Results for 'David Diehl'

961 found
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  1. Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis.R. Karp David, Marthandan Nishanth, G. E. Marsh Steven, Ahn Chul, C. Arnett Frank, S. DeLuca David, D. Diehl Alexander, Dunivin Raymond, Eilbeck Karen, Feolo Michael & Barry Smith - 2009 - Human Molecular Genetics 19 (4):707-719.
    Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...)
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  2. OBO Foundry in 2021: Operationalizing Open Data Principles to Evaluate Ontologies.Rebecca C. Jackson, Nicolas Matentzoglu, James A. Overton, Randi Vita, James P. Balhoff, Pier Luigi Buttigieg, Seth Carbon, Melanie Courtot, Alexander D. Diehl, Damion Dooley, William Duncan, Nomi L. Harris, Melissa A. Haendel, Suzanna E. Lewis, Darren A. Natale, David Osumi-Sutherland, Alan Ruttenberg, Lynn M. Schriml, Barry Smith, Christian J. Stoeckert, Nicole A. Vasilevsky, Ramona L. Walls, Jie Zheng, Christopher J. Mungall & Bjoern Peters - 2021 - BioaRxiv.
    Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...)
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  3. Philosophers on Philosophy: The 2020 PhilPapers Survey.David Bourget & David J. Chalmers - 2023 - Philosophers' Imprint 23 (11).
    What are the philosophical views of professional philosophers, and how do these views change over time? The 2020 PhilPapers Survey surveyed around 2000 philosophers on 100 philosophical questions. The results provide a snapshot of the state of some central debates in philosophy, reveal correlations and demographic effects involving philosophers' views, and reveal some changes in philosophers' views over the last decade.
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  4. What do philosophers believe?David Bourget & David J. Chalmers - 2014 - Philosophical Studies 170 (3):465-500.
    What are the philosophical views of contemporary professional philosophers? We surveyed many professional philosophers in order to help determine their views on 30 central philosophical issues. This article documents the results. It also reveals correlations among philosophical views and between these views and factors such as age, gender, and nationality. A factor analysis suggests that an individual's views on these issues factor into a few underlying components that predict much of the variation in those views. The results of a metasurvey (...)
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  5.  79
    Political Ethics: Voters, Lobbyists, and Politicians.Emily Crookston, David Killoren & Jonathan Trerise (eds.) - 2016 - New York: Routledge.
    Most research in political philosophy focuses on issues related to states and governments. Only rarely do political philosophers focus on the ethical actions of individuals—voters, lobbyists, politicians, party members—acting within large-scale political systems. _Political Ethics _works against the dominant paradigm, offering twenty-one, never before-published essays on the ethics of non-statist political agents. The chapters cover three major areas of political ethics: The Rights and Obligations of Politicians; The Rights and Obligations of Citizens; and Political Parties. The volume is a ground-breaking (...)
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  6. Eight Arguments for First‐Person Realism.David Builes - 2024 - Philosophy Compass 19 (1):e12959.
    According to First-Person Realism, one's own first-person perspective on the world is metaphysically privileged in some way. After clarifying First-Person Realism by reference to parallel debates in the metaphysics of modality and time, I survey eight different arguments in favor of First-Person Realism.
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  7. Center indifference and skepticism.David Builes - 2024 - Noûs 58 (3):778-798.
    Many philosophers have been attracted to a restricted version of the principle of indifference in the case of self‐locating belief. Roughly speaking, this principle states that, within any given possible world, one should be indifferent between different hypotheses concerning who one is within that possible world, so long as those hypotheses are compatible with one's evidence. My first goal is to defend a more precise version of this principle. After responding to several existing criticisms of such a principle, I argue (...)
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  8. The World Just Is the Way It Is.David Builes - 2021 - The Monist 104 (1):1-27.
    What is the relationship between objects and properties? According to a standard view, there are primitive individuals that ‘instantiate’ or ‘have’ various properties. According to a rival view, objects are mere ‘bundles’ of properties. While there are a number of reasons to be skeptical of primitive individuals, there are also a number of challenges that the bundle theorist faces. The goal of this paper is to formulate a view about the relationship between objects and properties that avoids many of the (...)
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  9. A Humean Non-Humeanism.David Builes - 2023 - Philosophical Studies 180 (3):1031-1048.
    How should we account for the extraordinary regularity in the world? Humeans and Non-Humeans sharply disagree. According to Non-Humeans, the world behaves in an extraordinarily regular way because of certain necessary connections in nature. However, Humeans have thought that Non-Humean views are metaphysically objectionable. In particular, there are two general metaphysical principles that Humeans have found attractive that are incompatible with all existing versions of Non-Humeanism. My goal in this paper is to develop a novel version of Non-Humeanism that is (...)
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  10. Utopophobia.David Estlund - 2014 - Philosophy and Public Affairs 42 (2):113-134.
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  11. The Role of Consciousness in Grasping and Understanding.David Bourget - 2017 - Philosophy and Phenomenological Research 95 (2):285-318.
    One sometimes believes a proposition without grasping it. For example, a complete achromat might believe that ripe tomatoes are red without grasping this proposition. My aim in this paper is to shed light on the difference between merely believing a proposition and grasping it. I focus on two possible theories of grasping: the inferential theory, which explains grasping in terms of inferential role, and the phenomenal theory, which explains grasping in terms of phenomenal consciousness. I argue that the phenomenal theory (...)
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  12. A Phenomenal Theory of Grasping and Understanding.David Bourget - 2025 - In Andrei Ionuț Mărăşoiu & Mircea Dumitru (eds.), Understanding and conscious experience: philosophical and scientific perspectives. New York, NY: Routledge.
    There is a difference between merely thinking that P and really grasping that P. For example, Jackson's (1982) black-and-white Mary cannot (before leaving her black-and-white room) fully grasp what it means to say that fire engines are red, but she can perfectly well entertain the thought that fire engines are red. The contrast between merely thinking and grasping is especially salient in the context of certain moral decisions. For example, an individual who grasps the plight of starving children thanks to (...)
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  13. Statistical Evidence, Sensitivity, and the Legal Value of Knowledge.David Enoch, Levi Spectre & Talia Fisher - 2012 - Philosophy and Public Affairs 40 (3):197-224.
    The law views with suspicion statistical evidence, even evidence that is probabilistically on a par with direct, individual evidence that the law is in no way suspicious of. But it has proved remarkably hard to either justify this suspicion, or to debunk it. In this paper, we connect the discussion of statistical evidence to broader epistemological discussions of similar phenomena. We highlight Sensitivity – the requirement that a belief be counterfactually sensitive to the truth in a specific way – as (...)
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  14. The Ineffability of Induction.David Builes - 2020 - Philosophy and Phenomenological Research 104 (1):129-149.
    My first goal is to motivate a distinctively metaphysical approach to the problem of induction. I argue that there is a precise sense in which the only way that orthodox Humean and non-Humean views can justify induction is by appealing to extremely strong and unmotivated probabilistic biases. My second goal is to sketch what such a metaphysical approach could possibly look like. After sketching such an approach, I consider a toy case that illustrates the way in which such a metaphysics (...)
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  15. Fairness and the Architecture of Responsibility.David Brink & Dana Nelkin - 2013 - Oxford Studies in Agency and Responsibility 1:284-313.
    This essay explores a conception of responsibility at work in moral and criminal responsibility. Our conception draws on work in the compatibilist tradition that focuses on the choices of agents who are reasons-responsive and work in criminal jurisprudence that understands responsibility in terms of the choices of agents who have capacities for practical reason and whose situation affords them the fair opportunity to avoid wrongdoing. Our conception brings together the dimensions of normative competence and situational control, and we factor normative (...)
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  16. Lawful Persistence.David Builes & Trevor Teitel - 2022 - Philosophical Perspectives 36 (1):5-30.
    The central aim of this paper is to use a particular view about how the laws of nature govern the evolution of our universe in order to develop and evaluate the two main competing options in the metaphysics of persistence, namely endurantism and perdurantism. We begin by motivating the view that our laws of nature dictate not only qualitative facts about the future, but also which objects will instantiate which qualitative properties. We then show that both traditional doctrines in the (...)
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  17. Human Nature and the Limits (If Any) of Political Philosophy.David Estlund - 2011 - Philosophy and Public Affairs 39 (3):207-237.
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  18. Why Aren’t I Part of a Whale?David Builes & Caspar Hare - 2023 - Analysis 83 (2):227-234.
    We start by presenting three different views that jointly imply that every person has many conscious beings in their immediate vicinity, and that the number greatly varies from person to person. We then present and assess an argument to the conclusion that how confident someone should be in these views should sensitively depend on how massive they happen to be. According to the argument, sometimes irreducibly de se observations can be powerful evidence for or against believing in metaphysical theories.
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  19. Consciousness is Underived Intentionality.David Bourget - 2010 - Noûs 44 (1):32 - 58.
    Representationalists argue that phenomenal states are intentional states of a special kind. This paper offers an account of the kind of intentional state phenomenal states are: I argue that they are underived intentional states. This account of phenomenal states is equivalent to two theses: first, all possible phenomenal states are underived intentional states; second, all possible underived intentional states are phenomenal states. I clarify these claims and argue for each of them. I also address objections which touch on a range (...)
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  20. Tracking Representationalism.David Bourget & Angela Mendelovici - 2014 - In Andrew Bailey (ed.), Philosophy of mind: the key thinkers. New York: Bloomsbury Academic. pp. 209-235.
    This paper overviews the current status of debates on tracking representationalism, the view that phenomenal consciousness is a matter of tracking features of one's environment in a certain way. We overview the main arguments for the view and the main objections and challenges it faces. We close with a discussion of alternative versions of representationalism that might overcome the shortcomings of tracking representationalism.
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  21. False Consciousness for Liberals, Part I: Consent, Autonomy, and Adaptive Preferences.David Enoch - 2020 - Philosophical Review 129 (2):159-210.
    The starting point regarding consent has to be that it is both extremely important, and that it is often suspicious. In this article, the author tries to make sense of both of these claims, from a largely liberal perspective, tying consent, predictably, to the value of autonomy and distinguishing between autonomy as sovereignty and autonomy as nonalienation. The author then discusses adaptive preferences, claiming that they suffer from a rationality flaw but that it's not clear that this flaw matters morally (...)
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  22. Derivatives and Consciousness.David Builes - 2020 - Journal of Consciousness Studies 27 (9-10):87-103.
    Many philosophers of physics think that physical rates of change, like velocity or acceleration in classical physics, are extrinsic. Many philosophers of mind think that phenomenal properties, which characterize what it’s like to be an agent at a time, are intrinsic. I will argue that these two views can’t both be true. Given that these two views are in tension, we face an explanatory challenge. Why should there be any interesting connection between these physical quantities and consciousness in the first (...)
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  23. There is no such thing as doxastic wrongdoing.David Enoch & Levi Spectre - forthcoming - Philosophical Perspectives.
    People are often offended by beliefs, expect apologies for beliefs, apologize for their own beliefs. In many mundane cases, people are morally criticized for their beliefs. Intuitively, then, beliefs seem to sometimes wrong people. Recently, the philosophical literature has picked up on this theme, and has started to discuss it under the heading of doxastic wrongdoing. In this paper we argue that despite the strength of such initial intuitions, at the end of the day they have to be rejected. If (...)
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  24. An Empirical Argument for Presentism.David Builes & Michele Odisseas Impagnatiello - forthcoming - Oxford Studies in Metaphysics.
    According to orthodoxy, our best physical theories strongly support Eternalism over Presentism. Our goal is to argue against this consensus, by arguing that a certain overlooked aspect of our best physical theories strongly supports Presentism over Eternalism.
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  25. Dilating and contracting arbitrarily.David Builes, Sophie Horowitz & Miriam Schoenfield - 2020 - Noûs 56 (1):3-20.
    Standard accuracy-based approaches to imprecise credences have the consequence that it is rational to move between precise and imprecise credences arbitrarily, without gaining any new evidence. Building on the Educated Guessing Framework of Horowitz (2019), we develop an alternative accuracy-based approach to imprecise credences that does not have this shortcoming. We argue that it is always irrational to move from a precise state to an imprecise state arbitrarily, however it can be rational to move from an imprecise state to a (...)
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  26. Ontology and Arbitrariness.David Builes - 2022 - Australasian Journal of Philosophy 100 (3):485-495.
    In many different ontological debates, anti-arbitrariness considerations push one towards two opposing extremes. For example, in debates about mereology, one may be pushed towards a maximal ontology (mereological universalism) or a minimal ontology (mereological nihilism), because any intermediate view seems objectionably arbitrary. However, it is usually thought that anti-arbitrariness considerations on their own cannot decide between these maximal or minimal views. I will argue that this is a mistake. Anti-arbitrariness arguments may be used to motivate a certain popular thesis in (...)
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  27. Relational vs Adverbial Conceptions of Phenomenal Intentionality.David Bourget - 2019 - In Arthur Sullivan (ed.), Sensations, Thoughts, and Language: Essays in Honor of Brian Loar. New York, NY: Routledge. pp. 137-166.
    This paper asks whether phenomenal intentionality (intentionality that arises from phenomenal consciousness alone) has a relational structure of the sort envisaged in Russell’s theory of acquaintance. I put forward three arguments in favor of a relation view: one phenomenological, one linguistic, and one based on the view’s ability to account for the truth conditions of phenomenally intentional states. I then consider several objections to the relation view. The chief objection to the relation view takes the form of a dilemma between (...)
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  28. Does Success Entail Ability?David Boylan - 2021 - Noûs 56 (3):570-601.
    This paper is about the principle that success entails ability, which I call Success. I argue the status of Success is highly puzzling: when we focus on past instances of actually successful action, Success is very compelling; but it is in tension with the idea that true ability claims require an action be in the agent's control. I make the above tension precise by considering the logic of ability. I argue Success is appealing because it is classically equivalent to two (...)
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  29. Representationalism, perceptual distortion and the limits of phenomenal concepts.David Bourget - 2015 - Canadian Journal of Philosophy 45 (1):16-36.
    This paper replies to objections from perceptual distortion against the representationalist thesis that the phenomenal characters of experiences supervene on their intentional contents. It has been argued that some pairs of distorted and undistorted experiences share contents without sharing phenomenal characters, which is incompatible with the supervenience thesis. In reply, I suggest that such cases are not counterexamples to the representationalist thesis because the contents of distorted experiences are always impoverished in some way compared to those of normal experiences. This (...)
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  30. Implications of Intensional Perceptual Ascriptions for Relationalism, Disjunctivism, and Representationalism About Perceptual Experience.David Bourget - 2017 - Erkenntnis 84 (2):381-408.
    This paper aims to shed new light on certain philosophical theories of perceptual experience by examining the semantics of perceptual ascriptions such as “Jones sees an apple.” I start with the assumption, recently defended elsewhere, that perceptual ascriptions lend themselves to intensional readings. In the first part of the paper, I defend three theses regarding such readings: I) intensional readings of perceptual ascriptions ascribe phenomenal properties, II) perceptual verbs are not ambiguous between intensional and extensional readings, and III) intensional perceptual (...)
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  31. Representationalism and Sensory Modalities: An Argument for Intermodal Representationalism.David Bourget - 2017 - American Philosophical Quarterly 54 (3):251-268.
    Intermodal representationalists hold that the phenomenal characters of experiences are fully determined by their contents. In contrast, intramodal representationalists hold that the phenomenal characters of experiences are determined by their contents together with their intentional modes or manners of representation, which are nonrepresentational features corresponding roughly to the sensory modalities. This paper discusses a kind of experience that provides evidence for an intermodal representationalist view: intermodal experiences, experiences that unify experiences in different modalities. I argue that such experiences are much (...)
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  32. Statistical resentment, or: what’s wrong with acting, blaming, and believing on the basis of statistics alone.David Enoch & Levi Spectre - 2021 - Synthese 199 (3-4):5687-5718.
    Statistical evidence—say, that 95% of your co-workers badmouth each other—can never render resenting your colleague appropriate, in the way that other evidence (say, the testimony of a reliable friend) can. The problem of statistical resentment is to explain why. We put the problem of statistical resentment in several wider contexts: The context of the problem of statistical evidence in legal theory; the epistemological context—with problems like the lottery paradox for knowledge, epistemic impurism and doxastic wrongdoing; and the context of a (...)
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  33. Modal Idealism.David Builes - forthcoming - Oxford Studies in Philosophy of Mind.
    I argue that it is metaphysically necessary that: (i) every fundamental entity is conscious, and (ii) every fundamental property is a phenomenal property.
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  34. Humean Rationalism.David Builes - 2024 - Philosophical Studies 181 (10):2563-2576.
    According to the Principle of Sufficient Reason, every fact has an explanation. An important challenge to this principle is that it risks being a counterexample to itself. What explains why everything needs to be explained? My first goal is to distinguish two broad kinds of answers to this question, which I call “Humean Rationalism” and “Non-Humean Rationalism”. My second goal will be to defend the prospects of Humean Rationalism.
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  35. How to ground powers.David Builes - 2024 - Analysis 84 (2):231-238.
    According to the grounding theory of powers, fundamental physical properties should be thought of as qualities that ground dispositions. Although this view has recently been defended by many different philosophers, there is no consensus for how the view should be developed within a broader metaphysics of properties. Recently, Tugby has argued that the view should be developed in the context of a Platonic theory of properties, where properties are abstract universals. I will argue that the view should not be developed (...)
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  36. Opinion leaders, independence, and Condorcet's Jury Theorem.David M. Estlund - 1994 - Theory and Decision 36 (2):131-162.
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  37. Time-Slice Rationality and Self-Locating Belief.David Builes - 2020 - Philosophical Studies 177 (10):3033-3049.
    The epistemology of self-locating belief concerns itself with how rational agents ought to respond to certain kinds of indexical information. I argue that those who endorse the thesis of Time-Slice Rationality ought to endorse a particular view about the epistemology of self-locating belief, according to which ‘essentially indexical’ information is never evidentially relevant to non-indexical matters. I close by offering some independent motivations for endorsing Time-Slice Rationality in the context of the epistemology of self-locating belief.
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  38. Beyond Fairness and Deliberation: The Epistemic Dimension of Democratic Authority.David Estlund - 1997 - In James Bohman & William Rehg (eds.), Deliberative Democracy: Essays on Reason and Politics. MIT Press. pp. 173-204.
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  39. A puzzle about rates of change.David Builes & Trevor Teitel - 2020 - Philosophical Studies 177 (10):3155-3169.
    Most of our best scientific descriptions of the world employ rates of change of some continuous quantity with respect to some other continuous quantity. For instance, in classical physics we arrive at a particle’s velocity by taking the time-derivative of its position, and we arrive at a particle’s acceleration by taking the time-derivative of its velocity. Because rates of change are defined in terms of other continuous quantities, most think that facts about some rate of change obtain in virtue of (...)
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  40. Intensional Perceptual Ascriptions.David Bourget - 2017 - Erkenntnis 82 (3):513-530.
    This paper defends the view that perceptual ascriptions such as “Jones sees a cat” are sometimes intensional. I offer a range of examples of intensional perceptual ascriptions, respond to objections to intensional readings of perceptual ascriptions, and show how widely accepted semantic accounts of intensionality can explain the key features of intensional perceptual ascriptions.
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  41. Is Intentionality a Relation? A Dialogue.David Bourget & Angela Mendelovici - forthcoming - Argumenta.
    This dialogue explores the question of whether intentionality—the “ofness”, “aboutness”, or “directedness” of mental states—is a relation. We explore three views: the Naive View, on which intentionality is a relation to ordinary, everyday objects, facts, and other such items; the Abstract Contents View, on which intentionality is a relation to mind-independent abstract entities that are our contents; and the Aspect View, on which intentionality is a matter of having intentional states with particular (non-relational) aspects that are our contents. We consider (...)
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  42. How Are Basic Belief-Forming Methods Justified?David Enoch & Joshua Schechter - 2008 - Philosophy and Phenomenological Research 76 (3):547–579.
    In this paper, we develop an account of the justification thinkers have for employing certain basic belief-forming methods. The guiding idea is inspired by Reichenbach's work on induction. There are certain projects in which thinkers are rationally required to engage. Thinkers are epistemically justified in employing any belief-forming method such that "if it doesn't work, nothing will" for successfully engaging in such a project. We present a detailed account based on this intuitive thought and address objections to it. We conclude (...)
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  43. Counterfactual skepticism is (just) skepticism.David Boylan - 2023 - Philosophy and Phenomenological Research 108 (1):259-286.
    Counterfactual skepticism says that most ordinary counterfactuals are false. While few endorse counterfactual skepticism, the precise costs of the view are disputed and not generally well-understood. I have two aims in this paper. My first and primary aim is to establish, on grounds acceptable to all parties, that counterfactual skepticism is not benign. I argue it leads to significant skepticism about the future: if counterfactual skepticism is true, then we can have only very limited knowledge about the future. I give (...)
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  44. Why Can’t There Be Numbers?David Builes - forthcoming - The Philosophical Quarterly.
    Platonists affirm the existence of abstract mathematical objects, and Nominalists deny the existence of abstract mathematical objects. While there are standard arguments in favor of Nominalism, these arguments fail to account for the necessity of Nominalism. Furthermore, these arguments do nothing to explain why Nominalism is true. They only point to certain theoretical vices that might befall the Platonist. The goal of this paper is to formulate and defend a simple, valid argument for the necessity of Nominalism that seeks to (...)
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  45. The Epistemic Value of Democratic Deliberation.David Estlund - 2018 - In André Bächtiger, Jane Mansbridge, John Dryzek & Mark Warren (eds.), Oxford Handbook of Deliberative Democracy. Oxford University Press.
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  46. A Paradox of Evidential Equivalence.David Builes - 2020 - Mind 129 (513):113-127.
    Our evidence can be about different subject matters. In fact, necessarily equivalent pieces of evidence can be about different subject matters. Does the hyperintensionality of ‘aboutness’ engender any hyperintensionality at the level of rational credence? In this paper, I present a case which seems to suggest that the answer is ‘yes’. In particular, I argue that our intuitive notions of independent evidence and inadmissible evidence are sensitive to aboutness in a hyperintensional way. We are thus left with a paradox. While (...)
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  47. Look at the time!David Builes - 2022 - Analysis 82 (1):15-23.
    I argue that we can get evidence for the temporal ontology of the universe simply by looking at the time. The argument is an extension of the ‘epistemic objection’ towards Growing Block theories.
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  48. Sensitivity, safety, and the law: A reply to Pardo.David Enoch & Levi Spectre - 2019 - Legal Theory 25 (3):178-199.
    ABSTRACTIn a recent paper, Michael Pardo argues that the epistemic property that is legally relevant is the one called Safety, rather than Sensitivity. In the process, he argues against our Sensitivity-related account of statistical evidence. Here we revisit these issues, partly in order to respond to Pardo, and partly in order to make general claims about legal epistemology. We clarify our account, we show how it adequately deals with counterexamples and other worries, we raise suspicions about Safety's value here, and (...)
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  49. Does legal epistemology rest on a mistake? On fetishism, two‐tier system design, and conscientious fact‐finding.David Enoch, Talia Fisher & Levi Spectre - 2021 - Philosophical Issues 31 (1):85-103.
    Philosophical Issues, Volume 31, Issue 1, Page 85-103, October 2021.
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  50. How Strong Is a Counterfactual?David Boylan & Ginger Schultheis - 2021 - Journal of Philosophy 118 (7):373-404.
    The literature on counterfactuals is dominated by strict accounts and variably strict accounts. Counterexamples to the principle of Antecedent Strengthening were thought to be fatal to SA; but it has been shown that by adding dynamic resources to the view, such examples can be accounted for. We broaden the debate between VSA and SA by focusing on a new strengthening principle, Strengthening with a Possibility. We show dynamic SA classically validates this principle. We give a counterexample to it and show (...)
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