Results for 'David Diehl'

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  1. Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis.R. Karp David, Marthandan Nishanth, G. E. Marsh Steven, Ahn Chul, C. Arnett Frank, S. DeLuca David, D. Diehl Alexander, Dunivin Raymond, Eilbeck Karen, Feolo Michael & Barry Smith - 2009 - Human Molecular Genetics 19 (4):707-719.
    Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...)
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  2. OBO Foundry in 2021: Operationalizing Open Data Principles to Evaluate Ontologies.Rebecca C. Jackson, Nicolas Matentzoglu, James A. Overton, Randi Vita, James P. Balhoff, Pier Luigi Buttigieg, Seth Carbon, Melanie Courtot, Alexander D. Diehl, Damion Dooley, William Duncan, Nomi L. Harris, Melissa A. Haendel, Suzanna E. Lewis, Darren A. Natale, David Osumi-Sutherland, Alan Ruttenberg, Lynn M. Schriml, Barry Smith, Christian J. Stoeckert, Nicole A. Vasilevsky, Ramona L. Walls, Jie Zheng, Christopher J. Mungall & Bjoern Peters - 2021 - BioaRxiv.
    Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...)
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  3. Non-ideal Theory as Ideology.Jordan David Thomas Walters - forthcoming - Journal of Ethics and Social Philosophy.
    In the wake of the non-ideal theory turn in political philosophy, few have paused to ask: Is non-ideal theory a form of ideology? And perhaps even fewer have paused to ask: Is the debate between ideal/non-ideal theorists itself a form of ideology? To the first question, I argue that non-ideal theory is ideological in virtue of the fact that it rules out more utopian ways of theorizing by methodological fiat, and in so doing, risks entrenching an unjust status quo. To (...)
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  4. (1 other version)Idealism and the Mind-Body Problem.David Chalmers - 2019 - In William Seager (ed.), The Routledge Handbook of Panpsychism. Routledge. pp. 353-373.
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  5. (1 other version)Epistemology of disagreement: The good news.David Christensen - 2007 - Philosophical Review 116 (2):187-217.
    How should one react when one has a belief, but knows that other people—who have roughly the same evidence as one has, and seem roughly as likely to react to it correctly—disagree? This paper argues that the disagreement of other competent inquirers often requires one to be much less confident in one’s opinions than one would otherwise be.
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  6. The Unity of the Moral Domain.Jeremy David Fix - forthcoming - European Journal of Philosophy.
    What is the function of morality—what is it all about? What is the basis of morality—what explains our moral agency and patiency? This essay defends a unique Kantian answer to these questions. Morality is about securing our independence from each other by giving each other equal discretion over whether and how we interact. The basis of our moral agency and patiency is practical reason. The first half addresses objections that this account cannot explain the moral patiency of beings who are (...)
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  7. Parmenides as a Thinker of Fate.David Torrijos-Castrillejo - 2024 - Religions 15:1295.
    Although some ancient sources relate Parmenides to the religious doctrine of fate, this concept is not usually prominent in the scholarly presentation of the Eleatic thinker. Here, we offer a tentative interpretation of the notion of necessity in Parmenides’ poem, as a peculiar philosophical understanding of the presence of fate in reality. Necessity, divinised by Parmenides, implies that all things are bound together by the chains of fate. Therefore, his philosophical proposal consists in understanding this unity of reality originated by (...)
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  8. (1 other version)Are we free to break the laws?David Lewis - 1981 - Theoria 47 (3):113-21.
    I insist that I was able to raise my hand, and I acknowledge that a law would have been broken had I done so, but I deny that I am therefore able to break a law. To uphold my instance of soft determinism, I need not claim any incredible powers. To uphold the compatibilism that I actually believe, I need not claim that such powers are even possible. My incompatibilist opponent is a creature of fiction, but he has his prototypes (...)
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  9. On distinguishing epistemic from pragmatic action.David Kirsh & Paul Maglio - 1994 - Cognitive Science 18 (4):513-49.
    We present data and argument to show that in Tetris - a real-time interactive video game - certain cognitive and perceptual problems are more quickly, easily, and reliably solved by performing actions in the world rather than by performing computational actions in the head alone. We have found that some translations and rotations are best understood as using the world to improve cognition. These actions are not used to implement a plan, or to implement a reaction; they are used to (...)
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  10.  50
    Legislative Intent and Agency: A Rational Unity Account.Stephanie Collins & David Tan - 2024 - Oxford Journal of Legal Studies 44 (2):231-256.
    Realist theories of legislative intent can be divided between aggregative theories (on which legislative intent is what some proportion of legislators intend) and common intent theories (on which legislative intent is a unanimous intent among legislators). In this paper, we advance and defend an alternative realist conception of legislative intent: the Rational Unity Account. On this account, the legislature is an agent with a distinctive ‘rational point of view’—a concept we adopt from social ontology. The legislature’s rational point of view (...)
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  11. Consciousness is Underived Intentionality.David Bourget - 2010 - Noûs 44 (1):32 - 58.
    Representationalists argue that phenomenal states are intentional states of a special kind. This paper offers an account of the kind of intentional state phenomenal states are: I argue that they are underived intentional states. This account of phenomenal states is equivalent to two theses: first, all possible phenomenal states are underived intentional states; second, all possible underived intentional states are phenomenal states. I clarify these claims and argue for each of them. I also address objections which touch on a range (...)
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  12. Connectionism and compositionality: Why Fodor and Pylyshyn were wrong.David J. Chalmers - 1993 - Philosophical Psychology 6 (3):305-319.
    This paper offers both a theoretical and an experimental perspective on the relationship between connectionist and Classical (symbol-processing) models. Firstly, a serious flaw in Fodor and Pylyshyn’s argument against connectionism is pointed out: if, in fact, a part of their argument is valid, then it establishes a conclusion quite different from that which they intend, a conclusion which is demonstrably false. The source of this flaw is traced to an underestimation of the differences between localist and distributed representation. It has (...)
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  13. Personal Identity.David Shoemaker & Kevin P. Tobia - 2022 - In Manuel Vargas & John Doris (eds.), The Oxford Handbook of Moral Psychology. Oxford, U.K.: Oxford University Press.
    Our aim in this entry is to articulate the state of the art in the moral psychology of personal identity. We begin by discussing the major philosophical theories of personal identity, including their shortcomings. We then turn to recent psychological work on personal identity and the self, investigations that often illuminate our person-related normative concerns. We conclude by discussing the implications of this psychological work for some contemporary philosophical theories and suggesting fruitful areas for future work on personal identity.
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  14.  24
    El concurso divino y la gracia eficaz en Pedro de Ledesma.David Torrijos-Castrillejo - 2024 - Cuadernos Doctorales de la Facultad de Teología 75:227-291.
    The Dominican Pedro de Ledesma was a member of the School of Salamanca, professor of Theology in the late 16th and early 17th century. Here we investigate for the first time his contribution to the «de auxiliis» controversy, in which mainly the Dominicans and the Jesuits contended about human free will and God’s influence on it. Among the various theological problems involved, this thesis examines the nature of the divine concurrence in free human action and, in particular, divine concurrence in (...)
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  15. Evolving resolve.Walter Veit & David Spurrett - 2021 - Behavioral and Brain Sciences 44.
    The broad spectrum revolution brought greater dependence on skill and knowledge, and more demanding, often social, choices. We adopt Sterelny's account of how cooperative foraging paid the costs associated with longer dependency, and transformed the problem of skill learning. Scaffolded learning can facilitate cognitive control including suppression, whereas scaffolded exchange and trade, including inter-temporal exchange, can help develop resolve.
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  16. Human Nature and the Limits (If Any) of Political Philosophy.David Estlund - 2011 - Philosophy and Public Affairs 39 (3):207-237.
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  17. Why Take Painkillers?David Bain - 2019 - Noûs 53 (2):462-490.
    Accounts of the nature of unpleasant pain have proliferated over the past decade, but there has been little systematic investigation of which of them can accommodate its badness. This paper is such a study. In its sights are two targets: those who deny the non-instrumental disvalue of pain's unpleasantness; and those who allow it but deny that it can be accommodated by the view—advanced by me and others—that unpleasant pains are interoceptive experiences with evaluative content. Against the former, I argue (...)
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  18. Folk teleology drives persistence judgments.David Rose, Jonathan Schaffer & Kevin Tobia - 2020 - Synthese 197 (12):5491-5509.
    Two separate research programs have revealed two different factors that feature in our judgments of whether some entity persists. One program—inspired by Knobe—has found that normative considerations affect persistence judgments. For instance, people are more inclined to view a thing as persisting when the changes it undergoes lead to improvements. The other program—inspired by Kelemen—has found that teleological considerations affect persistence judgments. For instance, people are more inclined to view a thing as persisting when it preserves its purpose. Our goal (...)
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  19. How Are Basic Belief-Forming Methods Justified?David Enoch & Joshua Schechter - 2008 - Philosophy and Phenomenological Research 76 (3):547–579.
    In this paper, we develop an account of the justification thinkers have for employing certain basic belief-forming methods. The guiding idea is inspired by Reichenbach's work on induction. There are certain projects in which thinkers are rationally required to engage. Thinkers are epistemically justified in employing any belief-forming method such that "if it doesn't work, nothing will" for successfully engaging in such a project. We present a detailed account based on this intuitive thought and address objections to it. We conclude (...)
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  20. Debate: Liberalism, equality, and fraternity in Cohen's critique of Rawls.David Estlund - 1998 - Journal of Political Philosophy 6 (1):99–112.
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  21. The insularity of the reasonable: Why political liberalism must admit the truth.David Estlund - 1998 - Ethics 108 (2):252-275.
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  22. The impotence of the demandingness objection.David Sobel - 2007 - Philosophers' Imprint 7:1-17.
    Consequentialism, many philosophers have claimed, asks too much of us to be a plausible ethical theory. Indeed, the theory's severe demandingness is often claimed to be its chief flaw. My thesis is that as we come to better understand this objection, we see that, even if it signals or tracks the existence of a real problem for Consequentialism, it cannot itself be a fundamental problem with the view. The objection cannot itself provide good reason to break with Consequentialism, because it (...)
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  23. Against Quantum Indeterminacy.David Glick - 2017 - Thought: A Journal of Philosophy 6 (3):204-213.
    A growing literature is premised on the claim that quantum mechanics provides evidence for metaphysical indeterminacy. But does it? None of the currently fashionable realist interpretations involve fundamental indeterminacy and the ‘standard interpretation’, to the extent that it can be made out, doesn't require indeterminacy either.
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  24. Moral responsibility and unavoidable action.David P. Hunt - 2000 - Philosophical Studies 97 (2):195-227.
    The principle of alternate possibilities (PAP), making the ability to do otherwise a necessary condition for moral responsibility, is supposed by Harry Frankfurt, John Fischer, and others to succumb to a peculiar kind of counterexample. The paper reviews the main problems with the counterexample that have surfaced over the years, and shows how most can be addressed within the terms of the current debate. But one problem seems ineliminable: because Frankfurt''s example relies on a counterfactual intervener to preclude alternatives to (...)
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  25. On following orders in an unjust war.David Estlund - 2007 - Journal of Political Philosophy 15 (2):213–234.
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  26. Conservatism in epistemology.David Christensen - 1994 - Noûs 28 (1):69-89.
    A wide range of prominent epistemological theories include a principle of conservatism. Such principles take the fact that an agent currently holds a certain belief to constitute at least some measure of epistemic justification for her to maintain that belief. I examine the main arguments that have been made in conservatism's behalf, and find them unsound. Most interestingly, conservatism does not fall out of confirmational holism (the view that the justification of each of our beliefs is in part determined by (...)
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  27. Why can’t I change Bruckner’s Eighth Symphony?David Friedell - 2020 - Philosophical Studies 177 (3):805-824.
    Musical works change. Bruckner revised his Eighth Symphony. Ella Fitzgerald and many other artists have made it acceptable to sing the jazz standard “All the Things You Are” without its original verse. If we accept that musical works genuinely change in these ways, a puzzle arises: why can’t I change Bruckner’s Eighth Symphony? More generally, why are some individuals in a privileged position when it comes to changing musical works and other artifacts, such as novels, films, and games? I give (...)
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  28. Fundamental and Emergent Geometry in Newtonian Physics.David Wallace - 2020 - British Journal for the Philosophy of Science 71 (1):1-32.
    Using as a starting point recent and apparently incompatible conclusions by Saunders and Knox, I revisit the question of the correct spacetime setting for Newtonian physics. I argue that understood correctly, these two versions of Newtonian physics make the same claims both about the background geometry required to define the theory, and about the inertial structure of the theory. In doing so I illustrate and explore in detail the view—espoused by Knox, and also by Brown —that inertial structure is defined (...)
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  29. Letting Go of “Natural Kind”: Toward a Multidimensional Framework of Nonarbitrary Classification.David Ludwig - 2018 - Philosophy of Science 85 (1):31-52.
    This article uses the case study of ethnobiological classification to develop a positive and a negative thesis about the state of natural kind debates. On the one hand, I argue that current accounts of natural kinds can be integrated in a multidimensional framework that advances understanding of classificatory practices in ethnobiology. On the other hand, I argue that such a multidimensional framework does not leave any substantial work for the notion “natural kind” and that attempts to formulate a general account (...)
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  30. What is Wrong with Self-Grounding?David Mark Kovacs - 2018 - Erkenntnis 83 (6):1157-1180.
    Many philosophers embrace grounding, supposedly a central notion of metaphysics. Grounding is widely assumed to be irreflexive, but recently a number of authors have questioned this assumption: according to them, it is at least possible that some facts ground themselves. The primary purpose of this paper is to problematize the notion of self-grounding through the theoretical roles usually assigned to grounding. The literature typically characterizes grounding as at least playing two central theoretical roles: a structuring role and an explanatory role. (...)
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  31. Quine, Putnam, and the ‘Quine–Putnam’ Indispensability Argument.David Liggins - 2008 - Erkenntnis 68 (1):113 - 127.
    Much recent discussion in the philosophy of mathematics has concerned the indispensability argument—an argument which aims to establish the existence of abstract mathematical objects through appealing to the role that mathematics plays in empirical science. The indispensability argument is standardly attributed to W. V. Quine and Hilary Putnam. In this paper, I show that this attribution is mistaken. Quine's argument for the existence of abstract mathematical objects differs from the argument which many philosophers of mathematics ascribe to him. Contrary to (...)
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  32. Dutch-book arguments depragmatized: Epistemic consistency for partial believers.David Christensen - 1996 - Journal of Philosophy 93 (9):450-479.
    The most immediately appealing model for formal constraints on degrees of belief is provided by probability theory, which tells us, for instance, that the probability of P can never be greater than that of (P v Q). But while this model has much intuitive appeal, many have been concerned to provide arguments showing that ideally rational degrees of belief would conform to the calculus of probabilities. The arguments most frequently used to make this claim plausible are the so-called "Dutch Book" (...)
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  33. Intentional Psychologism.David Pitt - 2009 - Philosophical Studies 146 (1):117-138.
    In the past few years, a number of philosophers ; Horgan and Tienson 2002; Pitt 2004) have maintained the following three theses: there is a distinctive sort of phenomenology characteristic of conscious thought, as opposed to other sorts of conscious mental states; different conscious thoughts have different phenomenologies; and thoughts with the same phenomenology have the same intentional content. The last of these three claims is open to at least two different interpretations. It might mean that the phenomenology of a (...)
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  34. Morality and virtue: An assessment of some recent work in virtue ethics.David Copp & David Sobel - 2004 - Ethics 114 (3):514-554.
    This essay focuses on three recent books on morality and virtue, Michael Slote's 'Morals from Motives', Rosalind Hursthouse's 'On Virtue Ethics', and Philippa Foot's 'Natural Goodness'. Slote proposes an "agent-based" ethical theory according to which the ethical status of acts is derivative from assessments of virtue. Following Foot's lead, Hursthouse aims to vindicate an ethical naturalism that explains human goodness on the basis of views about human nature. Both Hursthouse and Slote take virtue to be morally basic in a way (...)
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  35. La providencia divina en la vida humana según santo Tomás de Aquino.David Torrijos Castrillejo - 2024 - Revista Aragonesa de Teología 30:55-88.
    Divine providence, according to Aquinas, is the order of divine wisdom by which it leads creatures to their end. The existence of necessary, contingent and free things is part of this disposition. The infallible character of divine knowledge and will is not at odds with the fallible nature of things ordained by God: providence has infallibly disposed things to happen in a fallible way. Even the acts of human freedom are under the direction of divine mind, for the creator cooperates (...)
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  36. Moral responsibility and buffered alternatives.David P. Hunt - 2005 - Midwest Studies in Philosophy 29 (1):126–145.
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  37. (1 other version)When is information explicitly represented?David Kirsh - 1990 - In Philip P. Hanson (ed.), Information, Language and Cognition. University of British Columbia Press.
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  38. Punishing Intentions and Neurointerventions.David Birks & Alena Buyx - 2018 - American Journal of Bioethics Neuroscience 9 (3):133-143.
    How should we punish criminal offenders? One prima facie attractive punishment is administering a mandatory neurointervention—interventions that exert a physical, chemical or biological effect on the brain in order to diminish the likelihood of some forms of criminal offending. While testosterone-lowering drugs have long been used in European and US jurisdictions on sex offenders, it has been suggested that advances in neuroscience raise the possibility of treating a broader range of offenders in the future. Neurointerventions could be a cheaper, and (...)
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  39. Permissive Metaepistemology.David Thorstad - 2019 - Mind 128 (511):907-926.
    Recent objections to epistemic permissivism have a metaepistemic flavor. Impermissivists argue that their view best accounts for connections between rationality, planning and deference. Impermissivism is also taken to best explain the value of rational belief and normative assessment. These objections pose a series of metaepistemic explanatory challenges for permissivism. In this paper, I illustrate how permissivists might meet their explanatory burdens by developing two permissivist metaepistemic views which fare well against the explanatory challenges.
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  40. Testimony, memory and the limits of the a priori.David Christensen & Hilary Kornblith - 1997 - Philosophical Studies 86 (1):1-20.
    A number of philosophers, from Thomas Reid1 through C. A. J. Coady2, have argued that one is justified in relying on the testimony of others, and furthermore, that this should be taken as a basic epistemic presumption. If such a general presumption were not ultimately dependent on evidence for the reliability of other people, the ground for this presumption would be a priori. Such a presumption would then have a status like that which Roderick Chisholm claims for the epistemic principle (...)
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  41. Is there a good epistemological argument against platonism?David Liggins - 2006 - Analysis 66 (2):135–141.
    Platonism in the philosophy of mathematics is the doctrine that there are mathematical objects such as numbers. John Burgess and Gideon Rosen have argued that that there is no good epistemological argument against platonism. They propose a dilemma, claiming that epistemological arguments against platonism either rely on a dubious epistemology, or resemble a dubious sceptical argument concerning perceptual knowledge. Against Burgess and Rosen, I show that an epistemological anti- platonist argument proposed by Hartry Field avoids both horns of their dilemma.
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  42. Lying, liars and language.David Simpson - 1992 - Philosophy and Phenomenological Research 52 (3):623-639.
    This paper considers the phenomenon of lying and the implications it has for those subjects who are capable of lying. It is argued that lying is not just intentional untruthfulness, but is intentional untruthfulness plus an insincere invocation of trust. Understood in this way, lying demands of liars a sophistication in relation to themselves, to language, and to those to whom they lie which exceeds the demands on mere truth-tellers.
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  43. Pain for objectivists: The case of matters of mere taste.David Sobel - 2005 - Ethical Theory and Moral Practice 8 (4):437 - 457.
    Can we adequately account for our reasons of mere taste without holding that our desires ground such reasons? Recently, Scanlon and Parfit have argued that we can, pointing to pleasure and pain as the grounds of such reasons. In this paper I take issue with each of their accounts. I conclude that we do not yet have a plausible rival to a desire-based understanding of the grounds of such reasons.
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  44. You are simple.David Barnett - 2010 - In Robert C. Koons & George Bealer (eds.), The waning of materialism. New York: Oxford University Press. pp. 161--174.
    I argue that, unlike your brain, you are not composed of other things: you are simple. My argument centers on what I take to be an uncontroversial datum: for any pair of conscious beings, it is impossible for the pair itself to be conscious. Consider, for instance, the pair comprising you and me. You might pinch your arm and feel a pain. I might simultaneously pinch my arm and feel a qualitatively identical pain. But the pair we form would not (...)
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  45. Varieties of hedonism.David Sobel - 2002 - Journal of Social Philosophy 33 (2):240–256.
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  46. Introduction: The Metaphysics of Relations.David Yates & Anna Marmodoro - 2016 - In Anna Marmodoro & David Yates (eds.), The Metaphysics of Relations. Oxford, GB: Oxford University Press UK. pp. 1-18.
    An introduction to our edited volume, The Metaphysics of Relations, covering a range of issues including the problem of order, the ontological status of relations, reasons for ancient scepticism about relational properties, and two ways of drawing the distinction between internal and external relations.
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  47. Democracy without preference.David M. Estlund - 1990 - Philosophical Review 99 (3):397-423.
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  48. The myth of the myth of supervenience.David Mark Kovacs - 2019 - Philosophical Studies 176 (8):1967-1989.
    Supervenience is necessary co-variation between two sets of entities. In the good old days, supervenience was considered a useful philosophical tool with a wide range of applications in the philosophy of mind, metaethics, epistemology, and elsewhere. In recent years, however, supervenience has fallen out of favor, giving place to grounding, realization, and other, more metaphysically “meaty”, notions. The emerging consensus is that there are principled reasons for which explanatory theses cannot be captured in terms of supervenience, or as the slogan (...)
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  49. Diachronic coherence versus epistemic impartiality.David Christensen - 2000 - Philosophical Review 109 (3):349-371.
    It is obvious that we would not want to demand that an agent' s beliefs at different times exhibit the same sort of consistency that we demand from an agent' s simultaneous beliefs; there' s nothing irrational about believing P at one time and not-P at another. Nevertheless, many have thought that some sort of coherence or stability of beliefs over time is an important component of epistemic rationality.
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  50. Responsibility, Libertarians, and the “Facts as We Know Them”: A Concern-Based Construal of Strawson’s Reversal.David Beglin - 2018 - Ethics 128 (3):612-625.
    Here, I put forth a construal of P. F. Strawson’s so-called reversal, his view that what it means to be morally responsible is determined by our practices of holding responsible. The “concern-based” construal that I defend holds that what it means to be morally responsible is determined by the basic social concerns of which our practices are an expression. This construal, I argue, avoids a dilemma that Patrick Todd has recently raised for the reversal.
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