism by reference to parallel debates in the metaphysics of modality and time, I survey eight different arguments in favor of First-Person Realism.
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  5. Center indifference and skepticism.David Builes - 2024 - Noûs 58 (3):778-798.
    Many philosophers have been attracted to a restricted version of the principle of indifference in the case of self‐locating belief. Roughly speaking, this principle states that, within any given possible world, one should be indifferent between different hypotheses concerning who one is within that possible world, so long as those hypotheses are compatible with one's evidence. My first goal is to defend a more precise version of this principle. After responding to several existing criticisms of such a principle, I argue (...)
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  6. The World Just Is the Way It Is.David Builes - 2021 - The Monist 104 (1):1-27.
    What is the relationship between objects and properties? According to a standard view, there are primitive individuals that ‘instantiate’ or ‘have’ various properties. According to a rival view, objects are mere ‘bundles’ of properties. While there are a number of reasons to be skeptical of primitive individuals, there are also a number of challenges that the bundle theorist faces. The goal of this paper is to formulate a view about the relationship between objects and properties that avoids many of the (...)
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  7. A Humean Non-Humeanism.David Builes - 2023 - Philosophical Studies 180 (3):1031-1048.
    How should we account for the extraordinary regularity in the world? Humeans and Non-Humeans sharply disagree. According to Non-Humeans, the world behaves in an extraordinarily regular way because of certain necessary connections in nature. However, Humeans have thought that Non-Humean views are metaphysically objectionable. In particular, there are two general metaphysical principles that Humeans have found attractive that are incompatible with all existing versions of Non-Humeanism. My goal in this paper is to develop a novel version of Non-Humeanism that is (...)
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  8. Nothing at Stake in Knowledge.David Rose, Edouard Machery, Stephen Stich, Mario Alai, Adriano Angelucci, Renatas Berniūnas, Emma E. Buchtel, Amita Chatterjee, Hyundeuk Cheon, In-Rae Cho, Daniel Cohnitz, Florian Cova, Vilius Dranseika, Ángeles Eraña Lagos, Laleh Ghadakpour, Maurice Grinberg, Ivar Hannikainen, Takaaki Hashimoto, Amir Horowitz, Evgeniya Hristova, Yasmina Jraissati, Veselina Kadreva, Kaori Karasawa, Hackjin Kim, Yeonjeong Kim, Minwoo Lee, Carlos Mauro, Masaharu Mizumoto, Sebastiano Moruzzi, Christopher Y. Olivola, Jorge Ornelas, Barbara Osimani, Carlos Romero, Alejandro Rosas Lopez, Massimo Sangoi, Andrea Sereni, Sarah Songhorian, Paulo Sousa, Noel Struchiner, Vera Tripodi, Naoki Usui, Alejandro Vázquez del Mercado, Giorgio Volpe, Hrag Abraham Vosgerichian, Xueyi Zhang & Jing Zhu - 2019 - Noûs 53 (1):224-247.
    In the remainder of this article, we will disarm an important motivation for epistemic contextualism and interest-relative invariantism. We will accomplish this by presenting a stringent test of whether there is a stakes effect on ordinary knowledge ascription. Having shown that, even on a stringent way of testing, stakes fail to impact ordinary knowledge ascription, we will conclude that we should take another look at classical invariantism. Here is how we will proceed. Section 1 lays out some limitations of previous (...)
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  9. Utopophobia.David Estlund - 2014 - Philosophy and Public Affairs 42 (2):113-134.
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  10. The Role of Consciousness in Grasping and Understanding.David Bourget - 2017 - Philosophy and Phenomenological Research 95 (2):285-318.
    One sometimes believes a proposition without grasping it. For example, a complete achromat might believe that ripe tomatoes are red without grasping this proposition. My aim in this paper is to shed light on the difference between merely believing a proposition and grasping it. I focus on two possible theories of grasping: the inferential theory, which explains grasping in terms of inferential role, and the phenomenal theory, which explains grasping in terms of phenomenal consciousness. I argue that the phenomenal theory (...)
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  11. Statistical Evidence, Sensitivity, and the Legal Value of Knowledge.David Enoch, Levi Spectre & Talia Fisher - 2012 - Philosophy and Public Affairs 40 (3):197-224.
    The law views with suspicion statistical evidence, even evidence that is probabilistically on a par with direct, individual evidence that the law is in no way suspicious of. But it has proved remarkably hard to either justify this suspicion, or to debunk it. In this paper, we connect the discussion of statistical evidence to broader epistemological discussions of similar phenomena. We highlight Sensitivity – the requirement that a belief be counterfactually sensitive to the truth in a specific way – as (...)
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  12. The Ineffability of Induction.David Builes - 2020 - Philosophy and Phenomenological Research 104 (1):129-149.
    My first goal is to motivate a distinctively metaphysical approach to the problem of induction. I argue that there is a precise sense in which the only way that orthodox Humean and non-Humean views can justify induction is by appealing to extremely strong and unmotivated probabilistic biases. My second goal is to sketch what such a metaphysical approach could possibly look like. After sketching such an approach, I consider a toy case that illustrates the way in which such a metaphysics (...)
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  13. Fairness and the Architecture of Responsibility.David Brink & Dana Nelkin - 2013 - Oxford Studies in Agency and Responsibility 1:284-313.
    This essay explores a conception of responsibility at work in moral and criminal responsibility. Our conception draws on work in the compatibilist tradition that focuses on the choices of agents who are reasons-responsive and work in criminal jurisprudence that understands responsibility in terms of the choices of agents who have capacities for practical reason and whose situation affords them the fair opportunity to avoid wrongdoing. Our conception brings together the dimensions of normative competence and situational control, and we factor normative (...)
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  14. Lawful Persistence.David Builes & Trevor Teitel - 2022 - Philosophical Perspectives 36 (1):5-30.
    The central aim of this paper is to use a particular view about how the laws of nature govern the evolution of our universe in order to develop and evaluate the two main competing options in the metaphysics of persistence, namely endurantism and perdurantism. We begin by motivating the view that our laws of nature dictate not only qualitative facts about the future, but also which objects will instantiate which qualitative properties. We then show that both traditional doctrines in the (...)
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  15. Human Nature and the Limits (If Any) of Political Philosophy.David Estlund - 2011 - Philosophy and Public Affairs 39 (3):207-237.
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  16. Why Aren’t I Part of a Whale?David Builes & Caspar Hare - 2023 - Analysis 83 (2):227-234.
    We start by presenting three different views that jointly imply that every person has many conscious beings in their immediate vicinity, and that the number greatly varies from person to person. We then present and assess an argument to the conclusion that how confident someone should be in these views should sensitively depend on how massive they happen to be. According to the argument, sometimes irreducibly de se observations can be powerful evidence for or against believing in metaphysical theories.
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  17. Knowledge entails dispositional belief.David Rose & Jonathan Schaffer - 2013 - Philosophical Studies 166 (S1):19-50.
    Knowledge is widely thought to entail belief. But Radford has claimed to offer a counterexample: the case of the unconfident examinee. And Myers-Schulz and Schwitzgebel have claimed empirical vindication of Radford. We argue, in defense of orthodoxy, that the unconfident examinee does indeed have belief, in the epistemically relevant sense of dispositional belief. We buttress this with empirical results showing that when the dispositional conception of belief is specifically elicited, people’s intuitions then conform with the view that knowledge entails (dispositional) (...)
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  18. Tracking Representationalism.David Bourget & Angela Mendelovici - 2014 - In Andrew Bailey (ed.), Philosophy of mind: the key thinkers. New York: Bloomsbury Academic. pp. 209-235.
    This paper overviews the current status of debates on tracking representationalism, the view that phenomenal consciousness is a matter of tracking features of one's environment in a certain way. We overview the main arguments for the view and the main objections and challenges it faces. We close with a discussion of alternative versions of representationalism that might overcome the shortcomings of tracking representationalism.
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  19. False Consciousness for Liberals, Part I: Consent, Autonomy, and Adaptive Preferences.David Enoch - 2020 - Philosophical Review 129 (2):159-210.
    The starting point regarding consent has to be that it is both extremely important, and that it is often suspicious. In this article, the author tries to make sense of both of these claims, from a largely liberal perspective, tying consent, predictably, to the value of autonomy and distinguishing between autonomy as sovereignty and autonomy as nonalienation. The author then discusses adaptive preferences, claiming that they suffer from a rationality flaw but that it's not clear that this flaw matters morally (...)
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  20. Derivatives and Consciousness.David Builes - 2020 - Journal of Consciousness Studies 27 (9-10):87-103.
    Many philosophers of physics think that physical rates of change, like velocity or acceleration in classical physics, are extrinsic. Many philosophers of mind think that phenomenal properties, which characterize what it’s like to be an agent at a time, are intrinsic. I will argue that these two views can’t both be true. Given that these two views are in tension, we face an explanatory challenge. Why should there be any interesting connection between these physical quantities and consciousness in the first (...)
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  21. There is no such thing as doxastic wrongdoing.David Enoch & Levi Spectre - forthcoming - Philosophical Perspectives.
    People are often offended by beliefs, expect apologies for beliefs, apologize for their own beliefs. In many mundane cases, people are morally criticized for their beliefs. Intuitively, then, beliefs seem to sometimes wrong people. Recently, the philosophical literature has picked up on this theme, and has started to discuss it under the heading of doxastic wrongdoing. In this paper we argue that despite the strength of such initial intuitions, at the end of the day they have to be rejected. If (...)
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  22. An Empirical Argument for Presentism.David Builes & Michele Odisseas Impagnatiello - forthcoming - Oxford Studies in Metaphysics.
    According to orthodoxy, our best physical theories strongly support Eternalism over Presentism. Our goal is to argue against this consensus, by arguing that a certain overlooked aspect of our best physical theories strongly supports Presentism over Eternalism.
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  23. Dilating and contracting arbitrarily.David Builes, Sophie Horowitz & Miriam Schoenfield - 2020 - Noûs 56 (1):3-20.
    Standard accuracy-based approaches to imprecise credences have the consequence that it is rational to move between precise and imprecise credences arbitrarily, without gaining any new evidence. Building on the Educated Guessing Framework of Horowitz (2019), we develop an alternative accuracy-based approach to imprecise credences that does not have this shortcoming. We argue that it is always irrational to move from a precise state to an imprecise state arbitrarily, however it can be rational to move from an imprecise state to a (...)
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  24. Ontology and Arbitrariness.David Builes - 2022 - Australasian Journal of Philosophy 100 (3):485-495.
    In many different ontological debates, anti-arbitrariness considerations push one towards two opposing extremes. For example, in debates about mereology, one may be pushed towards a maximal ontology (mereological universalism) or a minimal ontology (mereological nihilism), because any intermediate view seems objectionably arbitrary. However, it is usually thought that anti-arbitrariness considerations on their own cannot decide between these maximal or minimal views. I will argue that this is a mistake. Anti-arbitrariness arguments may be used to motivate a certain popular thesis in (...)
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  25. Does Success Entail Ability?David Boylan - 2021 - Noûs 56 (3):570-601.
    This paper is about the principle that success entails ability, which I call Success. I argue the status of Success is highly puzzling: when we focus on past instances of actually successful action, Success is very compelling; but it is in tension with the idea that true ability claims require an action be in the agent's control. I make the above tension precise by considering the logic of ability. I argue Success is appealing because it is classically equivalent to two (...)
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  26. Teleological Essentialism.David Rose & Shaun Nichols - 2019 - Cognitive Science 43 (4):e12725.
    Placeholder essentialism is the view that there is a causal essence that holds category members together, though we may not know what the essence is. Sometimes the placeholder can be filled in by scientific essences, such as when we acquire scientific knowledge that the atomic weight of gold is 79. We challenge the view that placeholders are elaborated by scientific essences. On our view, if placeholders are elaborated, they are elaborated Aristotelian essences, a telos. Utilizing the same kinds of experiments (...)
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  27. Statistical resentment, or: what’s wrong with acting, blaming, and believing on the basis of statistics alone.David Enoch & Levi Spectre - 2021 - Synthese 199 (3-4):5687-5718.
    Statistical evidence—say, that 95% of your co-workers badmouth each other—can never render resenting your colleague appropriate, in the way that other evidence (say, the testimony of a reliable friend) can. The problem of statistical resentment is to explain why. We put the problem of statistical resentment in several wider contexts: The context of the problem of statistical evidence in legal theory; the epistemological context—with problems like the lottery paradox for knowledge, epistemic impurism and doxastic wrongdoing; and the context of a (...)
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  28. Modal Idealism.David Builes - forthcoming - Oxford Studies in Philosophy of Mind.
    I argue that it is metaphysically necessary that: (i) every fundamental entity is conscious, and (ii) every fundamental property is a phenomenal property.
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  29. Teleological Essentialism: Generalized.David Rose & Shaun Nichols - 2020 - Cognitive Science 44 (3):e12818.
    Natural/social kind essentialism is the view that natural kind categories, both living and non-living natural kinds, as well as social kinds (e.g., race, gender), are essentialized. On this view, artifactual kinds are not essentialized. Our view—teleological essentialism—is that a broad range of categories are essentialized in terms of teleology, including artifacts. Utilizing the same kinds of experiments typically used to provide evidence of essentialist thinking—involving superficial change (study 1), transformation of insides (study 2) and inferences about offspring (study 3)—we find (...)
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  30. The Lesson of Bypassing.David Rose & Shaun Nichols - 2013 - Review of Philosophy and Psychology 4 (4):599-619.
    The idea that incompatibilism is intuitive is one of the key motivators for incompatibilism. Not surprisingly, then philosophers who defend incompatibilism often claim that incompatibilism is the natural, commonsense view about free will and moral responsibility (e.g., Pereboom 2001, Kane Journal of Philosophy 96:217–240 1999, Strawson 1986). And a number of recent studies find that people give apparently incompatibilist responses in vignette studies. When participants are presented with a description of a causal deterministic universe, they tend to deny that people (...)
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  31. Humean Rationalism.David Builes - 2024 - Philosophical Studies 181 (10):2563-2576.
    According to the Principle of Sufficient Reason, every fact has an explanation. An important challenge to this principle is that it risks being a counterexample to itself. What explains why everything needs to be explained? My first goal is to distinguish two broad kinds of answers to this question, which I call “Humean Rationalism” and “Non-Humean Rationalism”. My second goal will be to defend the prospects of Humean Rationalism.
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  32. How to ground powers.David Builes - 2024 - Analysis 84 (2):231-238.
    According to the grounding theory of powers, fundamental physical properties should be thought of as qualities that ground dispositions. Although this view has recently been defended by many different philosophers, there is no consensus for how the view should be developed within a broader metaphysics of properties. Recently, Tugby has argued that the view should be developed in the context of a Platonic theory of properties, where properties are abstract universals. I will argue that the view should not be developed (...)
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  33. Opinion leaders, independence, and Condorcet's Jury Theorem.David M. Estlund - 1994 - Theory and Decision 36 (2):131-162.
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  34. Time-Slice Rationality and Self-Locating Belief.David Builes - 2020 - Philosophical Studies 177 (10):3033-3049.
    The epistemology of self-locating belief concerns itself with how rational agents ought to respond to certain kinds of indexical information. I argue that those who endorse the thesis of Time-Slice Rationality ought to endorse a particular view about the epistemology of self-locating belief, according to which ‘essentially indexical’ information is never evidentially relevant to non-indexical matters. I close by offering some independent motivations for endorsing Time-Slice Rationality in the context of the epistemology of self-locating belief.
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  35. Beyond Fairness and Deliberation: The Epistemic Dimension of Democratic Authority.David Estlund - 1997 - In James Bohman & William Rehg (eds.), Deliberative Democracy: Essays on Reason and Politics. MIT Press. pp. 173-204.
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  36. A puzzle about rates of change.David Builes & Trevor Teitel - 2020 - Philosophical Studies 177 (10):3155-3169.
    Most of our best scientific descriptions of the world employ rates of change of some continuous quantity with respect to some other continuous quantity. For instance, in classical physics we arrive at a particle’s velocity by taking the time-derivative of its position, and we arrive at a particle’s acceleration by taking the time-derivative of its velocity. Because rates of change are defined in terms of other continuous quantities, most think that facts about some rate of change obtain in virtue of (...)
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  37. How Are Basic Belief-Forming Methods Justified?David Enoch & Joshua Schechter - 2008 - Philosophy and Phenomenological Research 76 (3):547–579.
    In this paper, we develop an account of the justification thinkers have for employing certain basic belief-forming methods. The guiding idea is inspired by Reichenbach's work on induction. There are certain projects in which thinkers are rationally required to engage. Thinkers are epistemically justified in employing any belief-forming method such that "if it doesn't work, nothing will" for successfully engaging in such a project. We present a detailed account based on this intuitive thought and address objections to it. We conclude (...)
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  38. Why Can’t There Be Numbers?David Builes - forthcoming - The Philosophical Quarterly.
    Platonists affirm the existence of abstract mathematical objects, and Nominalists deny the existence of abstract mathematical objects. While there are standard arguments in favor of Nominalism, these arguments fail to account for the necessity of Nominalism. Furthermore, these arguments do nothing to explain why Nominalism is true. They only point to certain theoretical vices that might befall the Platonist. The goal of this paper is to formulate and defend a simple, valid argument for the necessity of Nominalism that seeks to (...)
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  39. Counterfactual skepticism is (just) skepticism.David Boylan - 2023 - Philosophy and Phenomenological Research 108 (1):259-286.
    Counterfactual skepticism says that most ordinary counterfactuals are false. While few endorse counterfactual skepticism, the precise costs of the view are disputed and not generally well-understood. I have two aims in this paper. My first and primary aim is to establish, on grounds acceptable to all parties, that counterfactual skepticism is not benign. I argue it leads to significant skepticism about the future: if counterfactual skepticism is true, then we can have only very limited knowledge about the future. I give (...)
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  40. Debate: Liberalism, equality, and fraternity in Cohen's critique of Rawls.David Estlund - 1998 - Journal of Political Philosophy 6 (1):99–112.
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  41. The insularity of the reasonable: Why political liberalism must admit the truth.David Estlund - 1998 - Ethics 108 (2):252-275.
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  42. The Epistemic Value of Democratic Deliberation.David Estlund - 2018 - In André Bächtiger, Jane Mansbridge, John Dryzek & Mark Warren (eds.), Oxford Handbook of Deliberative Democracy. Oxford University Press.
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  43. Persistence through function preservation.David Rose - 2015 - Synthese 192 (1):97-146.
    When do the folk think that material objects persist? Many metaphysicians have wanted a view which fits with folk intuitions, yet there is little agreement about what the folk intuit. I provide a range of empirical evidence which suggests that the folk operate with a teleological view of persistence: the folk tend to intuit that a material object survives alterations when its function is preserved. Given that the folk operate with a teleological view of persistence, I argue for a debunking (...)
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  44. A Paradox of Evidential Equivalence.David Builes - 2020 - Mind 129 (513):113-127.
    Our evidence can be about different subject matters. In fact, necessarily equivalent pieces of evidence can be about different subject matters. Does the hyperintensionality of ‘aboutness’ engender any hyperintensionality at the level of rational credence? In this paper, I present a case which seems to suggest that the answer is ‘yes’. In particular, I argue that our intuitive notions of independent evidence and inadmissible evidence are sensitive to aboutness in a hyperintensional way. We are thus left with a paradox. While (...)
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  45. Look at the time!David Builes - 2022 - Analysis 82 (1):15-23.
    I argue that we can get evidence for the temporal ontology of the universe simply by looking at the time. The argument is an extension of the ‘epistemic objection’ towards Growing Block theories.
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  46. On following orders in an unjust war.David Estlund - 2007 - Journal of Political Philosophy 15 (2):213–234.
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  47. When Words Speak Louder Than Actions: Delusion, Belief, and the Power of Assertion.David Rose, Wesley Buckwalter & John Turri - 2014 - Australasian Journal of Philosophy (4):1-18.
    People suffering from severe monothematic delusions, such as Capgras, Fregoli, or Cotard patients, regularly assert extraordinary and unlikely things. For example, some say that their loved ones have been replaced by impostors. A popular view in philosophy and cognitive science is that such monothematic delusions aren't beliefs because they don't guide behaviour and affect in the way that beliefs do. Or, if they are beliefs, they are somehow anomalous, atypical, or marginal beliefs. We present evidence from five studies that folk (...)
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  48. Sensitivity, safety, and the law: A reply to Pardo.David Enoch & Levi Spectre - 2019 - Legal Theory 25 (3):178-199.
    ABSTRACTIn a recent paper, Michael Pardo argues that the epistemic property that is legally relevant is the one called Safety, rather than Sensitivity. In the process, he argues against our Sensitivity-related account of statistical evidence. Here we revisit these issues, partly in order to respond to Pardo, and partly in order to make general claims about legal epistemology. We clarify our account, we show how it adequately deals with counterexamples and other worries, we raise suspicions about Safety's value here, and (...)
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  49. Does legal epistemology rest on a mistake? On fetishism, two‐tier system design, and conscientious fact‐finding.David Enoch, Talia Fisher & Levi Spectre - 2021 - Philosophical Issues 31 (1):85-103.
    Philosophical Issues, Volume 31, Issue 1, Page 85-103, October 2021.
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  50. In Defense of a Broad Conception of Experimental Philosophy.David Rose & David Danks - 2013 - Metaphilosophy 44 (4):512-532.
    Experimental philosophy is often presented as a new movement that avoids many of the difficulties that face traditional philosophy. This article distinguishes two views of experimental philosophy: a narrow view in which philosophers conduct empirical investigations of intuitions, and a broad view which says that experimental philosophy is just the colocation in the same body of (i) philosophical naturalism and (ii) the actual practice of cognitive science. These two positions are rarely clearly distinguished in the literature about experimental philosophy, both (...)
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