Results for 'David Diehl'

964 found
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  1. Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis.R. Karp David, Marthandan Nishanth, G. E. Marsh Steven, Ahn Chul, C. Arnett Frank, S. DeLuca David, D. Diehl Alexander, Dunivin Raymond, Eilbeck Karen, Feolo Michael & Barry Smith - 2009 - Human Molecular Genetics 19 (4):707-719.
    Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...)
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  2. OBO Foundry in 2021: Operationalizing Open Data Principles to Evaluate Ontologies.Rebecca C. Jackson, Nicolas Matentzoglu, James A. Overton, Randi Vita, James P. Balhoff, Pier Luigi Buttigieg, Seth Carbon, Melanie Courtot, Alexander D. Diehl, Damion Dooley, William Duncan, Nomi L. Harris, Melissa A. Haendel, Suzanna E. Lewis, Darren A. Natale, David Osumi-Sutherland, Alan Ruttenberg, Lynn M. Schriml, Barry Smith, Christian J. Stoeckert, Nicole A. Vasilevsky, Ramona L. Walls, Jie Zheng, Christopher J. Mungall & Bjoern Peters - 2021 - BioaRxiv.
    Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...)
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  3. (1 other version)Epistemology of disagreement: The good news.David Christensen - 2007 - Philosophical Review 116 (2):187-217.
    How should one react when one has a belief, but knows that other people—who have roughly the same evidence as one has, and seem roughly as likely to react to it correctly—disagree? This paper argues that the disagreement of other competent inquirers often requires one to be much less confident in one’s opinions than one would otherwise be.
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  4. (1 other version)Are we free to break the laws?David Lewis - 1981 - Theoria 47 (3):113-21.
    I insist that I was able to raise my hand, and I acknowledge that a law would have been broken had I done so, but I deny that I am therefore able to break a law. To uphold my instance of soft determinism, I need not claim any incredible powers. To uphold the compatibilism that I actually believe, I need not claim that such powers are even possible. My incompatibilist opponent is a creature of fiction, but he has his prototypes (...)
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  5. On distinguishing epistemic from pragmatic action.David Kirsh & Paul Maglio - 1994 - Cognitive Science 18 (4):513-49.
    We present data and argument to show that in Tetris - a real-time interactive video game - certain cognitive and perceptual problems are more quickly, easily, and reliably solved by performing actions in the world rather than by performing computational actions in the head alone. We have found that some translations and rotations are best understood as using the world to improve cognition. These actions are not used to implement a plan, or to implement a reaction; they are used to (...)
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  6. Inquiry and the epistemic.David Thorstad - 2021 - Philosophical Studies 178 (9):2913-2928.
    The zetetic turn in epistemology raises three questions about epistemic and zetetic norms. First, there is the relationship question: what is the relationship between epistemic and zetetic norms? Are some epistemic norms zetetic norms, or are epistemic and zetetic norms distinct? Second, there is the tension question: are traditional epistemic norms in tension with plausible zetetic norms? Third, there is the reaction question: how should theorists react to a tension between epistemic and zetetic norms? Drawing on an analogy to practical (...)
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  7. Utopophobia.David Estlund - 2014 - Philosophy and Public Affairs 42 (2):113-134.
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  8. Connectionism and compositionality: Why Fodor and Pylyshyn were wrong.David J. Chalmers - 1993 - Philosophical Psychology 6 (3):305-319.
    This paper offers both a theoretical and an experimental perspective on the relationship between connectionist and Classical (symbol-processing) models. Firstly, a serious flaw in Fodor and Pylyshyn’s argument against connectionism is pointed out: if, in fact, a part of their argument is valid, then it establishes a conclusion quite different from that which they intend, a conclusion which is demonstrably false. The source of this flaw is traced to an underestimation of the differences between localist and distributed representation. It has (...)
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  9. Statistical Evidence, Sensitivity, and the Legal Value of Knowledge.David Enoch, Levi Spectre & Talia Fisher - 2012 - Philosophy and Public Affairs 40 (3):197-224.
    The law views with suspicion statistical evidence, even evidence that is probabilistically on a par with direct, individual evidence that the law is in no way suspicious of. But it has proved remarkably hard to either justify this suspicion, or to debunk it. In this paper, we connect the discussion of statistical evidence to broader epistemological discussions of similar phenomena. We highlight Sensitivity – the requirement that a belief be counterfactually sensitive to the truth in a specific way – as (...)
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  10. There are no epistemic norms of inquiry.David Thorstad - 2022 - Synthese 200 (5):1-24.
    Epistemic nihilism for inquiry is the claim that there are no epistemic norms of inquiry. Epistemic nihilism was once the received stance towards inquiry, and I argue that it should be taken seriously again. My argument is that the same considerations which led us away from epistemic nihilism in the case of belief not only cannot refute epistemic nihilism for inquiry, but in fact may well support it. These include the argument from non-existence that there are no non-epistemic reasons for (...)
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  11. Human Nature and the Limits (If Any) of Political Philosophy.David Estlund - 2011 - Philosophy and Public Affairs 39 (3):207-237.
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  12. High Risk, Low Reward: A Challenge to the Astronomical Value of Existential Risk Mitigation.David Thorstad - 2023 - Philosophy and Public Affairs 51 (4):373-412.
    Philosophy &Public Affairs, Volume 51, Issue 4, Page 373-412, Fall 2023.
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  13. Clever bookies and coherent beliefs.David Christensen - 1991 - Philosophical Review 100 (2):229-247.
    A critical examination of the Reflection principle in Bayesian epistemology, and of the diachronic Dutch-book-style arguments that have been invoked to support Reflection and Conditionalization.
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  14. Against the singularity hypothesis.David Thorstad - forthcoming - Philosophical Studies:1-25.
    The singularity hypothesis is a radical hypothesis about the future of artificial intelligence on which self-improving artificial agents will quickly become orders of magnitude more intelligent than the average human. Despite the ambitiousness of its claims, the singularity hypothesis has been defended at length by leading philosophers and artificial intelligence researchers. In this paper, I argue that the singularity hypothesis rests on scientifically implausible growth assumptions. I show how leading philosophical defenses of the singularity hypothesis (Chalmers 2010, Bostrom 2014) fail (...)
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  15. False Consciousness for Liberals, Part I: Consent, Autonomy, and Adaptive Preferences.David Enoch - 2020 - Philosophical Review 129 (2):159-210.
    The starting point regarding consent has to be that it is both extremely important, and that it is often suspicious. In this article, the author tries to make sense of both of these claims, from a largely liberal perspective, tying consent, predictably, to the value of autonomy and distinguishing between autonomy as sovereignty and autonomy as nonalienation. The author then discusses adaptive preferences, claiming that they suffer from a rationality flaw but that it's not clear that this flaw matters morally (...)
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  16. Measuring confirmation.David Christensen - 1999 - Journal of Philosophy 96 (9):437-461.
    The old evidence problem affects any probabilistic confirmation measure based on comparing pr(H/E) and pr(H). The article argues for the following points: (1) measures based on likelihood ratios also suffer old evidence difficulties; (2) the less-discussed synchronic old evidence problem is, in an important sense, the most acute; (3) prominent attempts to solve or dissolve the synchronic problem fail; (4) a little-discussed variant of the standard measure avoids the problem, in an appealing way; and (5) this measure nevertheless reveals a (...)
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  17. Full information accounts of well-being.David Sobel - 1994 - Ethics 104 (4):784-810.
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  18. Inverse functionalism and the individuation of powers.David Yates - 2018 - Synthese 195 (10):4525-4550.
    In the pure powers ontology (PPO), basic physical properties have wholly dispositional essences. PPO has clear advantages over categoricalist ontologies, which suffer from familiar epistemological and metaphysical problems. However, opponents argue that because it contains no qualitative properties, PPO lacks the resources to individuate powers, and generates a regress. The challenge for those who take such arguments seriously is to introduce qualitative properties without reintroducing the problems that PPO was meant to solve. In this paper, I distinguish the core claim (...)
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  19. There is no such thing as doxastic wrongdoing.David Enoch & Levi Spectre - forthcoming - Philosophical Perspectives.
    People are often offended by beliefs, expect apologies for beliefs, apologize for their own beliefs. In many mundane cases, people are morally criticized for their beliefs. Intuitively, then, beliefs seem to sometimes wrong people. Recently, the philosophical literature has picked up on this theme, and has started to discuss it under the heading of doxastic wrongdoing. In this paper we argue that despite the strength of such initial intuitions, at the end of the day they have to be rejected. If (...)
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  20. Thinking about Spacetime.David Yates - 2021 - In Christian Wüthrich, Baptiste Le Bihan & Nick Huggett (eds.), Philosophy Beyond Spacetime: Implications From Quantum Gravity. Oxford: Oxford University Press.
    Several different quantum gravity research programmes suggest, for various reasons, that spacetime is not part of the fundamental ontology of physics. This gives rise to the problem of empirical coherence: if fundamental physical entities do not occupy spacetime or instantiate spatiotemporal properties, how can fundamental theories concerning those entities be justified by observation of spatiotemporally located things like meters, pointers and dials? I frame the problem of empirical coherence in terms of entailment: how could a non-spatiotemporal fundamental theory entail spatiotemporal (...)
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  21. Fundamental and Emergent Geometry in Newtonian Physics.David Wallace - 2020 - British Journal for the Philosophy of Science 71 (1):1-32.
    Using as a starting point recent and apparently incompatible conclusions by Saunders and Knox, I revisit the question of the correct spacetime setting for Newtonian physics. I argue that understood correctly, these two versions of Newtonian physics make the same claims both about the background geometry required to define the theory, and about the inertial structure of the theory. In doing so I illustrate and explore in detail the view—espoused by Knox, and also by Brown —that inertial structure is defined (...)
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  22. How Are Basic Belief-Forming Methods Justified?David Enoch & Joshua Schechter - 2008 - Philosophy and Phenomenological Research 76 (3):547–579.
    In this paper, we develop an account of the justification thinkers have for employing certain basic belief-forming methods. The guiding idea is inspired by Reichenbach's work on induction. There are certain projects in which thinkers are rationally required to engage. Thinkers are epistemically justified in employing any belief-forming method such that "if it doesn't work, nothing will" for successfully engaging in such a project. We present a detailed account based on this intuitive thought and address objections to it. We conclude (...)
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  23. The General Theory of Second Best Is More General Than You Think.David Wiens - 2020 - Philosophers' Imprint 20 (5):1-26.
    Lipsey and Lancaster's "general theory of second best" is widely thought to have significant implications for applied theorizing about the institutions and policies that most effectively implement abstract normative principles. It is also widely thought to have little significance for theorizing about which abstract normative principles we ought to implement. Contrary to this conventional wisdom, I show how the second-best theorem can be extended to myriad domains beyond applied normative theorizing, and in particular to more abstract theorizing about the normative (...)
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  24. Political Ideals and the Feasibility Frontier.David Wiens - 2015 - Economics and Philosophy 31 (3):447-477.
    Recent methodological debates regarding the place of feasibility considerations in normative political theory are hindered for want of a rigorous model of the feasibility frontier. To address this shortfall, I present an analysis of feasibility that generalizes the economic concept of a production possibility frontier and then develop a rigorous model of the feasibility frontier using the familiar possible worlds technology. I then show that this model has significant methodological implications for political philosophy. On the Target View, a political ideal (...)
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  25. Debate: Liberalism, equality, and fraternity in Cohen's critique of Rawls.David Estlund - 1998 - Journal of Political Philosophy 6 (1):99–112.
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  26. The insularity of the reasonable: Why political liberalism must admit the truth.David Estlund - 1998 - Ethics 108 (2):252-275.
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  27. The impotence of the demandingness objection.David Sobel - 2007 - Philosophers' Imprint 7:1-17.
    Consequentialism, many philosophers have claimed, asks too much of us to be a plausible ethical theory. Indeed, the theory's severe demandingness is often claimed to be its chief flaw. My thesis is that as we come to better understand this objection, we see that, even if it signals or tracks the existence of a real problem for Consequentialism, it cannot itself be a fundamental problem with the view. The objection cannot itself provide good reason to break with Consequentialism, because it (...)
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  28. Statistical resentment, or: what’s wrong with acting, blaming, and believing on the basis of statistics alone.David Enoch & Levi Spectre - 2021 - Synthese 199 (3-4):5687-5718.
    Statistical evidence—say, that 95% of your co-workers badmouth each other—can never render resenting your colleague appropriate, in the way that other evidence (say, the testimony of a reliable friend) can. The problem of statistical resentment is to explain why. We put the problem of statistical resentment in several wider contexts: The context of the problem of statistical evidence in legal theory; the epistemological context—with problems like the lottery paradox for knowledge, epistemic impurism and doxastic wrongdoing; and the context of a (...)
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  29. Against Ideal Guidance.David Wiens - 2015 - Journal of Politics 77 (2):433-446.
    Political philosophers frequently claim that political ideals can provide normative guidance for unjust and otherwise nonideal circumstances. This is mistaken. This paper demonstrates that political ideals contribute nothing to our understanding of the normative principles we should satisfy amidst unjust or otherwise nonideal circumstances.
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  30. Moral responsibility and unavoidable action.David P. Hunt - 2000 - Philosophical Studies 97 (2):195-227.
    The principle of alternate possibilities (PAP), making the ability to do otherwise a necessary condition for moral responsibility, is supposed by Harry Frankfurt, John Fischer, and others to succumb to a peculiar kind of counterexample. The paper reviews the main problems with the counterexample that have surfaced over the years, and shows how most can be addressed within the terms of the current debate. But one problem seems ineliminable: because Frankfurt''s example relies on a counterfactual intervener to preclude alternatives to (...)
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  31. On following orders in an unjust war.David Estlund - 2007 - Journal of Political Philosophy 15 (2):213–234.
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  32. Conservatism in epistemology.David Christensen - 1994 - Noûs 28 (1):69-89.
    A wide range of prominent epistemological theories include a principle of conservatism. Such principles take the fact that an agent currently holds a certain belief to constitute at least some measure of epistemic justification for her to maintain that belief. I examine the main arguments that have been made in conservatism's behalf, and find them unsound. Most interestingly, conservatism does not fall out of confirmational holism (the view that the justification of each of our beliefs is in part determined by (...)
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  33. Norms of inquiry.David Thorstad - forthcoming - Philosophical Topics.
    Epistemologists have recently proposed a number of norms governing rational inquiry. My aim in this paper is to unify and explain recently proposed norms of inquiry by developing a general account of the conditions under which inquiries are rational, analogous to theories such as evidentialism and reliabilism for rational belief. I begin with a reason-responsiveness conception of rationality as responding correctly to possessed normative reasons. I extend this account with a series of claims about the normative reasons for inquiry that (...)
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  34. Counterpossibles and Similarity.David Vander Laan - 2004 - In Frank Jackson & Graham Priest (eds.), Lewisian Themes: The Philosophy of David K. Lewis. Oxford, England: Oxford University Press UK. pp. 258-275.
    Several themes of David Lewis's theory of counterfactuals, especially their sensitivity to context, pave the way for a viable theory of non-trivial counterpossibles. If Lewis was successful in defending his account against the early objections, a semantics of counterpossibles can be defended from similar objections in the same way. The resulting theory will be extended to address 'might' counterfactuals and questions about the relative "nearness" of impossible worlds.
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  35. Quine, Putnam, and the ‘Quine–Putnam’ Indispensability Argument.David Liggins - 2008 - Erkenntnis 68 (1):113 - 127.
    Much recent discussion in the philosophy of mathematics has concerned the indispensability argument—an argument which aims to establish the existence of abstract mathematical objects through appealing to the role that mathematics plays in empirical science. The indispensability argument is standardly attributed to W. V. Quine and Hilary Putnam. In this paper, I show that this attribution is mistaken. Quine's argument for the existence of abstract mathematical objects differs from the argument which many philosophers of mathematics ascribe to him. Contrary to (...)
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  36. Dutch-book arguments depragmatized: Epistemic consistency for partial believers.David Christensen - 1996 - Journal of Philosophy 93 (9):450-479.
    The most immediately appealing model for formal constraints on degrees of belief is provided by probability theory, which tells us, for instance, that the probability of P can never be greater than that of (P v Q). But while this model has much intuitive appeal, many have been concerned to provide arguments showing that ideally rational degrees of belief would conform to the calculus of probabilities. The arguments most frequently used to make this claim plausible are the so-called "Dutch Book" (...)
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  37. (2 other versions)The explanation game: a formal framework for interpretable machine learning.David S. Watson & Luciano Floridi - 2020 - Synthese 198 (10):1–⁠32.
    We propose a formal framework for interpretable machine learning. Combining elements from statistical learning, causal interventionism, and decision theory, we design an idealised explanation game in which players collaborate to find the best explanation for a given algorithmic prediction. Through an iterative procedure of questions and answers, the players establish a three-dimensional Pareto frontier that describes the optimal trade-offs between explanatory accuracy, simplicity, and relevance. Multiple rounds are played at different levels of abstraction, allowing the players to explore overlapping causal (...)
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  38. Opinion leaders, independence, and Condorcet's Jury Theorem.David M. Estlund - 1994 - Theory and Decision 36 (2):131-162.
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  39. Intentional Psychologism.David Pitt - 2009 - Philosophical Studies 146 (1):117-138.
    In the past few years, a number of philosophers ; Horgan and Tienson 2002; Pitt 2004) have maintained the following three theses: there is a distinctive sort of phenomenology characteristic of conscious thought, as opposed to other sorts of conscious mental states; different conscious thoughts have different phenomenologies; and thoughts with the same phenomenology have the same intentional content. The last of these three claims is open to at least two different interpretations. It might mean that the phenomenology of a (...)
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  40. Existential risk pessimism and the time of perils.David Thorstad - manuscript
    When our choice affects some other person and the outcome is unknown, it has been argued that we should defer to their risk attitude, if known, or else default to use of a risk avoidant risk function. This, in turn, has been claimed to require the use of a risk avoidant risk function when making decisions that primarily affect future people, and to decrease the desirability of efforts to prevent human extinction, owing to the significant risks associated with continued human (...)
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  41. Clinical applications of machine learning algorithms: beyond the black box.David S. Watson, Jenny Krutzinna, Ian N. Bruce, Christopher E. M. Griffiths, Iain B. McInnes, Michael R. Barnes & Luciano Floridi - 2019 - British Medical Journal 364:I886.
    Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.
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  42. Dispositionalism and the Modal Operators.David Yates - 2015 - Philosophy and Phenomenological Research 91 (2):411-424.
    Actualists of a certain stripe—dispositionalists—hold that metaphysical modality is grounded in the powers of actual things. Roughly: p is possible iff something has, or some things have, the power to bring it about that p. Extant critiques of dispositionalism focus on its material adequacy, and question whether there are enough powers to account for all the possibilities we intuitively want to countenance. For instance, it seems possible that none of the actual contingent particulars ever existed, but it is impossible to (...)
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  43. The Rhetoric and Reality of Anthropomorphism in Artificial Intelligence.David Watson - 2019 - Minds and Machines 29 (3):417-440.
    Artificial intelligence has historically been conceptualized in anthropomorphic terms. Some algorithms deploy biomimetic designs in a deliberate attempt to effect a sort of digital isomorphism of the human brain. Others leverage more general learning strategies that happen to coincide with popular theories of cognitive science and social epistemology. In this paper, I challenge the anthropomorphic credentials of the neural network algorithm, whose similarities to human cognition I argue are vastly overstated and narrowly construed. I submit that three alternative supervised learning (...)
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  44. Morality and virtue: An assessment of some recent work in virtue ethics.David Copp & David Sobel - 2004 - Ethics 114 (3):514-554.
    This essay focuses on three recent books on morality and virtue, Michael Slote's 'Morals from Motives', Rosalind Hursthouse's 'On Virtue Ethics', and Philippa Foot's 'Natural Goodness'. Slote proposes an "agent-based" ethical theory according to which the ethical status of acts is derivative from assessments of virtue. Following Foot's lead, Hursthouse aims to vindicate an ethical naturalism that explains human goodness on the basis of views about human nature. Both Hursthouse and Slote take virtue to be morally basic in a way (...)
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  45. The Essence of Dispositional Essentialism.David Yates - 2013 - Philosophy and Phenomenological Research 87 (1):93-128.
    Dispositional essentialists argue that physical properties have their causal roles essentially. This is typically taken to mean that physical properties are identical to dispositions. I argue that this is untenable, and that we must instead say that properties bestow dispositions. I explore what it is for a property to have such a role essentially. Dispositional essentialists argue for their view by citing certain epistemological and metaphysical implications, and I appeal to these implications to place desiderata on the concept of essence (...)
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  46. (1 other version)A Defense of Shepherd’s Account of Cause and Effect as Synchronous.David Landy - 2020 - Journal of Modern Philosophy 2 (1):1.
    Lady Mary Shepherd holds that the relation of cause and effect consists of the combination of two objects to create a third object. She also holds that this account implies that causes are synchronous with their effects. There is a single instant in which the objects that are causes combine to create the object which is their effect. Hume argues that cause and effect cannot be synchronous because if they were then the entire chain of successive causes and effects would (...)
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  47. The Asceticism of the Phaedo: Pleasure, Purification, and the Soul’s Proper Activity.David Ebrey - 2017 - Archiv für Geschichte der Philosophie 99 (1):1-30.
    I argue that according to Socrates in the Phaedo we should not merely evaluate bodily pleasures and desires as worthless or bad, but actively avoid them. We need to avoid them because they change our values and make us believe falsehoods. This change in values and acceptance of falsehoods undermines the soul’s proper activity, making virtue and happiness impossible for us. I situate this account of why we should avoid bodily pleasures within Plato’s project in the Phaedo of providing Pythagorean (...)
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  48. Self to self.David Velleman - 1996 - Philosophical Review 105 (1):39-76.
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  49. Permissive Metaepistemology.David Thorstad - 2019 - Mind 128 (511):907-926.
    Recent objections to epistemic permissivism have a metaepistemic flavor. Impermissivists argue that their view best accounts for connections between rationality, planning and deference. Impermissivism is also taken to best explain the value of rational belief and normative assessment. These objections pose a series of metaepistemic explanatory challenges for permissivism. In this paper, I illustrate how permissivists might meet their explanatory burdens by developing two permissivist metaepistemic views which fare well against the explanatory challenges.
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  50. Can We Detect Bias in Political Fact-Checking? Evidence from a Spanish Case Study.David Teira, Alejandro Fernandez-Roldan, Carlos Elías & Carlos Santiago-Caballero - 2023 - Journalism Practice 10.
    Political fact-checkers evaluate the truthfulness of politicians’ claims. This paper contributes to an emerging scholarly debate on whether fact-checkers treat political parties differently in a systematic manner depending on their ideology (bias). We first examine the available approaches to analyze bias and then present a new approach in two steps. First, we propose a logistic regression model to analyze the outcomes of fact-checks and calculate how likely each political party will obtain a truth score. We test our model with a (...)
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