Results for 'David Diehl'

959 found
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  1. Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis.R. Karp David, Marthandan Nishanth, G. E. Marsh Steven, Ahn Chul, C. Arnett Frank, S. DeLuca David, D. Diehl Alexander, Dunivin Raymond, Eilbeck Karen, Feolo Michael & Barry Smith - 2009 - Human Molecular Genetics 19 (4):707-719.
    Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...)
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  2. OBO Foundry in 2021: Operationalizing Open Data Principles to Evaluate Ontologies.Rebecca C. Jackson, Nicolas Matentzoglu, James A. Overton, Randi Vita, James P. Balhoff, Pier Luigi Buttigieg, Seth Carbon, Melanie Courtot, Alexander D. Diehl, Damion Dooley, William Duncan, Nomi L. Harris, Melissa A. Haendel, Suzanna E. Lewis, Darren A. Natale, David Osumi-Sutherland, Alan Ruttenberg, Lynn M. Schriml, Barry Smith, Christian J. Stoeckert, Nicole A. Vasilevsky, Ramona L. Walls, Jie Zheng, Christopher J. Mungall & Bjoern Peters - 2021 - BioaRxiv.
    Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...)
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  3. (2 other versions)The Paradoxes of Time Travel.David Lewis - 1976 - American Philosophical Quarterly 13 (2):145-152.
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  4. The Phenomenology of Cognition, Or, What Is It Like to Think That P?David Pitt - 2004 - Philosophy and Phenomenological Research 69 (1):1-36.
    A number of philosophers endorse, without argument, the view that there’s something it’s like consciously to think that p, which is distinct from what it’s like consciously to think that q. This thesis, if true, would have important consequences for philosophy of mind and cognitive science. In this paper I offer an argument for it, and attempt to induce examples of it in the reader. The argument claims it would be impossible introspectively to distinguish conscious thoughts with respect to their (...)
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  5. (1 other version)Epistemology of disagreement: The good news.David Christensen - 2007 - Philosophical Review 116 (2):187-217.
    How should one react when one has a belief, but knows that other people—who have roughly the same evidence as one has, and seem roughly as likely to react to it correctly—disagree? This paper argues that the disagreement of other competent inquirers often requires one to be much less confident in one’s opinions than one would otherwise be.
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  6. Searle on Institutional Obligation.David–Hillel Ruben - 1972 - The Monist 56 (4):600-611.
    John Searle sets out five statements, the relation of each to its successor being one of entailment.
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  7. A Guided Tour Of Conceptual Engineering and Conceptual Ethics.Herman Cappelen & David Plunkett - 2019 - In Alexis Burgess, Herman Cappelen & David Plunkett (eds.), Conceptual Engineering and Conceptual Ethics. New York, USA: Oxford University Press. pp. 1-26.
    In this Introduction, we aim to introduce the reader to the basic topic of this book. As part of this, we explain why we are using two different expressions (‘conceptual engineering’ and ‘conceptual ethics’) to describe the topics in the book. We then turn to some of the central foundational issues that arise for conceptual engineering and conceptual ethics, and finally we outline various views one might have about their role in philosophy and inquiry more generally.
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  8. The Causal and Deliberative Strength of Reasons for Action.David-Hillel Ruben - 2010 - In Jesús Humberto Aguilar & Andrei A. Buckareff (eds.), Causing Human Actions: New Perspectives on the Causal Theory of Action. Bradford.
    Is the thought that having a reason for action can also be the cause of the action for which it is the reason coherent? This is an attempt to say exactly what is involved in such a thought, with special reference to the case of con-reasons, reasons that count against the action the agent eventually choses.
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  9. Causation, Norm violation, and culpable control.Mark D. Alicke, David Rose & Dori Bloom - 2011 - Journal of Philosophy 108 (12):670-696.
    Causation is one of philosophy's most venerable and thoroughly-analyzed concepts. However, the study of how ordinary people make causal judgments is a much more recent addition to the philosophical arsenal. One of the most prominent views of causal explanation, especially in the realm of harmful or potentially harmful behavior, is that unusual or counternormative events are accorded privileged status in ordinary causal explanations. This is a fundamental assumption in psychological theories of counterfactual reasoning, and has been transported to philosophy by (...)
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  10. (1 other version)Are we free to break the laws?David Lewis - 1981 - Theoria 47 (3):113-21.
    I insist that I was able to raise my hand, and I acknowledge that a law would have been broken had I done so, but I deny that I am therefore able to break a law. To uphold my instance of soft determinism, I need not claim any incredible powers. To uphold the compatibilism that I actually believe, I need not claim that such powers are even possible. My incompatibilist opponent is a creature of fiction, but he has his prototypes (...)
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  11. On distinguishing epistemic from pragmatic action.David Kirsh & Paul Maglio - 1994 - Cognitive Science 18 (4):513-49.
    We present data and argument to show that in Tetris - a real-time interactive video game - certain cognitive and perceptual problems are more quickly, easily, and reliably solved by performing actions in the world rather than by performing computational actions in the head alone. We have found that some translations and rotations are best understood as using the world to improve cognition. These actions are not used to implement a plan, or to implement a reaction; they are used to (...)
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  12. Connectionism and compositionality: Why Fodor and Pylyshyn were wrong.David J. Chalmers - 1993 - Philosophical Psychology 6 (3):305-319.
    This paper offers both a theoretical and an experimental perspective on the relationship between connectionist and Classical (symbol-processing) models. Firstly, a serious flaw in Fodor and Pylyshyn’s argument against connectionism is pointed out: if, in fact, a part of their argument is valid, then it establishes a conclusion quite different from that which they intend, a conclusion which is demonstrably false. The source of this flaw is traced to an underestimation of the differences between localist and distributed representation. It has (...)
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  13. Clever bookies and coherent beliefs.David Christensen - 1991 - Philosophical Review 100 (2):229-247.
    A critical examination of the Reflection principle in Bayesian epistemology, and of the diachronic Dutch-book-style arguments that have been invoked to support Reflection and Conditionalization.
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  14. Measuring confirmation.David Christensen - 1999 - Journal of Philosophy 96 (9):437-461.
    The old evidence problem affects any probabilistic confirmation measure based on comparing pr(H/E) and pr(H). The article argues for the following points: (1) measures based on likelihood ratios also suffer old evidence difficulties; (2) the less-discussed synchronic old evidence problem is, in an important sense, the most acute; (3) prominent attempts to solve or dissolve the synchronic problem fail; (4) a little-discussed variant of the standard measure avoids the problem, in an appealing way; and (5) this measure nevertheless reveals a (...)
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  15. Humean Rationalism.David Builes - 2024 - Philosophical Studies 181 (10):2563-2576.
    According to the Principle of Sufficient Reason, every fact has an explanation. An important challenge to this principle is that it risks being a counterexample to itself. What explains why everything needs to be explained? My first goal is to distinguish two broad kinds of answers to this question, which I call “Humean Rationalism” and “Non-Humean Rationalism”. My second goal will be to defend the prospects of Humean Rationalism.
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  16. Conservatism in epistemology.David Christensen - 1994 - Noûs 28 (1):69-89.
    A wide range of prominent epistemological theories include a principle of conservatism. Such principles take the fact that an agent currently holds a certain belief to constitute at least some measure of epistemic justification for her to maintain that belief. I examine the main arguments that have been made in conservatism's behalf, and find them unsound. Most interestingly, conservatism does not fall out of confirmational holism (the view that the justification of each of our beliefs is in part determined by (...)
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  17. Dutch-book arguments depragmatized: Epistemic consistency for partial believers.David Christensen - 1996 - Journal of Philosophy 93 (9):450-479.
    The most immediately appealing model for formal constraints on degrees of belief is provided by probability theory, which tells us, for instance, that the probability of P can never be greater than that of (P v Q). But while this model has much intuitive appeal, many have been concerned to provide arguments showing that ideally rational degrees of belief would conform to the calculus of probabilities. The arguments most frequently used to make this claim plausible are the so-called "Dutch Book" (...)
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  18. Intentional Psychologism.David Pitt - 2009 - Philosophical Studies 146 (1):117-138.
    In the past few years, a number of philosophers ; Horgan and Tienson 2002; Pitt 2004) have maintained the following three theses: there is a distinctive sort of phenomenology characteristic of conscious thought, as opposed to other sorts of conscious mental states; different conscious thoughts have different phenomenologies; and thoughts with the same phenomenology have the same intentional content. The last of these three claims is open to at least two different interpretations. It might mean that the phenomenology of a (...)
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  19. Responsibility, Libertarians, and the “Facts as We Know Them”: A Concern-Based Construal of Strawson’s Reversal.David Beglin - 2018 - Ethics 128 (3):612-625.
    Here, I put forth a construal of P. F. Strawson’s so-called reversal, his view that what it means to be morally responsible is determined by our practices of holding responsible. The “concern-based” construal that I defend holds that what it means to be morally responsible is determined by the basic social concerns of which our practices are an expression. This construal, I argue, avoids a dilemma that Patrick Todd has recently raised for the reversal.
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  20. Motivational Limitations on the Demands of Justice.David Wiens - 2016 - European Journal of Political Theory 15 (3):333-352.
    Do motivational limitations due to human nature constrain the demands of justice? Among those who say no, David Estlund offers perhaps the most compelling argument. Taking Estlund’s analysis of “ability” as a starting point, I show that motivational deficiencies can constrain the demands of justice under at least one common circumstance — that the motivationally-deficient agent makes a good faith effort to overcome her deficiency. In fact, my argument implies something stronger; namely, that the demands of justice are constrained (...)
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  21. Self to self.David Velleman - 1996 - Philosophical Review 105 (1):39-76.
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  22. Confirmational holism and bayesian epistemology.David Christensen - 1992 - Philosophy of Science 59 (4):540-557.
    Much contemporary epistemology is informed by a kind of confirmational holism, and a consequent rejection of the assumption that all confirmation rests on experiential certainties. Another prominent theme is that belief comes in degrees, and that rationality requires apportioning one's degrees of belief reasonably. Bayesian confirmation models based on Jeffrey Conditionalization attempt to bring together these two appealing strands. I argue, however, that these models cannot account for a certain aspect of confirmation that would be accounted for in any adequate (...)
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  23. On Spacetime Functionalism.David John Baker - manuscript
    Eleanor Knox has argued that our concept of spacetime applies to whichever structure plays a certain functional role in the laws (the role of determining local inertial structure). I raise two complications for this approach. First, our spacetime concept seems to have the structure of a cluster concept, which means that Knox's inertial criteria for spacetime cannot succeed with complete generality. Second, the notion of metaphysical fundamentality may feature in the spacetime concept, in which case spacetime functionalism may be uninformative (...)
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  24. Preference-based arguments for probabilism.David Christensen - 2001 - Philosophy of Science 68 (3):356-376.
    Both Representation Theorem Arguments and Dutch Book Arguments support taking probabilistic coherence as an epistemic norm. Both depend on connecting beliefs to preferences, which are not clearly within the epistemic domain. Moreover, these connections are standardly grounded in questionable definitional/metaphysical claims. The paper argues that these definitional/metaphysical claims are insupportable. It offers a way of reconceiving Representation Theorem arguments which avoids the untenable premises. It then develops a parallel approach to Dutch Book Arguments, and compares the results. In each case (...)
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  25. Diachronic coherence versus epistemic impartiality.David Christensen - 2000 - Philosophical Review 109 (3):349-371.
    It is obvious that we would not want to demand that an agent' s beliefs at different times exhibit the same sort of consistency that we demand from an agent' s simultaneous beliefs; there' s nothing irrational about believing P at one time and not-P at another. Nevertheless, many have thought that some sort of coherence or stability of beliefs over time is an important component of epistemic rationality.
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  26. Building Compressed Causal Models of the World.David Kinney & Tania Lombrozo - forthcoming - Cognitive Psychology.
    A given causal system can be represented in a variety of ways. How do agents determine which variables to include in their causal representations, and at what level of granularity? Using techniques from Bayesian networks, information theory, and decision theory, we develop a formal theory according to which causal representations reflect a trade-off between compression and informativeness, where the optimal trade-off depends on the decision-theoretic value of information for a given agent in a given context. This theory predicts that, all (...)
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  27. Glymour on evidential relevance.David Christensen - 1983 - Philosophy of Science 50 (3):471-481.
    Glymour's "bootstrap" account of confirmation is designed to provide an analysis of evidential relevance, which has been a serious problem for hypothetico-deductivism. As set out in Theory and Evidence, however, the "bootstrap" condition allows confirmation in clear cases of evidential irrelevance. The difficulties with Glymour's account seem to be due to a basic feature which it shares with hypothetico-deductive accounts, and which may explain why neither can give a satisfactory analysis of evidential relevance.
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  28. Exploitative informing.David Thorstad - forthcoming - British Journal for the Philosophy of Science.
    Informing others about the world is often a helpful act. In this paper, I study agents who conduct experiments to gather information about the world, committing in advance to fully disclose the nature of the experiment together with all experimental findings. While this appears to be a benign activity, I characterize a type of exploitative informing that is possible even within this restricted setup. I show how exploitative informants use public experiments to predictably manipulate interlocutors’ beliefs and actions to their (...)
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  29. Explanationism about Freedom and Orthonomy.David Heering - forthcoming - Journal of Philosophy.
    According to a popular idea, freedom is grounded in orthonomy – the ability to be responsive to normative demands. But how exactly must an agent’s action relate to their reasons in order for this orthonomous relationship to hold? In this paper, I propose a novel explanationist answer to this question. I argue that extant answers – causalism and modalism about orthonomy – fail because they fail to account for the fact that intuitions about freedom and orthonomy track facts about explanation. (...)
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  30. Shepherd’s Claim that Sensations Are too Fleeting to Stand in Causal Relations with Other Sensations.David Landy - forthcoming - Journal of Scottish Philosophy.
    Shepherd argues that we can know that there exists a universe external to the mind because that universe is the only possible cause of our sensations. As a part of that argument, Shepherd eliminates the possibility that sensations might be caused by other sensations on the grounds that sensations are merely momentary existences and so not capable of standing in causal relations with each other. And yet she claims that sensations do stand in causal relations to other objects, both as (...)
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  31. The irrelevance of bootstrapping.David Christensen - 1990 - Philosophy of Science 57 (4):644-662.
    The main appeal of the currently popular "bootstrap" account of confirmation developed by Clark Glymour is that it seems to provide an account of evidential relevance. This account has, however, had severe problems; and Glymour has revised his original account in an attempt to solve them. I argue that this attempt fails completely, and that any similar modifications must also fail. If the problems can be solved, it will only be by radical revisions which involve jettisoning bootstrapping's basic approach to (...)
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  32. (1 other version)Lifeworld, Place, and Phenomenology: Holistic and Dialectical Perspectives.David Seamon - 2024 - Journal of Philosophical Investigations at University of Tabriz 18 (48):31-52.
    In this article, I clarify the phenomenological concept of lifeworld by drawing on the geographical themes of place, place experience, and place meaning. Most simply, lifeworld refers to a person or group’s day-to-day, taken-for-granted experience that typically goes unnoticed. One aim of phenomenological research is to examine the lifeworld as a means to identify and clarify the tacit, unnoticed aspects of human life so that they can be accounted for theoretically and practically. Here, I discuss some key phenomenological principles and (...)
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  33. Why AIs Cannot Play Games.David Koepsell - manuscript
    This paper explores the human experience of game-playing and its implications for artificial intelligence. The author uses phenomenology to examine game-playing from a human-centered perspective and applies it to language games played by artificial intelligences and humans. The paper argues that AI cannot truly play games because it lacks the intentionality, embodied experience, and social interaction that are fundamental to human game-playing. Furthermore, current AI lacks the ability to converse, which is argued to be equivalent to Wittgenstein’s view of engaging (...)
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  34.  97
    Semantic Error Prediction: Estimating Word Production Complexity.David Strohmaier - 2024 - Proceedings of the 13Th Workshop on Natural Language Processing for Computer Assisted Language Learning 13:209-225.
    Estimating word complexity is a well-established task in computer-assisted language learning. So far, however, complexity estimation has been largely limited to comprehension. This neglects words that are easy to comprehend, but hard to produce. We introduce semantic error prediction (SEP) as a novel task that assesses the production complexity of content words. Given the corrected version of a learner-produced text, a system has to predict which content words replace tokens from the original text. We present and analyse one example of (...)
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  35. In Defense of Definitions.David Pitt - 1999 - Philosophical Psychology 12 (2):139-156.
    The arguments of Fodor, Garret, Walker and Parkes [(1980) Against definitions, Cognition, 8, 263-367] are the source of widespread skepticism in cognitive science about lexical semantic structure. Whereas the thesis that lexical items, and the concepts they express, have decompositional structure (i.e. have significant constituents) was at one time "one of those ideas that hardly anybody [in the cognitive sciences] ever considers giving up" (p. 264), most researchers now believe that "[a]ll the evidence suggests that the classical [(decompositional)] view is (...)
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  36.  91
    Toothlessness Is Not a Problem for Normative Realism: A Reply to Barta.DiDomenico David - 2024 - Southwest Philosophy Review 40 (2):83-88.
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  37. What is relative confirmation?David Christensen - 1997 - Noûs 31 (3):370-384.
    It is commonly acknowledged that, in order to test a theoretical hypothesis, one must, in Duhem' s phrase, rely on a "theoretical scaffolding" to connect the hypothesis with something measurable. Hypothesis-confirmation, on this view, becomes a three-place relation: evidence E will confirm hypothesis H only relative to some such scaffolding B. Thus the two leading logical approaches to qualitative confirmation--the hypothetico-deductive (H-D) account and Clark Glymour' s bootstrap account--analyze confirmation in relative terms. But this raises questions about the philosophical interpretation (...)
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  38. Skeptical problems, semantical solutions.David Christensen - 1993 - Philosophy and Phenomenological Research 53 (2):301-321.
    This paper defends the legitimacy of semantical responses to certain skeptical challenges, with a particular focus on Putnam’s treatment of a particular version of Brain-in-Vat skepticism. It argues that while Putnam’s argument does not provide a general reply to Brain-in-Vat skepticism, the general approach it exemplifies is actually crucial in replying to other skeptical challenges that are otherwise hard to rebut.
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  39.  64
    Plurals, mass nouns and reference: philosophical issues.David Nicolas - forthcoming - In Hilary Nesi & Petar Milin (eds.), International Encyclopedia of Language and Linguistics. Elsevier.
    How do plurals and mass nouns refer? What kind of logic should be used in order to account for the truth-conditions of the sentences they appear in? For linguists, first-order predicate logic is adequate, provided it is supplemented by a notion of mereological sum for plurals and for mass nouns. On the contrary, according to some philosophers, new logics must be used, plural logic for plurals and mass logic for mass nouns. We survey these debates in this entry.
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  40.  60
    The Epistemic Insignificance of Doxastic Wronging.DiDomenico David - forthcoming - Southwest Philosophy Review.
    Doxastic wronging is wronging that occurs in virtue of a belief. What epistemic significance, if any, does doxastic wronging have for the normativity of inquiry? Recently, some philosophers have defended views according to which doxastic wronging has an epistemic impact on the norms governing belief formation and revision. In this paper, I sketch a theory of the zetetic significance of doxastic wronging that denies its epistemic significance. In other words, although doxastic wronging is relevant to the normativity of inquiry, it (...)
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  41.  60
    The Conceptual Ecology of “Dysbiosis”.David Kelley - forthcoming - Biological Theory.
    “Dysbiosis” is a common but vague term featured in the microbiome literature, often invoked to indicate some kind of imbalance among microbiota. There is no agreement on how to define or even characterize dysbiotic microbiomes. Building on the work of Morar and Bohannan, who explore five interpretations of “microbiome,” I offer a short supplemental analysis of what plausibly counts as “dysbiosis” according to each of the five distinct conceptions. My aim is to provide a more nuanced basis for interpreting claims, (...)
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  42.  58
    Autism is not a spectrum.David Kelley - 2024 - Research in Autism Spectrum Disorders 115.
    Autism Spectrum Disorder is a diagnosis applicable to a vast range of presentations. However, there are disadvantages to theorizing and communicating about autism as a single spectrum. This paper suggests an alternative or supplementary multi-dimensional approach for diagnosticians and educators – an approach that more accurately reflects our understanding of autism.
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  43.  38
    The Meno.David Ebrey - 2024 - In Vasilis Politis & Peter Larsen (eds.), The platonic mind. New York, NY: Routledge. pp. 32-45.
    The Meno includes some of Plato’s best known epistemological puzzles and theories, as well as classic discussions of so called Socratic ethics. It also includes important examples from mathematics and an argument that the soul exists before birth – topics which, as far as we can tell, did not especially interest the historical Socrates. Because it discusses these topics without presenting bold metaphysical claims about the forms, it is often considered a “transitional dialogue,” coming between Plato’s (allegedly) early, Socratic dialogues (...)
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  44. The Listening Self: Personal Growth, Social Change and the Closure of Metaphysics.David Michael Levin - 1989 - Routledge.
    In a study that goes beyond the ego affirmed by Freudian psychology, David Levin offers an account of personal growth and self-fulfillment based on the development of our capacity for listening. Drawing on the work of Dewey, Piaget, Erikson, and Kohlberg, he uses the vocabulary of phenomenological psychology to distinguish four stages in this developmental process and brings us the significance of these stages for music, psychotherapy, ethics, politics, and ecology. This analysis substantiates his claim that the development of (...)
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  45.  36
    Straff som fortjent: Et negativt krav eller et selvstendig formål for norsk strafferett?David C. Vogt - 2024 - Tidsskrift for Strafferett 24 (2):122-144.
    Ideen om at lovbrytere fortjener straff, må legges til grunn dersom vi skal kunne forstå og begrunne strafferetten i Norge og i andre rettsstater. Av noen teoretikere har dette kravet til fortjent straff blitt forstått som et negativt krav, som setter en begrensning på oppnåelsen av straffens formål. Straffen må da være «ikke ufortjent». I denne artikkelen argumenterer jeg for at en slik forståelse av fortjenesteideen er utilstrekkelig. Straff som fortjent må ansees som et positivt, selvstendig formål for strafferetten. Artikkelen (...)
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  46.  16
    Philosophy moves and meta-moves.David Kelley - 2024 - Analysis.
    Philosophers sometimes refer to ‘moves’ made in the context of a philosophical debate. Once familiar with these recognizable tropes, we then possess them as tools – a suite of possible moves to make in novel contexts. In this paper, I outline three such philosophy moves, then demonstrate how moves can be combined. Examples of moves and some combinations feature throughout the paper.
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  47. The completeness of physics.David Spurrett - 1999 - Dissertation, University of Natal, Durban
    The present work is focussed on the completeness of physics, or what is here called the Completeness Thesis: the claim that the domain of the physical is causally closed. Two major questions are tackled: How best is the Completeness Thesis to be formulated? What can be said in defence of the Completeness Thesis? My principal conclusions are that the Completeness Thesis can be coherently formulated, and that the evidence in favour if it significantly outweighs that against it. In opposition to (...)
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  48. The God of Abraham, Isaac, and (william) James.David W. Paulsen - 1999 - Journal of Speculative Philosophy 13 (2):114-146.
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  49. Introduction.Suzanne Foisy & David Kolb - 2000 - Dialogue 39 (4):651.
    Introduction to a volume on Hegel, asking why his thought continues to be relevant today.
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  50. Causally Inefficacious Moral Properties.David Slutsky - 2001 - Southern Journal of Philosophy 39 (4):595-610.
    In this paper, I motivate skepticism about the causal efficacy of moral properties in two ways. First, I highlight a tension that arises between two claims that moral realists may want to accept. The first claim is that physically indistinguishable things do not differ in any causally efficacious respect. The second claim is that physically indistinguishable things that differ in certain historical respects have different moral properties. The tension arises to the extent to which these different moral properties are supposed (...)
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